iii centrally acting skeletal muscle relaxants
Báo cáo y học: "Skeletal muscle sodium glucose co-transporters in older adults with type 2 diabetes undergoing resistance training"
... fashion with the exception of muscle strength hSGLT3 and GLUT4 gene expression RNA Extraction Skeletal muscle samples were obtained in the non-dominant vastus lateralis muscle by percutaneous needle ... exercise subjects (n=5) for whom skeletal muscle tissue was available Figure Int J Med Sci 2006, shows the immunohistochemical determination of hSGLT3 in skeletal muscle before (Figure 2A) and after ... utilization in skeletal muscle It has been proposed that insulin resistant individuals have a defect in GLUT4 trafficking and targeting leading to reduced GLUT4 in the cell membrane in skeletal muscle...
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Tài liệu Báo cáo khoa học: Subproteomics analysis of Ca2+-binding proteins demonstrates decreased calsequestrin expression in dystrophic mouse skeletal muscle pdf
... Company Preparation of total muscle extracts For the comparative gel electrophoretic analysis of normal vs dystrophic skeletal muscle fibres, total extracts of the muscle protein complement were ... proteomics analysis of the protein complement of normal mouse skeletal muscle (Fig 1A) vs dystrophin-deficient mdx mouse skeletal muscle (Fig 1B) can be used, in conjunction with the Swiss-Prot ... ion-binding and ion-fluxes may render skeletal muscles more susceptible to necrosis Owing to the enormous complexity of the triadic signal transduction mechanism [52], skeletal muscle proteomics has not...
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Tài liệu Báo cáo khoa học: Effect of gadolinium on the ryanodine receptor/ sarcoplasmic reticulum calcium release channel of skeletal muscle docx
... of skeletal muscle Ca2+ release channel (ryanodine receptor) Biophys J 69, 106–119 Buratti R, Prestipino G, Menegazzi P, Treves S & Zorzato F (1995) Calcium dependent activation of skeletal muscle ... R (1988) Ryanodine receptor of skeletal muscle is a gap junction-type channel Science 242, 99–102 13 Sitsapesan R & Williams AJ (1995) The gating of the sheep skeletal sarcoplasmic reticulum ... of skeletal muscle Ca2+ release channel Biophys J 70, 2600–2615 16 Herrmann-Frank A & Lehmann-Horn F (1996) Regulation of the purified Ca2+ release channel ⁄ ryanodine receptor complex of skeletal...
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Báo cáo khoa học: Cardiac ankyrin repeat protein is a marker of skeletal muscle pathological remodelling pot
... forming the muscle differs between muscles: the quadriceps muscle is composed roughly of 50% type fibres and 50% type fibres, the TA and EDL muscles contain about 5–10% type fibres, the soleus muscle ... T, Matsuda J, Aburatani H et al (2004) Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, downregulated type I (slow twitch/red muscle) fiber genes, and impaired glycemic ... fibres composing the muscle In the C3-null model, the quadriceps muscle is unaffected by the disease, the EDL and TA muscles are weakly affected, and the soleus and psoas muscles are the most...
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Báo cáo khoa học: Progressive decrease of phosphocreatine, creatine and creatine kinase in skeletal muscle upon transformation to sarcoma pot
... in striated skeletal and heart muscles and ubiquitous uMitCK is present in smooth muscle, brain, neuronal and other non -muscle Table Creatine and phosphocreatine content in normal muscle (NM) ... [1–4] There are two cytosolic CK isoforms Whereby muscle- specific cytosolic (MCK) is expressed specifically in sarcomeric skeletal and cardiac muscles, brain-specific cytosolic (BCK) is mainly expressed ... in normal skeletal muscle of the same tumor-bearing animal, as observed in this study This raises the possibility that the creatine transporter that allows entry of creatine into the muscle may...
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Báo cáo khoa học: Mapping contacts between regulatory domains of skeletal muscle TnC and TnI by analyses of single-chain chimeras potx
... primary structure of troponin I from white skeletal muscle of the rabbit Biochem J 153, 375–387 Herzberg O & James MN (1985) Structure of the calcium regulatory muscle protein troponin-C at 28 A resolution ... is necessary for full comprehension of Tn function To investigate the interactions between skeletal muscle TnC(1–91) and TnI(98–182), we have constructed two single chain chimeras composed of ... The troponin complex and regulation of muscle contraction FASEB J 9, 755– 767 Gordon AM, Homsher E & Regnier M (2000) Regulation of contraction in striated muscle Physiol Rev 80, 853–924 Potter...
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Skeletal Muscle – From Myogenesis to Clinical Relations pdf
... tissues, including skeletal muscle, express LIF LIF is constitutively expressed at a low level in type I muscle fibers [45, 46] and is implicated in conditions affecting skeletal muscle growth and ... the decreased regenerative potential of aged skeletal muscle Indeed, enhancement of Notch-1 signaling promotes muscle regeneration in old skeletal muscle [8, 9] Although these experiments suggest ... concentrated, in skeletal and/or cardiac muscle, suggesting 18 Skeletal Muscle – From Myogenesis to Clinical Relations specific roles in myogenesis [174] The expression of the muscle- specific...
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Báo cáo Y học: Fluorescence study of the high pressure-induced denaturation of skeletal muscle actin pdf
... glycerinated rabbit muscle ®bers Proc Natl Acad Sci USA 88, 7323±7327 Fortune, N.S., Geeves, M.A & Ranatunga, K.W (1994) Contractile activation and force generation in skeletal rabbit muscle ®bres eects ... stored at )20 °C after lyophilization Myosin was extracted with Guba±Straub solution from rabbit skeletal muscle according to the method of Perry [14] and heavy meromyosin (HMM) was obtained by limited ... behaviour under pressure MATERIALS AND METHODS Protein preparations Actin preparations from rabbit skeletal muscle were obtained from acetone dried powder according to the procedure of Pardee & Spudich...
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Body composition in the elderly: Reference values and bioelectrical impedance spectroscopy to predict total body skeletal muscle mass pot
... ALSTDxA ¼ appendicular lean soft tissue TBSMMDxA ¼ total body skeletal muscle mass, calculated as 1.19 Â ALSTDxA À 1.65.11 SMMIDxA ¼ skeletal muscle mass index, calculated as TBSMMDxA/(height in m2) ... Comparison of BIS and DXA Differences of FFM and BF measured by DXA and BIS, BIA skeletal muscle mass estimates4,8 and muscle mass measured by DXA, in 98 noninstitutionalized 75-year-old subjects, ... systematic negative bias, reciprocal to FFMBIS bias 4.4 Muscle mass prediction Previously published BIA-equations4,8 overestimated skeletal muscle mass in our subjects The overestimations were larger...
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Báo cáo khoa học: A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-jB pathway in skeletal muscle pdf
... [17,19–21] Although the three MARPs are expressed in both heart and skeletal muscle [18,22,23], Ankrd2 is mainly expressed in skeletal muscle [18,24,25], CARP in the heart [18,21,26–28] and DARP in ... established that NF-jB is a major inducer of muscle atrophy in the skeletal muscle Indeed, NF-jB inhibition in mice models invariably protects against muscle atrophy, whereas NF-jB activation promotes ... in skeletal muscle during disuse atrophy FASEB J 16, 529–538 Judge AR, Koncarevic A, Hunter RB, Liou HC, Jackman RW & Kandarian SC (2007) Role for IkappaBalpha, but not c-Rel, in skeletal muscle...
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Báo cáo hóa học: " Overexpression of microRNA-206 in the skeletal muscle from myotonic dystrophy type 1 patients" docx
... expressed only in skeletal muscles, and promotes muscle differentiation if induced by MyoD and myogenin during myogenesis [16,17] These muscle- specific miRNAs seem to participate in muscle diseases, ... [31] It is the unique myomiR exclusively expressed in skeletal muscle [32-36] and has been rarely detectable in the heart [37-41] The skeletal muscle- specific expression of miR-206 was first clearly ... pathohistological features of each DM1 specimens used in this study (sex, muscle, lysosomal activity and muscle pathohistological aspects) Muscle biopsies from VL of female and males have been used as control...
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Báo cáo hóa học: "Assessment of skeletal muscle fatigue of road maintenance workers based on heart rate monitoring and myotonometry" docx
... reliable device for measuring skeletal muscle viscoelastic parameters; therefore, such electro-mechanical characterization of the skeletal muscle may provide new insights into muscle function and can ... in their muscle tone depending on the length of occupational service is shown in Table 6: Category III – muscle is not able to relax Discussion Category I – subject is able to relax the muscle; ... 13% III – 77% 0.68 0.68 0.68 0.48 0.41 0.53 I – 12% II – 17% III – 70% 0.68 0.68 0.68 0.45 0.35 0.25 I – 8% II – 12% III – 80% 0.68 0.68 0.68 12.0 62.8 89.3 Pavers (n = 25) I – 14% II – 40% III...
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báo cáo hóa học:" Isokinetic eccentric exercise can induce skeletal muscle injury within the physiologic excursion of muscle-tendon unit: a rabbit model" doc
... three-dimensional muscle model: a quantified relation between form and function of skeletal muscles J Morphol 1984, 182:95-113 Kaufman KR, An KN, Chao EYS: Incorporation of muscle architecture into the muscle ... the treatment and prevention of muscle strains Certain muscles (muscles that cross several joints or those with com- Table 2: Energy absorption of triceps surae muscle- tendon units during eccentric ... injured muscles include the hamstring, rectus femoris, gastrocnemius, and adductor longus muscles All of these muscles have a strain threshold for both passive and active injury [35] Eccentric muscle...
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báo cáo hóa học:" Initial intramuscular perfusion pressure predicts early skeletal muscle function following isolated tibial fractures" pptx
... regeneration of skeletal muscle morphology, biomechanical in vitro investigations, also demonstrated a faster return of muscle strength to the level of the uninjured contralateral muscle, following ... isokinetic skeletal muscle performance is only partly understood Therefore, this study was aimed to quantitatively analyze the effect of soft tissue injury after isolated tibial fracture on the skeletal ... gastrocnemius muscle contu- Figure Regression analysis of perfusion pressure on the muscle deficit after 24 hours, in dorsiflexion at weeks after trauma Regression analysis of perfusion pressure on the muscle...
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báo cáo hóa học: " Influence of dietary state and insulin on myocardial, skeletal muscle and brain [18F]fluorodeoxyglucose kinetics in mice" pptx
... after insulin administration corresponded to an increase in Ki for myocardium and skeletal muscle Because skeletal muscle constitutes a significant fraction of the body mass in mice [19], the observed ... to insulin stimulation regarding glucose metabolism between heart and skeletal muscle, indicate that myocardium and skeletal muscle might have different mechanisms for regulation of glucose or ... and skeletal muscle Conversely, insulin raised whole-body FDG and glucose disposal rates and increased transmembranous transport of FDG and, by inference, glucose into myocardium and skeletal muscle...
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SKELETAL MUSCLE – FROM MYOGENESIS TO CLINICAL RELATIONS pptx
... tissues, including skeletal muscle, express LIF LIF is constitutively expressed at a low level in type I muscle fibers [45, 46] and is implicated in conditions affecting skeletal muscle growth and ... the decreased regenerative potential of aged skeletal muscle Indeed, enhancement of Notch-1 signaling promotes muscle regeneration in old skeletal muscle [8, 9] Although these experiments suggest ... concentrated, in skeletal and/or cardiac muscle, suggesting 18 Skeletal Muscle – From Myogenesis to Clinical Relations specific roles in myogenesis [174] The expression of the muscle- specific...
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Section III - Drugs Acting on the Central Nervous System docx
... incidence of explicit recall is 0.15% following general anesthesia (0.18% when using muscle relaxants, 0.10% without muscle relaxants) in patients undergoing surgery and anesthesia when interviewed three ... itself is of no use in the large number of patients who receive muscle relaxants Other indicators of awareness that are independent of muscle relaxation include lacrimation, diaphoresis, and pupillary ... agents, which are halogenated hydrocarbons and ethers, are modeled after halothane The skeletal muscle relaxants (neuromuscular blocking agents) also were discovered and their pharmacological...
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Báo cáo y học: " Chronic alcohol ingestion exacerbates skeletal muscle myopathy in HIV-1 transgenic rats" docx
... (SAIDS), alcohol abuse increased expression of two muscle- specific E3 ubiquitin ligases, atrogin-1 and muscle ring finger protein-1, and drove skeletal muscle proteolysis [10] These data clearly show ... development of overt skeletal muscle atrophy For example, in the early stages of SIV infection, binge-like alcohol ingestion in asymptomatic Rhesus macaques did not alter skeletal muscle protein synthesis ... a member of the TGFb super family and implicated in various models of skeletal muscle atrophy, likely influences skeletal muscle mass via cell cycle regulation and alterations to myogenic stem...
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Báo cáo y học: "Insulin alleviates degradation of skeletal muscle protein by inhibiting the ubiquitin-proteasome system in septic rats" pps
... considered significant Results Proteolytic rate in extensor digital longus muscle The proteolytic rate of skeletal muscle was measured as net release of tyrosine for total protein and 3-MH for ... excessive loss of body protein Muscle catabolism, resulting in muscle wasting and fatigue, is a characteristic metabolic response to sepsis [1-3] Sepsisinduced muscle catabolism is mainly caused ... in muscle tissue from septic patients, concomitant with increased muscle levels of phenylalanine and 3-MH [8] These data support our results that the Ub-proteasome system was activated in skeletal...
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