... that the Eavalue in thistemperature range is considerably lowered. On the basis of the model, the behavior ofthe G261A variant can beinterpreted in terms of constraints introduced by the ... our incomplete under-standing ofthe relation between enzyme properties andconformational flexibility limits the exploitation ofthe fullpotential of protein engineering inthe redesign of psychro-philic ... respectively. By introducing an Ala residue inthe place of Gly it is expected that the conformational flexibility of the main chain can be constrained with a minimum perturba-tion ofthe local structure,...
... greenfield direct investments, total capitalinthe banking sector increasesleading to an overall improvement ofthe banking system and a decrease in ratio. On the other hand, foreign bank ownership ... does a transfer for the loan manager to cover the gain or lossgiven the realizations of M such that the net profit ofthe loan aggregator iszero. The insurance mechanism, or the transfer, is ... andchange in real exchange rate.While the minimum variance portfolio rationale may be true, it relieson obtaining forward looking variances ofin ation and change inthe realexchange rate. As these...
... UniversityRegional Learning Alliance – workforce development and training/collaborations with business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern Allegheny ... Programs and InitiativesBusiness accelerators and/or entrepreneurial initiativesLinking teaching and research to business opportunitiesCollaboration with local business and industrySmall Business ... innovation that can provide the impetus for economic developmentApplying knowledge and forming intellectual capital Nearly two-thirds of National Association of State Universities and Land-Grant Colleges...
... observed.SPR analysis of antigen-binding affinityFor the quantitative evaluation ofthe H39 mutation,kinetic analysis for antigen–Fv interaction of the wild-type and H39KQ mutant of purified Fv and scFvproteins ... not H39 is dominantly tuning the VH⁄ VLinteraction of other Fvs, including HyHEL-10. In addition, the effect ofthe H39 mutation on antigenbinding has not yet been analyzed. The reason for ... enhancement in VH⁄ VLinteraction signifi-cantly improved the antigen-binding affinity of Fv,similarly to the level of scFv (Table 2).Some single VHdomains of anti-protein IgG, inclu-ding...
... example, inthe case of questionQ209: “Who invented the paper clip ?”, the expected answer type is PERSON and so is the subject ofthe verb invented , lexicalized as the nominalization inventor. ... connect it to the original keyword. Theserelations can be translated in axiomatic form andthus participate to the abductive backchainingfrom the answer to the question - to justify the answer. For ... using PIRCS. Proceedings ofthe Text Re-trieval Conference (TREC-9), pages 26–35, 2000.Dan Magerman. Statistical decision-tree models of parsing. In Proceedings ofthe 33rd Annual Meeting of...
... understanding the psychological mechanism of changing consumers’ attitudes in gift receiving to establish appropriate marketing strategies. First, company can create, maintain or enhance the ... gift giving is instrumental in maintaining social ties and serves as a mean of symbolic communication in social relationship. Most ofthe researches before and after the appearance of Sherry’s ... easily change their brand attitude, may suggest an interesting implication for the new brand advertising strategy. Instead of focusing on the content ofthe message which only emphasizes the benefits...
... Opiela. Bank size, bank capital, and the bank lending channel.Journal of Money, Credit, and Banking, 32:121–141, 2000.R. P. Kishan and T. Opiela. Bank capital and loan asymmetry inthe transmission ... transmission of monetary policy. Journal of Banking and Finance, 30:259–285, 2006.B. Markovic. Bank capital channels inthe monetary transmission mechanism. Bank of England Working Paper 313, ... alsopresent in Canadian data (Illing and Paulin, 2004) and using alternative data sources(Adrian and Shin, 2008).15 The bank capital- asset ratio is the sum of tier1 and tier2 capital, over...
... college. These findings suggest that the process of accumulating school savings may have effects apart from financing school. Conley (2001) finds that a doubling of net worth results inan 8.3% increase ... factors other than desire and ability play an important rolein determining whether attending a four-year college is more than a dream for many American youth. Somewhat surprisingly, family income, ... significant. In addition to net worth, Nam and Huang (2009) include liquid assets (sum offinancial assets minus unsecured debt) and homeownership. They find that net worth is significant at the...
... This anomaly can beexplained by sequestration of Glc6P derived from glu-cokinase and hexokinase I in distinct pools [3,24], orby the involvement of mechanisms, additional toGlc6P, in mediating ... control of glycolysis and glycogen synthesis by glucokinase overexpres-sion. The validity of S4048 for testing theroleof Glc6P was supported byits lack of effect on glucokinase binding and its ... inhibitor of Glc6P transport into the endoplas-mic reticulum and thereby of Glc6P hydrolysis [31], as an experimental tool to modulate the Glc6P content in the absence of changes in rates of glucose...
... documents and find that the fea-ture vectors corresponding to some of these docu-ments (particularly the short ones) have all zeroes in them. In other words, none ofthe bigrams from the training ... processing techniques. In Proc. ofthe IEEE International Conference on Data Min-ing (ICDM).H. Yu and V. Hatzivassiloglou. 2003. Towards answer-ing opinion questions: Separating facts from opinions ... question answering. In New Di-rections in Question Answering. AAAI Press/MIT Press.K. Dave, S. Lawrence, and D. M. Pennock. 2003. Mining the peanut gallery: Opinion extraction and semantic clas-sification...
... required forbreaking the plant’s defence but, on the other hand,alkanes serve as nutritional input during the initial col-onization steps. Insect cuticle consists of protein andchitin, and is covered ... alkenes and methyl-branched chains in various ratios, depending on the insect species. In general, alkanes make up the biggest part of the hydrocarbon moiety and their chain length rangesbetween ... significant part of them. P450s areheme–thiolate proteins involved inthe hydroxylation of a wide range of endogenous and xenobiotic com-pounds. They are present in every eukaryotic organismand in...
... financing.Now examine the transaction from the vantage point of firm A, the floating-rate payer. The cost of synthetic floating-rate financing is determined by the cost of servicing fixed-rate debt plus the net ... can demand a higher interest rate upon refinancing, canfurther restrict the discretion of management, can engage in more intensivemonitoring, can take some combination of these actions, or can ... argue, trading in interest rate swaps has helped to complete forward markets and to lower the cost to firms of managing their exposure to interest rate risk. The Role for Hedging inthe Theory of Corporate...
... bridging the A’ and G b-strands ofthe I27 protein during the main unfold-ing barrier.[39]To further validate this view and gain insight into the roleof solvent hydrogen bonds in protein unfolding, ... rapidly, causing the unfolding of one of the I27 modules inthe chain. Unfolding then extends the over-all length ofthe protein, relaxing the pulling force to a lowvalue. As the slack inthe length ... A and B b-strands near the amino terminus of the protein domain causes an initial extension ofthe protein,before the unfolding transition state is reached.[53] The humpobserved both in the...
... can in turn encourage innovation inthe online marketplace and create new ways of doing business. It can also encourage social interactions and the exchange of ideas between organisations and ... Privacy Guidelines continue to serve as an international benchmark, providing guidance on the handling of personal information inthe private and public sectors, and the OECD‟s Information and Network ... maintained in multiple accounts within the organisation. The organisation is in some sense wasting resources and duplicating efforts in maintaining separate profiles with (mostly) the same information....
... favour ofan effect of the detergent on the interaction that maintains the recep-tor associated to these fractions rather than a conse-quence of a methodological artefact [91]. Importantly, in the ... muscarinic receptors, endo-thelin receptors, rhodopsin) are located in lipid rafts[65–70] where they are in close proximity to theirtransducing GTP-binding protein (Gs, Gi, Go, Gq andtransducin ... enriched in cholesterol and (glycero-)sphingolipids. In addition the fatty acid chains ofthe phospholipids composingthese rigid domains are generally more saturated thanthose inthe lipids of the...