Tài liệu Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients pdf
Tài liệu Báo cáo khoa học: An immunomodulator used to protect young in the pouch of the Tammar wallaby, Macropus eugenii pptx
... production of inter-leukins and secretion of immunoglobulins on the mucosal surface of the intestine [49,50]. The antibacte-rial defence of the intestinal mucosa depends in parton stimulation of CCK ... euge-nin, indicating that eugenin is indeed acting throughCCK2receptors.To further investigate the interaction of eugenin withCCK2receptors, we investigated the effect of eugeninon lymphocyte ... fractioncontaining eugenin is indicated by an asterisk in Fig. 2.Two further HPLC separations of the initial eugenin frac-tion (10–75% acetonitrile over a period of 60 min at a flowrate of 1 mLÆmin)1.)...
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Tài liệu Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients pdf
... various chemokines stimu-lated mainly by in ammatory cytokines, including IL-1b, TNF-a andIFN-c. (B) Chemokines expressed in the joint recruit leukocytes into the joints. In addition to functioning ... aG-protein that transduces the intracellular signal. The two major subclasses include the CC chemokines (where the cysteines are neighboring) and the CXC chemokines (where the cysteines are ... MINIREVIEW Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients Takuji Iwamoto1,2, Hiroshi Okamoto1, Yoshiaki Toyama2and Shigeki Momohara11 Institute of Rheumatology,...
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Tài liệu Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: role of environmental factors pdf
... 50–60% of the risk of devel-oping RA. Thus, environmental factors may explain the remaining risk of developing RA. A large variety of environmental factors such as infectiousagents, smoking, ... consequences of jointdestruction. Joint surgery is performed more frequently in female RA patients than in male patients. In addition,gender in uences the risk, as well as the pattern, of organ involvement ... replicative antigen impli-cated in the control of infection and that is expressedon the surface of lymphoblastoid cell lines and on the envelope of the budding virion during EBV replication.Table...
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Tài liệu Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: role of transcription factors ppt
... control of their synthesis or activity,including the inhibition of protein–protein interactions in the activating signaling cascade of the transcriptionfactor of interest. Specific inhibitors ... tissue. These compounds bindto two different intracellular proteins, namely FK506-binding protein (FKBP) and cyclophilin, and the drug–protein complex then binds to the interface of the calcineurin ... chronic in ammation of the joints. Both genetic and environmental factors areinvolved in the pathogenesis leading to joint destruction and ultimately dis-ability. In the in amed RA joint the synovium...
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Tài liệu Báo cáo khoa học: Erythrochelin – a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea docx
... attack of the L-hOrn3a-amino group onto l-haOrn4. Takinginto account that the synthetases involved in the bio-synthesis of the DKP-inheriting toxins thaxtominand fumitremorgin also contain ... pathogens, the interest in the structuraland functional characterization of these compounds isgrowing and may result in the synthesis of specificinhibitors based on the structure of the pathogensiderophore ... domains,suggesting the function of an initiation module mediat-ing the condensation of an external building blockwith the PCP-tethered substrate. Module 4 contains aC-terminal C-domain instead...
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Tài liệu Báo cáo khóa học: Point mutations associated with insecticide resistance in the Drosophila cytochrome P450 Cyp6a2 enable DDT metabolism doc
... respectively. Thesevariations of the ratios of the metabolites suggest modifi-cations in the catalytic mechanism responsible for the metabolism of DDT.Substrate binding The substrate induced binding ... mutatedpositions in CYP6A2 (helix J and vicinity of the b sheet 3–3).These results are also original because this is the firstdescription of the role of mutations in the metabolism of aninsecticide ... the opening of the pore containing helix I when placed on a spatial model(Fig. 3). This cluster is located diametrically to the polecarrying the amino acids involved in substrate binding. Asfar...
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Tài liệu Báo cáo khoa học: Control analysis as a tool to understand the formation of the las operon in Lactococcus lactis doc
... all the genesinvolved in the pathway in the same operon; the cellcan then respond quickly to changes in the environ-ment by changing the expression of only a few genesand using the protein-synthesizing ... by the second gene in the las operon (Fig. 1). In order to obtain strains with increased PK activity anadditional copy of the pyk gene was recombined into the TP901-1 attachment site using the ... contains only a singlepyk gene under the control of a synthetic promoter. The relative PFK activity in strain CS1929 was foundto increase to over 160% of the wild-type level,whereas the relative...
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Tài liệu Báo cáo khoa học: Long-distance interactions between enhancers and promoters The case of the Abd-B domain of the Drosophila bithorax complex pdf
... shifts the ratio between the strength (indica-ted by the thickness of the curved arrows) of the cis and transinteractions in favor of the latter. An increase in the trans inter-action results in ... pairing between these sequences within the BX-C plays a role in restricting the extent of loop-ing-out domains.Tethering elementsDeletion analysis of the Abd-B gene strongly suggests the existence ... difference in the tim-ing of somatic pairing perhaps reflects the differencebetween the complexities of the regulation of the twosystems: a longer time is required for the formation of the complex...
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Tài liệu Báo cáo khoa học: "Using adaptor grammars to identify synergies in the unsupervised acquisition of linguistic structure" docx
... terminal in the grammar. If Ais a terminal then GAis the distribution that puts all of its mass on the unit tree (i.e., tree consisting of asingle node) labeled A. If A is a nonterminal thenGAis ... parse of thatstring with a PCFG approximation to the adaptorgrammar. This PCFG contains a production for eachadapted subtree in the parses of the other strings in the training corpus. A final ... grammar, in which the subtrees are specified in advance, in an adaptor grammar the subtrees, aswell as their probabilities, are learnt from the train-ing data. In order to make parsing and inferencetractable...
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Tài liệu Báo cáo khoa học: "Man* vs. Machine: A Case Study in Base Noun Phrase Learning" pdf
... presented in one of four colors indicating that they: 1. are not part of an NP either in the truth or in the output of the person's rule set 2. consist of an NP both in the truth and in the ... recall vs. the number of appearances in the training set of each tag sequence for the machine and the mean of the top 3 students is shown in figure 3. For instance, for base NPs in the test ... for the extraction of terminological noun phrases. In Proceedings of the 30th Annual Meeting of the Association of Computational Linguistics, pages 977-981. Association of Computational Linguistics....
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