sources and bodily effects of drugs
Tài liệu The Economic and Social Effects of Financial Liberalization: A Primer for Developing Countries pptx
... #14-12 Cấu trúc tài (Q (Quản trò tài chính) ò ) – Trong đo: đó: EBIT (Earnings before interest and taxes) T : Ta es Taxes EBIT x (1- T)= Lợi nhuận sau thuế nợ vàø vốán cổå phầàn h ka : Chi phí ... dòng vốn p g ị g y g Các trung gian tài giảm chi phí giao dịch nào? Tạo kinh tế quy mơ (economies of scale) 2 Phát triển nghiệp vụ chun mơn làm giảm chi phí giao dịch (Puzzle 3) Copyright © 2000 ... Các nhà đầu tư khơng muốn mua chứng khốn xấu, thị trường khơng vân hành tốt g g Giải thích Puzzle and Puzzle Cũng giải thích Puzzle 6: Càng thơng tin bất cân xứng cho cơng ty hoạt động tốt vấn đề...
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Tài liệu NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-Isodecyl Phthalate (DIDP) pdf
... pregnancy and gestation Complete details of the study, including a description of reproductive effects in parents and offspring, are included in Section In the F1 offspring there were no effects ... Some evidence of no adverse effects Clear evidence of no adverse effects development and reproduction These studies reported that exposure of pregnant dams to relatively high doses of DIDP causes ... adverse effects Concern for adverse effects Some concern for adverse effects Developmental effects Reproductive effects Minimal concern for adverse effects Negligible concern for adverse effects...
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Tài liệu A Dissertation on the Medical Properties and Injurious Effects of the Habitual Use of Tobacco pptx
... variety of computers including obsolete, old, middle-aged and new computers It exists because of the efforts of hundreds of volunteers and donations from people in all walks of life Volunteers and ... moral character of men; that it often creates a thirst for spirituous liquors; that it allures to clubs, and grog-shops, and taverns, and thus helps to make idlers and spendthrifts; and finally, ... meeting of the Medical Society of the County of Oneida, on the 5th of March, 1830, a communication was received, signed by a number of highly respectable gentlemen from this and other counties of...
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NTP-CERHR MONOGRAPH ON THE POTENTIAL HUMAN REPRODUCTIVE AND DEVELOPMENTAl EFFECTS OF BISPHENOL A pot
... than the developmental effects observed at “high” doses on survival and growth and the “low” dose effects on brain and behavior, mammary gland, prostate gland, and onset of puberty in females ... the incidence of a variety of other ovarian and uterine proliferative lesions and cysts were also reported Replication of these findings and further study of the linkage of early and late occurring ... confirm these findings and include longer periods of follow-up to understand the significance of the structural and cellular effects observed in fetuses and to clarify the relevance of prostate intraepithelial...
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Báo cáo khoa học: Alternative splicing: good and bad effects of translationally silent substitutions pdf
... splicing A variety of tools are available to us for this purpose and further investigation of these sequence variants will not only further our understanding of the splicing mechanism and improve clinical ... sites, most of them still lack experimental approaches directed at identifying the exact mechanism involved In spite of the well-known lack of reliability of in silico approaches, many of the synonymous ... (mouse–rat and human–dog) [10] This analysis showed a strong purifying selection at silent sites in a critical region of this gene [10], spanning the 3¢ end of exon 10 and the 5¢ end of exon 11...
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Báo cáo khoa học: Structural and biological effects of a b2- or b3-amino acid insertion in a peptide Application to molecular recognition of substance P by the neurokinin-1 receptor ppt
... screening of 4Ær and no cut-off was used Minimum-energy conformers of b- and a-amino acids were generated by molecular dynamics at high temperature followed by energy minimization Two thousand structures ... grid searches of b-amino acids were initially carried out at intervals of 30° for each torsion angle /, h, and w and were subsequently refined by varying /, w angles in intervals of 10° and setting ... shifts and random coil values, are commonly used to detect secondary structures in peptides and proteins [38] They are reported in Fig Stronger upfield shifts of Ha (Fig 3A) and downfield shifts of...
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The Effects of Land Use on the Mobility of Elderly and Disabled and Their Homecare Workers, and the Effects of Care on Client Mobility: Findings from Contra Costa, California pdf
... ii Abstract The Effects of Land Use on the Mobility of Elderly and Disabled and Their Homecare Workers, and the Effects of Care on Client Mobility: Findings from Contra ... University of California, Berkeley, for his advice and encouragement at every step of the way; Professor Elizabeth Deakin, Department of City & Regional Planning, Director of the University of California ... with survey design and thinking about the interaction of land use and transportation variables; Professor Paola Timiras, Department of Molecular & Cell Biology, University of California, Berkeley,...
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industry and the effects of climate in italy
... depositing at the feet of the chains of huge deposits of sand, gravel and clay There then followed a phase of general increased marine predominance, lasting a good part of the Miocene and all the Pliocene ... submersion of the margins of this major Tyrrhenian island The coastlineThe complexity of the peninsula's relief is echoed in the diversity of its coastal profile Along the low and sandy Adriatic ... with the exceptions of the bulge of the Po delta and of the two rocky promontories of the Conero and Gargano The Ionian and Tyrrhenian shores are very different, their extensive sandy curves, corresponding...
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Báo cáo khoa học: A distinct sequence in the adenine nucleotide translocase from Artemia franciscana embryos is associated with insensitivity to bongkrekate and atypical effects of adenine nucleotides on Ca2+ uptake and sequestration pdf
... protein sequence with that of other species (Xenopus, Drosophila, mouse isoforms 1, 2, and 4, rat isoforms and 2, bovine isoforms 1, 2, 3, and 4, and human isoforms 1, 2, 3, and 4) is shown in Fig ... applies to Artemia mitochondria, we tested the effect of ADP and ATP in the presence and absence of the ANT inhibitory ligand cATR, and of the F0F1ATP synthase inhibitor oligomycin The results ... well-characterized, inhibitors of ANT have also been reported [37] Mindful of (a) the well-established ligand profile of ANT, (b) the modulatory role of ANT in the mammalian PTP, and (c) the absence of a Ca2+-induced...
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Báo cáo khoa học: Prohibitin is expressed in pancreatic b-cells and protects against oxidative and proapoptotic effects of ethanol pdf
... proof of apoptosis, cleaved caspase-3 was determined in cell extracts by western blot (G) Representative blot of n = experiments showing 17 and 19 kDa caspase-3 cleavage bands and the levels of ... pancreatic b-cells The objective of the present study was to investigate the expression and antioxidant effects of PHB in pancreatic b-cells exposed to ethanol Effects of prohibitin in b-cells * 80 ... production of reactive oxygen species (ROS) and mitochondrial dysfunction [9,10] Increased ROS production is one of the earliest events in glucose intolerance and it may be a mechanism of pancreatic...
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Báo cáo hóa học: "Regulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high-dose interferon-a 2b treatment" pptx
... understanding of the mechanism of action of IFN-a 2b may facilitate the development of treatment strategies to increase efficacy and reduce toxicity, ultimately leading to a better standard of care ... understanding of the mechanism of action may help to potentiate the clinical efficacy and reduce the toxicity [13] of IFN-a 2b/PegIFN-a 2b Numerous studies suggest that the mechanism of action of ... stage and course, and modulating effects of high-dose interferon-a 2b treatment Journal of Translational Medicine 2010 8:76 Submit your next manuscript to BioMed Central and take full advantage of: ...
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báo cáo hóa học: " Dexamethasone diminishes the pro-inflammatory and cytotoxic effects of amyloid β-protein in cerebrovascular smooth muscle cells" docx
... the risk of AD, delaying the age of onset, and slowing the progression of disease and cognitive impairments [42,43] Despite the potential for NSAIDs and steroidal anti-inflammatory drugs in the ... understand how steroidal anti-inflammatory drugs may suppress CAA-related neuroinflammation and cellular pathology within the cerebral vessel wall, we determined the effects of dexamethasone and ... expression and activation of MMP-2 in response to Dutch mutant Aβ40 (Figure 5) On the other hand, indomethacin and ibuprofen, which did not block HCSM cell death, did not suppress expression and activation...
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báo cáo hóa học: " Pro-inflammatory gene expression and neurotoxic effects of activated microglia are attenuated by absence of CCAAT/enhancer binding protein b" potx
... absence of C/EBPb specifically in microglia This strongly supports a role of C/EBPb in the regulation of potentially neurotoxic effects of microglia and suggests that the neuroprotective effects of ... Ascherio A: Use of ibuprofen and risk of Parkinson disease Neurology 2011, 76:863-869 59 in’t Veld BA, Ruitenberg A, Hofman A, Stricker BH, Breteler MM: Antihypertensive drugs and incidence of dementia: ... treatment, and in nuclear levels of both activating (Full/LAP) and inhibitory (LIP) C/EBPb isoforms 24 h after treatment The increases in C/EBPb mRNA and protein induced by LPS and LPS+IFNg were of similar...
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báo cáo hóa học:" Proliferating and differentiating effects of three different growth factors on pluripotent mesenchymal cells and osteoblast like cells" pdf
... as a substrate of the enzyme After rinsing the cells the freshly prepared AP-buffer was added and Page of (page number not for citation purposes) Journal of Orthopaedic Surgery and Research 2007, ... concerning the effect of both factors (PDGFbb and IGF-I) on osteoblast differentiation are controversy Page of (page number not for citation purposes) Journal of Orthopaedic Surgery and Research 2007, ... synergistically [40] Therefore, for optimal stimulation of bone repair the controlled and local delivery of factors and factor combinations is mandatory [14,41,42] In the present study the growth...
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báo cáo hóa học:" Pain in cancer. An outcome research project to evaluate the epidemiology, the quality and the effects of pain treatment in cancer patients" pptx
... usual practice (standard of care) and followed over time using standardized methods and forms to make possible a valid and reliable description of case-mix, pattern of care and outcomes Subjects ... characteristics of a large sample of cancer patients in terms of case mix (patients characteristics), pattern of care (pharmacological and non-pharmacological treatments) and relevant efficacy (analgesic and ... epidemiology of cancer pain and of its treatments, the quality of analgesic-drug therapy and the effect of alternative analgesic strategies in a large, prospective, unselected cohort of cancer patients...
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Báo cáo khoa học: "Genotoxicity and toxicological effects of acrylamide on reproductive system in male rats" ppsx
... 30 mM MgCl , mM KCl salt solution, and 4% of S9 fraction Each of fresh bacterial suspension, 0.1 ml of S9 mixture (or 0.5 ml phosphate buffer), and 0.1 ml of the test substance were mixed in ... administration of acrylamide were measured and compared Rats were sacrificed by decapitation, and testes were removed and weighed After isolation of left epididymis from each testis, the tail region of each ... concentration of acrylamide (2,500 and 5,000 µg/plate) in the presence and absence of S9 mixture Moreover, numbers of revertants in TA100 increased significantly (p < 0.01) at higher concentration of acrylamide...
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Báo cáo khoa học: "Protective and therapeutic effects of an extract mixture of alder tree, labiate herb, milk thistle green bean-rice bran fermentation, and turnip against ethanol-induced toxicity in the rat" pdf
... indicated the presence of foci of inflammatory cells and corresponded to diffuse inflammation The sum of steatosis and inflammation scores was used in the results Persons unaware of our experimental ... Protective effects of herbal extract mixture against toxicity 35 Table Results from serum analysis and histopathological grade of the protective effect of herbal extract mixture and yogurt to ... Protective effects of herbal extract mixture and yogurt with a single ethanol challenge Ethanol-induced liver damage was evaluated by measuring liver injury markers (AST, ALT and total bilirubin) and...
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Báo cáo lâm nghiệp: "Carbon pool and substitution effects of an increased use of wood in buildings in Switzerland: first estimates" pdf
... works, and the energetic substitution effects of a consequent energetic use of residual and (post-consumer) waste wood For the political assessment, GHG effects occurring abroad and GHG effects ... heavy and thus nationally produced, C-pool and substitution effects of wood products 895 Figure Substitution effects of different wood products due to an increased use of wood, in Switzerland (CH) ... storage effects in landfills of wood are disregarded, as the dumping of waste wood is prohibited in Switzerland 3.4 GHG emissions dynamics of an increased use of wood The GHG emissions dynamics of...
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Báo cáo lâm nghiệp: " Seed germination of Quercus robur, Q. pyrenaica and Q. ilex and the effects of smoke, heat, ash and charcoal" ppsx
... distribution of germination The species of Quercus, which not have dormancy, have transient soil seed banks and one of the features of their reproductive strategies is based on the development of banks of ... another group of treatments with germination rates of between 80 and 90% These are 60 ºC–5 and 110 ºC–5 Finally, the treatment of 150 ºC–5 obtained the lowest value with a germination rate of only ... Germination rates at the end of a year of incubation The germination rates of Q robur and Q pyrenaica after a year of incubation are very high: around 85% in Q robur and at 93% in Q pyrenaica (Fig...
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