justice involved drug abusers and addicts
Báo cáo sinh học: " Common Genotypes of Hepatitis B virus prevalent in Injecting drug abusers (addicts) of North West Frontier Province of Pakistan" doc
... in intravenous drug users (IDU) at Taiwan were as: mixed genotype A and B in 18 (5.5%); genotype B and C in 30 (9.2%); genotype B and D in (0.3%); genotype A and C in (0.3%); and mixed infections ... intravenous drug abusers are highly vulnerable for blood borne infections and Peshawar is harboring a high number of drug addicts, the present study was designed to collect epidemiological information and ... hepatitis B and C infections This situation needs to be addressed immediately, as a political and policy issue, with responsibilities clearly defined at the country and community levels Drug addicts...
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Báo cáo hóa học: " Common Genotypes of Hepatitis B virus prevalent in Injecting drug abusers (addicts) of North West Frontier Province of Pakistan" potx
... in intravenous drug users (IDU) at Taiwan were as: mixed genotype A and B in 18 (5.5%); genotype B and C in 30 (9.2%); genotype B and D in (0.3%); genotype A and C in (0.3%); and mixed infections ... intravenous drug abusers are highly vulnerable for blood borne infections and Peshawar is harboring a high number of drug addicts, the present study was designed to collect epidemiological information and ... hepatitis B and C infections This situation needs to be addressed immediately, as a political and policy issue, with responsibilities clearly defined at the country and community levels Drug addicts...
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Báo cáo y học: "Open Access Substance abuse and psychiatric co-morbidity as predictors of premature mortality in Swedish drug abusers a prospective longitudinal study 1970 - 2006" docx
... admission and at follow up Substance type and other drugs including alcohol were identified with interviews and validated by mandatory urine samples Demographic data, types of substances used and psychiatric ... diagnoses were collected in a standardized manner Standardized clinical interviews (SWEDATE) and hospital records contained background data and mandatory information on length and intensity of Nyhlén ... Bejerot N: Drug abuse and drug policy An epidemiological and methodological study of drug abuse of intravenous type in the Stockholm police arrest population 1965–1970 in relation to changes in drug...
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Báo cáo y học: "Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes involved in transcriptional and translational processes"
... fives genes involved in transcriptional and translational processes As shown in Table 1, the up-regulated genes were COBRA1, ITGB4, STAU2, and HMGN3 with a SLR of 3.30, 2.61, 1.68 and 1.52, respectively ... anchoring and signal transduction Additionally, we evaluated the functional pathways in which the ethanol-regulated genes were involved using KEGG (Kyoto Encyclopedia of Genes and Genomes) [36] and ... induction of transcription factors (AP1, Elk1, Stat1, SRF and NFκB) and expression of apoptotic genes (Fas receptor, Fas ligand, FADD and caspase 8) [19] In addition, as confirmed by the functional...
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Báo cáo khoa học: Nuclear localization of human spermine oxidase isoforms – possible implications in drug response and disease etiology pptx
... existence of SMO5 in human normal and tumor cell lines SMO5 cDNA was subcloned and sequenced, and active protein was produced, purified and assayed for kinetic properties and substrate specificities NCI-H157 ... to inclusion bodies, and therefore was denatured and refolded prior to analysis All SMO5 protein production and purification steps were performed in parallel with SMO ⁄ PAOh1 and PAOh4 proteins ... decreases in intracellular spermine pools and increased spermidine levels in SMO1 and SMO5 cells These changes in spermine and spermidine levels in both SMO1 and SMO5 overexpressing cell lines were...
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ECONOMIC AND SOCIAL CONSEQUENCES OF DRUG ABUSE AND ILLICIT TRAFFICKING doc
... between east and west in Europe facilitated contacts and communication that were also used by drug traffickers, increasing the number of transit routes for drugs and markets for drug consumption.21 ... Sweden, Switzerland and the United Kingdom of Great Britain and Northern Ireland Sources: UNDCP country profiles United States Department of Health and Human Services (Substance Abuse and Mental Health ... widely abused synthetic drug, cutting across all social classes 11 II Economic consequences of drug abuse and trafficking A Apparent "benefits" and costs of drug abuse and trafficking “Benefits”...
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Báo cáo khoa học: The HNF1b transcription factor has several domains involved in nephrogenesis and partially rescues Pax8/lim1-induced kidney malformations docx
... to R Vignali and P.D Vize for the Xenopus HNF1b and lim1, Pax2/8 cDNAs, respectively, and Elizabeth A Jones for antibodies 3G8 and 4A6 We thank Kathy Astrahantseff, Christoph Waldner and Karin Dudziak ... Identical amino acids between b and a or human b and Xenopus b sequences are shown and conserved amino acid changes are indicated by + well as the developing kidney, liver, gut and pancreas express HNF1b ... domains between HNF1a and HNF1b is 16 shown in bold (homology) The 26 aa segment between the POUS and POUH domains of the human HNF1a and HNF1b proteins as well as of the human and Xenopus HNF1b...
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Báo cáo khoa học: Lipid droplet and milk lipid globule membrane associated placental protein 17b (PP17b) is involved in apoptotic and differentiation processes of human epithelial cervical carcinoma cells pptx
... factors, AP-2, GCF and PAX-2 [49]; (h) factors abundant in placenta, AHR [50], AP-2 and PPARc; (i) proliferation and/ or apoptosis regulators, AP-2, c-MYC [51] and NF-jB; (j) embryo- and organogenic ... from milk and its cDNA was isolated from a mammary gland clone collection [57], while human mammary gland and mammary adenocarcinoma ESTs similar to PP17b cDNA was found by BLAST, and subsequently ... purified 30-, 48- and 60-kDa proteins Protein identification and sequencing are described in Materials and methods Most of the input masses matched candidate protein sequences, and the majority...
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MASS SPECTROMETRY IN DRUG METABOLISM AND DISPOSITION docx
... Chemistry 43 Amit S Kalgutkar Drug- Metabolizing Enzymes, Transporters, and Drug Drug Interactions 83 Steven W Louie and Magang Shou Experimental Models of Drug Metabolism and Disposition 151 Gang ... of drug metabolism and disposition These concepts are intended to build a unique foundation of knowledge for drug metabolism and the subsequent studies performed during drug discovery and drug ... White RE Short and long-term projections about the involvement of drug metabolism in drug discovery and development Drug Metab and Dispos 1998;26:1213À1216 Wu CY, Benet LZ Predicting Drug Disposition...
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Báo cáo khoa học: Role of the plasma membrane leaflets in drug uptake and multidrug resistance ppt
... incoming drugs before they reach the cytoplasm and at a transient high local concentration Moreover, in the latter case, Pgp is expected to handle incoming drugs more efficiently compared to drugs ... By contrast, in the case where drug concentrations in the cytoplasm and the cytoplasmic leaflet are in equilibrium, Pgp is expected to treat incoming drugs and drugs already present within the ... only transports a variety of drugs conjugated to glutathione, sulfate or glucuronate, as well as anionic drugs and dyes, but also neutral ⁄ basic amphipathic drugs and even oxyanions Previously,...
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For Medicare Advantage Plans, Medicare Advantage Prescription Drug Plans, Prescription Drug Plans, and 1876 Cost Plans ppt
... management restrictions, drugs that are available via mail-order, excluded drugs, free first fill drugs, limited access drugs, drugs covered in the coverage gap, and drugs covered under the medical ... and generic drugs A generic drug is approved by the FDA as having the same active ingredient as the brand name drug Generally, generic drugs cost less than brand name drugs A statement describing ... below Drug Name: We suggest capitalizing brand name drugs, (e.g., LIPITOR), and listing generic drugs in lowercase italics, (e.g., penicillin) Part D plans may include the generic name of a drug...
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fragment based drug discovery and x-ray crystallography
... (2009) Ligand efficiency and fragment-based drug discovery Drug Discov Today 14:278–283 83 Orita M, Ohno K, Niimi T (2009) Two ‘golden ratio’ indices in fragment-based drug discovery Drug Discov ... Potent and Selective BACE-1 Inhibitors Daniel F Wyss, Yu-Sen Wang, Hugh L Eaton, Corey Strickland, Johannes H Voigt, Zhaoning Zhu, and Andrew W Stamford 83 Combining Biophysical Screening and X-Ray ... Marsh, Sandra Greive, and Marko Hyvonen Fragment Screening and HIV Therapeutics 181 Joseph D Bauman, Disha Patel, and Eddy Arnold Fragment-Based Approaches and Computer-Aided...
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DRUG DISCOVERY AND DEVELOPMENT – PRESENT AND FUTURE pptx
... Contemporary and Ancient Sciences Bhushan Patwardhan and Kapil Khambholja Chapter Evolutionary Biology and Drug Development 25 Pierre M Durand and Theresa L Coetzer Chapter Novel Oncology Drug Development ... process excellence handcuff drug development? Drug Discov Today 16: 377-381 Drug Discovery and Development – Present and Future [11] Kola I (2008) The State of Innovation in Drug Development Clin ... Safety Pharmacology and Drug Interaction Evidencebased Complementary and Alternative Medicine Vol.2011,No., 24 Drug Discovery and Development – Present and Future Sharma H , Chandola HM (2011) Prameha...
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Báo cáo y học: " Injection drug use and patterns of highly active antiretroviral therapy use: an analysis of ALIVE, WIHS, and MACS cohort" ppt
... contributions to conception and design, acquisition of data, and analysis and interpretation of data; 2) have been involved in drafting the manuscript; and 3) have read and given approval of the ... injection drug use Patterns and trends of HAART use The longitudinal trends in the use of HAART by class of drug are depicted in Figure Both individuals with and without a history of injection drug ... one NRTI and at least one PI and at least one NNRTI, 3) an abacavir- or tenofovir-containing regimen with at least NRTIs, 4) a regimen containing ritonavir and saquinavir and one NRTI, and no NNRTIs...
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Báo cáo y học: "Impact of drug classes and treatment availability on the rate of antiretroviral treatment change in the TREAT Asia HIV Observational Database (TAHOD" pdf
... antiretroviral drugs and who had baseline and at Page of 10 (page number not for citation purposes) AIDS Research and Therapy 2007, 4:18 least follow-up visit were included in this study Retrospective and ... Thailand; T Sirianthana* and W Kotarat, Research Institute for Health Sciences, Chiangmai, Thailand; J Chuah*, Gold Coast Sexual Health Clinic, Miami, Queensland, Australia; K Frost*, J Smith* and ... efficient, and standardized first line regimen First line regimens usually include nucleoside reverse transcriptase inhibitors (NRTI) and one non- nucleoside reverse transcriptase inhibitors (NNRTI), and...
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báo cáo khoa học: "Computerized clinical decision support systems for drug prescribing and management: A decision-maker-researcher partnership systematic review" pot
... prophylaxis, and b-blockers Alerts for drug allergies 6*/276/5,219 and drug- drug interactions, and options for cost-effective testing in inpatients Length of hospital stay and resource ... prescribing of antibiotics and drugs for asthma, COPD, and dyslipidaemia 23*/53/3,496 Sum scores for appropriate prescribing of antibiotics, statins, cholesterollowering drugs or drugs for asthma or ... acquired, analyzed, and interpreted data; drafted the manuscript; and provided statistical analysis LWK and TN acquired data and drafted the manuscript NLW acquired, analyzed, and interpreted data;...
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báo cáo khoa học: "Computerized clinical decision support systems for therapeutic drug monitoring and dosing: A decision-maker-researcher partnership systematic review" doc
... different drugs, and provided clinical guidance for data analysis and the manuscript The Health Information Research Unit research staff searched and selected studies, and extracted and synthesised ... data and was handled by a healthcare professional In our previous review [1], randomized and nonrandomized trials assessing the effect of a CCDSS on TDMD were identified until September 2004, and ... had a perfect score and concealed study group allocation before randomization and cluster randomization were infrequent CCDSS and study characteristics CCDSSs were generally stand-alone computer...
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báo cáo khoa học: " The Chinese government’s response to drug use and HIV/AIDS: A review of policies and programs" potx
... HIV, AIDS, drug use, narcotic control, incarceration, voluntary counseling and testing and harm reduction intervention Results Current policies regarding drug use and HIV prevention among drug users ... Narcotics”, the main purpose of the compulsory and voluntary detoxification is to reduce demands for drug use, drug related crimes, and injection drug use, which are designed to eventually reduce ... reduction (e.g MMT and NEP) and HIV prevention (e.g VCT) were successful and had positive effects in reducing drug related risk behaviors among drug users in both institution-based and community-based...
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báo cáo khoa học: " Drug use and opioid substitution treatment for prisoners" pot
... adequate treatment, drug addiction and dependence and their attendant dangers persist after the prisoner’s release into the community and are associated with a high rate of overdose and other harms ... aged 25 and older who used illegal drugs for ≥ 10 years and heroin for ≥ years [29] Other limitations related to OST in prisons include a deficiency of psychological and social support for drug- using ... exchange of knowledge and experience among scientists, politicians and practitioners through international and national conferences of experts from various fields; and organising local and regional discussions...
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báo cáo khoa học: " Rapid assessment response (RAR) study: drug use and health risk - Pretoria, South Africa" ppsx
... equipment and/ or drug- related unprotected sex, as was found in the rapid assessment of drug use and sexual HIV risk patterns among vulnerable drugusing populations in Cape Town, Durban and Pretoria ... youth and young adults in particular who are not educated and who are economically disadvantaged are at a higher risk in terms of drug experimentation and drug use, education for children, youth and ... about where to access HIV treatment and preventative services, and numerous barriers to accessing appropriate HIV and drug- intervention services such as long waits and appointments being cancelled...
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