... a,AP-2b and AP-2e inchondrogenesis and skeletal development In addition to Sox and Runx transcription factors,members of the AP-2 family also have important func-tions in chondrogenesis and development ... review givesan overview of AP-2s, and discusses the recent findings on the AP-2 family,in particular AP-2a, AP-2b, and AP-2e, as regulators of cartilage and skeletal development. AbbreviationsNCC, ... ED-rich tail 2 interacts with and co-activates all isoforms of AP-2, and the interaction withAP-2a is suggested to be necessary for normal neuraltube and cardiac development [30,31]. The Kru¨ppel-related...