sites initial methionines utrs and other aspects of protein coding gene structure
Báo cáo y học: "Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas" ppsx
... activation of target genes Repression of target genes by MYC proteins has also been described [7] This seems to be independent of the binding of MYC proteins to E-boxes, but involves a cofactor, ... Nevertheless, the lack of binding of MYCN to a large set of target gene promoters in the c-MYCexpressing cells, SJ-NB12 and SY5Y, and the positive binding of c-MYC to almost all of these target gene promoters ... expression of MYCN or cMYC Direct regulation of these target genes by MYCN/cMYC was assessed by analyzing the binding of MYCN and cMYC protein to target gene promoters using PCR- and arraybased...
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báo cáo khoa học: "Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties" pot
... regulated by other tumour suppressor genes such as p53 and p73 products [46,67] This suggests that the appearance of genetic and/ or epigenetic abnormalities of TSGs including p53 and p73 genes, in ... hemi-methylated strands, UHRF1 is recruited with DNMT1 and/ or likely DNMT3a and DNMT3b, in order to perpetuate gene repression, and particularly that of TSGs in cancer cells Recently, two novel and interesting ... potentially others (Figure 4) are triggering a series of events that involve cell cycle arrest, apoptosis and inhibition of angiogenesis, all under the control of UHRF1 UHRF1 is a key component of a...
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Báo cáo y học: "Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units"
... and noninfection and infectionC-reactive protein level for discrimination of noninfection and infection Receiver operating characteristic (ROC) curve of eosinophil cell count and C-reactive protein ... response syndrome and infection (P
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Báo cáo sinh học: " High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916" potx
... B-ALL, and CML) and two subtypes of NHL (Burkitt’s, Large B-Cell Lymphoma) These findings are generally consistent with response profiles observed with other Aurora inhibitors [29,31,33] and suggests ... expression of the Aurora genes at the time of mitosis, the relationship of Aurora expression and response to GSK1070916 is still unclear In a subsequent analysis of the background genetics, we ... cycle and response studies CM participated in the design of the study and performed the statistical analysis YD, MAH, CM conceived of the study, and participated in its design and coordination and...
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o cáo hóa học:" High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916" ppt
... B-ALL, and CML) and two subtypes of NHL (Burkitt’s, Large B-Cell Lymphoma) These findings are generally consistent with response profiles observed with other Aurora inhibitors [29,31,33] and suggests ... expression of the Aurora genes at the time of mitosis, the relationship of Aurora expression and response to GSK1070916 is still unclear In a subsequent analysis of the background genetics, we ... cycle and response studies CM participated in the design of the study and performed the statistical analysis YD, MAH, CM conceived of the study, and participated in its design and coordination and...
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C elegans PRDM1 blimp1 homolog BLMP 1 is a positive regulator of bed 3 transcription
... enhancer activity analysis of NspI, F1, F2, F3 and sub-fragments of F2 (including SF1, SF2 and SF3) B: Location and enhancer activity analysis of SF2-1~SF2-9, and verification of possible important ... PR-SET domain and Zinc finger domains, the length of the protein is 825AA B: C elegans BLMP-1 protein isoform b with the PR-SET domain and Zinc finger domains, the length of the protein is 817AA ... Wnt8 and Otx genes in a Cisregulatory module and induces the transcription of eve and hox11/13b (Davidson et al., 2002b; Yuh et al., 2004; Minokawa et al., 2005; Livi and Davidson, 2006; Smith and...
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C elegans PRDM1 blimp1 homolog BLMP 1 is a positive regulator of bed 3 transcription
... enhancer activity analysis of NspI, F1, F2, F3 and sub-fragments of F2 (including SF1, SF2 and SF3) B: Location and enhancer activity analysis of SF2-1~SF2-9, and verification of possible important ... PR-SET domain and Zinc finger domains, the length of the protein is 825AA B: C elegans BLMP-1 protein isoform b with the PR-SET domain and Zinc finger domains, the length of the protein is 817AA ... Wnt8 and Otx genes in a Cisregulatory module and induces the transcription of eve and hox11/13b (Davidson et al., 2002b; Yuh et al., 2004; Minokawa et al., 2005; Livi and Davidson, 2006; Smith and...
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Báo cáo y học: "Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients"
... presence of low Ang-1 and VEGF; Ang-2 correlates with severity of illness (APACHE II and SOFA scores), pulmonary dysfunc- Page of (page number not for citation purposes) tion (PaO2/FiO2 and PaO2) and ... APACHE II scores, SOFA scores or C-reactive protein (CRP) levels Page of (page number not for citation purposes) Box plots of results healthy controls and study patients Box plots of results inin ... correlations of of results Correlations of Ang-2 serum concentrations with (a) the Acute Physiology and Chronic Health Evaluation (APACHE) II score and (b) the Sequential Organ Failure Assessment (SOFA)...
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Tài liệu .An ARCO Book ARCO is a registered trademark of Thomson Learning, Inc., and is used herein under pptx
... is made up of the radius of circle O and the radius of circle P To find the length of OP, you need to know the lengths of the two radii Since the length of the radius is one half that of the diameter, ... governments view software piracy as an industry in and of itself and look the other way U.S firms stand to lose millions of dollars in new business, and diminished U.S sales not only harm individual ... readers generally enjoy more than one type of magazine (B) most of the readers of Poets and Poetry subscribe to the magazine (C) the ratio of readers to copies is the same for Poets and Poetry...
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Tài liệu Báo cáo khoa học: Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase d and S6K1 and regulating cell growth docx
... glutathione-agarose Fig Proteins encoded by the POLDIP3 gene and the L7 insert (A) Schematic representation of both isoforms of the PDIP46 ⁄ SKAR protein encoded by POLDIP3 and the truncated form of PDIP ⁄ ... mass of 43 kDa, which differ only by an insertion of 29 amino acids in the middle of the protein These proteins are also known either as PDIP46 (polymerase d interacting protein 46) isoform and ... and did not show the b-galactosidase activity (Fig 1) There are at least two splicing variants of the human POLDIP3 gene encoding proteins of 421 amino acids with a molecular mass of 46 kDa and...
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Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx
... iNOS protein induction Effects of a-T and its derivatives on the enhancement by TS of LPS/IFN-induced NO production We compared the effects of a-T and its derivatives TA and TN with that of TS ... production with Ro31-2880 and GF109203X were approximately 70 and 30%, respectively Effects of TS on the amount of PKCa We further examined the effects of TS on the amounts of PKCa and PKCb by Western ... upregulation of PKCa DISCUSSION Fig Effects of PKA inhibitors (KT-5720 and H8) and PKC inhibitors (Ro31-8220 and GF109203X) on the enhancement by TS of LPS/IFNinduced NO production in VSMC (A), and Western...
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Báo cáo khoa học: Xenopus Rbm9 is a novel interactor of XGld2 in the cytoplasmic polyadenylation complex pptx
... RNA-binding protein Rbm9 (RNA-binding motif protein 9; also known as Fox2, fxh and RTA) is part of a family of proteins that includes A2BP1 (also called Fox1) and HRNbp3 Several of these homologues ... acceleration of the G2 ⁄ M transition in meiosis I This hastening of maturation was correlated with a precocious synthesis of Mos and AuroraA proteins, and with the activation of the mitogen-activated protein ... Identification of Rbm9, a novel Gld2-interacting protein (A) Schematic representation of the hGld2 fusion proteins used for the twohybrid screen The amino- and carboxy-terminal moieties of hGld2 (hGld2N and...
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Báo cáo khoa học: "Creative Language Retrieval: A Robust Hybrid of Information Retrieval and Linguistic Creativity" pot
... evaluate the effectiveness of ? and @, and indirectly that of ^ too, by comparing the use of ? and @ as category builders to a hand-crafted gold standard like WordNet Other researchers have likewise ... related at a generic level, as in “priests and imams” or “mosques and synagogues” More generally, consider the pattern “X and Y”, where X and Y are proper-names (e.g., “Zeus and Hera”), or X and Y are ... Nonetheless, ad-hoc categories in creative IR are often populated with the bindings produced by uses of @ and 284 ? and combinations thereof In a sense, ?X and @X and their variations are themselves ad-hoc...
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Báo cáo khoa học: Insect cytokine, growth-blocking peptide, is a primary regulator of melanin-synthesis enzymes in armyworm larval cuticle pptx
... Ninomiya and Y Hayakawa Stop 1884 531 3’UTR 5’UTR Fig Gene structures of P separata TH expressed in integuments and brains Epidermis (AB274834) and brain (AB274835) forms of P separata TH genes ... to northern blot of total RNAs from dorsal (D) and ventral (V) integuments rRNA TH and DDC Analysis of ~ kb of the 5¢-flanking region of both enzyme genes showed the presence of five common cis-elements ... 4) Mechanism of TH and DDC gene expression in epidermal cells To find sequence motifs commonly present in the upstream regions of the TH and DDC genes, we performed BLAST searches of the Bombyx...
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Báo cáo khoa học: A designed curved DNA segment that is a remarkable activator of eukaryotic transcription potx
... PmaCI and XhoI sites of pLHC20 ⁄ TLN Then, the KpnI–DraI region of the resulting construct was isolated and inserted between the KpnI and NruI sites of pLHC20 ⁄ TLN-6 Finally, to generate pLHC20 ... °C and for extension at 72 °C; and a final extension at 72 °C for 10 All amplified products were digested with KpnI and inserted between the KpnI and NruI sites of pLHC20 ⁄ TLN-6 Finally, each of ... contain a single copy of linearized pLHC20 ⁄ loxP ⁄ TLN-6, and the other two contain a single copy of linearized pLHC20 ⁄ loxP ⁄ -2 ⁄ TLN-6 By Fig Southern blot analysis of genomes of the established...
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Báo cáo khoa học: Ets-1/ Elk-1 is a critical mediator of dipeptidyl-peptidase III transcription in human glioblastoma cells pdf
... chemokine gene expression Blood 96, 3696–3706 Brown TA & McKnight SL (1992) Specificities of protein protein and protein DNA interaction of GABP alpha and two newly defined ets-related proteins Genes ... a heterodimer of Ets-1 and Elk-1 to the probe, and the N-terminus of Ets-1 and the C-terminus of Elk-1 were involved in the formation of the heterodimer Preincubation of nuclear proteins with ... phosphorylated form of Erk-1 or a-tubulin protein (E) Densitometric quantitation of the phosphorylated form of Erk-1 The bands of the blot given in (D) were subjected to densitometry and the values...
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Báo cáo khoa học: Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein potx
... of MSP/RON signaling involved in inflammation, wound healing and cancer progression Further experiments of tissue injury and inflammation using genetically engineered mouse models of the HGFA and ... Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome J Biol Chem ... processing of endogenous pro-MSP was analyzed by immunoblot KLKs, between wild-type mice and HGFA)/) mice We generated a small mechanical wound in the dorsal skin of mice and examined the infiltration of...
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Báo cáo khoa học: Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours pot
... The use of these techniques and their combination allow a better understanding of spatial and temporal changes in hypoxia in solid tumours, and also allow the linkage of these changes with other ... formation and, more particularly, in liver tumour development In this kind of tumour, AP-1 and c-fos were shown to be able to downregulate tumour suppressor genes and favour angiogenesis and tumour ... transcription of target genes involved, notably, in glycolysis (e.g the glyceraldehyde-3-phosphate dehydrogenase gene) and angiogenesis [e.g the vascular endothelial growth factor (VEGF) gene] [45],...
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Báo cáo khoa học: The leech product saratin is a potent inhibitor of platelet integrin a2b1 and von Willebrand factor binding to collagen pdf
... thank Steve P Watson and Andras Gruber for stimulating discussions, and Dr Barry Coller for the generous gifts of 6F1 and 6D1 Tara C White and Michelle A Berny are ARCS scholars, and David K Robinson ... adhesion and activation Three such molecules, LAPP (an approximately 13 kDa leech antiplatelet protein isolated from Haementeria of cinalis) and calin and saratin (approximately 65 kDa and 12 kDa proteins, ... dose–response and maximal aggregation of platelets did not differ in the presence of saratin (data not shown) However, onset of aggregation was significantly delayed in the presence of saratin (Fig 1A), and...
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Báo cáo khoa học: Myocyte enhancer factor 2 (MEF2) is a key modulator of the expression of the prothoracicotropic hormone gene in the silkworm, Bombyx mori ppt
... profiles of expression of BmMEF2 and PTTH genes RT-PCR and Southern blot analysis (A, B) were performed during embryogenesis h (2 h) and (3d), (5d), and (9d) days after oviposition (Em) and on ... the enhancement of PTTH gene expression in PTPCs A single MEF2 gene, d-mef2, has been identified in D melanogaster, and the isoforms of the D-MEF2 protein act as functional analogs of the vertebrate ... EGFP], v[PT ⁄ MEFs], and v[PT ⁄ MEFi] were 5.12, 5.37, and 3858 lane: ActA3 T1 MEF2 PTTH PTTH Fig Effect of PTTH gene expression on the overexpression and silencing of the BmMEF2 gene RT-PCR was performed...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25