the expression of proteoglycans pgs
Báo cáo y học: "Effect of antibodies on the expression of Plasmodium falciparum circumsporozoite protein gene"
... they were isolated had an inhibitory effect [7]. The number of mature liver schizonts increased in the presence of mAbs anti-CSP of P. yoelii and the authors suggested that enhancement of ... important role in the control of malaria infection. However, they can modulate parasite development enhancing infection. The effect of anti-Plasmodium antibodies on the expression of circumsporozoite ... This study sets to understand the role of anti-Plasmodium antibodies on the erythrocytic development of Plasmodium falciparum and their effect on the expression of csp gene. 2. Materials and...
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Tài liệu Báo cáo khoa học: ¨ Induction of Kruppel-like factor 4 by high-density lipoproteins promotes the expression of scavenger receptor class B type I pptx
... inhibition of proliferation of VSMC, which ismechanistically linked to a KLF4-induced enhance-ment of the expression of the tumour suppressor genep53 [5]. Because of the important roles of KLF4 on the ... found that the promoter of SR-BI contained multiple putative KLF4binding sites. However, the direct effect of KLF4 on the expression of SR-BI remains unknown.Here, the expression of KLF4 in ... important role in the activation of endothelialcells and macrophages, as well as the differentiationand proliferation of VSMCs. Overexpression of KLF4induced expression of multiple anti-inflammatory...
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Tài liệu Báo cáo khoa học: Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines A possible strategy for the maintenance of intracellular heme level pdf
... degrada-tion in the population of hemoglobin-positive cells.To the best of our knowledge, there has been noreport on the promoter function of the human HO-2Fig. 7. Characterization of the human ... Takentogether, these results indicate that hypoxia reduces the expression levels of HO-2 mRNA and protein infive out of six cell lines, with the exception of KG1myeloid cells.Hypoxia decreases the expression ... address the question of whether hypoxia influences the promoter activity of the human HO-1 or HO-2gene, we performed transient expression assays. Priorto the functional analysis of the HO-2 gene promoter,we...
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Tài liệu Báo cáo khoa học: Parvalbumin deficiency in fast-twitch muscles leads to increased ‘slow-twitch type’ mitochondria, but does not affect the expression of fiber specific proteins doc
... way [19]. When comparing the MLC region of the 2D gels between TA from PV– ⁄ –and PV+ ⁄ + mice, the pattern is virtually identicalwith the exception of the lack of the PV spot in PV– ⁄ –mice ... regions of the PV and MLC3F gene has been previouslyobserved. A segment of 32 bp was identical in bothgenes and, based on these findings, the authors pro-posed that the expression of PV and ... levels of MLC3 and PVare much higher in TA than in SOL, the ratio of the two proteins in each of the two muscles seemed to beconstant (Fig. 2C). A high degree of homologybetween short segments of...
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Tài liệu Báo cáo khoa học: Oxygen tension regulates the expression of a group of procollagen hydroxylases docx
... the question arisesconcerning the mechanisms underlying the orchestrated expression of these enzymes by the oxygen tension. The findings that the effect of hypoxia on the gene expression of the ... twofold increase of PDI mRNA,a more moderate increase of the mRNAs for prolylhydroxylases, and did not increase the mRNA abundance of the other enzymes.DiscussionOur data show that the expression ... hydroxylases. With the exception of PDI, whichis known to be induced by the UPR [41], however, none of the other enzymes was relevantly induced by the UPR,supporting the assumption that they are more...
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Tài liệu Báo cáo khoa học: Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia pptx
... and alters the expression of the twonuclear genome coded isoforms of CytOX V [10,32]. The regulation of genes CytOX5a and CytOX5b, coding for the two isofoms Va and Vb, parallels that of genes ... study therefore, we investigated how O2modulates the expression of mRNAs for CytOX subunits and also the catalytic activity of the enzyme complex. Our results showthat the levels of some of the ... 2003ResultsAs a measure of the hypoxic effect on CytOX gene expression, we measured the steady state CytOX mRNAlevels. The Northern blot in Fig. 1 shows the effect of hypoxia on the levels of mitochondrial...
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Báo cáo khoa học: Neural retina leucine-zipper regulates the expression of Ppp2r5c, the regulatory subunit of protein phosphatase 2A, in photoreceptor development pdf
... [34–36],might regulate the expression of Ppp2r5c mRNA priorto the appearance of Nrl in the retina. Like the increase in Nrl expression during development,Ppp2r5c mRNA expression was precisely ... To further examinewhether the increased expression of Ppp2r5c transcriptswas specifically modulated by Nrl, we used Nrl smallinterfering RNA (siRNA) transfectants in which the expression of Nrl ... &DePaoli-Roach AA (1996) High complexity in the expression of the B¢ subunit of protein phospha-tase 2A0. Evidence for the existence of at least sevennovel isoforms. J Biol Chem 271, 2578–2588.9...
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Báo cáo khoa học: Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways ppt
... effects on the expression of 12 genesand opposite effects on the regulation of eight genes.These results suggest that rapamycin inhibition of TORC1 modifies the expression of a set of genes thatonly ... from the intestinal digestion of proteins [4,5].Another example of the detection of the lack of anamino acid is metabolic adaptation to cope with epi-sodes of protein malnutrition. In these ... in bold). The enrichment for a given GO category was computed as the ratio of the distribution of the amino acid-regulated genes* versus the distribution of the genes spotted onto the microarray**....
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Báo cáo khoa học: Silencing the expression of mitochondrial acyl-CoA thioesterase I and acyl-CoA synthetase 4 inhibits hormone-induced steroidogenesis potx
... steroidsynthesis or the reduction in arachidonic acid releasemay regulate the expression of ACS4. The human gene encoding ACS4 is located in the chromosome Xq 22–23 region close to the a5 chain of the type ... mitochondria). The reason why the action of the two oppositeenzymes, namely the arachidonoyl-CoA synthetase and the arachidonoyl-CoA thioesterase, is needed may be the need to sequester AA from the free ... inhibitors of the acyl-CoA synthetase and the acyl-CoA thioesterase, we have previously postulated the existence of a new pathway for AA release thatoperates in the regulation of steroid synthesis...
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Báo cáo khoa học: The expression of retinoblastoma and Sp1 is increased by low concentrations of cyclin-dependent kinase inhibitors ppt
... that the inhibition of CDK activityincreases the expression of Rb and Sp1.Fig. 1. Effects of UCN-01 on the levels of Rb and Sp1 protein. (A), (B) Dose–response of the effect of UCN-01 on the levels ... However, there are also somedifferences, namely (a) in the case of Rb, there is an increasein both the levels of mRNA and the stability of the protein,while the degradation rate of Sp1 does ... annealing of primers to nontarget DNA. The lower solution contained the cDNA, the MgCl2, the dNTPs, the [32P]dATP[aP] and one half of the buffer, and the uppersolution contained the four...
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Báo cáo Y học: The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis doc
... occursin the nuclei and the tail during the maturation process in the epididymis. The greater the extent of oxidation in nuclei, the more potent are the spermatozoa. In addition, hyper-activation of ... it to the reduced form (GSH) usingan NADPH as the electron source. The function of GR in the male genital tract of the rat was examined by meas-uring its enzymatic activity and examining the ... W.R. & York, J.L.(1996) Differential expression of glutathione S-transferase iso-forms in compartments of the testis and segments of the epididy-mis of the rat. Drug Metab. Dispos. 24, 725–733.46....
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Báo cáo khoa học: Thyroid hormone induces the expression of 4-1BB and activation of caspases in a thyroid hormone receptor-dependent manner pptx
... On the other hand, in HeLa cells, it was reportedthat the expression of the full length TRAF1 potentiated the activation of NF-jB induced by TNFa or IL-1, butthat of the C-terminal part of ... (Affymetrix) and the levels of the expression of each cDNA and of the reliability (Present/Absent call)were calculated with software (AFFYMETRIX MICROARRAYSUITEver.4.0). For comparisons of the expression ... responses.We also examined the expression of TRAF1 and TRAF2because they interact and regulate the function of the 4-1BBproteins to induce NF-jB [18]. In the absence of T3, neitherHeLa nor HeLaTR...
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Báo cáo khoa học: Glutamine stimulates the gene expression and processing of sterol regulatory element binding proteins, thereby increasing the expression of their target genes docx
... imply the involvement of the O-glycosylation of Sp1 in the induction of SREBP-1a transcription byglutamine. The gene expression of SREBP-1c, whichrepresented less than 20% of the SREBP-1a gene expression ... after the addition of glutamine, the gene expression of the SREBP targets,such as HMG CoA synthase and the LDL receptor,was slightly increased, but then the mRNA levels of both SREBPs and their ... increase in the gene expression of SREBPs, and second, the enhancement of SREBPprocessing by glutamine. We therefore investigated the effect of glutamine on the gene expression of SREBPfamily members,...
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Báo cáo khoa học: Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73c in lung cancer doc
... as the overexpression of Q2-derived DM isoforms could be attributed to the overexpression of TAp73, which is known to activate the P2 promoter [13]. In this case, downregulation of DMp73 expression ... processes.Therefore, all of these issues should be addressed in the future.Taken together, our findings make it clear that thereis a link between the expression of Sp1 and p73isoforms in lung cancer. ... cellsAs the outcome of the action of TAp73 is dependenton the presence of the dominant negative DMp73 [13],an important issue to be considered is whether Sp1also affects DMp73 levels in the context...
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- the adventure of physics
- the nature of language
- we describe the cloning and expression of deoxyhypusine hydroxylase dohh
- the regulation of cdx1 expression in the intestinal metaplasia is poorly understood
- scientists use to observe the signs of expression or of the material and unusual nature to collect data
- the expression of local
- local expression of the south
- local expression of the midwest
- face expression recognition and analysis the state of the art
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