... enter the spinalcord via the dorsal root, ascend in the dorsolateral funiculus, and then syn-apse on second-order neurons in the dorsal horn. The axons of the second-or-der neurons cross the ... the acetyl residue. Hence, the duration of the effect depends on the rate of enzyme resynthesis. Further-more, salicylate may contribute to the effect. ASA irritates the gastric mucosa(direct ... vertigo,drowsiness, etc. The search for bettertolerated drugs led to the family of non-steroidal antiinflammatory drugs (NSAIDs). Today, more than 30 sub-stances are available, all of them sharing the organic...