... genefamily and the circadian clockRemco Nagel1, Linda Clijsters1 and Reuven Agami1,21 Division of Gene Regulation, The Netherlands Cancer Institute, Amsterdam, The Netherlands2 Center for Biomedical ... sites for miR-192 ormiR-194. Whereas the Per1 3¢UTR contains onepredicted target site for miR-194, Per2 has a site for miR-192 as well as miR-194, and Per3 harbours oneputative site for miR-192 ... (Per1,Per2 and Per3), the Cryptochromes (Cry1 and Cry2) and Rev-Erb a [3,5,6]. Rev-Erba binds the BMAL1promoter directly to inhibit BMAL1 transcription,resulting in reduced CLOCK ⁄ BMAL1 levels and decreased...