... [23,33–36,45] Therefore, the variation inthe concentrations of ATP, ADP and AMP was determined under the conditions ofthe experiments shown in Fig The results indicate that none ofthe adenine nucleotides ... revealed that the Glc6Pproducing block (GluT and hexokinase) exerted the main controlof flux The finding that the intracellular concentration of free glucose was high and saturating for hexokinase (Table ... determined inthe absence of their physiological activators and inhibitors, at saturating substrate concentrations, andinthe absence of products; these factors discard the role ofthe reversibility of...
... investigator ofthe study, analyzed the gait data and was involved in revising the manuscript JFS drafted the manuscript, was involved inthe design ofthe study andinthe data analysis MP and FK ... participants ofthe LBP group and were involved inthe design ofthe study PJB was involved in drafting and revising the manuscript All authors read and approved the final manuscript Appendix From these ... calculated by taking the difference inthe y-direction of each consecutive step Angular rotations ofthe pelvis and thorax were obtained form the angles ofthe segment with respect to the axial in the...
... consider because they are not hydrolysed by β-glucosidases inthe intestine and can be administered orally [27] Therefore, the aim ofthe present study was to evaluate the inhibitory effect of some thioglycosides ... hydrolysis-resistant, synthetic S-analogs of natural O-glucosides involved inthe biosynthesis of chrysomelidial and salicin These substances are synthesized and secreted as part of a defense mechanism used by larvae ... pioglitazone) and/ or to control hepatic glucose release (using biguanides) [7] In addition, manipulation of insulin through exogenous insulin administration or increase of endogenous insulin production,...
... value, the sustaining desire inthe marketplace to keep owning, buying, and wearing and having your brand on their bodies For many strong brands, three-fourths ofthe people buy them again and again ... company and brand inthe consumer’s mind, meaning inthe eyes ofthe end buyer at the retail level, the more you can turn your product into a recognized and prized and preferential brand, the more ... that they are much easier to follow The core ofthe speech centered around building, maintaining and sustaining a brand But I think you’ll see that building a sustainable brand also has a definitively...
... sometimes 2.1 Orofacial pain Orofacial pain is defined as pain within the structures ofthe oral cavity and face, usually of a diffuse pattern” (Zwemer, 1998) Orofacial pain includes pain disorders ... revealed that pain is one ofthe main reasons that patients look for medical attention and that the lifetime prevalence ofpain indications such as back pain, chest pain, headache and joint pain is around ... that are linked with the hard and soft tissues ofthe neck, head, face and all ofthe intraoral structures (American Academy of Orofacial Painand Okeson, 1996) The trigeminal nerve forms the primary...
... Loss of Associative Meaning In this thesis, Loss of Connotative Meaning and Loss of Collocative Meaning will be analyzed These kinds of meanings will be shown inthe table below 15 v Loss of Connotative ... loss of meaning 18 4.3.2 Gain of Meaning in lexical feature a Gain of Conceptual Meaning In this case, some words or phrases which are added inthe target language with the aim of making the source ... translating a text, the students as well as the teachers should notice the author’s message inthe ST, and then apply each case of loss and gain in meaning to the TT in order to make the translational...
... milk inoculum for the production ofthe vaccine The vaccine will be made by adding 100 ml of inoculum to 900 ml of UHT skim milk and incubating overnight at around 37’C This vaccine is fed to the ... Diagnosis andcontrolof diarrhoea in suckling pigs Characterization of vaccine candidate strains for E coli vaccine 27 Serogroup, fimbriae and enterotoxins possessed bythe candidate strains The virulence ... Characterization ofthe vaccine strain, in particular the isolation of novel fimbriae and identification ofthe genes encoding the fimbriae was undertaken by Dr Do Ngoc Thuy inthe laboratory of Dr John...
... during the process of germination, and their differing sensibility to high temperatures, ash, andthe effect of both of these together E globulus is the species with the smallest seeds, and is the ... species of pines and eucalyptus In both P pinaster and P radiata most ofthe treatments place the peaks of maximum germination between days and 25 These peaks are sharper in P radiata than in P pinaster ... RESULTS The germinative response of these three species to treatment with heat and ash was analysed by using the rate of germination, average germination time andthe period of time over which germination...
... trial and participated inthe study design The sponsor was not involved inthe collection, analysis, and interpretation of data, or inthe writing ofthe manuscript The sponsor was given a draft of ... used in this study; NJG and SJK performed these assays and participated with MSH and JSS in analyzing the data reported ES was the clinical coordinator, and JSS was the Principal Investigator, of ... [19] The duration ofthe effect on pUAc correlated with the level and persistence of uricase activity in plasma Circulating life was independent of dose, and was determined less bythe extent of...
... aldehyde 1, and using the synthetic route shown in Scheme 1, six analogues of sphingosine were synthesized Inthe first step, acetylides of various chain lengths, obtained from the treatment of alkynes ... was not inthe final list and not being tested further, is mainly because the yield of compound 2a3 is really low (~7%) Therefore, obtaining compound 3a3 requied a large amount ofthe starting material-Garner’s ... the newly developed inhibitors, a better understanding ofthe role of SPHK inthe process of stem cells differentiation will be studied as well In this chapter, only the compounds synthesis and...
... 3.2.3.1.2.2 Immunostaining of Osteocalcin, Osteopontin, and osteonectin The expression of osteocalcin, osteopontin, and osteonectin was measured by immunostaining after 28 days of culture with or ... Staining 3.1.3.1 Alizarin Red S Staining Alizarin Red S staining is widely used to evaluate the calcium-rich deposits generated by cells In this study, the staining was used to detect the mineralization ... staining in each sample was quantified by dissolving the staining with 100% of isopropanol and detecting the absorbance at 500nm 3.1.3.3 Fluorescence Immunostaining Fluorescence immunostaining...
... 2002) Inthe cells, NF-κB forms a complex with iκB, andthe phosphorylation of iκBα would cause the release andthe activation of NF-κB The activated NF-κB can then translocate into the nucleus and ... cuvette and placed in a spectrofluorophotometer (Shimadzu RF-5301 PC) Upon getting a stable basal reading, cells were triggered by adding S1P Readings were analyzed bythe software provided bythe ... passage they were considered to maintain their multipotency Cells cultured in S1P-supplemented media were then measured for their stemness maintenance by checking their morphology change, the cell...
... potential for the use of SPHK inhibitors in preconditioning stem cells before transplanting them into the body, by committing stem cells along specific differentiation path More work, including in vivo ... differentiation in most ofthe cases, while at higher amounts (1μM DMS and 5μM CP6) showed to inhibit the osteogenic differentiation in most ofthe experiments Interestingly, in human BM- and AD- MSCs ... Conclusion and Future Work being one ofthe most potent and specific SPHK1 inhibitors (chapter 2), DMS was continuously used as a reference inhibitor It is interesting to note that CP6 and DMS affected...
... (1998) “N,N-Dimethylsphingosine Is a Potent Competitive Inhibitor of Sphingosine Kinase but Not of Protein Kinase C: Modulation of Cellular Levels of Sphingosine 1-Phosphate and Ceramide.” Biochemistry, ... “Characterization of N, N-dimethyl-derythro-sphingosine-induced apoptosis and signaling in U937 cells: independence of sphingosine kinase inhibition.” Prostaglandins & Other Lipid Mediators 86(1-4):18-25 Kimura, ... result in a marked increase in osteocalcin secretion after 12 days ofin vitro culture, and formation of morphologically distinct nodule-like structures” Tissueand Cell 37:325-34 Chastain, S...
... effects of S1P by inhibiting proliferation and secretion of cytokines, while enhancing secretion ofthe suppressive cytokine Interleukin-10 (IL-10) S1PR5 is the most recent member in S1PRs family and ... activation, while HDL could inhibit all of these, by inhibiting the SPHK activity triggered by TNFα These findings suggested an atherogenic role for SPHK activation Interestingly, Nofer et al (2004) reported ... this increasing need for more MSCs is one ofthe main motivations ofthe present study, in particular, in studying the role of S1P in adult stem cell proliferation Another major motivation is the...
... Seng, Huibin, Yin Loon, Minh, Sandy, Phil and all other past and present members of Bing’s lab, thank you for your friendship, and for making the lab such a stimulating and fun place to work in I ... putative minimal promoter The number and precise sequences ofthe pre-microRNAs, their distance from the promoter andthe polyadenylation sites, the regions flanking the hairpins, andthe types, ... regulators of pluripotency and self-renewal Furthermore, the network of regulatory interactions that exists in ESCs as suggested bythe CHIP data offers the intriguing possibility that these transcription...
... presents the subject ofthe study, the scope, the content andthe research method ofthe study 3.1 Subjects ofthe study The subjects ofthe study are English and Vietnamese hyperbole used in daily ... On the other hand, the definitions, the functions, the syntax aspect andthe usage of hyperbole in each language Stage 3: Analyzing and concluding Fundamental knowledge regarding hyperbole in ... plenty of learners may give up their efforts on learning Furthermore, the attitudes of learners themselves decide the quality ofthe learning and teaching process Many students are not willing to involve...
... Disease Controland Prevention The role of BCG vaccine inthe prevention andcontrolof tuberculosis inthe United States: a joint statement bythe Advisory Council for the Elimination of Tuberculosis ... MMWR The Role of BCG Vaccine inthe Prevention andControlof Tuberculosis inthe United States A Joint Statement bythe Advisory Council for the Elimination of Tuberculosis andthe Advisory Committee ... re-evaluation ofthe role of BCG vaccination inthe prevention andcontrolof TB This updated report is being issued by CDC, the Advisory Committee for the Elimination of Tuberculosis, andthe Advisory...
... phosphine is a quick and effective tool for thecontrolof stored-product insect pests In view ofthe scheduled phaseout of methyl bromide under the Montreal protocol, the role of phosphine in grain ... of all oils tested The main component of one ofthe oils is pulegone The other is not yet identified and it is called SEM76 (Shaaya and Kostyukovsky, 2006) In our study ofthe mode of action of ... evaluate the toxicity of allyl ITC in grain, we could show that 20 μL·L−1 air (=20 g m−3 ) and exposure time of day were not effective in killing the insects at the bottom ofthe column when the fumigant...
... processing involves the use of mercury lamps, which generate 90% of their energy at a wavelength of 253.7 nanometers Exposure of bacteria to UV results in cross-linking ofthe thymine dimers ofthe ... growing of fruit, harvesting, postharvest handling, washing, and cooling and storage PREVENTIVE MEASURES INTHE ORCHARD Contamination of fruits with feces of animals such as deer,8 seagulls,9 and ... repair of DNA The use of combination treatments is expected to be more effective both in eliminating pathogens andin retaining quality attributes ofthe product.49 MICROWAVES The use of microwaves...