... to the EGF receptor. A deletion in the N-terminal region of domain I impaired the EGF binding of ErbB-1 [21]. The N-terminus of EGF was linked to Tyr101 in domain I by using a covalent cross-linking ... [19,22]. The b sheet of EGF may bind to domain I of ErbB-1, and the other surface of the ligand binds to domain III ofthe receptor. Recently,Gly441 ofthe ErbB-1 domain III was proposed to beinvolved ... of these domainsexhibited reduced binding of 125I-labeled EGF. Particularly, the contribution of domain III was appreciably larger thanthat of domain I of ErbB-1 in 125I-labeled EGF binding.Nevertheless,...
... Turkey and the European Court of Auditors, at their meeting in Bucharest, adopted a resolution that included the following statement: In view ofthe importance ofthe theme and increased awareness ... ofthe consistency ofthe policy: Are the means employed by the policy consistent with the set objectives? ã Evaluation ofthe impact ofthe policy: What is the economic and social impact of ... audited (including a summary of the results of previous audits and their impacts); 3. Reasons for the audit; 4. Factors affecting the audit, including those determining the materiality of matters...
... for the logistics inthe main colonos-copy study (Popcol).HN wasthe mentor of LK and participated inthe facevalidity process ofthe translation. LK also participated in the writing ofthe ... questionnaire was first administered, was deemed as "moderate", withthe best result for GERS. Weconsider this acceptable in view oftheoutcomeofthe fac-tor analysis, the conditioning inthe ... as well as in clinical tri-als questionnaires are useful tools for obtaining broadinformation ofthe frequency of certain symptoms, andfor clustering of symptoms into domains. In clinical prac-tice...
... of their parents inthe same way as inthe first instance the parents took care of them. Twins are usually hailed with delight, because they swell the power ofthe family, though in some instances ... interminable singing, shouting, bell-jingling, horn-blowing, and other such merry noises ofthe moving caravan, could be seen disappearing inthe distance. Leaving the park, we now entered the ... wet one. Rising inthe Usagara hills to the west ofthe hog-backed Mkambaku, this branch intersects the province of Ukhutu inthe centre, and circles round until it unites withthe Kingani about...
... everything was apparently going our way.We waited in silence for the coming of Darius, allowing the Avenger to remain inthe stream where some of the boys had anchored her while I was caring for the ... that he was running toward the stairway.Now it was possible to see faint gleams of light coming through the cracks ofthe floor, and I realized that the newcomers had with them a lantern. The report ... corner!"There came the sound of hurried footsteps, and then the light ofthe lantern so far illumined the head of the stairway that I could see Darius, lying at full length on the floor, within a...
... But inthe centre ofthe continent, within 5Đ ofthe equator, we find the rains much more lasting. For instance, at 5Đ south latitude, for the whole six months that the sun is in the south, rain ... parents inthe same way as inthe first instance the parents took care of them.Twins are usually hailed with delight, because they swell the power ofthe family, though in some instancesthey are ... forded the Gombe nullah again in its upper course, called Kuale.Rising again up to the main level ofthe plantation, we walked into the boma ofthe chief of Unyambewa,Singinya, whose wife was...
... indicating that interaction with Smac is notrequired with respect to the role of HSP70 inthe inhi-bition ofthe release of Smac and apoptosis. The role ofthe ATP-binding domain of HSP70 in ... transfectedC2C12 cells. Furthermore, there was no direct interac-tion between HSP70 and Smac proteins, and the ATP-binding domain of HSP70, rather than the pep-tide-binding domain, was essential for ... ATP-binding domain of HSP70,rather than the peptide-binding domain, was essential for these observedHSP functions. Taken together, our results provide evidence supporting the role of HSP70 inthe protection...
... Accounting Office, the smoking rate among teenage girls quintupled in a single year following the opening ofthe market to the multinational tobacco companies. The evidence on the impact of price ... an IPM training approach in which farmers learn to observe the development of their crops and the numbers of pests and beneficial insects in their fields. Based on their analysis ofthe agricultural ... OED expressed a continuing concern over the quality and frequency ofthe data used in assessing these M&E indicators. One ofthe biggest concerns in this regard is the problem that current...
... language learning motivation into two types: the extrinsic concerning with factors outside the classroom, and the intrinsic, relating to activities inthe classroom. In their study of extrinsic motivation, ... use ofin learning and using a language (Richards, 2000: 445).Second language reading is a process of how the mind functions during reading rather than the product of reading. The focus on individual ... type of interview the interviewer can specify a range of questions to be coved in advance, but they can also formulate the wording ofthe questions as well as the order ofthe questions as the...
... writings inthe history of medicine have empha-sized either the intellectual development of medicine (the “internalist”approach) or the social, economic, and political context of medicine (the “externalist” ... seekingto practice humane medicine. ( The secret ofthe care ofthe patient,” hewrote, in words that have been immortalized, “is in caring for the patient.”45) In Peabody, the concept ofthe ... result, inthe judgment of virtu-ally every university and medical school leader ofthe period, the greatestsingle deficiency of medical education inthe early 1900s wasthe conduct of work in the...