... 5B). The ER isthe site of synthesis of all secretory pro-teins and resident proteins ofthe membrane system,and any perturbation that compromises the protein-folding capacity ofthe organelle ... exposure of liver cells to FFAs. Interruption of TAG syn-thesis in conditions of excess availability of SFAs isthe key point in the molecular mechanism of SFA-induced lipotoxicity. It is suggestedthat ... of triacylglycerol synthesis in the endoplasmic retic-ulum, apparently because ofthe formation of a pool of oversaturated inter-mediates, represents the key initiating event in the mechanism...
... addition, thesequence encoding the HA epitope wasinserted at the end ofthe IFN-b coding sequence todistinguish the products resulting from the expression of the DNA constructs and the endogenous ... IL-3). However, the deadenylation anddegradation of IFN-b mRNA is under the control of twoindependent elements, one of which is located in the mRNAcoding region. The coexistence of two independent ... called the exosome [8]. This complexfirst discovered in yeast [9], is composed of proteins withribonuclease activity and is able to direct 3¢)5¢ mRNAdegradation. Therefore, the recruitment of the...
... portions of DNS areimportant for the nuclear import mediated by Trn-1.ResultsDetermination of hnRNP D NLS The exon 8 of hnRNP D encodes the 21 amino acids sequence common to all the isoforms ... inthis work, mutational analysis of DNS in the D02molecule suggested that D02 is able to shuttle alonebetween the nucleus and the cytoplasm. This discrep-ancy remains to be understood. The ... mutation of either ofthe last two C-terminal amino acids PYcompletely abolished the in vivo and in vitro nuclearimport activity as well as the binding to Trn-1. Ala-nine scanning mutagenesis of the...
... put across 52 The Ku Klux Klan and Real-Estate Agents the typical online dater is either a fabulist, a narcissist, or simply re-sistant to the meaning of “average.” (Or perhaps they are all ... were rash. Ofthe 243 “hap-pily married” men in the sample, only 12 chose to post a picture of themselves. The reward of gaining a mistress was evidently out-weighed by the risk of having your ... assumption of information, even if the information does not actu-ally exist, can have a sobering effect. Consider the case of a one-day-old car. The day that a car is driven off the lot isthe worst...
... participants. Therefore the total potential liquidity in the system isthe sum ofthe T2NDCs. In practice this is not quite true since the Bank of Canada is also a participant in the LVTS and ... that the acceptance probability is approximately 25%-30%. The drawing procedure consists of simultaneously drawing the mean of the θs, which is denoted¯θ, and then drawing deviations of this ... for the LVTS using the normalized BCL vectors for each bank. This approach is basedon the premise that money flows out of a bank in the proportions given by the BCLs the bank has with the other...
... communities, as isthe case for most ofthe interior portions ofthe United States, sewage overflows can put downstream users at risk. The Missouri River, for instance, isthe source of drinking ... Indianapolis, Indiana, covers the bulk of Marion County in the central part ofthe state, pop-ulation 860,454. The city is situated in the upper part ofthe White River watershed—a system of rivers ... percent over land areas ofthe Northern Hemisphere during the 20th century,155 and global warming is predicted to further increase the intensity of rainfall events for parts ofthe United States.156...
... regressions using the number of employees as the basis of discussion ofthe results. When conducting cross-sectional analysis, heteroskedasticity is often an issue to be addressed. Statistics suggested ... by other companies. The cost of sales of most physical dot coms consists ofthe cost of merchandise sold and inbound/outbound shipping. There are other important distinctions between these ... B.A. Dissertation Presented to the Faculty ofthe Graduate School of The University of Texas at Austin in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy...
... a cut-offdistance of 1.2 nm. The s ystem was equilibrated during1 n s, and then the rotation of c was forced by a constanttorque applied t o the coiled-coil portion of c at the level of cK18–cK21 ... clamping of the C-terminal c portion within (ab)3(this work). This wouldmake the proposed unwinding ofthe a-helix in c afeatureof the wild-type enzyme and an integral element ofthe catalyticmechanism. ... the C-terminal portion of c, thus allowingfor unimpaired rotation ofthe remainder of c.Furthermore, the calculations suggested the very end of c to be clampedwithin the N-terminal collar of...
... investigated the effect of adding the LA Times data to the total mix of Penn’s WSJ and NANC’s WSJ. Table 4 shows the results of this experiment, where the baseline of 0 sentences thus starts with the ... sum ofthe probabilities ofthe derivations producing that tree. The probability of a derivation is the product ofthe subtree probabilities. The original DOP model in Bod (1998) takes the occurrence ... joint probability of their shortest derivations (i.e. the derivations consisting ofthe fewest subtrees). This assumption is in consonance with the principle of simplicity, but there are also...
... factor of n. Adopt the conventions P+(1) = 0 and P−(1) = ∞.Also, ω(n) isthe number of distinct prime divisors of n, Ω(n) isthe number of prime power divisors of n, π(x) isthe number of primes ... τ(n) is the number of divisors of n. P(s, t) isthe set of positive integers composed of prime factors p satisfying s < p ≤ t. Note that for all s, t we have 1 ∈ P (s, t).P∗(s, t) isthe ... the set of square-free members of P (s, t).We list a few estimates from prime number theory and sieve theory. The first isthe Brun-Titchmarsh inequality and the second is a consequence of the Prime...