... accumulation of a somatic deletion ofmitochondrial DNA in aging human tissues. Proc. Natl Acad. Sci.USA 89, 7370–7374.24. Katayama, M., Tanaka, M., Yamamoto, H., Ohbayashi, T.,Nimura, Y. & ... MINIREVIEWMitochondrial DNA deletion mutations A causal role in sarcopeniaDebbie McKenzie, Entela Bua, Susan McKiernan, Zhengjin Cao, Jonathan Wanagat and Judd M. AikenDepartment of Animal ... lack of histone cognates [10] andthe minimal repair systems [11] in the mitochondria (ascompared to the nucleus) increase the likelihood ofoxidative damage occurring and being maintained in...