Báo cáo khoa học: Hierarchical subfunctionalization of fabp1a, fabp1b and fabp10 tissue-speciﬁc expression may account for retention of these duplicated genes in the zebraﬁsh (Danio rerio) genome docx

... during embryogenesis and there-fore may not perform a function equivalent to mam-malian FABP1 during zebrafish embryogenesis. The distinct patterns of expression for the fabp1b (in the intestine) ... pattern of expression for the fabp1a, fabp1b and fabp10 genes in zebrafish, suggesting a division of func-tion for these orthogolous and paralogous gene products following theirduplication in the ... differences in the bindingaffinities of the zebrafish FABP1a and zebrafish FABP1b to the ligand molecules.Transcription start sites for fabp1a, fabp1b and fabp10 genes Amplification of the capped and mature...

Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

... directly involved in ligandbinding, presumably abolishing the interaction withsignaling partners. The remaining mutations alteramino acids located outside the ligand-binding pocket and reduce ... disease, thereby providing the missing data. The phenotype of XLA and the potential of BTK and ITK inhibitors The outcome of defective BTK signaling in humanshas been described previously in detail ... lymphoproliferative dis-ease. Arginine 335 is found in the ‘BG loop’ notinvolved in phosphotyrosine binding and mutation totryptophan most probably causes instability of the SH2 domain. Thus, these patients...

Tài liệu Báo cáo khoa học: Competition between innate multidrug resistance and intracellular binding of rhodamine dyes pdf

... mechanism of rhodamine dyes,agents allowing the enhanced uptake of rhodaminedyes inhibited the efflux of these dyes from the cells. The efflux of rhodamine 123 and TMRM was inhib-ited by NBD-Cl and ... accumulation of dyes, and probably certain drugs, in the cytoplasm. On the other hand, high-affinitybinding of these agents to intracellular receptors over-whelms the low levels of ABC transporters ... allows the estimation of the effect of intracellular binding on the MDR phenomenon. The data detailed obtained in the present study indicatethat innate cellular MDR interferes successfully withthe...

Tài liệu Báo cáo khoa học: DNA modiﬁcation with cisplatin affects sequence-speciﬁc DNA binding of p53 and p73 proteins in a target site-dependent manner pptx

... probability of formation of the cisplatinIACs within the p53DBSs due to the occurrence of the GG, AG and ⁄ or GNG motifs, the stronger the inhibition of the p53 sequence-specific DNA bindingto these ... DNA cis-platination on sequence-specific DNA binding of p73 proteinsWe tested the in uence of DNA modification withcisplatin on the binding of two p73 isoforms, p73d and p73b, to the p21 target ... The intensity of the resulting R73dband decreased almost linearly withincrease in the cis-platination level; for rb¼ 0.06,about 90% inhibition of p73d–p21 binding wasobserved. Almost the...

Tài liệu Báo cáo khoa học: Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores pdf

... This may indicate a role for the C-terminal helix of Bax in the formation of large pores, although it may also bedue to the in uence of this domain on the efﬁciency of membrane insertion. The ... hairpin found in the core of water-soluble folds of these proteins has been reported to be the pore-forming domain. Here we show that peptides including any of the twoa-helix fragments of the ... signaturedomain of Bcl-2s and other structurally analogouspore-forming proteins. They contain the segments that in the full-length, water-soluble Bax make the ﬁfth and sixth a-helices of the protein structure...

Tài liệu Báo cáo khóa học: Mutations in the hydrophobic core and in the protein–RNA interface affect the packing and stability of icosahedral viruses doc

... to the formation of cavities, one in the hydrophobiccore (M88V) and the other in the protein–RNA interaction(T45S), decrease the stability of the capsid. Our ﬁndingsilluminate the role of ... different from those of other simple icosahedralviruses [13]. The main chain of the protein subunit foldsinto a ﬁve stranded antiparallel b-sheet (strands bC–bG)facing the interior of the phage particle, ... assembly of anicosahedral virus is encoded in the native conformation of the capsid protein and in its interaction with the nucleic acid.Here we investigated how the packing and stability of viruscapsids...

Tài liệu Báo cáo khóa học: Determination by electrospray mass spectrometry and 1H-NMR spectroscopy of primary structures of variously fucosylated neutral oligosaccharides based on the iso-lacto-N-octaose core doc

... Leadeterminant.As the C3aion is at m/z 690, this excludes the possibility of the other Fuc being at the Gal next to the subterminalGlcNAc. The position of the second Fuc 3-linked to the internal ... function.One of the early demonstrations of the role of carbo-hydrates in recognition was binding of the in uenza virus tored blood cells via sialic acid [1], and later by work on the chemical basis of ... types. For a 3-linked GlcNAc or Glc, the D-typecleavage occurs at the glycosidic bonds of both reducing and nonreducing sides of the residue, by combined C-type and Z-type cleavages (see Results for...

Tài liệu Báo cáo khoa học: Arginine ethylester prevents thermal inactivation and aggregation of lysozyme pptx

... that the molecular mechanism of ArgEE in preventing thermalinactivation and aggregation is different from that of Arg.Thermal unfolding proﬁle of proteins in the presence of ArgEE In order to investigate ... more of the enzymes retained the active form after heat treatmentat 98 °C for 10 min in the presence of 100 mMArgEEat pH 6.5; under the same conditions, only 30% of the enzymes retained the ... shifted toalkaline pH (Fig. 2B, n).Interestingly, in the presence of 1.0MNaCl, the inacti-vation and agg regation c urves i n the presence of Arg are the same as those in the absence of additives...

Tài liệu Báo cáo khoa học: "Hierarchical Chunk-to-String Translation" ppt

... merits of the two models. Instead of parse trees, our model intro-duces linguistic information in the form of chunks,so it does not need to care the internal structures and the roles in the main ... the tree-to-string model. The two models differ in the form of rules and the way of estimating rule probabilities.While for decoding, we employ the same decodingalgorithm for the two models: ... sentence. The speed for the tree-to-string decoder includes the parsing time (0.23s) and the speed for the tight and loose models includes the shallowparsing time, too.extraction as: the height...

Tài liệu Báo cáo khoa học: Long-distance interactions between enhancers and promoters The case of the Abd-B domain of the Drosophila bithorax complex pdf

... transinteractions in favor of the latter. An increase in the trans inter-action results in an increase in the level of the functional Abd-Bprotein. Continuous lines represent the DNA of homologous ... difference in the tim-ing of somatic pairing perhaps reflects the differencebetween the complexities of the regulation of the twosystems: a longer time is required for the formation of the complex ... [11].However, these effects are observed only if at least onecopy of them is present in a transgenic insert, and the significance of this high affinity pairing in the regula-tion of the Abd-B is therefore...

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