... cloned into pGEX-4T-2 The KIND domains of Spir-2 and PTPN13 were generated by RT-PCR and inserted into pEGFP-C1 and pGEX-4T-2 The N- and C-terminal regions ofthe v-KIND KIND2 andthe MAP2 CD were ... structural and functional importance ofthe v-KIND and MAP2 interaction core modules in the regulation of dendrite growth and branching in hippocampal neurons and cerebellar granule cells Further studies ... proteins of these subregions (Fig S1C) and 1654 Fig Of all members ofthe KIND family of proteins, only KIND2 binds to MAP2 Pull-down assay (PD) ofthe endogenous MAP2 from cerebellar lysates of P21...
... conformer ofthe C-domain (red and blue) on the crystal structure [20] ofthe complex ofhuman eRF1 (green) andthe truncated eRF3 (purple) The superposition was made using the Ca, C¢ and N atoms ofthe ... on one side ofthe b-sheet and two on the other side The rmsd ofthe heavy atoms (Ca, C, and N) ofthe protein core, when the NMR structures of both conformers are superimposed on the crystal ... between the signal ofthe HN of Gly337 in the open conformer andthe signal ofthe water protons All of these observations indicate that the loop region ofthe open conformer has a higher degree of...
... in the mutant First, there is an increase in the negative charge in the active site and, second, breaking the salt bridge would alter the quaternary structureofthe protein and therefore the ... in the ArCMLE1 structureThe figure was created from the coordinates ofthe P212121 structureof ArCMLE1 andof PpCMLE (Protein Data Bank code 1RE5) (B) Water cavity below the active site The ... structureThe variation in size andthe observed amino acid modification between PpCMLE and ArCMLE suggested important differences between the two enzymes Therefore, the crystal structureof the...
... STRUCTUREANDFUNCTIONOFTHE ARABIC VERB StructureandFunctionofthe Arabic Verb is a corpus-based study that unveils the morpho-syntax andthe semantics ofthe Arabic verb ... very indicative, in our opinion, ofthe adequacy andthe basis of this orientation, on the one hand, andthe destiny of linguistics, on the other hand Of course, these implications might be too ... constructions The frequency of WA, FA-, LA-, and Ø in front of QAD Frequency ofthe compound perfect The distribution and frequency of sawfa/saThe frequency of QAD, laʕalla, and rubbamaa The contextual...
... measuring and understanding the roles of different kinds of organisms in the flux and storage of elements in ecosystems The total biomass per unit area, W, is simply the sum ofthebody mass of all ... tradition of empirical and theoretical work in biological oceanography and limnology that relates the structure, functionand biotic composition of these systems to thebody sizes ofthe organisms ... reproduction, number and size of offspring, inter-clutch interval, and juvenile and adult survival The effects of changes in the magnitude of each of these traits on the others (e.g increased offspring...
... humanbodyThe position of proverbs referring to part ofthehumanbody Parts ofthehumanbody 21 21 21 The classification of parts ofthehumanbody according to position Graduation thesis ... three functions: thefunctionof comprehension, the aesthetic function, thefunctionof education, the words about parts ofhumanbody are used to form the meaning of proverbs, therefore, they ... diversified (multiple form) The classification of parts ofthehumanbody according to the position In the system ofthe proverbs, the system of words referring to parts ofthehumanbody is divided into...
... earth The hand of a child - The hand of a lock The heart of a man - The heart of a matter 37 The tongue of a man - The tongue of a shoe The tooth of a person - The tooth of a comb The head of a ... hands of a farm 13 The heel of a person - The heel ofthe hand 14 One's leg - The leg of a trip 15 One's brain - The brains of a family 16 The bosom of a person - The bosom ofthe church 17 The ... The head ofthe page The scar left on one's kin - The scars of war The arm of a person - The arm of jacket 10 One's breast - The chest 11 One's foot - The foot of sock 12 One's hands - The hands...
... above, the determination ofthe subunit composition ofthe nAChRs involved has been hindered by the lack of selective ligands and imperfect correlations between the characteristics of native and ... native and heterologously expressed nAChRs The examples presented above clearly demonstrate the usefulness of a-conotoxins in the determination ofthestructureandfunctionof native nAChRs, and ... Furthermore, the distance ofthe projection areas from the cell bodies andthe indistinct correlation between subunit mRNA levels and functional surface nAChRs hampers the interpretation of studies...
... Further examination ofthestructureand sequence of sbwAFP and TmAFP reveal other similarities (Fig 8C) The panel shows the similarity ofthe TXT face again, and also reveals the presence of ... changes in thestructureofthe insect AFPs and to further characterize the TXT face of these proteins, the backbone dynamics of TmAFP and sbwAFP were measured at 30 °C and °C [38,40] Overall, the results ... shown as smoothed, Ca traces, with thestructureand PDB code shown below each panel (A) Overlap of isoform 337 with thestructureofthe longer isoform CfAFP-501 using the main chain of residues...
... changes the conformation ofthe other subunit, thereby completely abolishing reaction of SDTG with the second subunit Analysis ofthe crystal structureofthe enzyme in complex with the S-atrazine–GSH ... hydrophobic pocket of domain II ofthe other monomer, physically anchors the two subunits together at either end ofthe interface Explanation ofthe biphasic kinetics An average incorporation of 0.5 mol ... concentration of SDTG, k3 is the maximal rate of inactivation (min)1), and Kd is the apparent dissociation constant ofthe E:SDTG complex From the data shown in Fig 2, Kd values of 107.9 ± 2.1 lM and 224.5...
... ago and since then the HAMLET field has widened in scope, acquiring new members and enriching our understanding ofthe basic principles underlying protein self-assembly and acquisition of new functionality ... radii of HAMLET (Rh = 26.9 A), which is intermediate ofthe hydrodynamic radii ofthe acidic molten globule state of a-lactalbumin ˚ (Rh = 20.9 A) andthe theoretically extreme expansion state of ... describing the form andfunctionof novel complexes such as HAMLET and ELOA, we have provided new evidence that a loss of native structure can endow proteins and their complexes with distinct and beneficial...
... 2A) and between the ratio ofthe length of appressed to non-appressed thylakoid membranes and photon fluence rate (Fig 2B) This suggests that, in the canopy, acclimation ofthe thylakoid structure ... below 1.4 (Fig B) The leaves examined from levels and were physiologically young andthe rates of C0 uptake recorded were from intermediate to high (Fig 2A) The ratio ofthe length of appressed to ... a lower rate of C0 uptake and an appressed/non-appressed membrane ratio of about In the present study, a tion was found between negative correla- N P andthe ratio ofthe length of appressed...
... Background The liver sinusoids are lined by endothelial cells that have a unique structureandfunction essential for hepatic and systemic homeostasis Much of our understanding ofthe biology ofthe ... IM and BS conceived ofthe study IM carried out most ofthe experimental work andthe writing AW and DGL participated in the determination of fenestration parameters, statistical analysis and ... arteriole andthe portal venule [10] In average, the oxygen content of hepatic blood is rather low (~55 mmHg) However, oxygen gradients normally exist between the periportal andthe perivenous areas of...
... comparative analysis between the architecture andfunctionofthe CHD andthestructureandfunctionof eukaryotic DNA, which we now define as the DNA hard drive (DHD) The computer ATA (Advanced ... correlations and expansions to these properties by structural and informational aspects oftheof DHD, 3) examination ofthe current discrepancies between the CHD andthe DHD, and how these discrepancies ... between the orthogonality of magnetic representation of data on the CHD to the orthogonal representation of information in the form of Qbits on the DHD The generation of various types of RNA from the...
... in the ubiquinone biosynthesis pathway The objective of this study is to understand thestructureandfunctionof these two MTases through the following experimental approaches1 To clone the ... nervous system, the head, the neck, the chest, the abdomen, the pelvis, the skin, andthe soft tissues) get infected by Bacteriodes, they can cause or exacerbate abscesses and other infections ... determine the Apo and complex structures of these proteins with ligands (AdoMet/SAM and AdoHcy/SAH) using X-ray crystallography Structurefunction analysis to understand the role of these enzymes...
... this area and gases from vehicles on Le Duan road HUMAN IMPACTS - CONSEQUENCES SOLUTIONS Increasing the number of wastebasket Planning the rubbish dumps and quick transporting the waste as ... penalties) for the restaurant and visitors to keep the park green, clean and beautiful CONCLUSIONS Plant species on peninsula are quite diverse People are having huge impacts on the formation and development ... Location Biotics and abiotics Energy and material flow Human impacts, consequences and solutions Conclusion LOCATION Thong Nhat Park Peninsula : 1200 m2 Including : mainland, lake, plants,...
... Hence, the maintenance of a condensed chromatin structure throughout the entire bodyof a gene may rely on the combined actions of Set3 at the 5¢ end and Set2 at the 3¢ end In yeast the cycle of ... cycle of transcription commences with the recruitment of transcription factors and co-factors bound at the promoter, which modify the local chromatin structureand enable the assembly ofthe pre-initiation ... bp intervals The lighter colour shades depict the bottom half ofthe nucleosome, andthe exploded view below the octamer depicts the arrangement ofthe histones contacting 73 bp of DNA within...
... functions, and topological features retain functionality and phylogeny However, the nature ofthe connections between these factors needs to be understood at the level ofthe protein domain The ... compares the studied network with randomized versions of it with the same size and degree distribution The so-called Z-score quantifies the difference between the studied network and an ensemble of randomized ... relation to thefunctionandstructureof TFs from available information From a structural point of view, the overabundance of self-interactions is associated with a majority group of 55% of basic...
... ofthe mature enzyme and by the ÔflapÕ The anchorage ofthe prosegment andof part ofthe N-terminus in the active site cleft is made by ionic interactions established between Lys11/Tyr13 ofthe ... other by three disulfide bridges A unique feature ofthe PSI is the swap ofthe N- and C-terminal portions ofthe saposin-like domain, where the C-terminal portion of one saposin is linked to the ... representation ofthestructureofthe PSI domain of barley prophytepsin [25] (N-terminal domain, blue; C-terminal domain, red) (C) Model structureofthe PSI domain of cardosin A based on the crystal structure...