regulator of stem cell fate
Báo cáo khoa học: Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours pot
... targets of these treatments comprises the endothelial cells One endothelial cell can control the survival of approximately 50–100 tumour cells [93] Therefore, the destruction of a few endothelial cells ... decreases could transiently arrest the division of tumour cells in S-phase [62] These cells are the main targets of chemotherapy, and the arrest of their cell cycle during S-phase reduces considerably ... observed after the repetition of cycles of of hypoxia followed by of reoxygenation for weeks [101] Moreover, in vitro, an increase in endothelial cell migration and formation of tubes was also reported...
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Báo cáo sinh học: " Risk factors in the development of stem cell therapy" pdf
... Limited lifespan (population doublings) Production of endless number of cells Production of endless number of cells Production of limited number of cells Chromosome length is maintained across serial ... in stem cell lines (i.e initially not intended for cell in case of autologous use clinical application) malignant counterparts of embryonic stem cells that originate from the inner cell mass of ... source of harm [35,37] Examples of risk factors are the type of stem cells used, their procurement and culturing history, the level of manipulation and site of injection Because of the variety of...
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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 1) ppt
... Sources of Stem Cells for Tissue Repair Different types of stem cells include embryonic stem (ES) cells, umbilical cord blood stem cells, organ-specific somatic stem cells (e.g., neural stem cells ... transdifferentiation of MSCs or other stem cell populations occurs at a high enough frequency to be useful for stem cell replacement therapy Regardless of the source of the stem cells used in regenerative ... pluripotent stem cell populations, such as bone marrow mesenchymal stem cells (MSCs) or adipose stem cells, for use in regenerative strategies Tissue culture evidence suggests that these stem cell...
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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 2) pps
... after transplantation of a variety of different cell types, including ES cells, bone marrow stem cells, endothelial stem cells, and adipose stem cells Bone marrow stem cells in particular have ... cells are also excellent vehicles for cellular gene therapy (Chap 65) Figure 67-1 Strategies for transplantation of stem cells Undifferentiated or partially differentiated stem cells may be injected ... disease; and (3) stimulation of endogenous stem cells to facilitate repair—e.g., administration of appropriate growth factors to amplify numbers of endogenous stem/ progenitor cells or direct them to...
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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 3) pot
... development of dyskinesia Transplantation of stem cell derived dopamine-producing cells offers a number of potential advantages over fetal transplants, including the ability of stem cells to migrate ... strategy Potential sources of stem cells include endogenous liver stem cells (such as oval cells), ES cells, bone marrow cells, and umbilical cord blood cells Although a series of studies in humans ... gastrointestinal precursor cells may be candidates for cell- based therapy of diabetes Nervous System Neural cells have been differentiated from a variety of stem cell populations Human ES cells can be induced...
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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 4) pot
... Applications of Stem Cell Research et al: Stem Cells and the Future of Regenerative Medicine Washington, D.C., National Academies Press, 2002 Holland S et al: The Human Embryonic Stem Cell Debate: ... et al (eds): Essentials of Stem Cell Biology San Diego, Elsevier Academic Press, 2006 Mimeault M et al: Stem cells: A revolution in therapeutics-recent advances in stem cell biology and their ... 2007 [PMID: 17671448] National Institutes of Health: Stem cell information page URL: http://stemcells.nih.gov/index.asp Puceat M, Ballis A: Embryonic stem cells: From bench to bedside Clin Pharmacol...
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báo cáo khoa học: "The transplant iron score as a predictor of stem cell transplant survival" pptx
... validate the detrimental impact of iron overload in the set- http://www.jhoonline.org/content/2/1/44 ting of stem cell transplantation and identify a potential mechanism of action Methods We evaluated ... associated with increased visible iron with a score of 6+ having large visible iron clumps that obscure cellular details The number of packed red cell blood cell (pRBC) transfusions prior to transplantation ... aplastic anemia plant echocardiogram or MUGA scan All measures of EF were performed within months of stem cell transplant The highest quartile of total transaminases, TB, and INR among our study group...
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báo cáo khoa học: "Hepatocyte growth factor incorporated chitosan nanoparticles augment the differentiation of stem cell into hepatocytes for the recovery of liver cirrhosis in mice" pptx
... which stem cells regenerate the respective parenchymal cells, heading to repair of the organs in vivo is yet to be completely understood Cell fusion, in which stem cells fuse with the somatic cell ... of activated myofibroblasts) Secretion of type I collagen by myofibroblasts that leads to fibrosis was analyzed by immunofluorescence The results of imunofluorescence study for distribution of ... differentiation of HGF after transplantation Differentiation of homed stem cells at the target site was monitored by the expression of sry gene after transplantation of stem cells in sex mismatched...
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báo cáo khoa học: "Public perception of stem cell and genomics research" ppt
... principles for responsible translational stem cell research Cell Stem Cell 2008, 3:607-609 ISSCR: A closer look at stem cell treatments [http://www closerlookatstemcells.org//AM/Template.cfm?Section=Home] ... hESC, human embryonic stem cell; HGP, Human Genome Project; hPSC, human pluripotent stem cell; iPSC, induced pluripotent stem cell; ISSCR, International Society for Stem Cell Research Competing ... New Era of Personalized Medicine New York: Free Press; 2010 Lau D, Ogbogu U, Taylor B, Stafinski T, Menon D, Caulfield T: Stem cell clinics online: the direct-to-consumer portrayal of stem cell...
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Báo cáo y học: "Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis" doc
... overall assessment of the importance of histone modifications on stem cell biology To evaluate the importance of histone acetylation on ES cell differentiation, we treated cells with the histone ... wildtype cells whereas Brachyury was up-regulated one day later than in wild-type cells These results show that 'ES re' cells are still capable of acquiring either one of the three cell fates To ... we analyzed the expression of Nanog, one of the master regulators of ES cell identity Nanog is down-regulated by TSA in a dose-dependent manner, with a concentration of 50 nM having maximal effect...
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Báo cáo y học: "Developmental stage related patterns of codon usage and genomic GC content: searching for evolutionary fingerprints with models of stem cell differentiation" potx
... models of stem cell differentiation Cell types of different developmental stages in two models of stem cell differentiation (a) Cell types of earlier developmental stages can differentiate into cell ... models of stem cell differentiation Model Descriptions Definitions Pluripotent stem cell C57Bl/6 cell line A Adult neural stem cell *Neurosphere LVB A Adult mature neural cell Lateral ventricles of ... hematopoietic stem cell †Lin- c-Kit+ Sca-1+ CD34- Hoelow BM A Non-hematopoietic stem cell Bone marrow main population ESC B Pluripotent stem cell CCE cell line FNSC B Fetal neural stem cell *†Hoelow...
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Báo cáo TYPES OF STEM CELL
... produce more stem cells Stem cell potency Stem cell properties Different types of stem cell Embryonic stem cells Presenter: Bach Thi Hoai Phuong Different kinds of stem cells • Embryonic stem cells ... dying cells and regenerate damaged tissue Adult stem cells reside in a specific area of each tissue called a stem cell niche” Adult stem cells Embryonic stem cells can become all cell types of ... Introduction Introduction of stem cell Presenter: Pham Quynh Hoa What are stem cells? • Stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide...
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Isolation and characterization of stem cell regulatory genes oct4 and stat3 from the model fish medaka
... I Introduction 1.1 Stem cells 1.1.1 Developmental potency of stem cells 1.1.2 Fundermental features of stem cells 1.1.3 Signalling pathways modulating pluripotency in stem cells 1.1.4 Transcription ... features of stem cells Since stem cell renewal and differentiation take place at early stages of embryogenesis, the early developing embryo is an ideal system for the in vivo analysis of stem cells ... undifferentiated status of self-renewing stem cells Stem cells show a hierarchy of developmental potency in mouse (Fig 1-1) Totipotent stem cells include the zygote and the 8 -cell morula that have...
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Effects of high glucose concentrations on the expression of genes involved in proliferation and cell fate specification of mouse embryonic neural stem cells
... expression of genes involved in proliferation and cell fate specification of embryonic neural stem cells Society for Neuroscience 35th Annual Meeting, Abstract Number 24.10 (24 Neural Stem Cells in ... viability of differentiated cells from NSCs···············160 Figure Effects of HG on proliferation of differentiated cells from NSCs ········162 Figure Effects of HG on apoptosis of differentiated cells ... EFFECTS OF HIGH GLUCOSE CONCENTRATIONS ON THE EXPRESSION OF GENES INVOLVED IN PROLIFERATION AND CELL- FATE SPECIFICATION OF MOUSE EMBRYONIC NEURAL STEM CELLS FU JIANG (MD, MMed)...
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Connecting brain tumor stem cells with their primary tumor and exploring glycogen synthase kinase 3ß regulation of cell fate
... have shed light on the role of neural stem cells as the transformational cells in GBM formation, hence their accurate terminology as glioma stem cells or -initiating cells14, 16, 17 Traditionally, ... consequence of the conditions employed in the xenograft model Despite the lack of ability of in vitro cultured stem celllike GPCs to reflect the actual transformational cell in tumorigenesis, these cells ... immunohistochemistry of a case of anaplastic oligoastrocytoma 32 Figure-6 NNI-8 glioma propagating cells exhibit stemness expression and extensive self-renewal 35 Figure-7 NNI-8 expresses stem- like cell phenotypes...
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Tài liệu Review of Chronic Graft- Versus-Host Disease in Children After Allogeneic Stem Cell Transplantation: Nursing Perspective pptx
... common after peripheral blood stem cell transplantation than BMT because it is generally accepted that peripheral blood stem cells con tain greater numbers of infused T-cells (Bishop, 2009; Schmitz ... to improve range of motion The immune system is profoundly altered by the direct consequences of alloreactivity and indirect effects of immu nosuppressive therapy for treatment of chronic GVHD ... capability of negative T -cell selection will release more autoreactive T-cells This process leads to more chronic GVHD with autoimmune similarities (Hollander, Widmer, & Burakoff, 1994) Management of...
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Autoimmune Diseases – Contributing Factors, Specific Cases of Autoimmune Diseases, and Stem Cell and Other Therapies pdf
... cells upon recognition of the beta -cell- specific peptide bound to MHC class I molecules in the presence of beta -cell- specific CD4+ T helper cells The cytotoxic CD8+ T cells then affect beta -cell ... T cells, which express high levels of VDR, but did not affect numbers of regulatory T cells, which express low levels of VDR (Mayne et al., 2011) An earlier study also showed that survival of ... CD4+ T cells, and CD8+ T cells synergistically destroy beta-cells, resulting in the onset of autoimmune Type (DM) Both direct and indirect killing of beta-cells, mediated by CD8+cytotoxic T cells...
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Báo cáo khoa học: Tec family kinases Itk and Rlk⁄ Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates pot
... amplification of expression of their master regulator GATA-3 For Th17 cells, transforming growth factor-b1 in the presence of IL-6 initiates differentiation of murine CD4 cells, leading to expression of ... the balance of conventional and innate T -cell lineages In the absence of Itk, there is a reduction of conventional CD4+ and CD8+ cells and an expansion of innate CD4+ and CD8+ T -cell lineages ... of Itk) ⁄ ) innate CD8+ T cells also occurred by a noncell autonomous mechanism [33] By contrast, expansion of the PLZF+, IL-4-producing CD4+ cells appeared to be cell autonomous Generation of...
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