protocol is approved by local ethical committee
Báo cáo y học: "What is the clinical and ethical importance of incidental abnormalities found by knee MRI" docx
... required to give a more precise prevalence estimate However, this is the first study in this area Our findings raise issues for the planning of studies and ethical issues related to the obligation ... cost of this is difficult to predict This is likely to be especially relevant in large studies examining healthy asymptomatic participants For example, the Osteoarthritis Initiative is a large ... result, research protocols now incorporate detailed consent forms addressing this issue and structured mechanisms to ensure that images are appropriately reviewed [7,8] This issue has prompted...
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The challenges for implementation of good manufacturing practices by local pharmaceutical manufactures in vietnam
... sector In this context, GMP is required With regards to the lawful issue, ISO 9000 series of standards is not required by federal or governmental authorizations ISO 9000 series of standards is optional ... over the world First established in 1967 by WHO Most important factor is documentation Certified by Drug Administration Agencies Issued by WHO, FDA, national drug administrations • • • • • • • ... However, this issue is out of this research’s scope, hence, it is not mentioned in detail herein 1.2 Problem Statement As aforementioned, the ongoing challenges faced by Vietnam’s Ministry of Health...
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Automated code generation by local search.pdf
... results are set to 23 000 The null hypothesis is that there is no difference between the two distributions The alternative hypothesis is that one distribution tends to have larger values than ... heuristics The difference between human designed heuristics and automatically designed heuristics for the three dimensional packing problem is investigated by Allen et al (2009) Hyper-heuristics ... hyper-heuristics for the onedimensional bin packing problem (Ross et al, 2002, 2003), in which the supplied local search heuristics have been created by humans, and the task of the hyper-heuristic is...
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KRONE - What is Patch by Exception
... even easier HOW TO GET THE MOST OUT OF PATCH BY EXCEPTION Many organisations have successfully implemented the Patch by Exception solution by establishing a maintenance contract with an installer ... competitor module by providing the maximum available headroom above category minimum standards This means that data integrity is preserved to the highest possible level Immunity to noise is also of ... easily administered by the IT Manager in a matter of seconds by using the patching facility If these changes are to become permanent the installer can hardwire them at the next monthly visit and...
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Tài liệu Báo cáo khoa học: TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor pdf
... of other TTSPs To test this possibility, we have searched for TTSPs targeted by HAI-1, and found that the activity of TMPRSS13 is potentially inhibited by HAI-1 TMPRSS13 is a splice variant of ... the tissues producing it In response to tissue injury, such as hepatic and renal injury, the inactive single-chain HGF is converted to a two-chain form exclusively in the injured tissue This conversion ... exclusively in the injured tissue This conversion is mediated by serine protease activity, which is induced in the injured tissue [28] The two-chain form is required for the biological activity of HGF...
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Tài liệu Báo cáo khoa học: Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT–MIM interaction pptx
... proteins (GST– IST1, GST–IST1MIM, GST–IST1MIML326D,L353A, GST– CHMP6NT, GST–pHis and GST–MIT–pHis) Expression of GST–IST1, GST–IST1MIM and GST–IST1L326D,L353A was induced with 0.5 mm isopropyl thio-b-d-galactoside ... followed by Strep-tag II was isolated by BamHI digestion and inserted into the BamHI site of pmGFP–calpain To construct pCMV3xFLAG–IST1 and pGEX–IST1, an IST1 cDNA fragment was amplified by PCR, ... Enhancement of calpain autolysis by IST1 detected This result strongly suggests that 30 K is generated by proteolytic activity of mGFP–calpain 7–Strep itself, not by potentially contaminating...
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Tài liệu Báo cáo khoa học: Reversible tetramerization of human TK1 to the high catalytic efficient form is induced by pyrophosphate, in addition to tripolyphosphates, or high enzyme concentration ppt
... values is exclusively displayed by the tetramer forms, and lowefficiency kinetics with high Km values is displayed by the dimer forms These observations strengthen the previous hypothesis that ... this would result in nonlinear progress curves However, slow dissociation from tetramer to dimer will result in linear progress curves, as consistently observed with this enzyme Such a slow dissociation ... behaviour after dilution to lgÆmL)1 indicate that dissociation of the tetramer to the dimer is a slowly progressing process This is supported by the kinetic behaviour of the recombinant enzyme...
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Tài liệu Báo cáo khoa học: Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1 pptx
... detected using MUPP1 antibodies Immunohistochemistry Mice were raised and maintained according to governmental and institutional care instructions Immunohistochemistry was carried out on 14 lm horizontal ... between MUPP1 and OR2AG1 is inhibited by over-expressing the interacting PDZ domains, the resulting response of OR2AG1 to odorant is modified in that the rapid decay of signal is impaired We finally ... visual signal transduction cascade Flies lacking INAD exhibit a profound reduction of the light response [28] Interestingly, INAD is also required for normal deactivation of visual signaling by...
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Tài liệu Báo cáo khoa học: Phosphorylation of cyclin dependent kinase 4 on tyrosine 17 is mediated by Src family kinases pptx
... and that this phosphorylation is independent of p27KIP1 The finding that Y17 phosphorylation is mediated by Src family kinases is completely novel and it is interesting to note how this fits in ... found in HeLa lysates C-YES is a 62 kDa nonreceptor tyrosine kinase of the Src family that is expressed in a wide range of tissues [24] The N-terminus of C-YES is dually myristoylated and palmitoylated ... this context, Y17 phosphorylation is thought to be modulated by loss of the phosphatase CDC25A Our data suggest that Src kinases are candidates to provide the phosphorylation of CDK4 If this is...
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Tài liệu Báo cáo khoa học: Staphylococcal enterotoxin C1-induced pyrogenic cytokine production in human peripheral blood mononuclear cells is mediated by NADPH oxidase and nuclear factor-kappa B doc
... were dissolved in distilled water Wort, HIMO, MK 886 and ETYA were dissolved in dimethylsulfoxide Apocynin was dissolved in ethanol Polymycin B was dissolved in normal saline Before use, all dissolved ... cytokine synthesis and febrile response induced by SEC1 is dependent on NADPH oxidase and not on PI3K ⁄ Akt or 5-LOX ⁄ 3640 FLAP because these phenomena are attenuated by apocynin and not by ETYA, MK ... IL-1b and IL-6 that is blocked by the NF-jB inhibitor (PDTC or SN-50) Moreover, the NF-jB binding ability is abrogated by binding site competition and antibody supershift analysis These findings...
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Tài liệu Báo cáo khoa học: Aggregative organization enhances the DNA end-joining process that is mediated by DNA-dependent protein kinase pdf
... precipitated DNA was analyzed by 1% agarose gel electrophoresis DNA was visualized by staining with ethidium bromide Results are represented by negative images Asterisks indicate nucleic acids ... cell lines, HeLa S3 cells and placenta tissue (unpublished work), implying that the promotion of EJ by aggregation is common to many types of human cells It is very likely that the resultant organization ... conditions (unpublished work) This predisposition implies the possibility that in vivo, instead of centrifugal force, the pre-existing aggregates may develop into damage-mediated ones It is presumable...
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Tài liệu Báo cáo khoa học: Transcription of individual tRNA1Gly genes from within a multigene family is regulated by transcription factor TFIIIB pdf
... family is modulated by distal cis elements J Biol Chem 271, 28146–28153 24 Sharma S & Gopinathan KP (1996) Role of TATATAA Gly element in the regulation of tRNA1 gene expression in Bombyx mori is ... Lanes as marked The heparin-resistant complex on tRNA1Gly -1 (left) is marked by an arrow; ++ denotes lg of protein (B) The specificity of complex formation was examined by the competition with 10 ... rescue of transcription by externally supplemented TFIIIB (lane 5; compare with lane 4) was abolished by the anti-TBP serum (lanes 7, 8) Inhibition was again rescued by increasing concentrations...
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Tài liệu Báo cáo khoa học: Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3 pdf
... presented in this study suggest that this PRD is necessary for the inducible expression of fgl2, we plan to undertake additional studies aimed at more precisely elucidating specific mechanisms regulating ... transcription initiation, the usage of this TATA box was not observed in our studies Determination of the 5¢-end of mRNAs isolated from liver tissue and cloned by 5¢-RACE showed similar results (data ... not formed by the binding of Sp1 or Sp3 However, we cannot rule out a Sp1 related transcription factor or an unknown factor at this time Future studies are required to address this issue We next...
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Tài liệu Báo cáo Y học: Thermostability of manganese- and iron-superoxide dismutases from Escherichia coli is determined by the characteristic position of a glutamine residue pdf
... SODs is not governed by one or even two residues, but is most likely accomplished by the concerted effects of a combination of key residues Further analysis of these and other mutant SODs is currently ... electrophoresis (PAGE) Native 8% polyacrylamide gels (acrylamide : N,N¢-methylenebisacrylamide, 29 : 1, w/w) containing NaCl/Tris, pH 8.8 utilized a Tris/glycine electrophoresis buffer system consisting ... originally identified to distinguish between FeSOD and MnSOD [7] The position of the glutamine residue, which is structurally equivalent in the enzymes, is contributed by the N domain of FeSODs...
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Tài liệu Báo cáo Y học: The binding of lamin B receptor to chromatin is regulated by phosphorylation in the RS region ppt
... semiquantitatively by this method The effects of enzymes, inhibitors and other reagents on the cell cycle– dependent interaction could also be examined very easily by means of this method This method is applicable ... chromatin is regulated by phosphorylation in the arginine-serine repeatcontaining region (RS-region) by multiple kinases The potential function of LBR and LAP2 in vesicle targeting to chromatin is discussed ... LBR and chromatin is important for elucidation of the nuclear envelope assembly/disassembly mechanism In this study, we first determined the chromatin binding region of LBR by using beads bearing...
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Tài liệu Báo cáo Y học: Progressive apoptosis in chorion laeve trophoblast cells of human fetal membrane tissues during in vitro incubation is suppressed by antioxidative reagents pptx
... progression of trophoblast cell apoptosis in the tissue, and that apoptosis of primary cultured human chorion trophoblast cells induced by TNFa was also suppressed by this lower concentration of glucocorticoid ... antagonist, RU-486, during incubation inhibited the suppression of trophoblast apoptosis in the tissue by glucocorticoid (data not shown) This suggests that the suppression of trophoblast apoptosis ... function, and that apoptosis suppression by glucocorticoid in the tissue may also be affected by suppression of specific gene functions, such as c-Jun It is known that there is an increase in fetal...
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Tài liệu Báo cáo Y học: Toxicity of substrate-bound amyloid peptides on vascular smooth muscle cells is enhanced by homocysteine docx
... ACKNOWLEDGEMENTS This work is supported by grants from the National Health and Medical Research Council (NH & MRC) of Australia KB is supported by the Deutsche Forschungsgemeinschaft and the Bundesministerium ... matrix [37] In this study, we demonstrate that substrate-bound Ab is toxic to VSMC by the activation of apoptotic cell death pathways and that a known risk factor for cerebrovascular disease, homocysteine, ... the mechanism of this toxicity is unclear Ab peptides have been shown to be neurotoxic both in vivo [22] and in vitro [23,24] Several studies have shown that Ab disrupts calcium homeostasis and...
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Báo cáo khoa học: Visfatin is induced by peroxisome proliferator-activated receptor gamma in human macrophages pdf
... circulating levels of visfatin have been observed in many inflammatory diseases such as rheumatoid arthritis, obesity, insulin resistance and type diabetes [5–7] Visfatin is secreted by neutrophils in ... precursor Thus, the NAD pool is maintained, at least in part, by visfatin, which is important, for instance, in b-cell insulin secretion [2] Although still controversial, visfatin is thought to have insulin ... regulates visfatin gene expression at the transcriptional level To determine whether visfatin is a direct PPARc target gene, the human visfatin promoter was examined by bio-informatic analysis Three...
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Báo cáo khoa học: Autocatalytic processing of procathepsin B is triggered by proenzyme activity doc
... proteinaceous substrate at neutral pH Moreover, this conformational change, which is the only unimolecular step of the mechanism, is not accompanied by any larger structural changes, such as unfolding ... Baici A, Lang A, Horler D, Kissling R & Merlin C (1995) Cathepsin B in osteoarthritis: cytochemical and histochemical analysis of human femoral head cartilage Ann Rheum Dis 54, 289–297 Coulombe R, ... direction opposite to that of the substrate, thereby preventing substrate hydrolysis The data thus suggest that substrate hydrolysis can be explained by the FEBS Journal 276 (2009) 660–668 ª 2008...
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Báo cáo khoa học: The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco⁄endoplasmic reticulum calcium stores ppt
... Parkinson’s diseases [6] In the heart, autophagy may protect against apoptosis activated by ischemic injury [7], and its chronic perturbation is causative in a genetic form of heart disease [8] ... punctae This result was surprising, as the upregulation of autophagy by starvation has been reported in vivo [19], in isolated primary cells [33], and in other cell lines [52] [14,20] This discrepancy ... content in HL-1 cardiac cells S ⁄ ER Ca2+ homeostasis is maintained by the opposing processes of release by the ryanodine receptor and re-uptake by SERCA Thapsigargin (TG), a selective SERCA inhibitor,...
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- it encounters a block before reverse transcription data have shown that this speciesspecific restriction is mediated by tripartite motif trim5a
- dna methylation affects important developmental processes in both plants and animals the process of methylation of cytosines at c5 is catalysed by dna methyltransferases mtases
- in this series of four minireviews the field of scaffold proteins and proteins of similar molecular⁄cellular functions is overviewed by binding and bringing into proximity two or more signaling proteins
- which works promptly on vascular injury and tissue damage the rapid response is generated by specific molecular interactions between components in these systems thus
- line protocol is down
- sentence ordering driven by local and global
- bacterial food poisoning is caused by
- financial sector reforms recommended by the narasimham committee
- the cartesian coordinate system is formed by the
- food poisoning is caused by bacteria only
- the cartesian coordinate system is formed by the intersection of number lines
- sentence ordering driven by local and global coherence for summary generation
- the purchase price of a noload fund is determined by
- what is meant by protocol architecture
- na channel block by local anesthetics is linked to channel inactivation
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng 9 tr 25