thông tin ve tác giả thuyết minh đề ctronng tác giả đề xuất đề tài
Energy level alignment of semiconducting organic electronic devices
... situation of vacuum level alignment (S =1) when the anode’s work vac function ele is between the energy level of OSC’s interface positive polaron level P+ and negative polaron level P-, which is ... work function vac ele Transition from vacuum level alignment (S=1) to Fermi level pinning (S=0) occurs at the positive (negative) polaron level osc vac Fig.1.5 illustrates the relation of ele ... surveys the Vbi of several systematic families of model diodes of ITO (indium -tin oxide)/ PEDT/ OSC/ metal, with different metal cathodes and PEDT anodes The existence of a relatively well-behaved...
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Báo cáo y học: " The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu" potx
... modified glycoproteins However, the overall difference in protein modification of endogenous versus exogenous BST-2 could be indicative of differences in their relative intracellular distribution ... the samples was verified by immunoblotting (Fig 3B, Vpu) and equal sample loading was verified by reprobing the blot with a tubulin-specific antibody (Fig 3B, tub) Of note, levels of wt BST-2 ... detect low levels of non-specifically secreted mature BST-2 [37] In this regard it is interesting to note that high-mannose forms of BST-2, which are heavily overexpressed relative to mature...
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Báo cáo y học: " Research In silico modeling of the specific inhibitory potential of thiophene-2,3-dihydro-1,5-benzothiazepine against BChE in the formation of β-amyloid plaques associated with Alzheimer''''s disease" doc
... Therefore, the discovery of novel enzyme inhibitors has been an exciting area for pharmaceutical research leading to many interesting advances in drug development We already have reported a number ... Stuctures = Evolution Programs Spinger-Verlag: University of North Carolina; 1996 41 Michalewiez Z, Fogel DB: How to Solve It: Modern Heuristics Spinger-Verlag: University of North Carolina; 2000 42 ... increases It is estimated that about 10% of people over 65 years of age and 50% of those over 85 suffer from AD Unless novel treatments are developed to reduce the risk, the number of individuals...
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Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"
... the logistic model to evaluate the multiplicative interactive effect of genes All tests were 2-tailed with statistical significance setting at the level of p
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Báo cáo y học: " High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease." docx
... the blood, with elevated levels persisting long after the levels of the cytokines in the blood have declined [40] This prolonged expression likely reflects the distinct manner in which HMGB1 ... preventing HMGB1-specific mAbs from recognizing any given epitope of the HMGB1 molecule In contrast, polyclonal antibodies reacting with multiple epitopes on the whole molecule could circumvent ... individual cells secreting HMGB1 can reliably measure such cells in cultures and provides a useful alternative to Western blotting [8,9] Cytokine activity of HMGB1 The discovery of HMGB1 as an...
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Báo cáo y học: "Protein Never in Mitosis Gene A Interacting-1 regulates calpain activity and the degradation of cyclooxygenase-2 in endothelial cells" pot
... death [17] COX-2 has a relatively short half-life, indicating that turnover may effectively control its expression [8] While COX-2 and iNOS can be degraded by several processes [6,8,18-20], calpain ... PIN1: Protein Never in Mitosis Gene A Interacting-1; shRNA: short hairpin RNA; zVF: carbobenzoxy-valinyl-phenylalaninal Competing interests The authors declare that they have no competing interests ... blotting A representative blot of COX-2 is shown Bars represent the average COX-2 signal intensity ± SE of independent cultures for each point, as a percent of the value without added calpain Overall,...
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Báo cáo y học: " Therapeutic efficacy of alpha-1 antitrypsin augmentation therapy on the loss of lung tissue: an integrated analysis of 2 randomised clinical trials using computed " potx
... to be as effective if the nadir AAT level is mostly above the putative protective threshold of 11 μM Preservation of normal lung structure has been the long-term aim of preventive therapy in chronic ... past years Never or ex-smokers for >6 months Cotinine checked every weeks Never or ex-smokers for >6 months Cotinine checked at 1, 6, 24 and 30 months Exacerbations Smoking history NA Never or ≤1 ... maintaining AAT above a protective level of 11 μM is the key to a successful therapeutic outcome, and both studies had treatment regimens that are able to maintain protective levels of AAT, either...
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Báo cáo y học: "Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies" ppsx
... HIV-1 postintegration latency [61] Lenasi and colleagues have shown that transcriptional interference could be reversed by inhibiting the upstream transcription or by cooperatively activating viral ... bryostatin and DPP, prostratin is an interesting compound as a PKC activator without tumor-promoting activity The non-mitogenic property of prostratin, its remarkable dual role in activating HIV-1 ... selectively acetylating or deacetylating the ε-amino groups of lysine residues in histone tails Generally, chromatin acetylation by HATs promotes chromatin opening and is associated with active euchromatin,...
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Báo cáo y học: " Changes in the accessibility of the HIV-1 Integrase C-terminus in the presence of cellular proteins" doc
... conceived of and supervised the study, and was involved in drafting the manuscript and revising it critically for intellectual content All authors read and approved the final manuscript Competing ... attenuated lentiviral vector achieves efficient gene delivery in vivo Nat Biotechnol 1997, 15:871-875 46 Delenda C, Gaillard C: Real-time quantitative PCR for the design of lentiviral vector analytical ... fully active in the context of a lentiviral vector The kinetics of viral DNA synthesis and integration were identical for IN-BAD and IN-WT vectors in HEK 293 cells IN-BAD is efficiently biotinylated...
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Báo cáo y học: "HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat" pps
... the paper All authors read and approved the final version of the manuscript Competing interests The authors declare that they have no competing interests Received: 15 April 2011 Accepted: 24 August ... between the averages of the various clones However, the viruses with mutations Table CA/p2 processing efficiencies of the HXB2 and PR-2 proteases Substrate Relative substrate conversion HXB2 ... conversion of substrates with V362I or A364V was measured relative to the conversion of the WT substrate The test was performed in triplicate only in the NC/p1 cleavage site appeared to have...
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Báo cáo y học: "The therapeutic potential of a venomous lizard: the use of glucagon-like peptide-1 analogues in the critically ill" pdf
... Sitagliptin Liraglutide Vildagliptin Saxagliptin Administration Intravenous Subcutaneous Oral Studied in the critically ill patient Yes Yes No Current cost Prohibitive Expensive Expensive Availability ... emptying is normal [10,13] GLP-1 analogues with half-lives between 12 hours and to days have been recently developed These analogues have less variation in plasma concentrations after once-daily ... well tolerated; but given the adverse effects associated with its use in ambulant diabetic patients, ongoing vigilance is warranted These adverse effects include nausea and vomiting (usually transient)...
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RESEARCH ON THE FIRST ORDER GAMMA AUTOREGRESSIVE GAR(1) MODEL TO APPLY IN THE FIELD OF HYDROLOGY
... Han, Hue University of Science Reviewer 3: Dr Pham Minh Tuan, DaNang University.of Technology The dissertation is defended at the Examination Committee at the level of Danang University on June ... coefficient ( ) between monthly flows into consecutive years may be negative and this may give rise to a negative value of the autoregressive coefficient ( ), therefore a modification of the ... have N fragments of twelve monthly flows The annual flows obtained from an annual model can be disaggregated by selecting the fragments at random Since the monthly parameters were not preserved...
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Tài liệu Báo cáo khoa học: Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane pdf
... reported [9] Several studies have demonstrated that the mitochondrial respiratory complexes are associated with each other when analyzed under nondenaturing conditions by blue native (BN) ⁄ PAGE ... Numerous previous studies on the bc1 biogenesis have postulated the existence of distinct sub-complexes in yeast mitochondria [12,24–27] However, it is uncertain whether these sub-complexes represent ... not prevent the binding of Qcr9p to the bc1 complex (Fig 1B) According to this model, the absence of Qcr9p in the 1902 DQCR9 yeast strain prevented the binding of both ISP and Qcr10p, even if...
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Tài liệu Báo cáo khoa học: DNA strand exchange activity of rice recombinase OsDmc1 monitored by fluorescence resonance energy transfer and the role of ATP hydrolysis pptx
... (RecA) from E coli has been extensively investigated both at the biochemical and molecular level [1] These studies revealed that RecA protein binds to single strand overhangs generated as a result ... homologous strands in the native state of the reaction and involve no protein removal steps Results Strand exchange activity of several recombinases have been investigated in vitro, typically ... temporal, we have cloned and overexpressed OsDmc1 protein in E coli [21] The overexpressed OsDmc1 protein was purified under denaturing conditions to homogeneity and renatured to its native state Renatured...
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Tài liệu Báo cáo khoa học: Control analysis as a tool to understand the formation of the las operon in Lactococcus lactis doc
... PFK on metabolic fluxes Curve fitting is described in Experimental procedures PK has no control over glycolysis but full control over mixed acid production PK, which converts phosphoenolpyruvate ... 2294 The relative PFK activity in strain CS1929 was found to increase to over 160% of the wild-type level, whereas the relative LDH activity was reduced to 80% of the wild-type level (Fig 3A) In ... Interestingly, we found a very high positive flux control coefficient by PK on the flux to formate at the wild-type level Jformate (CPYK ¼ 0:9 À 1:1) (Fig 5) Similarly, the control exerted by PK over...
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Tài liệu The Formation of Christendom, Volume VI pdf
... not only received them to your communion, but even set them over other Churches, which was not, even in the case of Catholics, allowable; or have even given them higher rank undeservedly John is ... he supplied the parish churches of Rome with silver plate from the six silver vessels, weighing each a hundred pounds, which Constantine had given to the basilicas of the Lateran, of St Peter, ... with firm and impartial hand to deal evenly between the two But the military service was reserved to the Goths alone Natives were forbidden even to carry knives The Goths were to maintain public...
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Tài liệu Báo cáo Y học: The insert within the catalytic domain of tripeptidyl-peptidase II is important for the formation of the active complex potx
... least two levels, dimerization and oligomerization, where the oligomeric complexes have a 10-fold higher specific activity than the dimers [15] Even though inactive dimers are formed when over-expressing ... outlined in Fig 2; the chimera was used for transfecting 293 cells This chimera behaved like the murine enzyme (Fig 2B), demonstrating that seven aminoacid substitutions of potential importance ... since their Mr was determined to be 2–3 · 105 However, no activity peak eluting at a Kav of 0.55 could be detected, indicating that they were inactive (Fig 1) This nonassociated form of the recombinant...
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Báo cáo khoa học: Protein aggregation and amyloid fibril formation prediction software from primary sequence: towards controlling the formation of bacterial inclusion bodies pot
... is a positive and a negative set that both sample well the amino acid space over the motif (hexapeptide) positions, one profile was created for each set (positive and negative, respectively) and ... experimentally verified amyloidogenic hexapeptides, consisting of 67 ‘positive’ and 91 ‘negative’ examples that have been used to benchmark novel prediction methods [20] The additional examples ⁄ ... the task of predicting amyloidogenic stretches [26] and we developed a consensus algorithm, amylpred [31], which combines some of these methods, representing most of the above-mentioned categories...
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Báo cáo khoa học: Assessment of porcine and human 16-ene-synthase, a third activity of P450c17, in the formation of an androstenol precursor doc
... in presence of endogenous levels of P450red In presence of these low levels of P450red, cyt b5 shows a slight stimulatory effect on DHEA formation However, we observe a more profound effect on ... the liver and many other peripheral tissues Furthermore, androstadienol is found in circulation suggesting that it is synthesized at the sites of expression of P450c17 and eventually converted ... these compounds may have significant effects on behavior, namely reducing nervousness, tension and other negative emotional states in women [16] Another study demonstrated a positive relationship between...
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Báo cáo Y học: Introducing Wilson disease mutations into the zinc-transporting P-type ATPase ofEscherichia coli The mutation P634L in theÔhingeÕ motif (GDGXNDXP) perturbs the formation of the E2P state pdf
... The overall consequence is that there is no active WD ATPase molecules in the trans-Golgi network, cytoplasmic vesicles or plasma membrane, which function in copper secretion in healthy liver ... motif (Fig 1) The cleaved protein can be phosphorylated by ATP and Pi While its phosphorylation by ATP seems very similar to that of the uncleaved monomer (Fig 4A), the cleaved fragment is more ... ATP, thus exhibiting a marked reduction in the formation of the ADP-sensitive phosphointermediate The mutants of the HP motif (H475Q and P476L) show ATP-driven phosphorylation levels of 32% and...
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- thông tin ve tác giả thuyết minh đề ctronng tác giả đề xuất đề tài
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25