epithelial mesenchymal transition and metastasis role of dicer expression
PRL 3 promotes epithelial mesenchymal transition and confers resistance to apoptosis
... levels of key epithelial and mesenchymal markers 20 There are several molecules that are important features of EMT and cell adhesions Paxillin is part of a complex of cytoskeletal proteins and ... Notably, high expression of PRL-3 was linked with venous invasion [44] PRL-3 expression level was found to have potential as a prognostic marker of development of liver and lung metastasis Out of 177 ... veins of nude mice produced metastasis in lungs of all the mice, and liver metastasis in out of 10 mice injected with Myc-PRL-3 expressing cells Wu et al also studied the promotion of motility and...
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Báo cáo y học: "Relevance of the stroma and epithelial-mesenchymal transition (EMT) for the rheumatic diseases" docx
... genes and initiate epithelial- mesenchymal transition Complexes of Smad7 and Smurf1 or Smurf2 promote ubiquination and degradation of activated receptors limiting the intensity and duration of signaling ... completion of EMT: loss of epithelial adhesion properties; de novo alpha smooth muscle actin (αSMA) expression and actin reorganization; disruption of TBM; and enhanced cell migration and invasion ... master regulator of morphogenesis, plays an essential role in tumor metastasis Cell 2004, 117:927-939 21 Kang Y, Massague J: Epithelial- mesenchymal transitions Twist in development and metastasis Cell...
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Báo cáo y học: " Effects of PPARg ligands on TGF-b1-induced epithelial-mesenchymal transition in alveolar epithelial cells" ppsx
... Page of 13 Figure Regulation of TGF-b1-induced E-cadherin expression by PPARg ligands (A) Effect of TGF-b1 on expression of epithelial marker E-cad (n = 4) (B) Effect of RGZ on regulation of E-cad ... http://respiratory-research.com/content/11/1/21 Page of 13 Figure Regulation of TGF-b1-induced N-cadherin expression by PPARg ligands (A) Effect of TGF-b1 on expression of mesenchymal marker N-cad (n = 4) (B) Effect of PPARg ligands on ... ligands (A) Effect of TGF-b1 or PPARg ligands on expression of epithelial marker E-cad (n = 4) (B) Effect of TGF-b1 or PPARg ligands on expression of mesenchymal marker N-cad (n = 4) Cell lysates...
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Runx3 protects gastric epithelial cells against epithelial mesenchymal transition induced cellular plasticity and tumorigenicity
... morphology and migration 73 Figure 4.3 Expression levels of epithelial- , EMT- and mesenchymalrelated markers in P1 and P2 cells 75 x Figure 4.4 Changes in the expression of EMT- and mesenchymalrelated ... staining profiles in GIF-14 cells 91 Figure 4.13 The effects of various growth factors on the expression of EMT- and mesenchymal- related genes 93 Figure 5.1 EpCAM/CD133 antigen profiles and the expression ... progression and metastasis via epithelial- mesenchymal transition (EMT), angiogenesis and immuno-suppression (Wakefield and Roberts, 2002) 11 Interestingly, some of the biological functions of the...
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Circuit theory of finance and the role of incentives in financial sector reform
... of CTF .10 I.1.3 Efficiency and stability implications of CTF: the role of incentives 14 I.1.4 Theoretical and methodological features of CTF 16 I.2 FINANCE, GROWTH, AND ... build up specialized knowledge of the enterprises’day-to-day business and liquidity, and of short-term developments of demand and supply in the specific sectors and markets where enterprises operate ... important role in influencing the degree and nature of competition both within the banking system and between banks and investment financial institutions Promotion of competition has to go hand in hand...
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Facts of Vietnam Freight forwarding industry and the role of Vietnam Freight Forwarders Association (VIFFAS) to the industry in international economic integration processhelpful to Oristar.doc
... need to be renewed to facilitate export and import The General Department of Customs, the Ministry of Trade and examining bodies, and the Bureau of Standards and Measures should have consensus on ... such professional colleagues on the world The Association has the role of coordinating the activities of the members in order to protect the interests of the members and improve the position of Vietnam ... Ministry of Trade and the Ministry of Transport Being the intermediary between enterprises and Government’s offices, VIFFAS has always made great efforts to catch the business needs and troubles and...
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Báo cáo y học: "Human toxoplasmosis and the role of veterinary clinicians"
... TY, et al Seroprevalence of Toxoplasma gondii infection and risk factors associated with seropositivity of pregnant women in Korea J Parasitol 2008; 94: 963-965 Grant S and Olsen CW Preventing ... consequences of infection can be very severe, while the risk of living with one’s beloved cat is practically nill References Angulo FJ, Glaser CA, Juranek DD et al Caring for pets of immunocompromised ... 963-965 Grant S and Olsen CW Preventing zoonotic diseases in immunocompromised persons: the role of physicians and veterinarians Emerg Infect Dis 1999; 5: 159-163 http://www.medsci.org ...
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Tài liệu Organization-internal Transfer of Knowledge and the Role of Motivation: A Qualitative Case Study pptx
... cognitive abilities of both the source of knowledge (Foss and Pedersen, 2002) and the recipient (Gupta and Govindarajan, 2000; Tsai, 2001) are key factors Absorptive and retentive capacity of the recipient, ... discuss knowledge transfer and the role of motivation in the way that we have The role of motivation is probably as important in a chain of hotels or supermarkets, a software vendor or a consulting ... increasing popularity of knowledge transfer and similar methods of learning Cases such as SCA Packaging highlight the need to understand better the role of motivation, and what corporate managers...
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Tài liệu Egypt''''s Water Warriors : Water Pollution in Egypt and the Role of NGOs in Reaching Integrated Management ppt
... contents of the majority of studied sites exceed the permissible level concentration for drinking water standards recommended by WHO and of Egyptian Standards Aspergillus niger and Spirogyra varians ... protection of Environment and Customer, Community and Environmental Service Association in St Kathrine, and an emerging Society15 for protection of environment and sustainability…etc) and have been leading ... investigating the physical, chemical and microbiological properties of groundwater in Saint Katherine, South Sinai, Egypt and exploring the diversity, occurrence and distribution of fungal taxa in groundwater...
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Tài liệu Báo cáo khoa học: DNA strand exchange activity of rice recombinase OsDmc1 monitored by fluorescence resonance energy transfer and the role of ATP hydrolysis pptx
... between donor and acceptor dyes, will therefore unveil the status of physical union and separation of complementary strands during renaturation and strand exchange, respectively, and thereby assesses ... labeled Phi-W and rhodamine labeled Phi-C (1) with 1.25 lM of OsDmc1 in absence of ATP; (2) with 1.25 lM of OsDmc1 in presence of 2.0 mM of AMP-PNP; (3) with 1.25 lM of OsDmc1 in presence of 2.0 mM ... strand exchange reaction Effect of homology dependence and ATP hydrolysis on strand exchange activity Strand exchange was monitored as a function of reaction time, at a fixed concentration of...
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Tài liệu Báo cáo khoa học: Unfolding of human proinsulin Intermediates and possible role of its C-peptide in folding/unfolding pptx
... Isolation and purification of the scrambled disulfide isomers of HPI In the presence of denaturant and thiol catalyst as indicated above, HPI was converted into the mixture of native and scrambled ... Possible role of C-peptide in the folding/unfolding of HPI (Eur J Biochem 271) 1739 difference between PIP and HPI in the refolding pathway However, our studies of the oxidized refolding process of ... (preproinsulin) and folded as proinsulin, in which a connecting peptide of 35 residues links the C terminus of the B chain and N terminus of the A chain After digestion by a specific set of protein...
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Tài liệu Báo cáo khoa học: Local stability identification and the role of a key aromatic amino acid residue in staphylococcal nuclease refolding pdf
... shows the fluorescence spectra of wild-type SNase and the four mutants E142O, K133A, W140A and W140O The fluorescence spectra of E142O and K133A are similar to that of the wild-type protein However, ... at 140 (W140A and W140O) was much lower than both the wild-type protein and mutants E142O and K133A Thermal analysis of protein unfolding The DSC curves of the wild-type protein and the mutants ... wild-type and mutant SNase Spectra of five proteins [wild-type (WT), W140A, E140O, W140O and K133A] Protein concentration was 0.4 mgÆmL)1 Fig Calometric melting curves of wild-type and mutants of SNase...
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Assessing and Managing Rapid Credit Growth and the Role of Supervisory and Prudential Policies docx
... Quality of data (transparency) and of supervision and regulation of markets and institutions emphasis on those countries that have experienced crises in the aftermath of credit booms and on the ... for macroeconomic and financial stability; and discusses the pros and cons of a number of instruments—both macroeconomic and prudential in nature—that could be used to counter and reduce these ... (2004a) and Gourinchas, Valdes, and Landerretche (2001) See Bernanke and Gertler (1995), Bernanke, Gertler and Gilchrist (1999), Borio, Furfine and Lowe (2001), Kindleberger (1996), Kiyotaki and...
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Enterprise Adjustment and the Role of Bank Credit in Russia: Evidence from a 420 Firm''''s Qualitative Survey pdf
... Dewatripont and Maskin (1995), Earle and alii (1996), Earle and alii (1997), Berglửf and Roland (1998), Bai and Wang (1998) For an analysis of the shortcomings and measurement errors of the accounting ... confirms one of the most standard hypothesis on the microeconomy of transition: the adjustment and growth of enterprises require that they meet a growing demand for their goods and adjust to ... sample 14 These phenomena are generated in a model of soft budget constraint in Berglof and Roland (1994) 22 Enterprise Adjustment and the Role of Bank Credit in Russia: Evidence from a 420 Firm's...
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DECISION MAKING AND THE ROLE OF ACCOUNTING pot
... information systems, budgeting, taxation and internal auditing Not-for-profit accounting involves many of the problems and decisions Decision Making and the Role of Accounting encountered in private ... individuals and business entities buy and sell shares people meet to swap, buy and sell hand-crafted and second-hand goods If accounting information is to be useful, it must be expressed in terms of: ... frequency of reports, (4) the content and format of reports, and (5) external verification How the accounting profession is organised in Australia Accountants in Australia are represented by two professional...
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THE ECONOMIC AND SOCIAL ROLE OF INTERNET INTERMEDIARIES pdf
... Digital Content and Convergence in Transition 14 ECONOMIC MODELS AND ROLE OF INTERMEDIARIES IN THE VALUE CHAIN ECONOMIC MODELS AND ROLE OF INTERMEDIARIES IN THE VALUE CHAIN Role of Internet intermediaries ... enabling the connection of large amounts of heterogeneous machines and networks, and the furthering of an environment of innovation and cross-fertilisation 75 An example of a very creative intermediary ... raising standards of living, wealth creation and competitiveness in global markets Users and consumers who play a growing role in the innovation process often drive demand for new products and services,...
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Báo cáo khoa học: Caenorhabditis elegans metallothionein isoform specificity – metal binding abilities and the role of histidine in CeMT1 and CeMT2 potx
... range of 0.5–2 · 10)4 m for Zn– and Cd–CeMT, and 0.5–1 · 10)4 m for Cu–CeMT, indicating an average of mg of pure metal–MT complex in L of E coli culture Zn(II)-binding abilities of CeMT1 and CeMT2 ... the number of CeMT1 and CeMT2 histidines contributing to divalent metal ion coordination, the Zn and Cd preparations of both C elegans CeMT1 and CeMT2, and the Cd complexes of CtCeMT1 and CtCeMT2, ... Call2 and CalliCu, Callinectes sapidus, 1, and Cu isoforms (Uniprot accession numbers Q548Y3, Q548Y2 and Q9U620, respectively); Scy1 and Scy2, Scylla serrata isoforms and (Uniprot P02805 and P02806);...
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Báo cáo khoa học: Expression and physiological role of CCN4⁄Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes potx
... the total outcome of the constitutive expression of the full-length and the differentiation stage-dependent expression of WISP1v in vitro Effect of overexpression of CCN4/WISP1 and its variants ... chondrosarcoma and it is one of the cell lines known to retain the characters of chondrocytes, as represented by the expression of type II and type X collagen genes To assess whether WISP1v and WISP1vx ... al Fig Production of the WISP1v proteins in HCS-2 ⁄ cells and their overexpression (A) Molecular constructs for the overexpression of WISP1, WISP1v and WISP1vx A mammalian expression vector,...
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Báo cáo khoa học: The essential tyrosine-containing loop conformation and the role of the C-terminal multi-helix region in eukaryotic phenylalanine ammonia-lyases docx
... partitioning of photosynthate into particular branches of phenylpropanoid metabolism may involve labile multienzyme complexes that include specific isoforms of PAL [22,23] Isolation and properties of PAL ... 93, 43 and 41% amino acid identity to that from human [32], Pseudomonas putida [33] and Bacillus subtilis [34], respectively On the basis of the functional similarity of HAL and PAL, of the same ... [40,41] and parsley PAL (Petroselinum crispum) [42] proved the presence of the MIO group and the homotetrameric nature of this enzyme as well The experimental structures of HAL [37] and PAL [40–42]...
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Báo cáo khoa học: Local stability identification and the role of key acidic amino acid residues in staphylococcal nuclease unfolding ppt
... difference of DHcal of mutant from wild-type (%), heat capacity (DCp) and difference of DCp of mutant from wild-type (%) were determined and the results for the wild-type protein and 20 mutants ... due to the loss of the hydrogen bonding among E75 and K9, Y93 and H121 [11] Instead, one water molecule hydrogen bonds to Y93 and H121 Both G75 and K9 are completely outside of this local bonding ... environment of the tryptophan and thus indicate a change in the overall (tertiary) structure of the protein [15] Figure Fig CD spectra of wild-type and SNase mutants CD spectra (far UV) of nine proteins...
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