... [Recommendations oftheGerman Society of Rheumatology for therapy with tumor necrosis factor inhibitors Pharmacotherapy Committee oftheGerman Society of Rheumatology] [http://dgrh.de/fileadmin/media/ ... associated with recurrence We defined recurrency as development of any cancer after a history of a prior malignancy, irrespective ofthe type ofthe recurrent tumor Tumor incidence We analysed the tumor ... include the relatively small sample size and the fact that physicians were less likely to prescribe cytokine inhibitors for patients with prior malignancy than for those without such a history Furthermore,...
... (Cys341) is involved in substrate binding at the S1 subsite and in maintaining the width and depth ofthe S1 subsite; (b) the rearrangement ofthe S1 subsite induced by the interaction between the SH ... support for a scenario in which the hydrophobicity ofthe SH group of Cys341 is important for substrate binding and maintaining the solvent-accessible cavity at the S1 subsite However, inthe ... lacks the ability to interact withthe protonated His397, this mutant enzyme is inefficient at utilizing the increased interaction energy to stabilize the tetrahedral intermediate inthe transition...
... fall planting is used, thereby avoiding cold storage Incorporating controlled-release fertilizers inthe root plug ofthe containerized stock is a practical way to increase seedling size without ... emission with digested plant tissue The remaining seedlings from each treatment were wrapped with plastic in bundles of 20 after lifting and placed into polylined wax boxes for cold storage The refrigerated ... adjacent to seedlings immediately after planting, incorporating the controlled-release prod- 123 uct inthe root plugs of containerized ponderosa pine stock inthe nursery probably is a more efficient...
... design and coordination, the rationale for the data analyses, and helped to draft the manuscript All authors read and approved the final manuscript Competing interests The authors declare that they ... Page of and helped to draft the manuscript TK participated inthe study design and coordination, the rationale for the data analyses and helped to draft the manuscript NDB participated inthe ... means and standard deviations ofthe items ofthe Patient Participation Scale (PPS) The means of all the items ofthe PPS were between the rating categories ‘totally agree’ and ‘agree.’ Therefore,...
... canals, orthe English language having a nice cup of tea, ortheGermanlanguage racing madly along the autobahn You only find discourse.” Robert de Beaugrande (1997: 36) It is unimaginable of a world ... Implications for Translation 41 4.5 Conclusion 42 REFERENCE 43 CHAPTER INTRODUCTION 1.1 Rationale Inthe world of human beings, you won't find a language by itself - the Dutch language strolling the canals, ... waves and orthographic forms to which we assign meaning on the basis of our past experience with them and on the basis ofthe situations in which these waves and forms are used Discourse analysis...
... man and a woman inthe clothes store 17 The teacher asks the students to work in groups They have to show the differences between sentences, about the form and the meaning; say the way to change ... verbs on the board, then asks the students to work in groups to find the verbs going withan -ing form, the verbs going withto + infinitive form The group which completes the game well and fastest ... students to work in groups The students will have to show the tense orthe form of verb in each clause of that sentence, guess the meaning and the usage of this condition The group which gives the...
... Phước, Tây Ninh thành phố Hồ Chí Minh; ĐBSCL gồm tỉnh Long An, Tiền Giang, An -18- Giang, Kiên Giang, Cà Mau, Sóc Trăng, Bạc Liêu, Đồng Tháp, Bến Tre, Hậu Giang, Vónh Long, Trà Vinh thành phố ... đó, chương quan tâm đến nội dung quy trình đònh danh, số đặc điểm đònh danh từ vựng, đặc trưng văn hoá đònh danh Ở đây, chọn cho quan niệm sở đònh danh (võ đoán phi võ đoán) trước quan niệm trái ... đònh danh “Sự khác từ chung với tên riêng nhóm từ thứ mang tính khái quát cao nhóm từ thứ hai mang tính đònh danh cao” [dẫn theo 79; 12] 1.2.2.2 Đònh danh từ vựng Hiện thực thường gọi tên theo...
... a role in liaising with IMO, FAO, NACA to enhance the effectiveness of existing instruments within APEC Institutional arrangements for managing the marine environment is fragmented in most ... Management Framework Conclusions, including the results ofthe November 2001 Workshop Management Framework - Introd uced Marine Pests Management capabilities and approaches APEC and the MRCWG have ... opportunities and adverse effects” Risk management can be achieved by Economies working collectively Opportunities for management at the preborder, border and post border levels Need to...
... prior tothe required disclosure of this information under International Financial Reporting Standards (IFRS) We find evidence that investor demand for fair value information—reflected in more ... is an indicator variable equal to if firm i provides investment property fair values inthe financial statements or annual report ofthe year preceding mandatory IFRS adoption, and otherwise The ... at the end ofthe mandatory IFRS adoption year Big4 is an indicator variable equal to if the firm employs a Big Four auditing firm inthe mandatory IFRS adoption year, and otherwise Ext is an indicator...
... (Wetzlar, Germany) For immunocytochemistry, the cells were fixed with 4% formaldehyde for 30 min, then treated with 0.1% Triton X-100 in NaCl ⁄ Pi for min, and incubated with NaCl ⁄ Pi containing 3% normal ... of lymphocytes towards in ammatory sites [35,36] SCs have been implicated in human in ammatory demyelinating neuropathies such as ´ Guillain–Barre syndrome and chronic in ammatory demyelinating ... mediates the rapid induction of cytokines and adhesion molecules that are implicated in immune and in ammatory responses [24,25] Mitogen-activated protein kinases (MAPKs) are important mediators of...
... through Labor Day due tothe summer event moratorium A waiver to apply for a special event permit to hold a special event in these parks during the summer moratorium or other moratorium time ... S TORM W ATER P OLLUTION P REVENTION Standard portable sinks or hand-sanitizing units must be placed on a liner to prevent spills and run-off into the storm drain system Accessible portable sinks ... Planning Guide OSE 1.2 Tow Authorization Only a representative ofthe San Diego Police Department can authorize a tow inthe public rightof-way As an event organizer, you must coordinate with the...
... reduced the response to eugenin, indicating that eugenin is indeed acting through CCK2 receptors To further investigate the interaction of eugenin with CCK2 receptors, we investigated the effect of ... but the sequence after the Tyr(SO3) residue of eugenin is different from those ofthe other mammalian and amphibian analogues shown in Table CCK-8 and caerulein bind to CCK receptors [42] There ... stimulation ofthe proliferation of lymphocytes, activation of CCK receptors stimulate production of interleukins and secretion of immunoglobulins on the mucosal surface ofthe intestine [49,50] The antibacterial...
... Journal of Child Language, 12:271296 Karin Mă ller 2001 Automatic detection of syllable u boundaries combining the advantages of treebank and bracketed corpora training In Proceedings ofthe 39th Annual ... Collocation morphology adaptor grammar One ofthe advantages of working within a grammatical framework is that it is often easy to combine Sentence Sentence Colloc Word Colloc Colloc Word Word Word Word ... application of adaptor grammars, since the grammar can learn the possible onset and coda clusters, rather than requiring them to be stipulated inthe grammar Inthe unigram syllable adaptor grammar...
... substitution ofthe arginine had not resulted in a distorted or misfolded receptor protein In contrast tothe three classes of antagonist, the binding of AVP was dramatically affected by the substitution ... off-state The unique ability of arginyl to fulfil this constraining function inthe N-terminus ofthe V1aR is similar tothe unique constraining role of alanyl previously reported for Ala293 inthe ... 10-fold and 600-fold respectively (Table 1) Indeed, there is no correlation between the Ki and EC50 values for the mutant receptors (Fig 4) The ratio of EC50 to Ki is an indicator of efficacy, i.e the...
... having no effect on the intensity ofthe DHS then the two bars in each pair would be ofthe same height For both panels A and B the increasing amounts of DNase show a proportionate increase inthe ... preliminary screen for these DHS in other cell lines [5] To look for tissue-speci®c DHS inthe pancreatic duct, the pancreatic cell lines Capan1 and NP31 were evaluated further DHS in airway epithelial ... showed the intron DHS that in intron 18 was not evident and the DHS in intron 10 at 1716 + 23 kb was strong The role of these DHS in CFTR expression inthe pancreas warrants further evaluation In the...
... by four or five washes ofthe gel in H2O The arrows indicate the stained bands inthe gel I is the major peroxidase activity of hydra residing inthe foot ofthe animal, II indicates another peroxidase ... peroxidase containing cells lying inthe ectoderm ofthe foot The diaminobenzidinestained granules are localized mainly inthe apical part ofthe foot mucous cells as indicated by the arrow in (B) (C,D) ... Methylene-blue staining ofthe same filter revealed the amounts of RNA loaded per lane The sizes ofan RNA marker are indicated the cloning ofthe 5¢ and 3¢ end ofthe clone, respectively Analysis ofthe nucleotide...
... juxtapositions ofthe works according to themes or particular interests; • by bringing the collections to new audiences and allowing new ways of exploring and enjoying them; • by offering the ability to ... evaluate the relevance of any particular text inthe growing corpus of material on project planning, digitization, the kinds of metadata that need to be included in any project, and the maintenance and ... withstand the test of time or is it only of ephemeral interest today? (Is it, for example, an important testimony ofthe past, of another culture or our own, ofan artistic movement, an author,...
... been involved in labourious and costly effort If the goal is known and sufficient ofthe theory and practice is known for the applicant to predict where he is going, without there being an original ... other workers were attempting to find recombinant methods of preparing t-PA at the same time as Genentech, was another reason for the Court finding the patent invalid However, in Chiron v Organon ... step inthe light of judgments ofthe UK courts and decisions ofthe EPO Boards of Appeal as they relate to biotechnology in particular, and by their relevance to a specific step ofthe Windsurfing/...
... 24-kDa a-zein and the 19-kDa a-zein endosperm storage proteins, respectively These mutant proteins are translocated into the lumen ofthe ER, but remain anchored tothe membranes through the noncleaved ... expressed in tobacco protoplasts inthe absence of a B chain [152] The degradation of ricin A chain is brefeldin A-insensitive and is inhibited by the proteasome inhibitor clasto-lactacystin b-lactone, ... subunits and accumulate in protein storage vacuoles In soybean cotyledon, PDI-related proteins GmPDIS-1 (an ortholog of At2g47470) [116] associates with a precursor ofthe storage protein glycinin in...