consolidation involved in the game
Risks Involved in the Use of Herbal Products
... aspirin or other NSAIDs may increase the risk of bleeding Ginseng may intensify the effects of these drugs, causing an excessive decrease in blood sugar levels (hypoglycemia) Ginseng may intensify ... from their ability to inhibit phase I and induce phase II carcinogen metabolizing enzymes that initiate carcinogenesis They also inhibit the promotion stage of carcinogenesis by inhibiting oxygen ... kava-containing products from the market Based on these and other reports in the United States, the Food and Drug Administration (FDA) issued a consumer advisory in March of 2002 regarding the “rare”...
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Tài liệu Báo cáo khoa học: Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid doc
... to these interfaces is located in the PYR and middle domains The interface contains 10 hydrogen bonds in IPDC The dimer–dimer interface in IPDC is smaller than the corresponding interface in ... orientation of the aminopyrimidine ring, are conserved in all ThDP-dependent enzymes One of these, the hydrogen bond between the N1¢ atom of the pyrimidine ring of ThDP and the side chain of an invariant ... Enterobacter cloacae The PYR domain is shown in blue, the middle domain in green and the PP domain in red The secondary structure elements are labelled as defined in Fig The cofactor ThDP and the magnesium...
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Tài liệu Báo cáo Y học: Identification of a set of genes involved in the biosynthesis of the aminonucleoside moiety of antibiotic A201A from Streptomyces capreolus pdf
... which lack this domain, is scant This domain promotes the binding of the acyl-CoA initiation unit to the ketosynthetase domain of the PKSs for polyketide biosynthesis [35] Therefore, AtaPKS1 could ... fragment only contains the initial 67 bp and the final 68 bp of the pur4 coding sequence It was inserted in plasmid pGM9 The resulting construct was introduced, via S lividans, into S alboniger ... point, the procedure described in Hopwood et al [14] was followed DNA sequencing was made by the dideoxy-chain termination method [25] using the Amplitaq dye-terminator sequencing system (Perkin...
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Tài liệu Báo cáo Y học: Granule-bound starch synthase I A major enzyme involved in the biogenesis of B-crystallites in starch granules ppt
... certainly does not exceed the rate of amylopectin synthesis The increase in crystallinity witnessed during these first 12 h is in line with the high rates observed for amylopectin synthesis However between ... accumulate at the final stage of starch synthesis in the absence of concomitant amylopectin synthesis (reviewed in [41]) In vitro synthesis of amylose Because in Chlamydomonas amylose synthesis remains ... granule in the Table In vitro synthesis of amylose Initial starch (13.9 mg) was subjected to in vitro synthesis in the presence of ADP-glucose at 3.2 mM at 30 °C under continuous shaking in a total...
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Báo cáo khoa học: Monomeric molten globule intermediate involved in the equilibrium unfolding of tetrameric duck d2-crystallin pdf
... [15] The protein appears to dissociate into monomers before further unfolding occurs The detailed dissociation/unfolding mechanism of the protein remains to be determined In this study, we examined ... is the dynamic quenching constant and fa was the fractional maximum accessible protein fluorescence ANS binding assay The exposed hydrophobic surfaces of the protein were assayed by incubating the ... and d2-crystallin was eluted in the same buffer containing 0.12 M NaCl The pooled d2-crystallin showed one major band upon SDS/ PAGE analysis The purity of the protein was further analyzed by...
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Báo cáo khoa học: Identification of two cysteine residues involved in the binding of UDP-GalNAc to UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) ppt
... University) [22,23], containing a cDNA encoding the insulin signal sequence and the Protein A-IgG binding domain, was inserted into NheI-HindIII digested pcDNA3.1, producing the vector, pInsProA pDN42 was ... GalNAc-T1, might be involved in the catalytic function of the enzyme To investigate whether the cysteine residues modified by PCMPS are involved in the binding of UDP-GalNAc, we treated recombinant GalNAc-T1 ... deleted from the rat isozyme, and an insulin signal sequence and a Protein A-IgG binding domain were fused to the resulting N terminus of the sequence The recombinant truncated GalNAc-T1 was then expressed...
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Báo cáo khoa học: Oxidative stress is involved in the permeabilization of the inner membrane of brain mitochondria exposed to hypoxia/reoxygenation and low micromolar Ca2+ Lorenz Schild1 and Georg Reiser2 doc
... ADP suggests that the mitochondrial injury is caused by opening of the mPTP There is evidence that ADP inhibits opening of the mPTP by occupying binding sites located in the inner and outer mitochondrial ... medium during H ⁄ R performed in the presence or absence of 3.5 lm Ca2+ The mitochondrial incubations were carried out in the cuvette of the luminescence spectrophotometer at 30 °C in the presence ... is shown In the hypoxic phase no relevant increase in H2O2 concentration in the medium was detected However, significant increase in H2O2 concentration was seen after reoxygenation in incubations...
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Báo cáo khoa học: Factors involved in the assembly of a functional molybdopyranopterin center in recombinant Comamonas acidovorans xanthine dehydrogenase pot
... adds further difficulty in the successful expression of molybdoenzymes in the xanthine oxidoreductase family The most important factor involved in producing a functional MPT center in recombinant ... identity is shown in Fig 9, where the structure around the MPT site in bovine XDH is shown and the corresponding amino acids in C acidovorans are shown in parenthesis The residues around the Mo site ... and an FAD into the recombinant enzyme Therefore, the host organism has to be able to provide these cofactors and the means for their incorporation into the expressed protein in order to form...
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Báo cáo khoa học: Amino acid residues on the surface of soybean 4-kDa peptide involved in the interaction with its binding protein potx
... of the active area in insulin (Fig 7F) If the mechanism of the interaction between the 4-kDa peptide and 43-kDa protein has the minimum components of insulin–insulin receptor interaction, the ... similar to the insulin– insulin receptor interaction system Interaction of insulin with the 43-kDa protein Acknowledgements Similarly to the 4-kDa peptide, insulin is able to interact with the 43-kDa ... amino acids (Val12 and Arg18), in addition to the 11 residues described above, were involved in binding to the 43-kDa protein The substitution of Val12 and Arg18 to alanine affected binding to the...
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Báo cáo khoa học: RNA-binding properties of HCF152, an Arabidopsis PPR protein involved in the processing of chloroplast RNA pdf
... when the yeast-tRNA was omitted from the binding assay, indicating a lesser specific binding to RNA Finally, the two truncated proteins containing a single PPR domain did not show any binding to ... the background The binding site was found to be located at the C-terminus of the protein although binding of the C-terminus half (CH) is only half of the full-length protein (Fig 3) Interestingly, ... analysis of the BDd RNA, the high affinity binding molecule Defining the binding site of HCF152 in the psbH-petB transcript In order to further characterize the HCF152 binding site, we synthesized...
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Báo cáo khoa học: The starch-binding capacity of the noncatalytic SBD2 region and the interaction between the N- and C-terminal domains are involved in the modulation of the activity of starch synthase III fromArabidopsis thaliana pdf
... acids of the N-terminal region responsible for SSIII regulation We found evidence indicating that two regions, D(316–344) in the D2 domain and D(495–535) in the D3 domain, are involved in the interaction ... interaction between the N- and C-terminal domains of SSIII in vitro Mapping of the CD-binding region in the N-terminal SBDs In order to identify the SBD region required for the SBD–CD interaction, we ... conservation of the tryptophan in binding site II and an aromatic residue (mainly tryptophan or tyrosine) in binding site I [22] We have shown that the tryptophan residue involved in binding site II...
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Báo cáo khoa học: Cell death-inducing DFF45-like effector, a lipid droplet-associated protein, might be involved in the differentiation of human adipocytes pdf
... analyses of the relative levels of the indicated proteins after western blotting (as in D) were carried out Similar experiments were performed five times and the intensity of the individual bands in each ... by inserting the DsRed1 and CIDEC DNA fragments into the vector pShuttle-CMV The plasmid pGFP-adipophilin was also a kind gift from Dr Peng Li The plasmids were transfected into COS-7 cells using ... adipocytic tumors, indicating that the expression of CIDEC decreases along with the de-differentiation of adipocytic tumors In summary, these results imply that CIDEC could be involved in the differentiation...
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Báo cáo khoa học: Identification of domains involved in the allosteric regulation of cytosolic Arabidopsis thaliana NADP-malic enzymes ppt
... are involved in fumarate activation (in yellow), CoA activation (underlined) and malate inhibition (in green) of the forward reaction are highlighted In addition, the regions involved in succinate ... nonconserved amino acid residues in the suggested domain involved in fumarate activation, the mutations at positions 357 and ⁄ or 360 could be involved in the differential regulation, as well as the conserved ... However, the three nonconserved amino acid changes between NADPME2 and NADP-ME3 are located in the amino-terminal region (Fig 1), which is not involved in succinate activation, as NADP-ME2 lacking the...
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Báo cáo khoa học: An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid b-protein doc
... Synoviolin is involved in the degradation of nicastrin gene p53 [19] and Parkin-associated endothelin receptor-like receptor [20] In this study, we addressed whether Synoviolin is involved in the ... also determined the levels of c-secretase-unrelated ER protein (calnexin) and cytoskeleton protein (tubulin) in these cells as the internal control proteins The calnexin and tubulin levels were ... ubiquitination confer specificity to the ubiquitin system by directly interacting with the substrate proteins and helping to transfer ubiquitin to them Therefore, to determine whether NCT is the...
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Báo cáo khoa học: Protein kinase Ch activity is involved in the 2,3,7,8tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line potx
... confirmed, by using the human lymphoblastic T-cell line, L-MAT, as the model, that the AhR-mediated pathway is in no way involved in TCDD-induced apoptosis, [7,8] Furthermore, neither TCDD-mediated ... described in 911 PKCh in TCDD-induced signaling for apoptosis the attached protocol The resin was washed once with 0.5 mL of 0.1 m glycine HCl, pH 3.5, for min, while thoroughly tapping and inverting ... used in combination with TCDD to clarify the involvement of PKC in the signal transduction mechanism participating in TCDD-induced cellular responses [14] We also looked for evidence of the involvement...
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Báo cáo khoa học: A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-jB pathway in skeletal muscle pdf
... are involved in the transmission of mechanical signals to signaling pathways In the M line, mechanical stimulation activates the interaction of a protein complex with the kinase domain of titin, ... pathway and an increase in muscle fiber apoptosis [8] The participation of NF-jB signaling in the pathogenesis of LGMD2A is therefore an interesting possibility The findings obtained in the present ... the binding to titin by improving the accessibility of the titin-binding domain Interestingly, the importance of CARP interaction for its function was recently demonstrated in a FEBS Journal...
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Báo cáo khoa học: Relaxin-3⁄ insulin-like peptide 7, a neuropeptide involved in the stress response and food intake Masaki Tanaka pptx
... relaxin-3 is considered to be different from that of other relaxin proteins involved in the growth and remodeling of reproductive and other tissues during pregnancy [10] In the mouse and rat brain, ... area dorsal to the substantia nigra in the midbrain reticular formation By immunostaining using monoclonal antibody against the N-terminus of the human relaxin-3 A-chain [2], relaxin-3-immunoreactive ... relaxin-3 transcripts in the NI [28] This supports the idea that relaxin-3-expressing neurons in the NI (and therefore relaxin-3) play a role in the central stress regulating system by mutual interaction...
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Báo cáo khoa học: Myocyte enhancer factor 2B is involved in the inducible expression of NOX1⁄ NADPH oxidase, a vascular superoxide-producing enzyme ppt
... be involved in an angiotensin II-induced vascular hypertrophy [15], and in inducing the expression of monocyte chemoattractant protein-1 [16], which plays a key role in the development of atherosclerosis ... are indicated with arrows (B) The exon ⁄ intron structure of the NOX1 gene and its splicing pathway Open boxes indicate exons Numbers in the box denote the size of each exon (bp) The size of the ... On the other hand, pre-incubation with an anti-ATF-1 IgG did not affect the mobility of the specific bands (lane 4, Fig 4B) These results suggest that PGF2a increases the binding of MEF2 to the...
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Báo cáo khoa học: Catalytic activation of human glucokinase by substrate binding – residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions ppt
... residues were individually mutated (C) The spacial proximity of active site residues in the L-domain and connecting region II which are potentially involved in the binding of D-glucose in the super-open ... to amino acids in the L-domain (residues N204, D205, N231, E256 and E290) and the S-domain (residues T168 and K169) (Fig 1B) To identify the contact residues involved in the initial binding of ... Glc binding; (b) to identify the active site residues involved in the binding of Glc to the super-open state (Fig 1C) of this two domain [large (L) and small (S)] enzyme, and thus the site of initiation...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25