regulation by the numbers
Guidance for Industry on Complementary and Alternative Medicine Products and Their Regulation by the Food and Drug Administration pptx
... be subject to regulation under the Act or the PHs Act; and a To show that neither the Act nor the PHs Act contains any exemption for CAM products In other words, if a product meets the statutory ... (such as a lotion, cream, or oil) to the skin or other parts of the body, those products may be subject to regulation under the Act, depending on the nature of the product and its intended use D ... supplements, foods, or drugs under the Act, depending on the product's intended use Other factors may also affect the classification of the product, e.g., whether the product contains a "dietary...
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OUTBREAKS BY THE NUMBERS: FRUITS AND VEGETABLES 1990-2005 potx
... from the Center for Science in the Public Interest (CSPI) CSPI conducted a hazard analysis on produce by identifying the most common food/pathogen combinations and ranked their risk based on their ... for four of the top five produce-pathogen combinations The domination of Norovirus as a major pathogen in recent years may be explained by improved lab detection of Norovirus or by the increasing ... produce in the CSPI database Produce outbreaks account for 13% of foodborne illness outbreaks and 21% of illnesses in the database (Figure 1) Fifty percent of the produce outbreaks are caused by food...
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Math Concept Reader MCR g3 party plans by the numbers!
... Day! The day of the picnic has arrived! Everyone in the chorus club worked hard to plan and prepare The decoration team painted bright banners and them up They decorated the tables, too The game ... Maria read the recipe together and multiply each ingredient by Claire makes a shopping list She lists each item they need and how much of it they need Maria’s dad will take them to the store 11 ... Plans by the Numbers! by Linda Bussell Copyright © Gareth Stevens, Inc All rights reserved Developed for Harcourt, Inc., by Gareth Stevens, Inc This edition published by Harcourt, Inc., by agreement...
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Báo cáo hóa học: " Comparison of p53 and the PDZ domain containing protein MAGI-3 regulation by the E6 protein from high-risk human papillomaviruses" pdf
... initially by directing its nuclear export and subsequently mediating the majority of p53 degradation in the cytoplasm [5] We thereby assayed for p53-mediated transcriptional activity in the presence ... where the E6 proteins differ by one or several amino acids, as shown in Table 1[27] It was therefore interesting to determine whether polymorphisms in these HPV type 33 E6 genes affect their ... levels in these cells [28] Under these experimental conditions it was therefore possible to compare the levels of transfected p53 and MAGI-3 in the presence Table 1: Sequence polymorphisms in the HPV-33...
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Báo cáo y học: "The terrestrial evolution of metabolism and life – by the numbers" doc
... Kleiber would have it, but also by the availability of energy to it, and by the ability of the organic battery to capture and expend this energy These two are expressed as the denominator and numerator ... claimed the equation applied to bacteria and to ecosystems The same study that found metabolic-rate-scaling for endotherms is far closer to the value predicted by Kleiber than that of ectotherms, ... against loss to heat ME is therefore a ratio of amperes of anabolism to amperes of catabolism The recharge rate of the organic battery is influenced not just by the size of the mass, as Kleiber would...
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Email marketing by the numbers chris baggott
... AM Page i Email Marketing by the Numbers bagg_a01ffirs.qxd 3/2/07 10:46 AM Page ii bagg_a01ffirs.qxd 3/2/07 10:46 AM Page iii Email Marketing by the Numbers How to Use the World’s Greatest Marketing ... Sam (the butcher) from the Brady Bunch Take the time to get to know your customers as individuals Pay attention to them Talk to them like human beings (and show them you are a human being rather ... bear the loss or the thought of rejection so we call, show up unexpectedly, and hang on to the relationship In the real world, this is called stalking The problem is that rather than leaving the...
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Tài liệu Báo cáo khoa học: Regulation of the actin–myosin interaction by titin doc
... solution On the other hand, the acceleration of the sliding velocity (and the lower number of stops) of thin filaments could be related to a diminution of the load in the actin–myosin interface The properties ... movements of the stage, which can upset the stability of image focusing during time-lapse recording The stability was further enhanced by the presence of a plexiglass box that protected the front ... digestion of T800 by trypsin The set of molecular weights corresponding to the resulting tryptic peptides was then examined by a search in the NCBI nonredundant protein database using the search engine...
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Báo cáo khoa học: Versatile regulation of multisite protein phosphorylation by the order of phosphate processing and protein–protein interactions pptx
... the binding affinity of the kinase or its catalytic activity at another site, so that the phosphorylation kinetics of one residue can depend on the phosphorylation state of other residues in the ... of the phosphorylation sites by the same kinase This study provides a link between the structural, kinetic and thermodynamic aspects of complex multisite phosphorylation on the one hand, and the ... state, the target can occur in free form or bound to kinase or phosphatase; the respective concentrations of the target will be denoted by Xn,0, Xn,K and Xn,P, respectively They are determined by the...
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Báo cáo khoa học: The catalysis of the SARS 3C-like protease is under extensive regulation by its extra domain doc
... The role of the identified residues other than Arg4 and Glu290 in dimerization might be in maintaining the correct sidechain conformations of the residues Glu290 and Arg4 by interacting with them ... amyloid formation The expressed GST-fusion proteins were purified by using the glutathione Sepharose affinity column and the pure mutated 3CL proteases were further obtained by in-gel thrombin-cleavage ... those of the wild-type protease, as exemplified by Fig 5F in which the HSQC spectra of the Arg298Ala and wild-type proteases were superimposed at a lower spectral level These results, together with...
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REGULATION OF INTEREST RATE BY THE STATE BANK OF VIETNAM (SBV) potx
... rate according to the policy adopted by the Conference of Bankers at the beginning of the year, the State Bank preserved the status quo on the grounds that the inflation rate in the first half of ... take the refinancing rate as the “ceiling rate”, because principally, the refinancing rate and the discount rate save only the outflow of money from the SBV to the other banks, which results in the ... Other medium-term and long-term bonds have not be put on the stage The auction is based more on the volume rather than the interest rate Therefore, the open market operation does not reflect the...
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Báo cáo khoa học: The lactate dehydrogenases encoded by the ldh and ldhB genes in Lactococcus lactis exhibit distinct regulation and catalytic properties ) comparative modeling to probe the molecular basis pdf
... encoded by the ldhB gene, and the activation of this gene was explained by the site-specific, oriented integration of an IS905-like element in the intergenic region upstream of the ldhB gene, thereby ... with the sequence analysis of the ldhB gene in strain FI9078, led to the conclusion that lactate production in strain FI9078 was mediated by the enzyme encoded by the ldhB gene As expected, the ... some extent mimic the role of Fru(1,6)P2 in the allosteric binding sites, thereby stabilizing the tetrameric active form when the preferred activator is absent This seems to be the case in LDHB...
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Báo cáo khoa học: pyr RNA binding to the Bacillus caldolyticus PyrR attenuation protein – characterization and regulation by uridine and guanosine nucleotides potx
... effects on RNA binding The implications of the the current findings for the physiological regulation of pyrimidine biosynthesis are presented; the most important of these is that regulation of pyr ... demonstrating the antagonism of the two effectors When the ratio of GTP to UTP was varied over the same range, the effects were similar to the effects of GMP and UMP; the values for the apparent ... experimental details are given in the Experimental procedures The vertical dotted line relates the protein peak to the other panels and the vertical dashed line does the same for the PyrR–RNA complex FEBS...
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Báo cáo khoa học: Transcriptional regulation of the desferrioxamine gene cluster of Streptomyces coelicolor is mediated by binding of DmdR1 to an iron box in the promoter of the desA gene doc
... interesting that the )10 sequence is located inside the iron box of desA (nucleotides 7–12 of the iron box), explaining the regulation of desA expression by binding of DmdR1 to the iron box The same ... decreases at 24 h The coordinated regulation by iron of the expression of the entire cluster ensures simple and efficient up -regulation of desferrioxamine biosynthesis after iron limitation The two upstream ... cluster expression of the des cluster is mediated by the DmdR1 regulator Results Deletion of the desA gene of S coelicolor blocks desferrioxamine biosynthesis The organization of the putative desferrioxamine...
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Báo cáo Y học: Irregular spiking in free calcium concentration in single, human platelets Regulation by modulation of the inositol trisphosphate receptors ppt
... [4] Because of the small size of platelets with nearby Ca2+ATPases throughout the cell, it is likely that the rate of Ca2+ pumping rather than the diffusion of released Ca2+ into the cytosol (as ... investigated the importance of InsP3 receptor-dependent CICR in the irregular Ca2+ signal generation by these agents, and the sensitivity of this signal toward cAMP elevation We found that the irregular ... spiking not by increasing the InsP3 level but by potentiating InsP3 receptor-mediated Ca2+ release This may explain why the Ca2+ response with thimerosal is only partially inhibitable by PGE1 The N-ethyl...
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Báo cáo Y học: Functional analysis of the rat bile salt export pump gene promoter Regulation by bile acids, drugs and endogenous compounds potx
... genes either by binding to-specific estrogen response elements or by stimulating the activity of factors of the AP1 complex [31,32] Both elements are located on the Bsep promoter and could therefore ... and BglII The DNA fragments were then cloned directionally into the MluI–BglII sites of the pGL3-Basic (Promega) luciferase reporter gene vector The plasmid constructs were verified by sequencing ... underlined with their names indicated above The TATA motif is boxed The minor transcription start site at nucleotide +10 is marked by an asterisk The complete nucleotide sequence of the Bsep promoter...
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Báo cáo khoa học: The regulation of the endosomal compartment by p53 the tumor suppressor gene docx
... within the repeats represent the spacer The lowercase letters on the flank of the repeats represent the flanking sequences around the p53RE (B) Regulation of gene expression was measured by real-time ... against p53 (siRNA-p53), followed by etoposide treatment (C) Putative p53RE was able to be bound by the p53 protein shown in the ChIP assay The samples were the input, the recovered DNA from incubation ... accelerate removal of the EGFR from the plasma membrane In H460 cells, the localization of the EGFR was determined by fluorescent immunostaining In the absence of etoposide, EGFR was all at the plasma membrane...
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Báo cáo khoa học: Regulation of the human leukocyte-derived arginine aminopeptidase/endoplasmic reticulum-aminopeptidase 2 gene by interferon-c pot
... in the ER [24,25] The peptides are first cleaved from endogenously synthesized proteins by proteasome or tripeptidyl peptidase II in the cytoplasm, transported into ER-lumen and then trimmed by ... region of the human L-RAP gene The transcriptional initiation site of the gene was determined by 5¢ RACE and is shown as nucleotide position +1 in the figure The site (TCAGTC) matches well with the ... of the IRF-E site caused a significant decrease in the promoter activity (Fig 3C) These results suggest that the IRF-E site is crucial for the maximum promoter activity of the L-RAP gene in the...
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Báo cáo khoa học: Regulation of the muscle-specific AMP-activated protein kinase a2b2c3 complexes by AMP and implications of the mutations in the c3-subunit for the AMP dependence of the enzyme docx
... equivalent to the R302Q substitution in c2, the dominant isoform of the c-subunit in the heart The R302Q mutation, together with several other substitutions identified in CBS domains of the c2 gene, ... Effect of the mutations in the AMPK c3 gene on the AMP dependence of the enzyme Fold stimulation reflects the activation of the corresponding AMPK complexes by 200 lM AMP relative to the basal ... to a single site formed by the CBS domains of the c-subunit [52] Nevertheless, the absence of regulation of Saccharomyces cerevisiae AMPK activity by AMP [53,54] raises the possibility that nucleotide...
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báo cáo hóa học:" Transcriptional regulation of bone formation by the osteoblast-specific transcription factor Osx Chi Zhang" pptx
... cells from the periosteum invade the zone of the hypertrophy chondrocyte as a wedge-shaped expansion of the periosteum in which osteoblast precursors are arrested in their differentiation These observations ... mechanism of the temporal and spatial regulation of Osx for bone formation and homeostatic regulation of skeletal system The need to develop novel drugs that stimulate bone formation and thereby elevate ... Competing interests The authors declare that they have no competing interests Authors' contributions The author contributed to the article The author has read and approved the final manuscript...
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Báo cáo y học: "Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes" pps
... at the time of joint replacement as described previously [3] The diagnosis of RA conformed to the American College of Rheumatology 1987 revised criteria [23] The protocol was approved by the ... deficient cells, these MAP3Ks appear to be redundant in JNK activation in cultured FLSs Therefore, the diverse and complex functions of MAP3Ks vary depending on the cell type as well as the stimulus ... 24 h The cells were incubated in fresh media for 48 h and subsequently serum starved (0.1% FCS/DMEM) for 48 h FLSs were then treated with either medium or IL-1β (2 ng/ml) for 60 minutes The cells...
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