... Also other amino-glycosides, as kanamycin A, neomycin B and a syntheticneomycin-neomycin dimer have been shown to inducefragmentation of tRNAPheat Y3 7 and additionally atm7G46 in the variable ... results of the strand-break assay of yeasttRNAPhe in the presence of Ami, Cu(II)-Ami and the Cu(II)-Ami-H2O2system, performed by means of poly-acrylamide gel electrophoresis. Strikingly, in the ... complexation and generation of hydroxylradicals by another aminoglycoside, gentamicin has recentlybeen implicated in the mechanism of its toxicity [18,19].Aminoglycosides themselves, including Ami,...