the role of serotonin receptor subtypes
Báo cáo khoa học: Studies on the role of the receptor protein motifs possibly involved in electrostatic interactions on the dopamine D1 and D2 receptor oligomerization pdf
... interpretation of the data suggests that the indicated basic region of ic3 of the D2 receptor and acidic region of the C-tail of the D1 receptor might be involved in the interactions between the two ... depended on the number of Arg residues that were replaced by Ala in the Arg-rich region of ic3 (residues 217–222) of the dopamine D2 receptor The efficiency of energy transfer in the wild-type of the ... residues in the C-terminal end of the D1 receptor, as well as the Arg-rich region of ic3 of the D2 receptor, not seem to take part in receptor homodimerization, but they influence D1–D2 receptor...
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Báo cáo y học: "Role of Leukotriene Receptor Antagonists in the Treatment of Exercise-Induced Bronchoconstriction: A Review" pot
... hyperresponsiveness.4 The occurrence of EIB in asthmatic persons is common and often signifies suboptimal control of asthma.8 The diagnosis of EIB is confirmed in the laboratory by a drop of 15% or more ... investigated for the treatment of EIB.12 Results are varied; routine use of these types of pharmacologic intervention is not recommended as primary treatment of EIB.12 Other therapies are still ... are the primary determinants of the degree of EIB a patient will experience.4 The exact mechanism leading to EIB is not yet fully understood but probably relates to drying and/or cooling of the...
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Báo cáo y học: "The role of the purinergic P2X7 receptor in inflammation" pot
... with all P2X receptors, elucidating the role of the P2X7R has been hampered by a paucity of receptor selective agonists and antagonists BzATP, widely viewed as a selective agonist of the P2X7R, ... a number of putatively selective P2X7R antagonists have recently been described [15-17], the effects of these agents in animal models of disease has yet to be published The role of the P2X7R ... detrimental to the host The putative role of the P2X7R in such processes is discussed below 3.1 P2X7R regulation of cytokine production in haemopoietic cells It has been clear since the cloning of the P2X7R...
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The role of downstream of kinase (DOK) 3 in toll like receptor signalling
... polyubiquitlation of the regulator IKK and activation of the kinase TAK1, a prerequisite for the activation of the IKK complex These events result in the degradation of the NFB inhibitor IB and the subsequent ... through the usage of two different adaptor proteins downstream of the receptors These adaptors include the TIRreceptor inducing to IFNβ (TRIF) and Myeloid-differentiation 88 (MyD88) which further ... 2003) Following the assembly of adaptor proteins and kinases, the TLR4 pathway leads to the activation of two distinct responses One of these pathways is required for the production of inflammatory...
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The role of paxillin superfamily members hic 5 and leupaxin in b cell antigen receptor signaling 1
... phosphorylation of p38 MAPK Despite the current findings, the detailed mechanism of the function of Hic-5 in BCR signaling remains to be elucidated The role of another member of paxillin superfamily proteins- ... spatial and temporal manner One of these adaptor proteins, Bam32, has been shown to regulate BCR signaling On the other hand, the role of paxillin superfamily of adaptor proteins in BCR signaling ... proximal to the LD3 domain of LPXN, which is the domain responsible for its interaction with Lyn The overexpression of LPXN in A20 B cells led to the suppression of BCR-induced activation of JNK,...
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The role of paxillin superfamily members hic 5 and leupaxin in b cell antigen receptor signaling 2
... negative role in the activation of JNK and p38 MAPK, but not ERK We next examined the effect of the overexpression of LPXN on the activation of Akt upon BCR ligation As shown in Fig 5C, the phosphorylation ... downstream of the BCR signaling pathway Besides the tyrosine phosphorylation of LPXN, we also observed the recruitment of LPXN to the plasma membrane of B cells upon BCR ligation Several proteins in the ... work The possible effect of LPXN on the activity of a downstream target of JNK, AP-1, also remains to be studied (47, 48) Besides the phosphorylation of JNK and p38, the phosphorylation of Akt...
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Elucidating the role of dok 3 in b cell receptor signaling using gene knockout mice 2
... Ligation-induced phosphorylation of ITIM motifs in the cytoplasmic tails of most of these receptors results in the recruitment of phosphatases These two classes of phosphatases prevent B-cell activation ... factor for the Rho/Rac family of GTPases), and the Shc/Grb2/son of sevenless (SOS) complex and promotes their translocation to the membrane compartment, thus, promoting the formation of the BCR ... calcium elevation are the phosphorylation of the transcription factor Ets-1 and the calcineurin-regulated dephosphorylation of the cytosolic component of the nuclear factor of activated T cells...
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Elucidating the role of dok 3 in b cell receptor signaling using gene knockout mice
... cell receptor signal transduction 1.3.1 The PLCγ2 pathway 1.3.2 The Ras signaling pathway 1.3.3 The Rho GTPase pathway 1.3.4 The PI3-K pathway 11 12 12 14 Negative regulators of B cell receptor ... the Histology Services for their assistance and imparting their knowledge on tissue sectioning and immunocytochemistry; to all the staffs from the Biological Resource Centre who had help in the ... Cloning of targeting construct Culturing of mouse embryonic fibroblasts Culturing of ES cells Preparation of DNA for transfection Transfection and selection of ES cells Picking and freezing down of...
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A study of bloating symptomatology, the role of gastrointestinal transit and the response to treatment with the 5 HT4 receptor agonist in patients with bloating predominant irritable bowel syndrome
... intestine transit in these patients Therefore, the objective of this study is to investigate the symptomatology of bloating, the role of gastrointestinal transit and effect of tegaserod in non-diarrhea ... Based on the above view, in this thesis, we are trying to find the role of GIT transit using bran scan in IBS patients with bloating (See later chapter) 1.3 The role of Serotonin in IBS Serotonin ... brain stem While in the gut, the EC cells containing 5-HT are localized primarily in the Lieberekuhn’s crypts and at the base of villi of the small intestine The amount of 5-HT in the tissue is a...
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The Role of Power
... who are truthful and demonstrate regard for their own outcomes and those of others • Moderately Politicized Area – greater acceptance of behind the scenes tactics so long as the goals of the group are achieved ... Outline Role of Power Rules for Using Power Role of Power Power defined: • Ability or official capacity to exercise control; authority • Ability to influence or control others Sources of Power ... Find the Soft Spot Encourage others to open up • Gain disclosure of something private or personal about your counterpart • Expression of trust Identify true motivations and sources of objections...
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Circuit theory of finance and the role of incentives in financial sector reform
... DC: The World Bank) Chernow, Ron, 1997, The Death of the Banker The Decline and the Fall of the Great Financial Dynasties The Triumph of the Small Investor (New York: Vintage Books, a Division of ... to further improve the bank’ risk position s and counterparties, on their side, might consider for them unnecessary to further assess the riskiness of the bank Finally, the inadequacy of the static ... factoring the long-term market potential of borrowing firms in their risk analysis The higher their reputational capital, the stronger their incentive to lengthen the time horizon of their approach...
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Facts of Vietnam Freight forwarding industry and the role of Vietnam Freight Forwarders Association (VIFFAS) to the industry in international economic integration processhelpful to Oristar.doc
... such professional colleagues on the world The Association has the role of coordinating the activities of the members in order to protect the interests of the members and improve the position of Vietnam ... to the realization of the objectives and duties of the Association, may be invited to join the Association as Honorary members In general, this stipulation on the membership in the Statue of the ... expanding With their experiences, they have learned the value of offering quality services In the way of growing, they have also open branches to establish a worldwide presence These companies...
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Báo cáo y học: "Human toxoplasmosis and the role of veterinary clinicians"
... where the consequences of infection can be very severe, while the risk of living with one’s beloved cat is practically nill References Angulo FJ, Glaser CA, Juranek DD et al Caring for pets of immunocompromised ... with the human immunodeficiency virus Clin Infect Dis.1994;18:14-24 Han K, Shin DW, Lee TY, et al Seroprevalence of Toxoplasma gondii infection and risk factors associated with seropositivity of ... 94: 963-965 Grant S and Olsen CW Preventing zoonotic diseases in immunocompromised persons: the role of physicians and veterinarians Emerg Infect Dis 1999; 5: 159-163 http://www.medsci.org ...
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The role of language in adult education and poverty reduction in Botswan
... and English at the expense of the other languages that exist in the country, the adult language program in Botswana maintains the hegemony and the gap between the poor and the rich, the major and ... improve the quality of life of the poor and rural people adult education programs should include as one of its components the observation and imitation of the artisans and other skilled persons in the ... for the betterment of their conditions It could mobilize the so called minorities to oppose their status and challenge the hegemony of the majority communities in Botswana 31 In most parts of the...
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153 The role of marketing activities to bankcard and actual state of Ngân hàng nông nghiệp và phát triển nông thôn (AgriBank) cards
... sells the transaction to the acquire and is reimbursed the amount of the sales ticket by the acquirer (4) - The acquirer then summits the ticket to the issuer for payment, via the ICO interchange ... system 9 (5) - The issuer bills the cardholder (6) - Finally, the cardholder repays the issuer for the goods or services originally purchased from the merchant ICO are at the centre of the transaction ... maintaining the flow of funds and information between issuing and acquiring members The exchange of financial information is called clearing The exchange of the actual funds for the transaction and the...
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494 The role of marketing activities to bankcard and actual state of Ngân hàng nông nghiệp và phát triển nông thôn (AgriBank) cards
... “bộ” “trọn gói” theo nguyên tắc giá gói nhỏ tổng số tiền mua hàng theo phương thức riêng rẽ Định giá theo nguyên tắc địa lý: cách thức mà doanhnghiệp định giá bán sản phẩm theo nguyên tắc địa ... sản phẩm Bề rộng chủng loại sản phẩm phân giải số lượng mặt hàng thành phần theo tiêu thức định ví dụ theo kích cỡ, theo công suất… Bề rộng chủng loại sản phẩm mục tiêu công ty định phần Những ... trường theo giác độ khác Theo quan điểm Marketing thị trường bao gồm tất khách hàng tiềm ẩn có nhu cầu mong muốn cụ thể sẵn sàng có khả tham gia vào trao đổi để thoả mãn nhu cầu Như vậy, theo khái...
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The role of advertising in society
... values, others say advertising merely reflects the values of society rather than shaping them They argue that consumers' values are defined by the society in which they live and are the results of ... in the other countries, partly due to the limitation of means of communication and citizens’ perception The most popular type of advertising is on TV Following is the advertising price chart of ... promotion, which is one of the most vital tools in Marketing The appearance and the role of advertising is increasingly higher in the market economy Advertising shows the rapid growth in technology...
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The role of leadership theory in raising the profile of women in management
... will further explore the recent theories of leadership, and evaluate if these make a further contribution to the recognition of the skills and attributes of women in management or leadership roles ... to the role each theory may have played in raising the profile of women in management or leadership roles Early leadership theories In the 18th and 19th centuries, philosophers suggested a theory ... Hence, the behavioural theories can be viewed as limited in raising the profile of women in management However, during this period of research, there was an emerging recognition of the importance of...
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Globalization: the Role of Institution Building in the Financial Sector _ The Case Study of China
... negotiated price The trade of inter-bank bond market relies on the securities booking system of the CGSDTC and the bond trading system of the inter-bank lending centre The trading system of the national ... bonds In the case of the latter, commercial banks trade with investors at the prices they offer through their outlets, and provide depositing and clearing services to the investors B Roles of the ... reflect the true quality of loans In recent years, the application of the fivecategory classification method has been advanced thanks to the strong push of the central bank and the efforts of commercial...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến tốc độ rôto n fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008