Báo cáo khoa học: Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade pptx
Báo cáo khoa học: Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade pptx
... 2002 Suppression of uPAR by bikunin (Eur. J. Biochem. 269) 3957 Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated ... uPAR possibly through suppression of upstream targets of ERK. Thus, one of the functions of bikunin is theregulation of uPA synthesis and uPA binding by modulat-ing uPAR. It is most likely that ... program of gene expression; (i) bikunin transfection experiments demon-strated that uPAR expression is associated with an activeERK and the bikunin expression is necessary for inhibition of uPAR expression...
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Tài liệu Báo cáo khoa học: 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-c-dependent and mediated by the caspase-3-dependent apoptotic pathway doc
... fullyunderstood. It is not by suppression of Akt-1 tran-scription, as Akt-1 transcription is independent of PPARc (Fig. 3D). The inhibition or reduction of Akt-1 activity by PPARc agonists has been ... 96 h.Apoptosis was analyzed by AO ⁄ EB or Hoe-chst 33258 (Hoe ⁄ B.F) staining. (C) Quantita-tive analysis of GW9662 inhibition of adipocyte apoptosis. AO ⁄ EB, apoptosismeasured by AO ⁄ EB ... tostudy the effect of TZDs and PPARc on adipocyteapoptosis.In comparison with other cell types, adipocytes arequite resistant to apoptosis. The expression of highlevel of PPARc protein in...
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Tài liệu Báo cáo khóa học: Suppression of b1,3galactosyltransferase b3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans Lydia Mare and Marco Trinchera pdf
... of the malignant phenotype.Synthesis and expression of sLea is a relevant issue per se,as it is the epitope of the CA19.9 antigen, sometimes found tobe elevated in the serum of patients with ... low expression of b3Gal-T5 transcript as in the parental cellline (Fig. 2A). This indicates that antisense-mediatedmechanism of gene suppression does not involve transcriptsynthesis in this ... authors wish to thank N. Hiraiwa (Aichi Cancer Center, Nagoya,Japan) for the gift of pEFneo vector, Prof. R. Tenni (Department of Biochemistry, University of Pavia) for the help with radioisotopefacilities,...
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Báo cáo khoa học: Suppression of a cold-sensitive mutant initiation factor 1 by alterations in the 23S rRNA maturation region pdf
... notstrain-specific, but is a function of the mutant IF1allele.Fig. 6. A model of possible mechanism of suppression of IF1R69 mutant by 23S processing stem mutations. (A) Effect of the mutantIF1R69L ... the 5¢-side of theprocessing stem, gave rise to rRNA with the majority of termini in the mature form, whereas pD3, with amutation on the 3¢-side, gave rise rRNA with themajority of the termini ... likely by RNase III or other RNases; however, the blockage is incomplete, as shown by the existence of mature 23Stermini in all mutants. As these mutations were iso-lated as suppressors of a...
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Báo cáo khoa học: Suppression of NADPH oxidase 2 substantially restores glucose-induced dysfunction of pancreatic NIT-1 cells doc
... reversed by down-regulation of PTEN (Fig. 3C).P38MAPK and p53 mediate the apoptosis of NIT-1 cells induced by D-glucoseWe next explored the molecular mechanisms involvedin apoptosis of b-cells ... the apoptosis of NIT-1 cellsinduced by d-glucose. Suppression of NOX2 substantially restoresD-glucose-induced dysfunction and apoptosis of NIT-cellsTo investigate the potential role of the NOX ... is involved in the process of apoptosis mediated by p53. In addition, it is consideredthat apoptosis induced by d-glucose is mitochondria-dependent. A high level of glucose serves as a stimulusto...
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Báo cáo khoa học: Epidermal growth factor receptor-regulated miR-125a-5p – a metastatic inhibitor of lung cancer potx
... cells,showing significant expression of endogenous miR-125a-5p (data not shown), with antisense miR-125a-5p.After culture, angiogenesis was assessed with tubeformation assays. Consistent with its potential ... forEGFR signaling in the expression of miRNA listed inTable 1, we blocked EGFR signaling with gefitinib.Gefitinib is an inhibitor of tyrosine kinase that competes with ATP for binding to the ... miR-125a-5p expression is clinicallycorrelated with lung cancer metastasis. Interestingly, thepresent results, which showed miR-125a-5p negativelyregulating cancer cell metastasis, are consistent with...
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Báo cáo khoa học: G protein-coupled receptor 30 down-regulates cofactor expression and interferes with the transcriptional activity of glucocorticoid pdf
... down-regulated cofactor expression in hTERT-HME cellsGR affects gene transcription by a mechanism which is enhanced by cofactors. We therefore characterized the effect of GPR30 on the expression of receptors ... the expression of cofactor were due to GPR30protein expression. DiscussionMolecular discrimination of cells differing in their sensitivityto steroids is essential in diseases involving resistance ... the mechanism by whichGPR30 would interfere with GR mediated activation of transcription. We established that GPR30 down-regulatedthe expression of cofactor TIF2. The crucial r ole of cofactors...
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Báo cáo khoa học: Suppression of nuclear factor-jB activity in macrophages by chylomicron remnants: modulation by the fatty acid composition of the particles pot
... changed by any of the four types of CRLPs.Effect of the fatty acid composition of CRLPs onCOX-2 mRNA expression The effect of CRLPs of varying fatty acid compositionon expression of COX-2, ... severalisoforms of IjB exist, the most predominant is IjBa[15]. Phosphorylation of IjB by upstream kinasesresults in its Lys48-linked polyubiquitylation anddegradation, permitting translocation of ... fats (SFA) is associated with increased risk of atherosclerosis development, whereas intake of monounsaturated fats (MUFA) and polyunsaturatedfats (PUFA) of both the n-6 and n-3 series is beneficial[26,27]....
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Báo cáo khoa học: Complement factor 5a receptor chimeras reveal the importance of lipid-facing residues in transport competence doc
... binding analysis verified two receptor populations with distinct binding characteristics. Thehigh-affinity population (Kd1and Bmax1) is consistent with the known binding characteristics of the C5aRand ... Surprisingly, substituting the lipid-facingresidues of any of the TMs does not significantly alteroligomerization of the C5aR, as assessed by BRET.This is an important conclusion and fits with ... titrations with 3 lg of untagged C5a receptor. The expression levels of the tagged or nontaggedC5aRs correlate well with the amount of cDNA used forthe transient transfections [26; unpublished results]....
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Báo cáo khoa học: Thyroid hormone induces the expression of 4-1BB and activation of caspases in a thyroid hormone receptor-dependent manner pptx
... levels of the expression of each cDNA and of the reliability (Present/Absent call)were calculated with software (AFFYMETRIX MICROARRAYSUITEver.4.0). For comparisons of the expression level of ... TR is expressed.As well as treatment of the HeLaTR cells with T3,overexpression of 4-1BB in the HeLaTR cells led to theactivation of caspases. Activation of caspases by theoverexpression of ... such as N-CoR or SMRT is associated with thehomo- or heterodimer of TR and represses the transcriptionmediated by TR. Upon binding of T3 to TR, thecorepressor is displaced by a coactivator such...
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