refractoriness to platelet transfusion

$Báo cáo khoa học: Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C pdf$

Báo cáo khoa học: Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C pdf

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... response to ligand In T84 cells, 18 h ST treatment led to cellular refractoriness to further ST stimulation and this refractoriness was contributed by both down-regulation of GC-C leading to reduced ... to Caco2 cells did not result in cellular refractoriness to ST (data not shown) In vitro guanylyl cyclase assay after ST-induced desensitization Fig Prolonged ST treatment leads to cellular refractoriness ... cells to ST to observe desensitization, is in contrast to the rapid inactivation that is seen for other members of the guanylyl cyclase receptors, such as GC-A and the sea urchin sperm receptor...

Báo cáo y học: "Using theories of behaviour to understand transfusion prescribing in three clinical contexts in two countries: Development work for an implementation trial" pps

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... for the reduction of transfusion studied in clinical trials seemed to be effective, with a reduction in inappropriate transfusions of 12% to 83% [8] and of 9% to 77% for the total number of units ... to optimize transfusion practice The clinical evidence base to support more restrictive transfusion practice is fairly new and, to our knowledge, there have been no investigations of the factors ... interventions to change physicians' transfusion practices Arch Intern Med 2005, 165(8):845-852 Tobin SN, Campbell DA, Boyce NW: Durability of response to a targeted intervention to modify clinician transfusion...

Báo cáo y học: " Protein kinase C promotes restoration of calcium homeostasis to platelet activating factor-stimulated human neutrophils by inhibition of phospholipase C" ppt

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... with its receptors on the membranes of calcium storage vesicles releasing Ca2+ into the cytosol [3] The intracellular concentration of IP3 peaks at about 10 - 15 sec following receptor ligation ... mechanism to expedite restoration of Ca2+ homeostasis and attenuate the Ca2+-dependent pro-inflammatory activities of these cells In the current study, we have utilized two selective PKC inhibitors to ... treated with the phosphodiesterase inhibitor, rolipram in order to investigate the effects of the PKC inhibitors on the rates of resequestration of Ca2+ into storage vesicles medi- http://www.journal-inflammation.com/content/6/1/29...

báo cáo khoa học: " Using theories of behaviour to understand transfusion prescribing in three clinical contexts in two countries: Development work for an implementation trial" pptx

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Guideline for platelet transfusion thresholds for pediatric hematology oncology patients

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... thrombocytopenia • Stable patients with chronic, stable, severe thrombocytopenia due to alloimmunization should be observed without prophylactic platelet transfusions These patients should receive platelet ... prophylactic platelet transfusions is 10 x 109/L (1C) Recommendations Threshold for patients with solid tumor Threshold for stable patients with solid tumors to receive prophylactic platelet transfusions ... month to 19 years) with cancer or serious hematologic disorders Interventions and Practices Considered • Platelet transfusion based on assessment of thresholds Description of Methods Used to Formulate...

The platelet contribution to cancer progression pot

Danh mục: Sức khỏe giới tính

... anchors platelet to subendothelium GPVI Platelet adhesion to collagen Not studied to date P-selectin P2Y receptors Mediates plateletleukocyte tethering; triggers leukocyte activation ADP-mediated platelet ... exposure to platelets [46,50] In the latter, both activated platelet membranes and platelet releasate increased invasion Platelet contents may be released into the peritumoral space following platelet ... receptors Thrombin mediated platelet activation Alpha granules Storage of proteins that enhance adhesive process: ﬁbrinogen, VWF, MMP-II, P-selectin, factor V, PF-4, platelet activating factor Platelet...

Báo cáo khoa học: Mitochondria regulate platelet metamorphosis induced by opsonized zymosan A – activation and long-term commitment to cell death docx

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... addition to energy supply, they have also been demonstrated to be involved in execution of apoptosis via the release of apoptogenic factors such as cytochrome c [5] Human blood platelet mitochondria ... has been reported to be a key step in platelet apoptosis, and mitochondrial membrane potential (MMP) is lost during storage and under other conditions [4,6,7] Changes in the mitochondrial permeability ... the pro-apoptotic Bcl-2 family member Bax [3] Hence, mitochondria integrity and function appear to act as general regulators of platelet fate in terms of both activation and apoptosis, two processes...

Báo cáo khoa học: Mitochondria regulate platelet metamorphosis induced by opsonized zymosan A – activation and long-term commitment to cell death potx

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... 5-bromo-4-chloro-3-indolyl-b-d-galactopyr- Active site residues of family 46 chitosanase anoside and isopropyl thio-b-d-galactoside, because the empty pAlter-1 vector directs b-galactosidase synthesis in E ... function as a resistance factor against the toxic effect of chitosan Besides a strictly metabolic function, consisting of the endohydrolysis of high molecular mass chitosan into oligosaccharides that ... 30 to stop the reaction, chilled on ice and lyophilized Number average molecular mass (Mn) of hydrolyzed chitosan was determined using the reducing sugars assay of Lever [36] The toxic chitosan...

Báo cáo khoa học: The leech product saratin is a potent inhibitor of platelet integrin a2b1 and von Willebrand factor binding to collagen pdf

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... individual platelets to be adherent to fibrillar collagen, platelets in citrated PRP were incorporated into a fibrous mesh along the collagen fibres (Fig 5B) The degree of platelet ⁄ fibrin deposition onto ... respect to platelet adhesion ⁄ surface area on untreated fibrillar or soluble collagen, respectively antagonists to VWF receptors on platelets, namely the mAb to GPIb, 6D1, and the mAb to aIIbb3, ... collagen Experiments were designed to evaluate the ability of saratin to inhibit platelet adhesion to collagen We gently pipetted purified human platelets onto surfaceimmobilized fibrillar collagen,...

Báo cáo khoa hoc:" Refractoriness of hepatitis C virus internal ribosome entry site to processing by Dicer in vivo" ppt

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... relative refractoriness of the HCV IRES to processing by Dicer A limited accessibility to the viral RNA may also be a contributing factor to the relative lack of reactivity of HCV IRES to Dicer ... may have evolved to adopt a structure efficient in translation initiation and permissive to miR-122-mediated facilitation of viral replication, while exhibiting refractoriness to processing by ... silencing pathway, Dicer converts pre-miRNAs into ~21 to 23-nucleotide (nt) RNA guide sequences [18,19], referred to as miRNAs These short regulatory RNAs initially mediate translational repression...

Báo cáo khoa học: " Randomized controlled trials are needed to determine appropriate blood transfusion strategies in patients with acute coronary syndromes" pdf

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... of transfusion strategies is warranted to resolve the disparity in results between our study and other observational studies We suggest caution regarding the routine use of blood transfusion to ... clinicians have commonly used blood transfusions to maintain hematocrit values in patients with ischemic heart disease The theory underlying this practice is that blood transfusion will increase oxygen ... which were designed to address the question of appropriate transfusion thresholds Thus the study is hypothesis generating and not intended to prove cause and effect Second, since transfusion was...

Báo cáo y học: "Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection" pdf

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... required to achieve maturation and display of effector phenotypes on CTL associated with effective virological control [26] To determine how these host genetic and immune factors combined to contribute ... effect of transfusion on immune function [3,4] Age is also an independent predictor for an increased rate of HIV disease progression [5,6] The bias toward an aged population requiring transfusion ... CD8+ T cells to HIV antigen was measured by IFNγ ELISPOT, using pre-coated ELISPOT kits according to the manufacture's protocol (Mabtech, Mosman, Australia) Firstly, the response to whole HIV...

Báo cáo y học: "The use of a blood conservation device to reduce red blood cell transfusion requirements: a before and after study" doc

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... appropriate To elucidate the independent predictors of transfusion requirement, the following variables were entered into a linear regression model: age, gender, Hb on admission and just before transfusions, ... need for transfusions (including transfusion as part of resuscitation, preoperatively, or in patients with coronary artery disease) Ultimately, however, the decision to transfuse was left to the ... proximal to the reservoir towards the patient's end is then closed The sample site is cleaned and a syringe with a custom-made cannula (Edwards Lifesciences) is attached A vacuum tube is attached to...

Báo cáo y học: "Is fibrinogen the answer to coagulopathy after massive transfusions" potx

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... dilutional coagulopathy, sufficient activators seem to be present Because of the question of activators, the authors see fibrinogen administration as adjunctive therapy to be used concomitantly with replacement ... Inflammation and Host Response to Injury Investigators: Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome J Trauma ... concentrates for patients with massive hemorrhage is concerned, there seem to be sufficient preclinical and preliminary clinical data to warrant a pivotal clinical trial in patients with massive hemorrhage...

Dual anti platelet therapy duration where to draw the line

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... Circulation 2007;115:2352 Cumulative Events (%) DAPT ASA and Thienopyridine Stopping Time from Antiplatelet Discontinuation to Late ST (Days) Eisenberg MJ et al Circulation 2009;119: 1634-1642 DAPT ... 0.14 V Late (>1yr) 0.25% 0.67% 0.43% 0.22% 0.11 Kirtane, AJ TCT 2014, Washington D.C Definite Stent Thrombosis Kyoto PCI/CABG Registry Tada T et al Circulation Int 2012;5:381-91 DAPT 12 vs 24 ... et al Circulation 2012;125: 505-513 Risk for Recurrent Events Related to Thrombotic Milieu PASSION HORIZONS TYPHOON TRITON Stent Thrombosis EES in STEMI EXAMINATION BMS EES Sabate M et al Lancet...