whose molecular function is still undefined
Báo cáo khoa học: Androgen receptor function is modulated by the tissue-specific AR45 variant ppt
... Identifica-tion of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct tran-scripts and that is able to repress hER-alpha activation function 1. EMBO J 19, ... signals were seen in other tis-sues, including testis (Fig. 2A). In comparison, verylow levels of the AR transcript were detected in heart,as compared to liver or testis (Fig. 2B). The transcriptlevels ... fluorescentbrainbraintestistestisliverliverprostateprostatelunglungtracheatracheamusclemusclebreastbreastheartheartkidneykidneyuterusbraintestisliverprostatelungtracheamusclebreastheartkidneyuterusuterusAR45S9ABCARFig. 2. Analysis of tissue distribution of AR45 by RT-PCR analysisof human RNA. First-strand cDNA from the indicated organswas used as...
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Tài liệu Chapter XIV Kinetic-molecular theory of gases – Distribution function doc
... field?Distribution of molecules is given by distribution functions.We will consider two such distribution functions:• Distribution on the height (or potential energy) in a gravitational field• Distribution ... :The function P(v) =gives the Maxwell-Boltzmann distribution function of molecular speeds.Remark that the Maxwell-Boltzmann distribution function dependson temperature. This dependence is shown ... CV= 3R The Maxwell-Boltzmann distribution function of molecular speedsP(v) =4/22/2008 19The function is known as the Maxwell-Boltzmannvelocity distribution function. In a velocity diagram,...
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Tài liệu Báo cáo khoa học: The Saccharomyces cerevisiae vacuolar acid trehalase is targeted at the cell surface for its physiological function docx
... alone is delivered to the vacuole by endocytosis,where it is hydrolyzed by the resident Ath1. However,this model requires the identification of a trehaloseendocytosis process and this is difficult ... that trehalase in the vacuole is likelyprompted to partial degradation and is not requiredfor cell growth on trehalose.The TM domain is indispensable for Ath1 function Previous studies have ... Arabidop-sis. Plant Physiol 125, 1086–1093.30 Frison M, Parrou JL, Guillaumot D, Masquelier D,Francois J, Chaumont F & Batoko H (2007) The Ara-bidopsis thaliana trehalase is a plasma...
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Tài liệu Báo cáo khoa học: The PA-TM-RING protein RING finger protein 13 is an endosomal integral membrane E3 ubiquitin ligase whose RING finger domain is released to the cytoplasm by proteolysis ppt
... TM sequence. Consistent with this, ouranalysis of cellular membranes washed with high-saltsolution establishes that RNF13 is indeed an integralmembrane protein. This is consistent with data ... that it is local-ized to the cytosol (data not shown).RNF13 expression is higher in adult than inembryonic tissuesGenome sequencing suggests that RNF13 is ubiqui-tously expressed. This is supported ... it has a TM domain. A recentstudy established that RNF13 is an E3 ubiquitin ligase whose expression is increased in pancreatic ductal ade-nocarcinoma tissues, suggesting that the protein mayparticipate...
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Tài liệu Báo cáo khoa học: It is all about resolution Meeting report based upon presentations at the 10th International Global BioMillennium 2006 symposium on molecular cell biology (Tbilisi, Georgia) docx
... geneexpression, and protein function. A particular aspect that is special to theBioMillenium series of conferences (this has been the 10th in this series) is the emphasis on new and emerging technologies; ... cellmasses. Pericellular proteolysis is hence a prerequisitefor expansive tumor growth, collective invasion andlarge-scale tissue reshaping. In contrast, single-cell dis-semination associated with ... interferon, butthe exchange rate in unstimulated cells is more than 10times lower. In this context Georgyi Los (Madison,WI, USA) and Marjeta Urh (Madison, WI, USA)described the use of a fusion between...
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Tài liệu Báo cáo khoa học: Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase d and S6K1 and regulating cell growth docx
... characteristic of thiskinase (Fig. 4D) [28].Comparison of the expression profiles of thehuman ER and POLDIP3 genesThe array of polyA+RNA isolated from 61 differenthuman adult tissues, seven ... conferringresistance to zeocin was transformed into the yeast strainL40 [MATa his3D200 trp1-901 leu2-3112 ade2 LYS2::(4-lexAop-HIS3) URA3::(8lexAop-lacZ) GAL4]. Five independ-ent zeocine-resistant ... gene has been iden-tified in eukaryotic organisms ranging from protists toplants to humans with the exception of fungi, in whichthis gene has not been isolated so far [1–5]. Moreover,it seems...
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Tài liệu Báo cáo khoa học: Identification of GAS-dependent interferon-sensitive target genes whose transcription is STAT2-dependent but ISGF3-independent doc
... targetgenes whose transcription is STAT2-dependent butISGF3-independentMelissa M. Brierley1, Katie L. Marchington1, Igor Jurisica2and Eleanor N. Fish11 Department of Cell and Molecular ... the existence of acollection of GAS-regulated target genes whose expression is IFN-inducibleand independent of ISGF3 but highly dependent on the STAT2 DNAbinding domain. This report is the ... genes.The c-fos gene was examined in this system as anexample of a GAS-driven gene whose IFN-inducibility is independent of both ISRE and STAT2. Our analysisconfirmed previous findings [21] that...
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Tài liệu Báo cáo khoa học: "THERE STILL IS GOLD IN THE DATABASE MINE" potx
... this panel, which is supposed to debate the necessity of continuing work in this area rather than to debate technical issues in the area. And yet if this problem has been solved, where is ... male or female". This same system, when asked for all the Michigan doctors and Pennsylvania dentists, produced a list of all the people who were either doctors or dentists and who lived in ... who lived in either Michigan or Pennsylvania. This is the state of our art? Instead of assuming that the problem is one of using typed English to access and/or update a file or files in a...
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Báo cáo khoa học: Molecular characterization of a novel nuclear transglutaminase that is expressed during starfish embryogenesis ppt
... nucleus of embryonic cells during theprogression of embryogenesis. This finding is consistentwith nTG being involved in the histone dimerizationreaction.We have shown that the treatment of ... Ikemagi, unpublished results).The acetylation of Lys5 of histone H4 competes with theTG-catalyzed histone dimerization reaction because a nacetylated lysine re sidue is not a functional amine ... uniqueproperty of nTG, not found in other TGs, is that itsdistribution is confined to the nucleus. Nuclear localizationof TG has been reported in the studies on tissue TG [8,9]. Anuclear transport protein,...
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Báo cáo khoa học: A region within the C-terminal domain of Ure2p is shown to interact with the molecular chaperone Ssa1p by the use of cross-linkers and mass spectrometry doc
... acquired in the data-depen-dent acquisition analysis or to build an inclusion list withthe light and heavy precursor masses for cross-linked candi-date peptides analysis. NanoLC-LTQ-Orbitrap data ... (2004)[URE3] prion propagation is abolished by a mutationof the primary cytosolic Hsp70 of budding yeast. Yeast21, 107–117.6 Savistchenko J, Krzewska J, Fay N & Melki R (2008) Molecular chaperones ... Ure2p is at the origin ofthe [URE3] trait in the baker’s yeast Saccharomycescerevisiae [1,2]. The propagation of the prion element[URE3] is highly dependent on the expression of anumber of molecular...
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Báo cáo khoa học: Weak oligomerization of low-molecular-weight protein tyrosine phosphatase is conserved from mammals to bacteria pot
... foruseful discussions. This work was partially supportedby funds from the Spanish Ministry of Education(BIO2007-63458 to MP). J.B. is a recipient of a pre-doctoral fellowship from the Spanish Ministerio ... witheukaryotic hosts. As such, the comparison with BPTP is expected to genuinely display the effects of evolution inlmwPTPs of two phylogenetically distant organisms.The very similar fold of YwlE ... Gaussian distribution. The newly gener-ated relaxation rate data set is fitted to the applied model.The process is repeated 100 times. The final error in the dis-sociation constants is equal...
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Báo cáo khoa học: Human haptoglobin structure and function – a molecular modelling study pptx
... variant displays two free Cys residues (Cys15and Cys74), whose participation in intermoleculardisulphide bonds gives rise to higher-order covalentmultimers [11].Data regarding the molecular ... presented here Cys15 is located on thetip of the N-terminal CCP domain. This latter location is consistent with the low steric hindrance required forthe formation of inter-chain disulphide bonds ... quaternary structure consists of a dimer cova-lently linked by a disulphide bond between Cys15 resi-dues of each a-chain. Accordingly, the molecular modelof dimeric HPT1 is formed through a tip-to-tiparrangement...
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Báo cáo khoa học: The highly conserved extracellular peptide, DSYG(893–896), is a critical structure for sodium pump function docx
... subsequently used to isolatemembrane fractions. Mutant or wild-type a1 subunits wereisolated from this mixture by immunoprecipitation with ananti-a1 immunoglobulin. As shown in Fig. 3, it is apparentFig. ... subunit is known to influence the interactions of theenzyme w ith K+and because Ser894 is within a sequenceknown to interact with the b subunits, it is possible thatmutations of this amino ... Scheiner-Bobis, G.(2001) A hybrid between Na+,K+-ATPase and H+,K+-ATPase is sensitive to palytoxin, ouabain, and SCH 28080. J. Biol. Chem.276, 2608–2615.27. Jaisser, F., Canessa, C.M., Horisberger,...
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Báo cáo khoa học: A hydrophobic segment within the C-terminal domain is essential for both client-binding and dimer formation of the HSP90-family molecular chaperone pptx
... proteins.Keywords: GRP94; HtpG; molecular chaperone; dimer;client binding.The 90-kDa heat shock protein (HSP90) is a ubiquitouslydistributed molecular chaperone and is an essential protein ineukaryotic ... possesses two distinct client-binding sites [14,15]: one of them is located in theN-terminal domain and its activity is modulated by ATPCorrespondence to T. K. Nemoto, Division of Oral Molecular Biology, ... charged region is truly indis-pensable for client binding or simply present adjacent to theclient-binding site with the result of being affinity-labeledwith the client peptide. This issue is now under...
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Báo cáo Y học: Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP pot
... not GSt alone, was ableto bind cytokeratin 18.Human tissular distributionTo examine the human tissue distribution of p76RBE,aMultiple Tissue Expression (MTETM) Array representing aFig. ... p76 in the uterus is restricted to the endometriumtissue and is not detectable in myometrium or uterine cervix.DISCUSSIONThyrotropin, via the adenylyl cyclase/cAMP pathway, is themost important ... [23]. This screening was aimed atisolating new proteins whose expression was regulated bythe thyrotropin-dependent pathway. Analysis of the aminoacid sequence of p76RBErevealed that it is homologous...
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- in this series of four minireviews the field of scaffold proteins and proteins of similar molecular⁄cellular functions is overviewed by binding and bringing into proximity two or more signaling proteins
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