mechanisms detection and pathological implications

Unraveling genomic instability in multiple myeloma mechanisms, biological and clinical implications

... et al 2003c) found N-RAS and K-RAS mutations, respectively, in 17% and 6% of tumors, whereas Kuehl and Shaughnessy found N-RAS and K-RAS mutations, respectively, in 14% and 17% of tumors (personal ... 1q gain (44% and 48% respectively) and 8p loss (27% and 28% respectively) had almost identical prevalence in both HRD and NHRD MM Figure 2.2 Penetrance plot of chromosome gains and losses by ... patients with high CI had high STK6 and/ or AURKB expression) and those over-expressing both STK6 and AURKB was significantly shorter (N=49 and N=14, median OS 42.7 and 39.8 months respectively, log-rank...

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báo cáo hóa học:" Of gastro and the gold standard: evaluation and policy implications of norovirus test performance for outbreak detection" ppt

Danh mục: Hóa học - Dầu khí

... EM, and EIA for norovirus using both LCM and CRS; and (ii) to evaluate the implications of these characteristics for outbreak testing practices Methods Both polymerase chain reaction (PCR) and ... conceived and participated in the design of the study, contributed to test development and laboratory testing of specimens, and contributed to the drafting of the manuscript All authors read and approved ... http://www.translational-medicine.com/content/7/1/23 "composite reference standards" (CRS), have emerged as preferred means for evaluating test characteristics (i.e., sensitivity and specificity) when gold standard tests are absent [11,12]...

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CARDIAC DEFIBRILLATION – MECHANISMS, CHALLENGES AND IMPLICATIONS pdf

Danh mục: Sức khỏe giới tính

... 22136011, and 21500420 for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (to T.A.), and by NIH grants R01 HL082729 and R01 HL103428 and NSF ... mismatch of device and lead size to the body Many of the advances in defibrillation have been accomplished through the developments in hardware and software and by experimental trial and error Further ... the challenges and implications of cardiac defibrillation, and specifically, on the subjects presented above Basic science chapters elucidate questions such as lead configurations and the reasons...

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Báo cáo y học: "dentification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels" ppt

Danh mục: Báo cáo khoa học

... ART-LGIC superfamily and discuss the general implications of these proteins for the mechanisms and origin of the Cys-loop receptors of the animal nervous system Results and discussion Volume ... light on the possible mechanisms of ligand interaction and channel gating of the ARTLGICs The current model for the mechanism of these channels posits that the binding of the ligand causes a preferential ... channels, including the acetylcholine and serotonin receptors, and the inhibitory anionic channels, including the GABA, glycine and invertebrate histamine and glutamate receptors [2,14,15] This...

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Significant substitutive figures of speech – linguistic functions and pedagogical implications part 1

Danh mục: Thạc sĩ - Cao học

...

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Significant substitutive figures of speech – linguistic functions and pedagogical implications part 2

Danh mục: Thạc sĩ - Cao học

... More importantly, unlike love and people and even more so than looks and hugs, eyes and arms are concrete, visible and touchable, and therefore seem closer to buyable and sellable items Although ... hire some more hands” or “She’s got new wheels,” which not literally refer to a hand or a set of wheels Instead, they stand for the whole person or object – hand for the whole person and wheels for ... instance, Sherwood Anderson may have well omitted the “ands” in italics in the following sentences in the short story “The Corn Planting.” “He made drawings of fish and pigs and cows and they looked...

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Detection and Locking

Danh mục: Kỹ thuật lập trình

... Indeed, some form of change detection is also needed In this section, we'll take what we've learned about locking and detection and formulate two pessimistic solutions and one optimistic solution ... statement and commits: update set where and person first_name = 'Tim' person_id = first_name = 'Tom'; Session two then executes the following UPDATE statement and commits: update set where and person ... tactics you can employ for detection Let me clarify that we are no longer discussing locking, but detection Detection is mutually exclusive of locking The first two detection tactics we will discuss...

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DEBT SUSTAINABILITY FRAMEWORK FOR LOW INCOME COUNTRIES : POLICY AND RESOURCE IMPLICATIONS - Part 1

Danh mục: Cao đẳng - Đại học

... of public and publicly guaranteed external debt to gross domestic product and to exports, and debt service on the same debt to exports to judge debt sustainability Country policies and institutional ... countries based on the performance of their institutions and policies and determine thresholds for selected debt indicators for each country grouping and then estimate the level of debt distress as measured ... Allocation System that uses the Country Policy and Institutional Assessment and governance rating of the country concerned The increase in grants has implications for the future of IDA funding which...

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Shame, Guilt, and Pathological Guilt

Danh mục: TOEFL - IELTS - TOEIC

... Williams’ and other philosophers’ attempted philosophical distinctions between guilt and shame fail My arguments here not rely on the earlier arguments about pathological and nonpathological guilt and ... and mistaken guilt and shame, about self-regarding and indecorous shame, identiﬁcatory shame, shame without responsibility, and shame’s and guilt’s understandings of each other and of themselves ... commonplace and are part and parcel of various therapeutic and liberation movements But there is the contrary conceptual view that justiﬁed, accurate shame does not require culpability and wrongdoing and...

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13-signal-detection-and-classification-13803335538269

Danh mục: Tâm lý - Nghệ thuật sống

... Signal Detection: Known Gains • Signal Detection: Unknown Gains • Signal Detection: Random Gains • Signal Detection: Single Signal 13.6 Spatio-Temporal Signals Detection: Known Gains and Known ... provides a brief and limited overview of some of the theory and practice of signal detection and classiﬁcation The focus will be on the Gaussian observation model For more details and examples see ... testing [1], invariant hypothesis testing [8, 9], sequential detection [10], simultaneous detection and estimation [11], and nonparametric detection [12] Detailed discussion of these strategies is...

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13-signal-detection-and-classification-13804470939958

Danh mục: Tâm lý - Nghệ thuật sống

... Signal Detection: Known Gains • Signal Detection: Unknown Gains • Signal Detection: Random Gains • Signal Detection: Single Signal 13.6 Spatio-Temporal Signals Detection: Known Gains and Known ... provides a brief and limited overview of some of the theory and practice of signal detection and classiﬁcation The focus will be on the Gaussian observation model For more details and examples see ... testing [1], invariant hypothesis testing [8, 9], sequential detection [10], simultaneous detection and estimation [11], and nonparametric detection [12] Detailed discussion of these strategies is...

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DEBT SUSTAINABILITY FRAMEWORK FOR LOW INCOME COUNTRIES : POLICY AND RESOURCE IMPLICATIONS - Part 2

Danh mục: Cao đẳng - Đại học

... balance and payments and budgets, the mix of loans and grants in its future financing arrangements, and the build-up of its repayment capacity relative to Gross Domestic Product (GDP) and export and ... Countries: Proposal for an Operational Framework and Policy Implications by Mark Allen and Gobind Nankani, IMF and IDA, February 3, 2004 Debt Sustainability and Financing Terms in IDA 14, IDA, June 2004 ... discussed above and in Annex These were the PV of public and publicly guaranteed external debt to GDP, exports, and government revenue, and debt service on the same debt to exports, and government...

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DEBT SUSTAINABILITY FRAMEWORK FOR LOW INCOME COUNTRIES : POLICY AND RESOURCE IMPLICATIONS - Part 3

Danh mục: Cao đẳng - Đại học

... policies and institutional capability and vulnerability to shocks are other factors identified as being important for assessing a country’s debt sustainability In particular, country policies and ... chosen indicators of countries with poor, medium and strong institutional capabilities and quality of policies with the cut offs at the 25th, 50th and 75th percentiles of the CPIA index ranked in ... the external debt outstanding; (b) an application to the Paris Club for debt restructuring of official debt when a breakdown in the payments system is judged to be imminent; and (c) the country...

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DEBT SUSTAINABILITY FRAMEWORK FOR LOW INCOME COUNTRIES : POLICY AND RESOURCE IMPLICATIONS - Part 4

Danh mục: Cao đẳng - Đại học

... resources, safety nets; and poverty monitoring and analysis; and • Public sector management and institutions, including property rights and rule-based governance; quality of budgetary and financial management; ... policy and foreign exchange regime; financial stability and depth; banking sector efficiency and resource mobilization; competitive environment for the private sector; factor and product markets; and ... criteria used and the CPIA for 2003 • Economic management, including management of inflation and the current account; fiscal policy; management of external debt; and management and sustainability...

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13 Signal Detection and Classification

Danh mục: Cơ khí - Chế tạo máy

... Signal Detection: Known Gains • Signal Detection: Unknown Gains • Signal Detection: Random Gains • Signal Detection: Single Signal 13.6 Spatio-Temporal Signals Detection: Known Gains and Known ... provides a brief and limited overview of some of the theory and practice of signal detection and classiﬁcation The focus will be on the Gaussian observation model For more details and examples see ... testing [1], invariant hypothesis testing [8, 9], sequential detection [10], simultaneous detection and estimation [11], and nonparametric detection [12] Detailed discussion of these strategies is...

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Tài liệu lecture 09: Error Sources, Detection and Correction doc

Danh mục: Cao đẳng - Đại học

... Fall 1999 Lecture-09 Error Sources, Detection and Correction Error Detection Methods: • Parity Checking The oldest, simplest and least effective method of error detection is parity checking One ... Error Sources, Detection and Correction Error Prevention: • Shielding (p.140) Covering a cable or equipment with a grounded metallic conductor shields it from electrical noise, and prevents it ... cables, fluorescent lights, and electrical machinery) • Changing Multiplexing Techniques - changing frequencies or guard bands • Improving Connection Quality • Amplifiers and Repeaters Amplifiers...

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Tài liệu DEBT SUSTAINABILITY FRAMEWORK FOR LOW INCOME COUNTRIES : POLICY AND RESOURCE IMPLICATIONS - Part 5 docx

Danh mục: Cao đẳng - Đại học

... charges and commitment fees) materialize and upfront charges for grants are levied (to replace foregone principal reflows) it would reduce the need to harden the credit terms for both IDA only and ... allocations thereby weakening the desired relationship between institutional capability and policy performance and the allocation of funds In view of this, IDA management has proposed an upfront ... proposes a combination of mechanisms such as replacing foregone reflows of credit principal through additional donor financing, reducing the concessionality of IDA credits, and imposing upfront charges...

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Tài liệu DEBT SUSTAINABILITY FRAMEWORK FOR LOW INCOME COUNTRIES : POLICY AND RESOURCE IMPLICATIONS - Part 6 docx

Danh mục: Cao đẳng - Đại học

... charges and commitment fees) materialize and upfront charges for grants are levied (to replace foregone principal reflows) it would reduce the need to harden the credit terms for both IDA only and ... allocations thereby weakening the desired relationship between institutional capability and policy performance and the allocation of funds In view of this, IDA management has proposed an upfront ... proposes a combination of mechanisms such as replacing foregone reflows of credit principal through additional donor financing, reducing the concessionality of IDA credits, and imposing upfront charges...

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Tài liệu DEBT SUSTAINABILITY FRAMEWORK FOR LOW INCOME COUNTRIES : POLICY AND RESOURCE IMPLICATIONS - Part 7 ppt

Danh mục: Cao đẳng - Đại học

... experience and little applied knowledge (e.g., institutional development, gender equality, and labor-intensive growth) The United Nations has a stronger mandate to work in the political arena and assess ... stock and flow problems in formulating an appropriate borrowing strategy A high current debt service ratio combined with a low level of debt stock needs to be handled as a liquidity problem and ... lending and grants Given the importance of DSAs for each low income country in the application of the DSF and borrowing from the IMF, it is necessary that these be conducted in a collaborative and...

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Tài liệu DEBT SUSTAINABILITY FRAMEWORK FOR LOW INCOME COUNTRIES : POLICY AND RESOURCE IMPLICATIONS - Part 8 doc

Danh mục: Cao đẳng - Đại học

... ratings and the inputs expected from and the involvement of national staff in the process There should be opportunities for the Bank to present their findings both to the country concerned and donor ... DSAs and consequently of government revenue in determining debt indicators and their threshold values Similarly, it is also recommended that studies be conducted on determining indicators and ... following conclusions and recommendations seek to enhance the prospects that, if approved, the DSF would provide a solid basis for the international community, in general, and IDA, in particular,...

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