... aA-crystallin R116 and both are conserved a-crystallin domain arginines R120G aB-crystallin permits intermediate filament self association in vitro, although binding of the modified protein to filaments increases ... formation of huntingtin-containing inclusion bodies in Huntington’s disease encourages cell survival, whereas monomers and small inclusion bodies of huntingtin, a protein possessing abnormal polyQ ... coexpression, indicating R120G aB-crystallin is chaperoned R120G aB-crystallin is disorganized and aggresome-like inclusions develop in cultured nonmuscle cells deficient in desmin, again demonstrating inclusion...
... same conclusion in Norway Lending margin was reduced after the years of crisis only in 1994 and then after a short time was increased again in 1998 In this study lending margin is calculated ... enterprises with debt in financial institutions in industry Transport via pipelines (code 603) in 1997 and in industry Private households with employed persons (code 950) in 1996, 1998 and 2000 ... bankruptcy probabilities and theirrolein explaining banks’ loan losses Research Department 2004, 44p 44 Olga Andreeva: Aggregate bankruptcy probabilities and theirrolein explaining banks’ loan losses...
... also contain a carboxy-terminal extension containing T-box and A-box motifs [124] In each zinc finger, four invariant cysteine residues coordinate tetrahedrically to a zinc ion, and both zinc fingers ... the HNF4 ligandbinding domain (LBD) between insects and vertebrates suggests that this type of ligand interaction may occur in insects The gene encoding HR78 has been identified in Drosophila [68], ... isoforms in D melanogaster [139], and probably multiple EcR isoforms exist in several, but not all, insect species In all cases described so far, the isoforms vary intheir amino-terminal domain and...
... but has rolein shuttling HIPK2 (homeodomaininteracting protein kinase 2) to the cytosol Abundantly expressed in undifferentiated and proliferating embryonic cells but usually undetectable in adult ... [112] S100G was also known as Vitamin D-dependent calcium-binding protein, intestinal CABP, Calbindin-3, and Calbindin-D9k [113] It is primarily a monomer in Page of 21 (page number not for citation ... phosphorylated where it has a major positive rolein regulating autophagy [63] Although HMGA1 has a rolein the export of HIPK2 (Homeodomain-interacting protein kinase 2, a proapoptotic activator of...
... scopolamine Other important alkaloids of plant origin include the addictive stimulants caffeine, nicotine, codeine, atropine, morphine, ergotamine, cocaine, nicotine and ephedrine (Fig 1) Amino acids ... application in the identification of an authentic drug, in excluding the adulterants and in maintaining the quality and consistency of the drug HPLC fingerprinting includes recording of the chromatograms, ... DNA-degradation in cancer Isothiocyanates and the indole-3-carbinols interfere categorically in the metabolism of carcinogens thus causing inhibition of procarcinogen activation, and thereby inducing the...
... to insulin Zinc can replace insulin in mammalian cells cultured in serum-free media [18] The actions of zinc are intracellular because zinc increases the phosphorylation state of the insulin ... diabetic laboratory animals and in humans The above findings indicate that differences in the cellular availability of zinc in both insulin producing b-cells and in insulin target cells are associated ... beginning of training, showed a poorer rate of learning during the training period In addition, the MT-1/MT-2-null mice showed significantly less choice of accuracy than the parental strain [15]...
... staining pattern in mouse knee joint was influenced by disease severity Mild inflammation (Figure 5a) was associated with discrete BMP7 staining in the lining layer of synovium (Figure 5b) and in ... of disease, starting, in the initial phase, at the synovial lining layer, gradually shifting toward the subintimal region and eventually, in the destructive phase, persisting in pannus tissue ... BMP7 stainings Arrows indicate BMP7-positive cells in synovium, and arrowheads indicate BMP7-positive cells in articular cartilage Asterisk indicates gradual clearing of the synovial lining layer...
... papillary cystadenocarcinoma; D: Ang-2 expression in ovarian borderline mucinous cystadenoma; E: Maspin expression in mucinous cystadenocarcinoma; F: Maspin expression in mucinous cystadenoma The ... with natural angiogenic inhibitors [3] Maspin, a serine protease inhibitor in the serpin superfamily, functions as a tumor suppressor by inhibiting tumor cell motility, invasion, metastasis and ... maspin in ovarian carcinoma Clin Cancer Res 2002, 8:2924-2932 doi:10.1186/1756-9966-30-31 Cite this article as: Lin et al.: Expression of Ets-1, Ang-2 and maspin in ovarian cancer and their role...
... hyroxymethyl cytosine or that they glycosylate their DNA In addition all of the r genes in T4 that are known to be involved in superinfection and lysis inhibition [45] are missing in cyanophage genomes, ... function In addition to maintaining PSII centres and altering bilin synthesis, a further mechanism for diverting the flow of electrons during photosynthesis may occur A plastoquinol terminal oxidase ... in S-PM2, P-SSM4 and S-RMS4 speD encodes S-adenosylmethionine decarboxylase a key enzyme in the synthesis of the polyamines spermidine and spermine With polyamines implicated in the stabilising...
... position -30 in the 5'UTR, (ACAAAAAAGG) position 1083 in the second intron, and (TCAAAAAAGG) position 3052 in intron We detected a single potential LEAFY binding site (CCATTGT) in the second intron ... (TCATATTTGG) is located in the second intron at position 785 Similarly LEAFY binding sites have been determined in intronic regions in Arabidopsis B class genes [34,35] The spinach SpAP3 sequences ... among the six individuals sequenced, including all coding and non-coding regions To determine if there was any variation that was obscured in a heterozygous state in the direct sequencing, we cloned...
... proteins are being defined, there is great interest in discovering their organization and interactions in response to microbial infection One hypothesis is that each TLR recognizes a distinct ... (see Fig 3) Further evidence for the role of TRAF6 and NF-κB-inducing kinase in TLR4 signaling came from the study of TRAF6 and NF-κB-inducing kinase dominant-negative (DN) variants, which could ... NIK, nuclear factor-κB inducing kinase; PKR, RNA binding protein kinase; TIR, Toll IL-1 receptor; TIRAP, Toll IL-1 receptor adapter protein; Tollip, Toll interactive protein; TRAF6, tumor necrosis...
... respondent pain may eventually evolve into operant and persisting pain if the environment offers pain contingent reinforcement Pain behaviour may also be learned by observing "pain models" i.e., individuals ... studied the influence of the meaning of pain to patients, and examined the effect of coping styles on pain, for further review see Weisenberg [10] Cognitive theory examines intervening variables ... the areas of screening for, intervening in and predicting those at risk of developing into a chronic and disabling situation [15,16,33] The recent New Zealand Government review into LBP, its subsequent...
... Apis nigrocincta Apis nuluensis Many species Stingless bees ‘Bee maintaining’ (guarding a wild nesting colony) Honeybees Stingless bees Beekeeping (keeping bees inside a hive) Honeybees Stingless ... on insect pollination, and among the pollinating insects, bees are the major pollinators In rain forests, especially in high mountain forests where it is too cold for most bees, other pollinators ... trees In spite of this, the bees perhaps play a minor role as pollinators in the rain forest compared to theirrolein temperate forests, monsoon forests and savannah woodland In tropical rain forests,...
... structural proteins (shaded) are located in the N terminus with the nonstructural proteins residing in the remainder of the genome Figure 1-1 HCV Genome and encoded viral proteins RNA Binding nucleocapsid ... This work Sing et al., 2001 26 Results 3.1 Characterization of NS3-NS3 interaction 3.1.1 Delineating the region of self-interaction in NS3 Protein-protein interactions among all HCV proteins were ... protein containing the RNA-binding motif reduces the strength of the interaction The NS3-NS3 interaction was also confirmed by co-expressing myc-tagged and flag-tagged NS3 in COS-7 cells and showing...
... atropine and 43 pirenzepine in controlling cell number is due mainly to an inhibition of cell proliferation mediated by muscarinic receptors DNA integrity was examined to ensure that atropine ... TGF-α) binds to the extracellular domain, resulting in autophosphorylation of the receptor’s intracellular tyrosine kinase domain (Cohen et al 1980, Schreiber et al 1983) Dimerisation and internalisation ... by two independent persons (Blinded) 2.2.4 In vivo atropine treatment Chicks were randomly divided into two groups: one group received atropine while the other received saline injections in the...
... produced dark brown stain in apoptic nuclei) B Atropine 0.1 µM C Atropine µM D Atropine 10 µM E Atropine 100 µM Fig10A Immumocytochemistry of mAchR subtypes in human SF in culture Subtype selective ... Fig 8A Effect of atropine inhibiting SF cell proliferation in culture Chick SF were incubated with atropine Phase contrast photomicrographs were taken after 24 ... Control culture without atropine B Atropine 100 µM caused a significant growth inhibition The cell morphology appeared to be undisturbed Fig8B Effect of atropine on DNA integrity (TUNNEL assay)...
... microbiological properties of groundwater in Saint Katherine, South Sinai, Egypt and exploring the diversity, occurrence and distribution of fungal taxa in groundwater in South Sainai, samples of groundwater ... Kathrine, and an emerging Society15 for protection of environment and sustainability…etc) and have been leading several initiatives aiming at raising public awareness, lobbying against water pollution, ... drainage, 226.6 million cm of sewage and 4.2 million cm of industrial drainage per year A need for international support, for more and real interventions to make sure that coordination and integration...
... Society of Civil Engineers (ASCE) Journal of Managementin Engineering (1995–2000) and as founding editor -in- chief of the ASCE publication Leadership and Managementin Engineering (2000–2003) He ... President, Lean Construction Institute Mastering the Leadership Rolein Project Management This page intentionally left blank Mastering the Leadership Rolein Project Management Practices that Deliver ... not everyone involved in the project, 14 Mastering the Leadership roLein project ManageMentin particular the German firm designing the equipment, was so willing to abruptly abandon their state-of-the-art...
... for each strain in a final volume of 500 lL The actual CFUs of each strain in both inocula were determined by plating serial dilutions on 7H11 plates containing either Km or Hyg before infection ... conditions Indeed, Cox et al [3] infected mice by intravenous injection with a high infectious dose (106 CFU), whereas Rousseau et al used, like us, the intranasal route of infection and a low infectious ... various strains, cells were labeled with [1-14C]propionate, a precursor known to be incorporated into methyl-branched fatty acyl-containing lipids, including DIMs Analysis of the labeling (Fig 2B)...