Báo cáo Y học: Changes in ultrastructure and the occurrence of permeability transition in mitochondria during rat liver regeneration ppt
Báo cáo Y học: Changes in ultrastructure and the occurrence of permeability transition in mitochondria during rat liver regeneration ppt
... phase of liver regeneration, the changes in mitochondrial ultrastructure observed in liver specimenswere correlated with Ca2+-induced permeability transition in mitochondria. Keywords: liver regeneration; ... Italy;2Department of Zoology, Laboratory of Histology and Comparative Anatomy, University of Bari, Italy;3Center for the Study of Mitochondria and Energy Metabolism (CNR) Bari, ItalyMitochondrial bioenergetic ... amount of cytochrome c in cytosol and mitochondria during rat liver regeneration was determined by SDSpolyacrylamide gel electrophoresis analysis, as described bySchaegger et al. [23]. Mitochondrial...
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Báo cáo y học: "HLA-DR regulation and the influence of GM-CSF on transcription, surface expression and shedding
... bbiiooggrraapphh y y Sara Perry obtained her BSc in Microbiology and Immunology from University of Leeds, and PhD in Immunology from University of Liverpool, where she worked on the expression of HLA-DR ... mentioned otherwise]. Both the percentage of cells expressing HLA-DR on monocytes and the density of HLA-DR was measured. Immuno-fluorescent microscopy of HLA-DR in PBMC Cytospins of PBMC obtained ... show the intracellular and surface staining of PBMC in a healthy control and from a septic patient. These images illustrated a high intracellular expression of HLA-DR within the PBMC in septic...
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Báo cáo y học: "Lifetime health effects and medical costs of integrated stroke services - a non-randomized controlled cluster-trial based life table approach"
... men and 69.84 per 100,000 women [1]. The incidence rates in the Netherlands have only fluctuatedaround the same level since the early 1990 s. Yet, mor-tality has been steadily declining [1]. The ... using original length of stay data and 2003nursing day prices. Subsequently, total individual costs of care during the first six months were computed byholding the original ratio between inpatient ... case-fatality rate of stroke, probability of dis-ability after stroke, and the four probabilities of death -affect patients’ courses in the same way as they did in the original life-table model [5]. The...
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Báo cáo khoa học: Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways ppt
... that the mecha-nism underlying the recognition of protein quality actsthrough the sensing of free circulating amino acidsresulting from the intestinal digestion of proteins [4,5].Another ... partially or totally devoid of a given essentialamino acid.Our data suggest that the GCN2 pathway is directlyinvolved in the regulation of amino acid and proteinmetabolism, as many of the genes involved ... accumulation during amino acid starvation[7,18]. Once activated, GCN2 phosphorylates the trans-lation initiation factor, eukaryotic initiation factor 2a,thereby impairing the synthesis of the 43S preinitiationcomplex...
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Báo cáo khoa học "ADIABATIC TEMPERATURE RISE AND REACTION RATE OF MASS STRUCTURE IN LOTTE CENTER HANOI PROJECT " pptx
... procedure in the case of using fly-ash in designing binder quantity it is assumed that the total hydration heat would be decreased and the peak point of hydration heat for the total amount of binder ... within 18 days through minimizing binders in concrete and adjusting hydration heat and delay setting time between the former and the latter placed concrete. Keywords: mass concrete, hydration ... temperature rise and reaction rate according to property and quantity of cement. In order to analyze hydration heat of concrete, thermal property of concrete that is related to Adiabatic temperature...
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Báo cáo Y học: A comparative biochemical and structural analysis of the intracellular chorismate mutase (Rv0948c) from Mycobacterium tuberculosis H37Rv and the secreted chorismate mutase (y2828) from Yersinia pestis pptx
... Yersiniapestis (*YpCM, y2 828), purification of the protein,investigation of the properties of the enzyme, and the crystal structure analysis of the protein.Results and DiscussionAnnotation of CMs in M. ... for the low kcat and high Kmexhibited by MtCM is the absence of two of the substrate-binding residues found in the C-terminus of EcCM (Fig. 1). In contrast,*YpCM, in which all the catalytic ... shown in stick form, and the rest of the structure is in cartoon form. In EcCM, one polypeptide chain is gray and the other is rose. In 90-MtCM, one polypeptide chain is blue and the other is...
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Báo cáo Y học: Synthesis, conformational analysis and biological activity of cyclic analogs of the octadecaneuropeptide ODN Design of a potent endozepine antagonist pot
... 2 s in the vicinity of individual cells by a pressureejection system. The indicated doses of peptides correspondto the concentration contained in the ejection pipette.Measurement of polyphosphoinositide ... reactivation,followed by side-chain deprotection and cleavage of the peptide from the resin, RP-HPLC analysis revealed the occurrence of a new major peak eluting at 18.6 min and the disappearance of the linear ... containing the Fmoc-peptidyl(resin)-OAl using an Ar flushed gas-tight syringe and gently agitated for 2.5 h at room temperature. The resinwas then washed sequentially with fresh catalyst dissolvingmixture,...
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Báo cáo Y học: Azidothymidine causes functional and structural destruction of mitochondria, glutathione deficiency and HIV-1 promoter sensitization pptx
... cysteine-containing tripeptide (c-glutamyl-cysteinyl-glycine), is abundantly expressed in eukaryoticcells, and plays an important role in regulation of cellularredox potential by eliminating ... detected in AZT-induced cardiomyopathy in rats [7]. Despite the significance of these problems in drugdesign and clinical application, the process of the functional and structural destruction of mitochondria caused ... directly impair the energy-producing system of mitochondria, causing dysfunction of cellular redox control,which eventually leads to loss of the mitochondrial DNAintegrity. The mechanism of cellular...
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Báo cáo Y học: Ascidian arrestin (Ci-arr), the origin of the visual and nonvisual arrestins of vertebrate pdf
... apparently close from the viewpoint of the aminoacid sequence similarity and the position of the intron to the vertebrate type of arrestin (Fig. 1). Therefore, it may bepresumed that the function ... Subsequently, asoluble regulatory protein, arrestin, binds with high affinityto the phosphorylated receptor to sterically inhibit the interaction of the receptor with G protein, resulting in the shutting-down ... Recently, the specificarginine residues (R394 and R396 for b-arrestin2) in b-arrestin that mediate its binding to AP2 were identified[23]. The presence of the clathrin-binding domain and AP2binding...
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Báo cáo y học: "Endoscopic Facet Debridement for the treatment of facet arthritic pain – a novel new technique
... present within the joint, dorsal root axons should be incapable of re-innervating the joint. In this study we investigate the long-term effi-cacy of facet debridement for the treatment of chronic ... is made in the skin at the entry site. A guide wire is inserted down to the facet joint and then secured into the joint surface. A dilation system is inserted over the guide wire and used ... surveys, 40-45% of patients had evidence of facet joint pain based on anesthetic nerve blocks 9 10. Conservative therapy for facet joint pain consists of rest, physical therapy, and short-term...
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