Báo cáo khoa học: Tumor necrosis factor-a converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation pptx

Tài liệu Báo cáo khoa học: Chromatin under mechanical stress: from single 30 nm ﬁbers to single nucleosomes pdf

... resistance of the DNA ⁄ histone contacts, amechanical unwrapping of DNA from the histone oct-amer will occur. If this release is discontinuous (i.e. acertain characteristic length of DNA is ... appeared not to be straightforward. Upon eviction of the histone octamer and histone H1 (i.e.the disruption of the chromatosome) 166 bp of DNA is expected to be released, i.e. 56.4 nm and not ... nucleosome (termedthe chromatosome [7]) is composed of an octamer ofcore histones (two each of H2A, H2B, H3 and H4), alinker histone and  166 bp ( 56 nm) of DNA [6].The histone octamer alone associates...

Tài liệu Báo cáo khoa học: Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo pptx

... et al. (2001) The mechanisms by which bothheterozygous peroxisome proliferator-activated receptorgamma (PPARgamma) deﬁciency and PPARgammaagonist improve insulin resistance. J Biol Chem 276,41245–41254.38 ... investigations that includeanalysis of pancreatic islet cells.The H-PGDS TG mouse is a novel obesity modelwith which to investigate the mechanism of adipogene-sis. As is the case for obese people ... min (Vector Laboratories, Burlingame,CA, USA), and this was followed by staining with theavidin–biotin–peroxidase complex system (Vectastain ABCKit; Vector Laboratories). Immunohistochemical...

Tài liệu Báo cáo khoa học: Regulators of G-protein signalling are modulated by bacterial lipopeptides and lipopolysaccharide pptx

... transcripts is regulated by a pathwayindependent of these two MAP kinases. It is possiblethat the modulation is due to the activation of JNK.Other MAP kinase inhibitors as well as G-proteininhibitors ... Kawai T, Kaisho T, Sato S,Sanjo H, Matsumoto M, Hoshino K, Wagner H,Takeda K et al. (2000) A Toll-like receptor recognizesbacterial DNA. Nature 408, 740–745.7 Latz E, Verma A, Visintin A, ... macrophages by microbes or their cel-lular components induces the release of differentinﬂammatory mediators. Stimulation of TLR leads to activation of a series of signalling proteins, and to theexpression...

Tài liệu Báo cáo khoa học: Limited suppression of the interferon-b production by hepatitis C virus serine protease in cultured human hepatocytes pptx

... Sciences, JapanPersistent infection by hepatitis C virus (HCV) fre-quently causes chronic hepatitis [1,2], which progresses to liver cirrhosis and hepatocellular carcinoma [3,4].This is a serious ... NF-kappaB by Toll-like receptor 3. Nature 413,732–738.14 Honda K & Taniguchi T (2006) IRFs: master regulatorsof signalling by Toll-like receptors and cytosolic pat-tern-recognition receptors. ... Julkunen I, Vitour D, Meurs E & Hiscott J(2006) Dissociation of a MAVS ⁄ IPS-1 ⁄ VISA ⁄ Cardif-IKKepsilon molecular complex from the mitochondrialouter membrane by hepatitis C virus NS3-4A...

Tài liệu Báo cáo khoa học: Regulation of dCTP deaminase from Escherichia coli by nonallosteric dTTP binding to an inactive form of the enzyme ppt

... similar froma regulatory point of view. dCMP deaminase is activa-ted by dCTP and inhibited by dTTP and both nucleo-tides act on the enzyme by binding to an allosteric site to alter the cooperativity ... dCTP and is inhibited by dTTP. Ourresults suggest that regulation of dCTP deaminase is not by a conventional allosteric mechanism, but appar-ently utilizes the property of the enzyme to exist intwo ... subtilis) a dCMP deaminase supplies dUMPdirectly by deamination of dCMP [4–6]. dCMP deami-nase is structurally related to cytosine- and cytidinedeaminases [7], which are all metallo enzymes...

Tài liệu Báo cáo khoa học: Protein kinase CK2 activates the atypical Rio1p kinase and promotes its cell-cycle phase-dependent degradation in yeast pdf

... Eukary-otic topoisomerase II is another target of proteinkinase CK2 which is essential for viability. However,the importance of CK2 phosporylation of topoisomer-ase II is not well understood, because ... ofprocesses, although within narrow limits, is likely to bedetrimental to cell life. Thus, moderate activation of theRio1p kinase upon phosphorylation by CK2 is in thesame range as observed with ... proteasome in order to establishcommitment for progression to the S phase. This wouldimply that Rio1p phosphorylation by CK2 constitutes asignal for its speciﬁc degradation upon G1⁄ S transitionand...

Tài liệu Báo cáo khoa học: A functional polymorphism of apolipoprotein C1 detected by mass spectrometry docx

... common form of TTr; 13881, the common form of TTrdisulﬁde-linked to cysteine; 13792, a variant form of TTr that mayconsist of G6S change; 13911, the variant protein that is disulﬁde-linked to ... ofb-VLDL to low-density lipoprotein receptor-relatedprotein [1,2]. It is implicated in regulation of severallipase enzymes [3–5]. An N-terminal 38-residue form ofApoC1 is able to inhibit cholesterol ... others to suggestthat the N-terminus is responsible for its regulatoryinteractions [28]. ApoC1 in HDLs [7] and an N-ter-minal 38-residue form of ApoC1 are able to inhibitcholesterol ester...

Tài liệu Báo cáo khoa học: Inhibition of pea ferredoxin–NADP(H) reductase by Zn-ferrocyanide docx

... theobserved Zn2+inhibition [15]. T his enzyme is a homo-dimeric molecule which contains FAD and belongs to theNAD-disulphide oxidoreductases class I group, which is led by the glutathione reductase ... obtained by expression inE. coli. B rieﬂy, a pET28-Fd expression vector was con-structed by inserting the cDNA corresponding to the mature pea Fd i nto the pET28a vector (Novagen Inc.,Madison, ... similarly to the pea enzyme withrespect to the inhibitor. In c ontrast, to obtain a compara bleinhibition of the Fd reduction catalyzed by pea FNR, $9times higher inhibitor concentration is needed....

Tài liệu Báo cáo khoa học: The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression ppt

... domain in its isolated form and in complex withRNAs and ⁄ or proteins. This review shows how such asimple domain can modulate its fold to recognizemany RNAs and proteins in order to achieve ... RNA-binding platform to regulate post-transcriptional gene expressionChristophe Maris*, Cyril Dominguez* and Fre´de´ric H T. AllainInstitute for Molecular Biology and Biophysics, Swiss Federal ... indicated in Figs 1 and 2) can havedifferent lengths and are often disordered in the free form. An exception to this is loop 5 that often formsa small two-stranded b-sheet (b3¢ and b3¢) (Fig. 2).The...

Tài liệu Báo cáo khoa học: Characterization of electrogenic bromosulfophthalein transport in carnation petal microsomes and its inhibition by antibodies against bilitranslocase docx

... cytoplasmand then translocated into the central vacuole, by mechanisms yet to befully characterized. The aim of this work was to determine whether ahomologue of rat liver bilitranslocase is ... on their protonation [15]. The thirdmodel is an ATP-energised mechanism catalysed by ATP-binding cassette transporters. They are insensitive to protonophores, strongly inhibited by vanadate ... site B afforded by bilirubin, or, other-wise, by an alternative conformation of the bilirubin–bilitranslocase complex, totally missed by antibody B.Cyanidin 3-glucoside was found to delay the...

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