Báo cáo khoa học: Cell biology, regulation and inhibition of b-secretase (BACE-1) potx

... biology, regulation and inhibition of b-secretase (BACE-1) Clare E. Hunt and Anthony J. TurnerProteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, ... Speciﬁcity of memapsin 1 and its implications on the design of memapsin 2 (b-secretase) inhibitor selectivity.Biochemistry 41, 8742–8746.Biology and chemistry of b-secretase (BACE-1) C. E. Hunt and ... Hunt and A. J. Turner Biology and chemistry of b-secretase (BACE-1) FEBS Journal 276 (2009) 1845–1859 ª 2009 The Authors Journal compilation ª 2009 FEBS 1859REVIEW ARTICLE Cell biology, regulation...

Tài liệu Báo cáo khoa học: Substrate speciﬁcity and inhibition of brassinin hydrolases, detoxifying enzymes from the plant pathogens Leptosphaeria maculans and Alternaria brassicicola ppt

... 85% inhibition of BHLmL2 and BHAb, respectively, while 1 mm 2-mer-captoethanol caused 85% and 97% inhibition of BHLmL2 and BHAb, respectively.The influence of pH on the activities of the BHenzymes ... 6 and Fig. 4, the Hill equation provided an excellent fit, withcoefficients of determination of 0.992 for BHLmL2 and 0.997 for BHAb. In addition, the fits of theV = f(S) curves were sigmoidal and ... methanol (200 lL) and ana-lyzed by HPLC using both methods A and B; quantifi-cation was carried out using integration of peak areas of 3-indolylmethanamine and a calibration curve of indolyl-3-methanamine...

Báo cáo khoa học: "SenseClusters: Unsupervised Clustering and Labeling of Similar Contexts" potx

... reported interms of the F-measure, which is the harmonic mean of precision and recall.The ﬁrst column in both tables indicates the possi-ble names or newgroups, and the number of contextsassociated ... thepercentage of the majority class (MAJ.) and count(N) of the total number of contexts for the namesor newsgroups. The majority percentage provides asimple baseline for level of performance, ... automat-ically assign descriptive and discriminating labels toeach discovered cluster that provide a characteriza-tion of the contents of the clusters that a human caneasily understand.2 Clustering MethodologyWe...

Tài liệu Báo cáo khoa học: Identiﬁcation, sequencing, and localization of a new carbonic anhydrase transcript from the hydrothermal vent tubeworm Riftia pachyptila docx

... overexpression approach of RpCAbr and RpCAtr, we cannot know the functionaleffect of changes of some key amino-acids.Origin and number of nonvertebrate CAsAlthough the bootstrap values of the deep branches ... 0.5 lL of BSA (10 mgÆmL)1),1 lL of total RNA (1.24 lgÆlL)1), 2.5 lL of dNTP (4 mmtotal), 1.5 lL of Random Primer 9 (Ozyme, St-Quentin-en-Yvelines, France) (100 ngÆlL)1), 3 lL of diethylpyro-carbonate. ... performed on cross sections of the branchial plume and of the trophosome asshown in Fig. 2A. The branchial plume is composed of a central obturaculum, mainly made of extracellularmatrix, supporting...

Tài liệu Báo cáo khoa học: ATP-dependent modulation and autophosphorylation of rapeseed 2-Cys peroxiredoxin docx

... (A)Expanded view of peaks at m ⁄ z 2800.36 and 2832.35 and the fragmentation of the peak at m ⁄ z 2800.36. (B) Expanded view of peaks atm ⁄ z 2934.36 and 2950.35 and the fragmentation of the ... C53S 2-Cys Prx. Expanded view of peaks at m ⁄ z 2800.36 and 2832.35 and thefragmentation of the peak at m ⁄ z 2832.35. 2-Cys Prx was digested with trypsin and prepared for MALDI-TOF MS as described ... group of peroxidases devoid of selenium- and heme-prosthetic groups, the peroxi-redoxins (Prx) (EC 1.11.1.15), catalyze the reduction of hydroperoxides and peroxinitrite [3–6]. The number of subfamilies...

Tài liệu Báo cáo khoa học: Preliminary molecular characterization and crystallization of mitochondrial respiratory complex II from porcine heart ppt

... G250, and the four bands corresponding tosubunits of porcine complex II were cut out and N-terminalsequenced by the Edman degradation method and amino acidanalyzer in the Department of Biology, ... preparation of complex II. The four subunits of complex II are labeled on the left, and the positions of molecular weight standards are indicated onlane 2.X. Huo et al. Characterization of respiratory ... activation and the conservation of energy in cell respiration.Nature 356, 301–309.9 Mitchell P (1961) Coupling of phosphorylation to elec-tron and hydrogen transfer by a chemi-osmotic type of mechanism....

Tài liệu Báo cáo khoa học: Unusual metal specificity and structure of the group I ribozyme fromChlamydomonas reinhardtii23S rRNA pptx

... Odom2 and David L. Herrin21 Department of Biochemistry, Tapei Medical University, Taiwan2 Section of Molecular Cell and Developmental Biology and Institute for Cellular and Molecular Biology, ... majority of product comes from the highly active fraction. Hence, plots of the percentage of total RNA that is InDGbyield n and m from Eqns 5 and 6.T C. Kuo et al. Mn2+ inhibition and structure of ... 23S.5DGbpre-RNA, and the binding of a minimum of n Mg2+ions leads to formation of theactive complex, whereas binding of a minimum of mMn2+ions forms the inactive complex. The sizes of the active and...

Tài liệu Báo cáo khoa học: Physico-chemical characterization and synthesis of neuronally active a-conotoxins docx

... spectrometry and the lability of the sulfogroup in mass spectrometryanalysis allows recognition of the modification, and differentiation of sulfotyrosine and phosphotyrosine [38].Characterization of the ... verification of tyrosine sulfation ina-PnIA and a-PnIB and revision of those sequences weremade in an investigation of labile sulfo- and phospho-peptides by electrospray MALDI and atmosphericpressure ... example of TVIIA [28] and perhaps the modifi-cation may not be critical. However there was no evidence of a variant of GID with proline in place of the singlehydroxyproline residue [5].Amidation of...

Tài liệu Báo cáo khoa học: "Beefmoves: Dissemination, Diversity, and Dynamics of English Borrowings in a German" ppt

... comparison of DU, DT,log10f with ∆ log10fquency (log10f). DU=Uw˜Uwis defined as the ratio of the actual number of users of word w (Uw) overthe expected number of users of w (˜Uw), ... in one of the German and English CELEXwordlists are automatically classified as such. Thisimproved classifier results over tokens and types, asseen in Table 1 in the comparison of token and typeprecision ... the number of cuts in each directionfrom the center, and m (=2), the minimum length of each part. Both halves are classified separately, and if the maximum anglicism classifier score out of allsplits...

Tài liệu Báo cáo khoa học: "Multi-Component TAG and Notions of Formal Power" docx

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