Báo cáo Y học: Suppression of apolipoprotein C-II amyloid formation by the extracellular chaperone, clusterin potx
Báo cáo Y học: Suppression of apolipoprotein C-II amyloid formation by the extracellular chaperone, clusterin potx
... to the inhibition observed at the higher concentrations of apoC-II. Amyloid fibril size is reduced by the presence of clusterin The effect of clusterin on the aggregation-state of apoC-II amyloid ... aninhibitory effect of clusterin on amyloid formation by Ab,and a fragment of the prion protein [26,27]. In thisinvestigation, we explore the effect of clusterin on amyloid formation by apoC-II and provide ... Biosciences, University of Sydney, NSW, Australia The effect of the extracellular chaperone, clusterin, on amyloid fibril formation by lipid-free human apolipoprotein C-II (apoC-II) was investigated....
- 6
- 300
- 0
Báo cáo y học: "Effect of corticosteroids on phlebitis induced by intravenous infusion of antineoplastic agents in rabbits"
... induced by intravenous infusion of antineoplastic agents re-duces the completion of chemotherapy. The causative factors of phlebitis include the pH and osmotic pres-sure of the solution, the size ... histopathologically. The effect of DEX on VNR-induced phlebitis was evaluated by infusion of DEX before or after VNR. The effect of PSL on DXR-induced phlebitis was similarly evaluated by co-infusion of PSL. ... was found in the proximal part of the vein in 6 of the 8 animals and in the distal part of the vein in 7 of the 8 animals. Epidermal degeneration (Grades 1-3) was found in both the proximal...
- 6
- 711
- 0
Tài liệu Báo cáo Y học: Inhibition of nuclear pre-mRNA splicing by antibiotics in vitro pot
... into the splicing-compatible tertiary structure by the charged groups of these antibiotics. The macrolide, erythromycin, the strongest inhibitor, had only a slight eect on formation o f the presplicing ... ininhibition of spliceosome assembly. Formation of the presplicing complexes A and B was slightly reduced by increasing concentrations of erythromycin (lanes 5±7).Interestingly, formation of complex ... extent of splicing inhibition by tetracycline is n egligible (Fig. 2). The sixfold stron gersplicing inhibition by Cl-tetracycline may be explained by the a dditional s ize and hydrophobicity introduced...
- 9
- 586
- 0
Tài liệu Báo cáo Y học: Induction of (2¢)5¢)oligoadenylate synthetase in the marine sponges Suberites domuncula and Geodia cydonium by the bacterial endotoxin lipopolysaccharide docx
... identified by thin-layer chromatog-raphy, immunologically and by high-performance liquidchromatography. The biological activity of (2–5)A oligo-mers was verified by inhibition of the protein synthesis ... the (2–5)A pathway is also induced by interferons [15]. The major enzyme in this pathway, the (2–5)A synthetase catalyzes the synthesis of a series of 2¢)5¢-linked oligoadenylates, termed (2–5)A ... microorganismsis the (2¢)5¢)oligoadenylate synthetase [(2–5)A synthetase]system [11–13]. The (2–5)A synthetase(s) is activated by certain classes of RNA, mainly double-stranded RNA [14].In vertebrates the...
- 11
- 578
- 0
Tài liệu Báo cáo Y học: Toxicity of substrate-bound amyloid peptides on vascular smooth muscle cells is enhanced by homocysteine docx
... University of Heidelberg, Heidelberg, Germany;4 The School of Chemistry, The University of Melbourne, Parkville, Victoria, Australia The main component of cerebral amyloid angiopathy(CAA) in ... aggregationwasshowntocorrelatewith the toxic response in the VSMC. The duration of the Abageing by incubation at 37 °C was related to the amount of lactate dehydrogenase activity measured in the medium. The effect of aggregation ... 1–2 h afterplating.Cytotoxicity assayRelease of the cytoplasmic enzyme lactate dehydrogenaseinto the culture medium was used as a measure of cytotoxicity. Lactate dehydrogenase was determined...
- 9
- 376
- 0
Báo cáo Y học: Mechanism of 1,4-dehydrogenation catalyzed by a fatty acid (1,4)-desaturase of Calendula officinalis pptx
... were prepared by routes which were very similar tothose reported previously for the synthesis of the corres-ponding chiral monodeutero analogues [27]. Thus, the tosylate of 8-hydroxy-[8,82H2]octanoic ... (10 mL) of the S. cerevisiaetransformant (pYJ/DTY10-a2) using conditions identical tothat of the trial experiment. The deuterium content of the olefinic fatty acid methyl esters in the cellular ... effect[40]. In addition, partial masking of the ÔintrinsicÕ KIE by Fig. 1. Biosynthesis of linoleate and calendate catalyzed by (1,2) and(1,4)-desaturases, respectively. OPL, phospholipid ester; X, undefinedheadgroup.Fig....
- 6
- 341
- 0
Báo cáo Y học: Binding of Thermomyces (Humicola) lanuginosa lipase to the mixed micelles of cis-parinaric acid/NaTDC Fluorescence resonance energy transfer and crystallographic study ppt
... revealed by TLL-OA complex crystal structure. (A) Anti sn-1 position of the OA in the hydrophobic catalytic cleft of the open conformation of TLL(S146A). The REFMAC 2Fo-Fc electron density map of the ... flexibility f or the putative ligand in the active site region. This relaxation,together with the lack of steric h indrance created usually by the hydroxyl g roup of Ser146 in the w ild-type enzyme,results ... cavity, capable of accommodation of lipid analogues normally not acceptable by the wild-typeactive site. Secondly, the local perturbation caused by Ser146fiAla mutation may affect the stability of...
- 9
- 424
- 0
Báo cáo Y học: Effect of coenzymes and thyroid hormones on the dual activities of Xenopus cytosolic thyroid-hormone-binding protein (xCTBP) with aldehyde dehydrogenase activity potx
... On the otherhand, the ALDH activity was inhibited by NADH,NADPH, disulfiram, iodothyronines and Triac, but not by any of the steroids tested. We initially expected xCTBP/xALDH1 to be one of the ... shown). Thus, the secondpossibility is unlikely to occur in xCTBP/xALDH1.There are many reports of the inhibitory effects of thyroidhormones upon the activity of several dehydrogenases: pigheart ... EffectofT3on retinoic acid synthesis from retinal, catalyzed by xCTBP/xALDH1. ALDH activity was measured as the rate of retinoicacid synthesis. The reaction was performed at 24 °Cwith5lgofxCTBP/xALDH1...
- 8
- 405
- 0
Báo cáo Y học: Ruk is ubiquitinated but not degraded by the proteasome ppt
... were lysed and the quantity of protein measured by Bradford assay. 10 lg of total protein from each cell lysate was separated by SDS/PAGE. The level of exogenous EE-Ruk L was determined by Western ... recognized by the 26Sproteasome or, in certain cases, by the lysosomes/vacuoleand rapidly degraded. Ubiquitination of target proteinsinvolves a cascade of reactions catalysed by the E1, E2 ... regulated by tyrosine phosphorylation of Cbl [27]. It isbelieved that tyrosine phosphorylation at the C-terminus of Cbl induces a conformational change of the protein from aclosed to an open conformation,...
- 7
- 317
- 0
Báo cáo y học: " Implementation of a new emergency medical communication centre organization in Finland an evaluation, with performance indicators"
... However, the assessment of the outcome of the money spent to finance the EMSis generally not evidence-based [4]. A lack of structuredevaluations of organizational changes in the EMCC isevident. The ... highest priority to 7.4 percent of the calls compared to 3.6 percent in the old system. The highpriority cases not detected by dispatchers increased significantly (p < 0.001) in the new EMCC ... emergency calls were analyzed. Of these, 54 026 were from the municipality-basedcenters and 13 584 were from the new EMCC. Compared to the old municipality-based centers the new EMCCdispatched the...
- 5
- 495
- 0
Từ khóa: báo cáo y họcbáo cáo y học cổ truyềnmẫu báo cáo y học cổ truyềnbao cao y hoc colchicinphan ban luan trong bao cao y hoc co truyentài liệu báo cáo khoa học bản chất của khủng hoảng kinh tế thế giới pdfbáo cáo khoa học y họcbáo cáo y tế học đườngmẫu báo cáo y tế học đườngbáo cáo y tế học đường cuối nămbáo cáo y tế học đường năm 2012báo cáo y tế học đường trường mầm nonbiểu mẫu báo cáo y tế trường họcbáo cáo y tế học đường trường tiểu họcbáo cáo y tế trường tiểu họcBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Báo cáo quy trình mua hàng CT CP Công Nghệ NPVMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Định tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Thiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)QUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ