... interactionswith indinavir. In contrast, PRL90Mshowed fewer van derWaals contacts with indinavir, the main chain atoms ofresidues 80–82 were further from the indinavir, and the sidechain of Met90 and ... flapsnear the mutated Ile46, and in the interactions of the mutated Thr82 and Val84 with indinavir [18]. Local changes in the mutated residues were also observed in the crystalstructure of the L63P/V82T/I84V ... a residue in the active site of the protease that is critical to inhibitor binding, L90M isdistal to the inhibitor-binding site and is located near the dimerization interface. The kinetic parameters...