what hormone is responsible for raising calcium blood levels
Báo cáo khoa học: A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme docx
... carnitine: 1 mm (for standard comparison withother published data), and a concentration equal tothe Km for carnitine of each enzyme (for comparisonbetween mutants). In this article, we show ... sequence as being responsible for the pecu-liar kinetic characteristics of this enzyme, acting as anegative determinant for malonyl-CoA sensitivity.Asp17 may account, at least in part, for the highdegree ... nat-urally occurring variation, Glu17, is responsible for both the low malonyl-CoA sensitivity and high carnitine affinity characteristics of the pig enzyme.This is the first demonstration that a single...
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Báo cáo khoa học: A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency doc
... active conformation, Val371 forms contactswith neighboring residues that are important for stabi-lizing the active state (e.g. Asp189, which is part of theS1 pocket responsible for the binding ... sequence identity of 30–45%), thisposition is occupied solely by a valine. This conservedamino acid is replaced by isoleucine in the Val371IleFXI mutant. Interestingly, an isoleucine residue natu-rally ... thesubstrate) [26]. Consequently, substitution of Val371 toisoleucine might prevent the full development of theactive conformation. This hypothesis is further con-firmed by the results of FIX proteolytic...
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Báo cáo khoa học: Direct CIII–HflB interaction is responsible for the inhibition of the HflB (FtsH)-mediated proteolysis of Escherichia coli r32 by kCIII docx
... factor that favors lysogeny and is responsible for primary control of the lambda develop-mental decision for lysis or lysogeny [4,7–9]. In theabsence of CIII, CII is rapidly degraded by the ATP-dependent ... However, this proteolysis is muchslower in vitro, because of a lack of chaperone machin-ery. The in vitro proteolysis requires ATP [14]. Weexamined the proteolysis of purified r32-C-his (1.2 ... CIII-mediated inhibition of proteolysis of r32by HflB is unknown.We tried to address this issue by studyingthe effects of CIII and CIIIC on the proteolysis ofKeywordsantiproteolytic activity;...
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Tài liệu Báo cáo khoa học: Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? docx
... prior to hydrolysis. The low-affinity state wasobserved to be retained immediately post-hydrolysis. Therefore, the dissoci-ation of phosphate and ⁄ or ADP is likely to be responsible for resettingof ... thatABCG2R482Gremains in a conformation that containsa low-affinity binding site for [3H]daunomycin imme-diately post-nucleotide hydrolysis.DiscussionA precise molecular mechanism for substrate translo-cation ... obtained from the hydrolysis process is used to reset the transporter. That ATP binding is responsible for the shift in binding affinity from high tolow has now been demonstrated for all three eukaryoticmultidrug...
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Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx
... hydrolysis), corresponding to that expected for theF variant. This result is the first evidence for the heterozy-gous status (M/F) of the individual goat milk analysed.In addition to this, t ... subsequently distin-guished after a second amplification which allows discrim-ination between the alleles on the basis of the f ragment sizes(Fig. 8 , Step IIA).In the first step, a 266-bp (265 bp for ... the origin of the as1-CasM allele. This is, to our knowledge, t he first hypothesis o f a genomicrecombination event to account for genetic polymorphismat a locus encoding a milk protein.MATERIALS...
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Báo cáo khoa học: The calcium-binding domain of the stress protein SEP53 is required for survival in response to deoxycholic acid-mediated injury pdf
... emission at 340 nmwhen Fura-2 is bound to calcium; B, excitation and emis-sion at 380 nm when Fura-2 is free). Intracellular calcium levels can then be calculated from Eqn (1) where Kd is ... clinical model that is giving novel molecularmechanistic insight is adenocarcinoma of the oesopha-gus [2]. This cancer is one of the fastest rising cancersin the west, is taking the place ... MoravianBiotechnologies. Calcium determinationsThe fluorescent indicator Fura-2 (Molecular Probes) wasused to measure cytosolic-free calcium levels in cells. WhenFura-2 is bound to calcium it is excited...
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Tài liệu What it is and How to Prepare pdf
... healthy adults may be at increased risk for problems. What Is Avian Flu? Avian flu, also called bird flu, is a disease found in wild and farm birds. There is a concern that the bird flu will ... 3. Listen for Information Stay calm and get as many facts as you can. • Listen for reports on the television, radio or Internet. • Go to www.pandemicflu.gov or www.ohiopandemicflu.gov for ... prepare: 1. Make a plan for you and your family at home. Plan for how a pandemic might affect your work. 2. Prepare an emergency kit of supplies. 3. Listen for information about what to do and where...
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Tài liệu Investigation of Organic Chemicals Potentially Responsible for Mortality and Intersex in Fish of the North Fork of the Shenandoah River, Virginia, during Spring of 2007 ppt
... (<34 ng/POCIS) NC (<14 ng/POCIS) 37 ng/POCIS 40 ng/POCIS20 ng/POCISEthopabate NC (<20 ng/POCIS) NC (<20 ng/POCIS) NC (<20 ng/POCIS) NC (<20 ng/POCIS) NC (<20 ng/POCIS) NC (<20 ... ng/POCIS)Endosulfan II NC (<10 ng/POCIS) NC (<10 ng/POCIS) NC (<10 ng/POCIS) NC (<10 ng/POCIS) NC (<10 ng/POCIS) NC (<10 ng/POCIS) NC (<10 ng/POCIS) NC (<10 ng/POCIS)cis-PermethrinNC ... (<4 ng/POCIS) NC (<4 ng/POCIS) NC (<4 ng/POCIS) NC (<4 ng/POCIS) NC (<4 ng/POCIS) NC (<4 ng/POCIS) NC (<4 ng/POCIS)Cyromazine NC (<20 ng/POCIS) NC (<20 ng/POCIS) NC (<20...
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Tài liệu Báo cáo khoa học: A DExD⁄ H box RNA helicase is important for K+ deprivation responses and tolerance in Arabidopsis thaliana docx
... re-organized for online delivery, but are notcopy-edited or typeset. Technical support issues arisingfrom supporting information (other than missing files)should be addressed to the authors.Analysis ... knowledge, this is the first reportof a plant DEVH box RNA helicase regulating K+deprivation tolerance. This study provides a valuablereference for future research in this area.ResultsAtHELPS is a ... worldwide distribution of K+ is incon-sistent [2]. In the tropics and subtropics, one-quarter ofthe soil has been threatened because of a lack of K+[3]. K+ is essential for plants, and is required...
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