... AhR, inducing CYP1A1 expression and activity (Meek 19 98; Bonvallot et al 20 01; Baulig et al 2003a) As shown in Figure 11 .1a, DEP and their organic extract induce a transient CYP1A1 mRNA expression ... FIGURE 11 .1 Induction of cytochrome P-450 1A1 (CYP1A1) and NADPH: quinone oxidoreductase (NQO1) gene expression in HBE cells (a and b respectively) Cells were treated or not with DEP (10 mg/cm2), ... 214 CYP1A1 18 S BaP CB OE-DEP DEP DPL DMSO BaP 48 h CB DEP OE-DEP DMSO DPL BaP 24 h CB DEP DMSO DPL BaP 6h CB OE-DEP DEP DMSO DPL 2h OE-DEP (a) 2.7 NQO1 1. 7 18 S 18 S (b) 2h 6h 24 h 48 h FIGURE 11 .1...
... receptor-tyrosine kinase and G -protein- receptor agonists and vitamin D3 [16 ] As shown in Fig 1, exposure of cultured SMCs to S1P stimulates the expression of the Cyr 61/ CCN1 at both the mRNA andprotein levels ... 14 41 14 50 12 Latinkic, B.V., O’Brien, T.P & Lau, L.F (19 91) Promoter function and structure of the growth factor-inducible immediate early gene cyr 61 Nucl Acids Res 19 , 32 61 3267 Ó FEBS 2003 13 ... mechanisms of the Cyr 61/ CCN1 gene (Eur J Biochem 270) 3 413 Fig Induction of the Cyr 61/ CCN1 promoter upon stimulation by S1P and mapping of the responsive elements in the Cyr 61/ CCN1 promoter sequence...
... 11 7 11 7 11 7 11 7 11 8 11 8 11 8 11 9 11 9 11 9 Contents ix A Return to Violence by the Sons of Iraq 12 0 Iraqi Security Forces ... timelines for the April 30, 2 010 , August 31, 2 010 , and December 31, 2 011 , drawdown dates There are logistical risks associated with the April 30, 2 010 , and August 31, 2 010 , deadlines that can be ... Pittsburgh, PA 15 213 -2665 RAND URL: http://www.rand.org To order RAND documents or to obtain additional information, contact Distribution Services: Telephone: ( 310 ) 4 51- 7002; Fax: ( 310 ) 4 51- 6 915 ; Email:...
... LRH -1 LRH -1 subnuclear localization in granulosa cells LRH -1 SUMO -1 A SUMO -1 A Vehicle GFP-LRH1 B B GFP-LRH1K173/289R Forskolin C C GFP-LRH1K289/389R CTX D D GFP-LRH1K173/ 213 /289R E GFP-LRH1K289/329/389R ... 429 LRH -1 subnuclear localization in granulosa cells LRH -1 SUMO -1 F.-M Yang et al Merged LRH -1 SUMO-1AA Merged G A GFP-LRH1 H B GFP-LRH1K173R C I GFP-LRH1K 213 R J D GFP-LRH1K289R E K GFP-LRH1K329R ... of Cpy11a1 were 14 -, 50- and 263-fold higher after 3, 12 and 24 h, respectively To determine the effect of cAMP on sumoylation pathway, the expression of the genes for SUMO E1 subunit SAE1 and...
... 0 .19 0 .12 5 Z c: 0.38 Z 0.35 Z 0.33 Z 0.30 Z 0.27 Z 0. 21 Z 0.20 Z 0 .14 Z 0 .14 Z [Source: Isakov – Kennametal Inc./pub in American Machinist, 19 96] inserts around the cutter’s periphery (Z) and ... clamping, dictating: how, where and what will be the optimum method of ‘location and restraint 17 of the workpiece, but on exit from cut, the sudden disengagement and release of cutting forces ... favourable/unfavourable cutter and workpiece placement – together with other important factors [Courtesy of Sandvik Coromant] Milling Cutters and Associated Technologies 16 3 Table 7: The ratio of...
... 2003, 17 :295-309 16 Boutros M, Paricio N, Strutt DI, Mlodzik M: Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling Cell 19 98, 94 :10 9 -11 8 17 ... kinase ROCK, and mediates cytoskeletal re-organization [8 ,13 ,14 ] Rac activation is independent of Daam1, requires the DEP domain of Dsh, and stimulates Jun kinase (JNK) activity [8 ,15 ,16 ] Other ... receptor-related  proteins and in Wnt/-catenin signaling: arrows point the way Development 2004, 13 1 :16 63 -16 77 Wharton KA Jr: Runnin’ with the Dvl: proteins that associate with Dsh/Dvl and their significance...
... WNT ligands (WNT -1, WNT5a, WNT-5b, WNT-9a /14 , and WNT16), receptors (FRZD -1 and FRZD-7), intracellular mediators such as β-catenin, and downstream transcription factors such as TCF and LEF -1 (data ... tissues, including bone marrow [54], synovial membrane [16 ], periosteum [13 ], and articular cartilage [12 ,14 ,15 ,18 ], opens the possibility to recruit and guide these cells locally using appropriate molecular ... 54 :12 09 -12 21 14 Alsalameh S, Amin R, Gemba T, Lotz M: Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage Arthritis Rheum 2004, 50 :15 22 -15 32 15 ...
... in TTBS 1 only The membranes were then washed once with TTBS 1 for 10 minutes and incubated in SuperBlock Blocking Buffer-Blotting and TTBS 1 (SuperBlock 1: 10 with TTBS 1 ) or in TTBS 1 (for ... PAR-2 (1: 1,000; Invitrogen Corporation) and with mouse anti-human antibodies against the phosphorylated forms of p38 (1: 1,000), Erk1/2 (1: 5,000), c -jun N-terminal kinase (JNK) (1: 5,000), and NF-κB ... Rheumatol 19 91, 18 :18 63 -18 71 Pap G, Eberhardt R, Rocken C, Nebelung W, Neumann HW, Roessner A: Expression of stromelysin and urokinase type plasminogen activatorprotein in resection specimens and...
... http://arthritis-research.com/content /11 /5/R136 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 Fuchs S, Skwara A, Bloch M, Dankbar B: Differential induction and regulation of matrix metalloproteinases in osteoarthritic tissue and ... http://arthritis-research.com/content /11 /5/R136 Figure 11 Stimulation of TNF-α and Il-6 by AGE-BSA (a) Transcripts for TNF-α were significantly increased after one and two days (*P < 0. 01, n = 15 ) (b) ILAGE-BSA ... in DMEM (with 10 % FCS and 10 0 μg/ml gentamicin) and cultured at 37°C in 5% CO2 and 95% air Outgrowing cells were isolated by trypsination two weeks later and expanded in DMEM with 10 % FCS Preparation...