networks involved in the control of movement
Báo cáo y học: " Characterization of two candidate genes, NCoA3 and IRF8, potentially involved in the control of HIV-1 latency" docx
... represses the IRF1-mediated activation of the HIV-1 ISRE element Implication of IRF8 in the maintenance and NCoA3 in the reactivation of the viral latency may thus provide new insights into the control ... for the low level of transcription observed during post-integration latency (reviewed in [9]): the inaccessibility of the integrated provirus to the transcriptional machinery, the absence in resting ... this study, the role of the HDAC inhibitor NaB on HIV-1 latently infected cells gene expression was explored using microarrays Since chromatin remodeling is involved in the regulation of HIV-1 gene...
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báo cáo khoa học: " Connectedness of healthcare professionals involved in the treatment of patients with Parkinson’s disease: a social networks study" pot
... respect to their prominence and influence in the network The aim of this study was to examine the connectedness in a newly established regional ParkinsonNet of health professionals involved in the treatment ... name indicating whether this person was known to the participant and another box to indicate whether this person was involved in professional contacts so far Knowing each other was defined in the ... following published guidelines [15] We examined the reciprocity of reported connections as an indicator of the reliability of the data collection instrument Then we replaced missing values of the...
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Risks Involved in the Use of Herbal Products
... aspirin or other NSAIDs may increase the risk of bleeding Ginseng may intensify the effects of these drugs, causing an excessive decrease in blood sugar levels (hypoglycemia) Ginseng may intensify ... making it less effective Ginger taken with anticoagulants may increase the risk of bleeding Ginkgo taken with anticoagulants or with aspirin or other NSAIDs may increase the risk of bleeding Ginkgo ... metabolizing enzymes that initiate carcinogenesis They also inhibit the promotion stage of carcinogenesis by inhibiting oxygen radical-forming enzymes, those acting as ATP mimics and inhibitors of...
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Tài liệu Báo cáo khoa học: Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid doc
... responsible for binding and proper orientation of the aminopyrimidine ring, are conserved in all ThDP-dependent enzymes One of these, the hydrogen bond between the N1¢ atom of the pyrimidine ring of ThDP ... structure Binding of the cofactors ThDP and Mg2+ The homo-tetrameric IPDC binds four molecules of the cofactors ThDP and Mg2+ The ThDP binding sites are located in narrow clefts at the interfaces ... to these interfaces is located in the PYR and middle domains The interface contains 10 hydrogen bonds in IPDC The dimer–dimer interface in IPDC is smaller than the corresponding interface in...
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Tài liệu Báo cáo Y học: Identification of a set of genes involved in the biosynthesis of the aminonucleoside moiety of antibiotic A201A from Streptomyces capreolus pdf
... implicated in the biosynthesis of the aminonucleoside moiety of A201A Here we report the sequencing of a total of 6946 bp, which include the ata genes most likely implicated in the biosynthesis of this ... be implicated in the biosynthesis of the aminonucleoside moiety of puromycin [6–8] Interestingly, their organization is identical to that of the pur cluster, with the exception of pur6, which ... [33,34] In contrast, its similarity to type III PKSs, which lack this domain, is scant This domain promotes the binding of the acyl-CoA initiation unit to the ketosynthetase domain of the PKSs...
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Tài liệu Báo cáo Y học: Granule-bound starch synthase I A major enzyme involved in the biogenesis of B-crystallites in starch granules ppt
... listed in Table that most, if not all, of the amylose is synthesized in vivo when the rate of amylopectin synthesis becomes minimal At these moments the rates of amylopectin synthesis are only 5% of ... rate of amylopectin synthesis The increase in crystallinity witnessed during these first 12 h is in line with the high rates observed for amylopectin synthesis However between 12 and 58 h the rate ... amylose continues to accumulate at the final stage of starch synthesis in the absence of concomitant amylopectin synthesis (reviewed in [41]) In vitro synthesis of amylose Because in Chlamydomonas...
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Báo cáo khoa học: Identification of two cysteine residues involved in the binding of UDP-GalNAc to UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) ppt
... GalNAc-T1, might be involved in the catalytic function of the enzyme To investigate whether the cysteine residues modified by PCMPS are involved in the binding of UDP-GalNAc, we treated recombinant GalNAc-T1 ... University) [22,23], containing a cDNA encoding the insulin signal sequence and the Protein A-IgG binding domain, was inserted into NheI-HindIII digested pcDNA3.1, producing the vector, pInsProA pDN42 was ... PCMPS in the presence of increasing concentrations of UDP-GalNAc (d) and UDP (s) Following incubation, the enzyme activity was determined as described in Fig Mutagenesis of the cysteine residues in...
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Báo cáo khoa học: Oxidative stress is involved in the permeabilization of the inner membrane of brain mitochondria exposed to hypoxia/reoxygenation and low micromolar Ca2+ Lorenz Schild1 and Georg Reiser2 doc
... treatment The high degree of protection by ADP suggests that the mitochondrial injury is caused by opening of the mPTP There is evidence that ADP inhibits opening of the mPTP by occupying binding sites ... the induction of oxidative stress during ischemia ⁄ reperfusion in brain There is a growing body of information concerning the mechanism of ROS generation by the respiratory chain in mitochondria ... during H ⁄ R performed in the presence or absence of 3.5 lm Ca2+ The mitochondrial incubations were carried out in the cuvette of the luminescence spectrophotometer at 30 °C in the presence of...
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Báo cáo khoa học: Factors involved in the assembly of a functional molybdopyranopterin center in recombinant Comamonas acidovorans xanthine dehydrogenase pot
... success in expressing a recombinant XDH in this organism Expression of XDH requires the incorporation of the MPT center, placement of the terminal sulfur ligand on the Mo, and the incorporation of ... stoichiometric and independent of the presence of xdhC, and their data suggest that the level of MPT sulfuration is lower in the absence of xdhC than in its presence Assuming that the level of incorporated ... effect of the level of culture aeration on the expression of recombinant protein Raising the cellular redox potential by increasing aeration levels is expected to reduce the level of cysteine and increase...
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Báo cáo khoa học: RNA-binding properties of HCF152, an Arabidopsis PPR protein involved in the processing of chloroplast RNA pdf
... that of the background The binding site was found to be located at the C-terminus of the protein although binding of the C-terminus half (CH) is only half of the full-length protein (Fig 3) Interestingly, ... only one, the atpF intron, while CRS2 is involved in the splicing of nine of the 10 chloroplast group IIB introns [6,15,37] The expression of CRS2 in E coli together with the corresponding RNA ... (35) is indicated promote the splicing A possible model of how HCF152 is involved in the stabilization of the splicing products of the petB intron could be that the protein binds to the UTR region...
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Báo cáo khoa học: The starch-binding capacity of the noncatalytic SBD2 region and the interaction between the N- and C-terminal domains are involved in the modulation of the activity of starch synthase III fromArabidopsis thaliana pdf
... synthesis of amylopectin, it has been suggested that SSI is mainly involved in the synthesis of small chains of this fraction Furthermore, SSIV has been found recently to be involved in the control ... interaction between the N- and C-terminal domains of SSIII in vitro Mapping of the CD-binding region in the N-terminal SBDs In order to identify the SBD region required for the SBD–CD interaction, we ... in the D2 domain and D(495–535) in the D3 domain This result is in agreement with our previous studies using truncated SSIII isoforms, showing the importance of the D23 domain in starch binding...
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Báo cáo khoa học: Cell death-inducing DFF45-like effector, a lipid droplet-associated protein, might be involved in the differentiation of human adipocytes pdf
... analyses of the relative levels of the indicated proteins after western blotting (as in D) were carried out Similar experiments were performed five times and the intensity of the individual bands in ... subcellular compartments other than lipid droplets The expression of CIDEC is elevated during the differentiation of adipocytes To gain further insight into the roles of CIDEC in adipocyte differentiation, ... obtained from the patient The COS-7 and 293T cells were obtained from the Cell Bank of the Chinese Academy of Sciences (Shanghai, China) Isolation and induction of pre-adipocytes Pieces of adipose...
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Báo cáo khoa học: An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid b-protein doc
... whether Synoviolin is involved in the degradation of PS cofactors using synoviolin-null cells, as PS cofactors undergo the ubiquitin ⁄ proteasome pathway We report that Synoviolin is involved in ... polyglutamine-expanded huntingtin [18], the tumor suppressor Synoviolin is involved in the degradation of nicastrin gene p53 [19] and Parkin-associated endothelin receptor-like receptor [20] In this ... (calnexin) and cytoskeleton protein (tubulin) in these cells as the internal control proteins The calnexin and tubulin levels were found to be similar between these cells, confirming that the same...
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Báo cáo khoa học: A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-jB pathway in skeletal muscle pdf
... are involved in the transmission of mechanical signals to signaling pathways In the M line, mechanical stimulation activates the interaction of a protein complex with the kinase domain of titin, ... pathway and an increase in muscle fiber apoptosis [8] The participation of NF-jB signaling in the pathogenesis of LGMD2A is therefore an interesting possibility The findings obtained in the present ... the binding to titin by improving the accessibility of the titin-binding domain Interestingly, the importance of CARP interaction for its function was recently demonstrated in a FEBS Journal...
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Báo cáo khoa học: Roles of prolactin-releasing peptide and RFamide related peptides in the control of stress and food intake potx
... pro-opiomelanocortin in the arcuate nucleus of the hypothalamus, both of which are key molecules in the control of energy balance [46] The administration of RFRPs induces Fos protein in the arcuate ... be involved in the integration in the control of energy metabolism and stress responses, whereas the underlying detailed mechanisms need further investigation RFRP The mammalian members of the ... distributed within the brain [44] Expression of the main receptor for RFRP, GPR147, is broadly distributed within the brain, including the septal areas, amygdala, bed nucleus of the stria terminalis,...
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Báo cáo khoa học: Role of calcium phosphate nanoclusters in the control of calcification pot
... describe the binding isotherms obtained previously for the b-casein 125 phosphopeptide in this pH range, and the same model was adapted to t the binding isotherm of OPN 1149 measured at pH 7.0 The ... osteopontin C Holt et al details of the model are provided in Doc S3 (see Supporting information) The Ca2+ binding isotherm of OPN 1149 was determined by measuring the concentration of free Ca ... metaPrDOS [32] According to PONDRề predictions, the positions of PC sequences in the SPs in Table were, with the exception of the globular protein riboavin-binding protein (RBP), disordered,...
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Báo cáo khoa học: Catalytic activation of human glucokinase by substrate binding – residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions ppt
... demonstrating that the binding of Glc at the active site indeed induces a large-scale domain movement that closes the active site cleft and creates the stereochemical environment for binding of the ... residues were individually mutated (C) The spacial proximity of active site residues in the L-domain and connecting region II which are potentially involved in the binding of D-glucose in the super-open ... E290) and the S-domain (residues T168 and K169) (Fig 1B) To identify the contact residues involved in the initial binding of Glc to the super-open state (Fig 1C) of this two domain hinge-bending enzyme,...
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Báo cáo khoa học: Towards understanding the functional role of the glycosyltransferases involved in the biosynthesis of Moraxella catarrhalis lipooligosaccharide ppt
... Lgt4 Results In order to investigate the function of the glycosyltransferase enzymes involved in the biosynthesis of LOS of M catarrhalis, and to gain some insights into the mechanism of serotype ... irradiating each of the anomeric signals in turn to obtain the H chemicals shifts of the corresponding remaining ring protons Again, assignment of the Kdo residue was possible from examination of ... obtain the 13C shift of the C1 and C2 resonances of Kdo Examination of the 400 ms NOESY spectrum confirmed each of the glycosidic linkages for the 2951lgt1 ⁄ 4D oligosaccharide and the terminal...
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Báo cáo khoa học: Geranylgeranyl reductase involved in the biosynthesis of archaeal membrane lipids in the hyperthermophilic archaeon Archaeoglobus fulgidus potx
... for the enzyme [21] These facts strongly suggest the involvement of the enzyme, GGR, in the biosynthesis of membrane lipids in the hyperthermophilic archaeon A fulgidus, as predicted in the previous ... Garmany) The flow rate of the scintillation cocktail was 0.5–2 mLÆmin)1 Extraction of archaeol from H salinalium H salinarum was cultured in L of culture medium, containing g of casamino acids, g of ... expression of AF0648 resulted in a change in the quinone profile of the host E coli, which led us to conclude that the menaquinone-specific PR is encoded in AF0648 However, the functions of the other...
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Báo cáo Y học: Molecular and biochemical characteristics of a gene encoding an alcohol acyl-transferase involved in the generation of aroma volatile esters during melon ripening pptx
... of octanol) In respect of aliphatic ester production, it was found that the longer the carbon chain of the alcohol, the higher the AAT activity The activity of ester formation was in increasing ... provided by the manufacturer (Invitrogen) The strain harbouring the correct construction was incubated in selecting liquid medium according to Invitrogen recommendations, until the D600 of the culture ... detected in fruit (Table 1), indicating that the availability of some acyl donors is a limiting factor in vivo Table shows some kinetic properties of the recombinant CM-AAT1 protein for some of the...
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