cytokine—igf interactions in vivo—behavior and learning
Báo cáo khoa học: A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer pot
... lymphomagenesis in mice [44] The miRNA miR-21 is overexpressed in many solid tumors, including breast, colon, lung, prostate and stomach, and in endocrine pancreas tumors, glioblastomas and uterine leiomyomas ... of essential proteins responsible for accelerating the cell cycle, including cyclin D and retinoblastoma [56,57] Moreover, alterations in the machinery responsible for processing miRNA contributes ... examined to date [8,52], a feature that could be particularly useful in diagnosing incident cancers in otherwise normal tissues Indeed, this approach discriminates normal and neoplastic tissues in...
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Báo cáo khoa học: The N-terminal cysteine pair of yeast sulfhydryl oxidase Erv1p is essential for in vivo activity and interacts with the primary redox centre doc
... are no clashes of amino acid side chains in the core of the structure, and most mutations occur on the protein surface The FAD binding groove is conserved with most ligand binding residues identical ... misfolding of the short Erv1p because FAD binding and in vitro enzyme activity are unchanged Changing C30 or C33 to serine drastically increases the amount of observed dimers Probably, the remaining ... The C-terminal FAD binding domain of Erv1p and Erv2p are conserved Partial structural information for the homologous Erv2p is available in the databases [11] The crystallized protein is a 119...
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Báo cáo khoa học: LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles pdf
... understanding pathogenic roles Z Yue function [5] LRRK2 also contains armadillo-like repeats, LRR, kinase and WD40 domains [6] In vitro biochemical analysis demonstrates that LRRK2 contains kinase and ... various model systems, including lower eukaryotes and invertebrates, in order to obtain clues for building important hypotheses The rapidity and efficiency of in vivo studies in many nonmammal models ... illustration of domain structures and alignment for LRRK2 and LRRK2 structure-related proteins ANK, N-terminal ankyrin repeat domain; DEP, Dishevelled, EGL-10, pleckstrin domain; GEF, guanine-exchange...
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Báo cáo khoa học: "Character-Level Dependencies in Chinese: Usefulness and Learning" pot
... B, and the other Scheme E 3.3 Learning Model and Features While memory-based and margin-based learning approaches such as support vector machines are popularly applied to shift-reduce parsing, ... Fangfang Feng, and Andrew McCallum 2004 Chinese segmentation and new word detection using conditional random fields In COLING 2004, pages 562–568, Geneva, Switzerland, August 23-27 Chooi-Ling GOH, Masayuki ... or tagging method d Using trivial internal dependencies in Scheme E e Using annotated internal character dependencies Is Word Still Necessary? Note that this work is not about joint learning of...
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Báo cáo khoa học: "In vivo morphological and antigenic characteristics of Photobacterium damselae subsp. piscicida" doc
... skin was disinfected with 70% (v/v) ethanol and a cm long incision, into which the dialysis bag was inserted, taking care not to injure internal organs The incision was sutured using polyglactin ... HMW bag in vivo had bands at 27, 34, 39, and 79 kDa Staining of the 27 and 79 kDa bands of bacteria cultured in HMW bag in vivo was particularly intense, as were the bands at 26, 27, and 79 kDa ... bacteria shown in Lane 2, Lane 4: bacteria maintained in vitro in 300 kDa dialysis tubing (HMW bag), Lane 5: concentrated ECP of bacteria shown in Lane 4, Lane 6: bacteria maintained in vivo in 25 kDa...
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Báo cáo y học: "Biology of recently discovered cytokines: Interleukin-17 – a unique inflammatory cytokine with roles in bone biology and arthrits" pdf
... protective roles in vivo Interleukin-17 and interleukin-17 receptor signaling 244 The signaling mechanisms used by IL-17 to regulate its downstream targets are surprisingly poorly defined As indicated ... [50]) In particular, both T cells and inflammatory cytokines have been implicated in this process Interestingly, activated T cells inducibly express RANKL, and can thus bypass osteoblasts in triggering ... metabolism, and in the context of arthritis it appears to be a bone destructive cytokine Interleukin-17 in other diseases IL-17 has been implicated in numerous other disease settings Intriguingly,...
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Báo cáo y học: " Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1, HIV-2 and SIV reveals an efficient SIV/HIV-2 lentiviral vector system with highly favourable features for in vivo testing and clinical usa
... coding regions (pSVR∆GP-CMVGFP) and also the generation of a self inactivating (SIN) vector (pSVR∆SIN-CMVGFP) created by additional deletion in the 3' UTR This will be copied into the 5'LTR during ... packaging relationship between SIV and HIV-2 Interestingly, the major packaging determinant of both HIV-2 and SIV has been shown to be upstream of the major splice donor [9,10] and by inference ... encompassing gag and pol sequences) was discarded The remaining fragment was religated and formed pSVR∆GP CMVGFP was obtained from SalI digestion of pSVR∆-CMVGFP and ligated into the SalI linker...
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reading in esp teaching and learning
... problems in teaching and learning English in linguistics In short, the data show that there are both strong points and weak point in the teaching and learning of reading skills to students of linguistics ... reading, reasons for reading, kinds of reading, reading skills and reading in ESP teaching and learning will be discussed 1.1 Reading redefined In the reading class, what the teacher understands ... the main kinds of reading according to purposes of reading are skimming, scanning, extensive reading and intensive reading 1.4.2.1 Skimming Skimming can be defined as follows: “By skimming we...
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A study on the effectiveness of the application of information technology in the teaching and learning of the grade 10 English listenning skill at Hermann Gmein
... CALL and language teaching and learning 1.4 Computer as an IT tool in language teaching and learning 1.5 CALL and listening skill 12 - - CHAPTER II: THE APPLICATION OF THE SOFTWARES IN TEACHING ... influence of utilizing those softwares in teaching and learning listening skill in Hermann Gmeiner School - Vinh Secondly, the teachers and learners‘ opinions about advantages and disadvantages ... CALL in language teaching and learning, the forth introduces two authoring softwares used in the study and the last looks at CALL and listening skills 1.1 How is technology intergrated into education?...
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An investigation into the use of translation method in vocabulary teaching and learning at Tran Nhan Tong High School, Hanoi = Nghiên cứu việc sử dụng phương ph
... Method in vocabulary teaching and learning field, not second language learning in general; therefore, the observation mainly happened in reading, language focus and writing periods The summary In ... other hand, incidental vocabulary learning can occur when learners focused on comprehending meaning rather than focusing on learning new vocabulary (Gass and Selinker, 2001) Incidental learning ... Method in vocabulary teaching and learning There are numbers of researches on the effectiveness of Translation Method in second language teaching in general, and in vocabulary teaching and learning...
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Biochemical identification and functional characterization of microrna target interactions in growth control and cancer transformation
... As shown in Fig 1.2, Ago are large proteins about 100kDa comprising a single variable N-terminal domain and three conserved C-terminal domains, including the PAZ, MID and PIWI domains (Vaucheret, ... complex in miRNA-mediated gene silencing RISC is represented as a complex minimally including an Argonaute protein (green) and GW182 (blue) GW182 proteins contain an N-terminal AGO-binding domain, ... crosslinking and thus more precisely indicate the site of targeting This is achieved by the fact that 4thiouridine incorporation into RNA during co-incubation in cell culture could result in thymidine...
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Study of biomolecular interactions in vivo by multicolour fluorescence spectroscopy
... quantitate protein-protein interactions in vivo The thesis contains six chapters and is structured into the following sections: Chapter introduces the basic principles and instrumentation of FCS and FCCS ... processes in a cell, protein-protein interactions play an important role in a cell system As a cell functions through a network of protein-protein interactions, it is vital to study these interactions ... photobleaching and endogenous proteins All these factors influence the quality of the determined Kd Major findings include quantitating the fraction of non-fluorescent red fluorescent proteins (mRFP and...
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Doxorubicin conjugated to d alpha tocopheryl polyethylene glycol 1000 succinate (TPGS) in vitro cytotoxicity, in vivo pharmacokinetics and biodistribution
... amphiphilic and can dissolve in both organic solvents and water In addition to linear PEG chains, there are also some branched PEGs in which two or more PEG chains may be joined through linkers such ... Feng and Huang 2001; Feng, Yuan et al 2002; Riebeseel, Biedermann et al 22 2002; Mu and Feng 2003; Mu and Feng 2003; Yin Win and Feng 2005; Dong and Feng 2006; Win and Feng 2006; Zhang and Feng ... p-glycoprotein inhibitor Instead, it applies high technologies such as nanotechnology and polymer-drug conjugation, to engineering the drugs to avoid being recognized by the p-glycoproteins (Feng and...
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IN VIVO MECHANICAL AND PHYSIOLOGICAL CHARACTERISATION OF LOWER LIMB SOFT TISSUE BY a LOCAL INDENTATION TECHNIQUE
... the stump’s soft tissues in contact with the prosthetic socket, liner and socks The main factor in determining comfort of the prosthesis and its effectiveness in restoring the amputee's mobility ... fact that the indentation probe is hand-held makes it difficult to ensure repeatability in the positioning and alignment of the probe Maintaining a constant indentation rate by hand is almost ... fitness by obtaining the pain-pressure threshold and tolerance for a below-knee amputee and combining this information with finite element analysis For residual limbs, the tolerant and sensitive...
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In vivo aspects of potential stereospecific drug interactions of oral warfarin and rutin in rats
... rutin treated rats in single dose study using WinNonlin 49 3.3 R- warfarin (mean) curve fitting for (a) control and (b) rutin treated rats in single dose study using WinNonlin 50 3.4 Changes in ... warfarin curve fitting for (a) control and (b) rutin treated rats using WinNonlin 71 4.3 Mean R- warfarin curve fitting for (a) control and (b) rutin treated rats using WinNonlin 72 4.4 Changes in ... warfarin elimination in different animal species 15 1.5 Warfarin drug interactions 23 1.6 Warfarin interactions with herbs and herbal products 26 1.7 Drug information: Rutin 30 1.8 Pharmacokinetic...
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Báo cáo y học: "Expression of Human Globular Adiponectin-Glucagon-Like Peptide-1 Analog Fusion Protein and Its Assay of Glucose-Lowering Effect In Vivo"
... characterized by insulin resistance and insulin secretion deficiency At present, there is no a single medication which treats type diabetes by improving both insulin resistance and insulin secretion ... fusion protein exhibited significant glucose-lowering effect in diabetic mice and may be a promising agent that can treat type daibetes by improving both insulin resistance and insulin secretion ... fusion protein in inclusion body was refolded in urea gradient refolding buffer And then, the refolded protein was incubated with enterokinase to remove the His-tag The fusion protein without...
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Using information technology in teaching and learning reading skill of english for biology for 2nd-year students
... (EFL) teaching and learning and computers in ESP teaching and learning I.1 Theoretical backgrounds of computers and EFL teaching and learning I.1.1 Introduction This section starts with the introduction ... teaching and learning and computer uses in EFL teaching learning are investigated I.1.2 Educational Technology and EFL teaching and learning Thanks to the achievements of international science and ... computer in reading ESP teaching and learning Three ideas will be mentioned and discussed: (1) model of teaching ESP reading with computers, (2) programmes used in reading ESP teaching and learning and...
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Warm – up activities in teaching and learning English at grade 10A5 in Cai Be high schoo
... make and sustain the effort of learning Warm-up activities provide language practice in the various skills- speaking, writing, listening and reading They encourage students to interact and communicate ... prepared the main components of your lesson, and made sure it is learning- rich, varied and interesting, you may find you still need some extra ingredients to make it into a smooth, integrated unit ... they can understand and take part in warm-up activities in learning period Question 2: Are you interested in yes c 35 no c % 81,4 % 18,6 Most of students interest in English I think teachers should...
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Stability and in vivo evaluation of pullulan acetate as a drug nanocarrier
... stability and toxicity of PANs, and further investigated the sustained release behavior in vivo of drug loading in PANs PA was firstly synthesized and characterized by FT-IR and 1H NMR, and then ... novel hydrophobized polysaccharide/oncoprotein complex vaccine induces in vitro and in vivo cellular and humoral immune responses against HER2-expressing murine sarcomas Cancer Res 58:3385–90 Gustafson, ... and 4) Figure shows the microscopic examination of major organs including a b heart, liver, spleen, lung, and kidney sections stained with H&E Pathological changes in the major organs including...
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Factors influencing borrower’s behavior and decision making patterns in the success of a micro finance model
... micro financing by realigning their marketing mechanisms and strategies to attract less educated masses through staff trainings and holding open sessions in these localities and persuading them in ... remaining market share in micro financing After reviewing the literature on the positive impact of micro financing in developing countries like Bangladesh, Zambia and Bolivia, it can be inferred ... attracted to debt financing On the other hand, the individual with low income and savings is more attracted towards debt financing The selection of income group and the means of income are very...
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