... isoniazid (INH) treatment of the latent TB infection (LTBI) according to the dynamic hypothesis. This treatment allows the drainage of the nonreplicating bacilli, and in the case of endogenous reinfection ... non-replicating bacilli resides in the necrotic tissue, and to drain all of the bacilli require the elimination of all this material, and this takes time. In fact, in the case of LTBI, where the lesions ... not obtain the real answer by just depleting the presence of a potential virulent factor in the cell wall of M.tb. In this context, efforts to discern the enzymes involved in the biosynthetic...