... TTOA01_vol1 3/9/07 10:46 AM Page i TEXTBOOK OF Hepatology FromBasic Science toClinicalPractice TTOA01_vol1 3/9/07 10:46 AM Page ii Textbook of Hepatology Third Edition ... highlighted in the text TTOA01_vol1 3/12/07 4:44 PM Page iii TEXTBOOK OF Hepatology FromBasic Science toClinicalPractice THIRD EDITION SECTIONS 110 AND INDEX EDITORS ASSOCIATE EDITORS Juan Rodộs MD ... Cataloging-in-Publication Data Textbook of hepatology : frombasic science toclinicalpractice 3rd ed / edited by Juan Rodộs [et al.] p ; cm Rev ed of: Oxford textbook of clinical hepatology 2nd ed 1999 Includes...
... MMMM An Introduction to Vascular Biology Frombasic science toclinicalpractice SECOND EDITION Edited by Beverley J Hunt Departments of Haematology and Rheumatology, Guy’s and St Thomas’ ... Growth factors Vascular growth factors are potent chemoattractants and mitogens Factors such as platelet-derived growth factor (PDGF) and basic Wbroblast growth factor (bFGF) are thought to play ... estimated to bind to proteins or to be taken up into stores (Kamishima and McCarron, 1996) Despite this, opening of Ca2+ channels causes [Ca2+]i to rise to micromolar levels This is suYcient to activate...
... Frémin and Meloche: Frombasicresearchtoclinical development of MEK1/2 inhibitors for cancer therapy Journal of Hematology & Oncology 2010 3:8 Submit your next manuscript to BioMed Central and ... proven to be invaluable academic research tools to investigate the role of the ERK1/2 MAP kinase pathway in normal cell physiology and disease To date, eleven MEK1/2 inhibitors have been tested clinically ... activated in response to virtually all mitogenic factors Second, several studies have reported that the mitogenic response to growth factors is correlated with their ability to induce sustained...
... 2007-1 Progestins and the Mammary Gland FromBasic Science toClinical Applications O Conneely, C Otto Editors With 43 Figures 123 Series Editors: G Stock and M Lessl Library of Congress Control ... hormone receptors are important drug targets and have been the focus of basic and applied research for decades Steroid hormone receptors act as ligand-dependent transcription factors Upon ligand ... hormone receptors to regulate distinct gene expression profiles in different tissues has been exploited in recent years in the clinical development of novel hormone receptor modulators that have...
... µm Localization in epidermis Up to stratum spinosum Up to granular layer Receptors (receptor for growth factors, other receptors) trkA, p75, e.g Histamine receptor, Trp-group c-RET, binding of ... IL-1 to its receptor and can be found in high concentrations in keratinocytes Mice deficient in IL-1ra have been shown to be more susceptible to lethal endotoxemia and this cytokine is thought to ... receptor stimulation, direct injury to keratinocytes, or APC-mediated triggers, the innate immune system functions to contain infection Inflammatory mediators originating from its effector cells...
... osteoclastic markers Receptor Activator of Nuclear Factor Kappa-B (RANK) and Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) strongly increased and cells showed the ability to resorb bone (Fig ... Regeneration – FromBasic Biology toClinical Application not required when the cell disassembles microtubules in the cell body to give rise to the formation of neurites, while TAU is required to add ... transition from inflammatory to the remodelling phase in tissue repair Advanced laser systems allow to apply more complex treatment protocols, to try to potentiate or to exploit synergistically...
... “Advanced Research Workshops”, and the NATO Science Series collects together the results of these meetings The meetings are co-organized by scientists from NATO countries and scientists from NATO’s ... of the NATO Advanced Study Institute on Carbon Nanotubes: FromBasicResearchto Nanotechnology Sozopol, Bulgaria 21-31 May 2005 A C.I.P Catalogue record for this book is available from the Library ... permission from http://www.photon.t.utokyo.ac.jp/~maruyama/agallery/agallery.html) A SWCNT is constituted from a one atomic layer thick sheet with graphitelike structure (graphene sheet) rolled into...
... osteoclastic markers Receptor Activator of Nuclear Factor Kappa-B (RANK) and Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) strongly increased and cells showed the ability to resorb bone (Fig ... Regeneration – FromBasic Biology toClinical Application not required when the cell disassembles microtubules in the cell body to give rise to the formation of neurites, while TAU is required to add ... transition from inflammatory to the remodelling phase in tissue repair Advanced laser systems allow to apply more complex treatment protocols, to try to potentiate or to exploit synergistically...
... functions as high affinity receptor 10 Pulmonary Hypertension – From Bench ResearchtoClinical Challenges and a cofactor for plasma factors VII/VIIa, the initiator of blood coagulation TF is ... Hypertension – From Bench ResearchtoClinical Challenges Angiolillo DJ, Ueno M, Goto S Basic principles of platelet biology and clinical implications Circ J 2010; 74:597-607 Atkinson C, Stewart S, Upton ... as inositol triphosphate receptor (IP3R), heterodimeric GTP binding protein, Ca2+ Pulmonary Hypertension – From Bench ResearchtoClinical Challenges ATPase and several transient receptor potential...
... coefficient was derived from fitting toclinical data 12 Progress in Hemodialysis – From Emergent Biotechnology toClinicalPractice 3.2 Urea KT/V and creatinine clearance for the kidneys To assess the ... of total solute mass removal from the body, dMR/dt, during hemodialysis is: dM R = K ( Ce − Cd ) + K rCe dt (9) Progress in Hemodialysis – From Emergent Biotechnology toClinicalPractice The total ... patient less prone to IDH in this vulnerable period 30 Progress in Hemodialysis – From Emergent Biotechnology toClinicalPractice Biofeedback system While monitoring may help to understand how...
... Evolution from Protein Chemistry to Proteomics Basic Science toClinical Application The Evolution from Protein Chemistry to Proteomics Basic Science toClinical Application Roger L Lundblad Boca Raton ... explanation without intent to infringe Library of Congress Cataloging-in-Publication Data Lundblad, Roger L The evolution from protein chemistry to proteomics : basic science toclinical application ... separate from translational processing as such modifications are of major interest to investigators using proteomics to study toxicology and environmental health The reader is directed to several...
... categorize the extent to which nurses use research in their clinicalpractice as follows: low (0 to 0.99), moderate-low (1.00 to 1.99), moderatehigh (2.00 to 2.99), and high (3.0 to 4.00) We used ... instrumental research use; CRU-conceptual research use; PRU = persuasive research use; ORU = overall research use = Item: Discontinue practice based on research = Items: (1) transfer knowledge from research; ... instrumental research use was reported as moderate-high to high, conceptual and persuasive research use ranged from moderate-low to high, and overall research use ranged from moderate-high to high...
... Principal Investigator of the Pacific Node of the NIDA Clinical Trials Network, designed to bring cutting-edge findings from treatment researchtopractice in community treatment programs throughout ... among persons ages 12 to 65 in 1998 and 2005 Use of amphetamine/ MA by males in Tijuana increased from 0.7% to 1.6%, and use by males in Juarez increased from 0.1% to 2.0% (Villatoro et al., 2006) ... Methamphetamine Users In addition toclinical and research work, Dr Shoptaw also volunteers as Executive Director for Safe House, a facility he started that provides high-tolerance emergency, transitional,...
... Leading experts from both academia and industry have contributed to this invaluable reference for graduate students, postdocs, and researchers from academia wanting to initiate RNAi research in their ... Contributors Yerramilli V B K Subrahmanyam, PhD QIAGEN, Inc 19300 Germantown Rd Germantown, MD 20874 USA E-mail: subu.yerramilli@qiagen.com Asako Sugimoto, Ph.D Laboratory Head Laboratory for ... clear that RNAi is a powerful tool that has revolutionized basicresearch and that the ability of RNAi to down-regulate almost any gene affords remarkable opportunities to explore the use of duplex...
... in cancer research He is the Editor of RNA Interference: FromBasic Science to Drug Development (2005) To my wife Shyamala for her 25 years companionship MicroRNAs FROMBASIC SCIENCE TO DISEASE ... post-doctoral researchers, and professors from academic research institutions who wish to initiate microRNA research in their own laboratories Additionally, this book will serve MicroRNAs: FromBasic ... resource for all those wishing to use miRNA techniques in their own research, from graduate students, post-docs and researchers in academia to those working in research and development in biotechnology...
... Inflammatory Bowel Disease Translating basic science into clinicalpractice EDITED BY STEPHAN R TARGAN MD Director, Cedars-Sinai Division of Gastroenterology and Inflammatory Bowel and Immunobiology Research ... potential of prevention into view As Editors, our intention is that this book will provide insight along the entire continuum frombasic science toclinicalpractice The basic science chapters present ... Disease Translating basic science into clinicalpractice EDITED BY STEPHAN R TARGAN MD Director, Cedars-Sinai Division of Gastroenterology and Inflammatory Bowel and Immunobiology Research Institute...
... TNF receptor-associated factor 2, TRAIL – TNF-related apoptosis inducing ligand Bladder Cancer Biology 13 The export of cytochrome c into the cytoplasm and its binding to APAF1 (apoptotic peptidase ... factors bind to their corresponding growth factor receptors on the cell surface leading to receptor activation and via several signal transduction events to the activation of downstream factors ... member, GF – growth factor, GFR – growth factor receptor, GRB2 – growth factor receptor-bound protein 2, MEK – mitogen-activated protein kinase kinase, MYC – v-myc myelocytomatosis viral oncogene...
... advances in basicresearch and clinical care of AMD. Different from other AMD books, this book aims to cover the new findings frombasic and translational research on the biological and genetic mechanism of AMD, and the new ... into cytosol upon cell injury has been found to activate thyroid cells in concert with histone H2B with cytokine production (Kawashima et al., 2011) Mitochondrial DNA released from injured mitochondria ... generating inflammatory mediators 4.1 Generation of inflammatory mediators by activating cell surface DAMP receptors Production of biologically active inflammatory mediators including cytokines and...
... of clinicalresearch into clinical practice, ranging from the need to evaluate whether treatments shown to be efficacious in clinical trials continue to be effective in real-world practice, and ... delivery systems and clinicalpracticeto support clinicalresearch in community practices After review of candidate bios, publications, and references pertinent to their clinical, published, ... the national clinicalresearch enterprise and clinical medicine is needed to tip the Page 10 of 11 balance toward community practitioner participation in clinical research, helping to bridge the...