common clotting factor deficiency disease states associated systemic and or local hemostasis adjuncts and dental management
Báo cáo khoa học: Adeno-associated virus gene transfer in Morquio A disease – effect of promoters and sulfatase-modifying factor 1 pot
... important clinical obstacles in Morquio A patients [2] Therefore, the enzyme and ⁄ or vector should be delivered mainly to bone cells Gene therapy studies for LSDs often use the liver as a ‘factory’ ... expression from an adeno -associated viral vector in the liver than the cytomegalovirus or elongation factor 1a promoter and results in therapeutic levels of human factor X in mice Hum Gene Ther ... Almeciga-Dıaz et al Promoter and SUMF1 effect on Morquio gene transfer Barrera conceived the study, its design and coordination, and helped to draft the manuscript All of the authors read and approved the...
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Tài liệu Báo cáo khoa học: The splicing factor ASF/SF2 is associated with TIA-1-related/ TIA-1-containing ribonucleoproteic complexes and contributes to post-transcriptional repression of gene expression doc
... authors and readers, this journal provides supporting information supplied by the authors Such materials are peer-reviewed and may be re-organized for online delivery, but are not copy-edited or ... (Fig 2B) ASF/SF2 is associated with TIAR and TIA-1 protein complexes and is a bona fide SG component Because ASF ⁄ SF2 and TIAR shared similar localization patterns both in normal and stressed cells, ... protein and were exposed to heat shock (43 °C for 50 min) or osmotic shock with sorbitol (600 mM for h 30 min) HA-ASF ⁄ SF2 sub-cellular localization was revealed by indirect immunofluorescence...
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Erectile Dysfunction – Disease-Associated Mechanisms and Novel Insights into Therapy Edited by Kenia Pedrosa Nunes potx
... to maintain or achieve a penile erection sufficient for satisfactory sexual performance Its etiology is multifactorial Various aspects affect the expression/degree of ED and risk factors include ... Endocrinological factors The endocrine disorders are directly or indirectly related with erection mechanism Endocrine disorders can be associated or worsen the pre-existing ED Among the etiological factors ... variable and the ethiology is multifactorial ED secondary to cerebral strokes depends on many factors such as age, location and extent of stroke Furthermore, co-morbidities and co-related diseases...
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ERECTILE DYSFUNCTION – DISEASE-ASSOCIATED MECHANISMS AND NOVEL INSIGHTS INTO THERAPY pdf
... to maintain or achieve a penile erection sufficient for satisfactory sexual performance Its etiology is multifactorial Various aspects affect the expression/degree of ED and risk factors include ... Endocrinological factors The endocrine disorders are directly or indirectly related with erection mechanism Endocrine disorders can be associated or worsen the pre-existing ED Among the etiological factors ... variable and the ethiology is multifactorial ED secondary to cerebral strokes depends on many factors such as age, location and extent of stroke Furthermore, co-morbidities and co-related diseases...
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Báo cáo y học: "Implication of granulocyte-macrophage colony-stimulating factor induced neutrophil gelatinase-associated lipocalin in pathogenesis of rheumatoid arthritis revealed by proteome analysis" doc
... intracellular or extracellular manner FGF-2 and EGF, as well as TGF- and other growth factors, are thought to be important for homeostasis of cartilage For example, FGF-2 has been reported to play ... Promotion and Mutual Aid Corporation for Private School of Medicine and from Uehara Memorial Foundation The authors thank Ms Mie Kanke, Hiroko Murakami, Michiyo Yokoyama, and Mayumi Tamaki for their ... has been reported to work as an antiapoptotic factor and promote metastasis of tumour cells through constant activation of NFB in vitro [43] and has been reported to play an important role in...
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Báo cáo y học: " γ δ Vγ9/Vδ2 T lymphocytes in Italian patients with Behçet’s disease – evidence for expansion, and tumour necrosis factor receptor II and interleukin-12 receptor β1 expression in active disease" pptx
... Goeddel DV: Ligand passing: the 75kDA tumor necrosis factor (TNF) receptor recruits TNF for signalling by the 55-kDA TNF receptor J Biol Chem 1993, 268: 18542-18548 Correspondence Professor Giovanni ... Expression of tumour necrosis factor receptor II and γ δ interleukin-12 receptor β1 on Vγ9/Vδ2 T cells We investigated the expression of TNF receptor II and IL-12 receptor β1, as cell activation ... active or inactive Behçet’s disease (BD) and healthy control individuals Results are expressed as percentage of Vγ9/Vδ2 T cells Tumour necrosis factor receptor II (TNF-RII) and IL-12 receptor β1...
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Báo cáo y học: "Serum levels of autoantibodies against monomeric C-reactive protein are correlated with disease activity in systemic lupus erythematosus" potx
... and laboratory disease activity measures, namely serum levels of anti-DNA antibodies, complement factors C1q, C3 and C4, and SLEDAI scores, regardless of whether complement components and anti-DNA ... one occasion and negative on another [25] This raised the question of whether anti-CRP levels might vary over time and be associated with disease activity or flares, and/ or certain disease manifestations ... for complement factors C1q, C3 and C4, and with lymphocyte counts Each anti-CRP-positive individual showed correlation with at least one variable, and patients with nephritis tended to have more...
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Báo cáo y học: "Definition of disease states in early arthritis: remission versus minimal disease activity" pot
... the wording disease state with low disease activity’ for this patient group Risk factors for a state of low disease activity in rheumatoid arthritis The clinical or serological risk factors for ... 13% and 55% Risk factors for natural remission in undifferentiated arthritis Both Harrison and colleagues [6] and Tunn and Bacon [7] performed logistic regression analyses to identify factors ... presence of rheumatoid factor and swollen joints [18] Risk factors for natural or drug-induced remission in rheumatoid arthritis Characteristics associated with natural or drug-induced remission...
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báo cáo khoa học: " Amyotrophic lateral sclerosis-motor neuron disease, monoclonal gammopathy, hyperparathyroidism, and B12 deficiency: case report and review of the literature" potx
... myelopathies, and typical laboratory investigations to search for any potential treatable metabolic abnormality In particular, among the most common laboratory tests ordered are ones for vitamin ... deteriorate Discussion ALS is a progressive and devastating neurodegenerative disorder that affects primarily motor neurons It is the most common type of motor neuron disorder The characteristic form ... metabolism or heavy metal absorption as a major causative factor in the development of neurodegenerative disease on the island of Guam Interestingly, patients with ALS have been found to have abnormalities...
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Báo cáo y học: "Hypoxia-inducible factor-1 a/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling" pps
... monocyte/macrophages and lymphocytes stimulates increased production of pro-inflammatory markers and/ or growth factors implicated in the pathogenesis of HIV-PAH such as platelet derived growth factor (PDGF)-BB ... Hypoxia-inducible factor- 1 a/platelet derived growth factor axis in HIV -associated pulmonary vascular remodeling Respiratory Research 2011 12:103 Submit your next manuscript to BioMed Central and take ... (Carlsbad, CA) and grown in endothelial cell basal media containing 2% fetal bovine serum (FBS), μg/ml hydrocortisone, 10 ng/ml human epidermal growth factor, ng/ml basic fibroblast growth factor, 10...
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Báo cáo y học: "TAM receptor ligands in lupus: Protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus." ppsx
... coagulation by serving as a cofactor for activated protein Cdependent proteolytic inactivation of factor Va and factor- VIIIa Protein S circulates as approximately 40% free protein S and 60% as a complex ... complex with C4-binding protein; only free protein S is active as a cofactor for activated protein C and a ligand for the TAM receptor kinases In the absence of free protein S, there is increased risk ... gender and ethnicity matched SLE and NC NC, normal controls; SLE, systemic lupus erythematosus and free protein S in SLE patient plasma (data not shown) Clinical characteristics and Gas6 and free...
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Báo cáo y học: "(Sub)clinical cardiovascular disease is associated with increased bone loss and fracture risk; a systematic review of the association between cardiovascular disease and osteoporosis" ppsx
... common risk factors in CV disease and osteoporosis Many candidate genes have been examined, mainly genes coding for known factors, such as cytokines, bone -associated factors and receptors The genes ... and osteoporosis [9] Estrogen deficiency is considered an important risk factor for osteoporosis [120] and some studies suggest estrogen deficiency to be a cardiovascular risk factor [121-123] ... between osteoporosis and specific categories of CV disease Links between CV disease and osteoporosis Common pathogenesis CV disease is preceded by atherosclerosis, for example, arterial disease Atherosclerosis...
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Báo cáo y học: "‘CFTR-opathies’: disease phenotypes associated with cystic fibrosis transmembrane regulator gene mutations" pps
... subtle lung disease is present Evidence of CFTR dysfunction may be found on laboratory testing, with abnormal or borderline sweat chloride levels and/ or abnormal CFTR-mediated chloride conductance ... sweat chlorides and pancreatic sufficiency [10] Thus, as with CBAVD, a careful work-up is mandatory This should include not only a standard diagnostic work-up, including a sweat chloride and radiologic ... different organ systems Clinically, this may be reflected in normal or borderline sweat chloride values in patients with atypical CF Other factors, including non-CFTR gene modifiers and environmental...
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Báo cáo y học: "PopMod: a longitudinal population model with two interacting disease states" ppsx
... births B and deaths D are special states in the sense that they only feed into or absorb from other states (while the states X, C, XC and S both feed into and absorb from other states) Special states ... probability notation π is used for prevalence, where πX|C is the probability of having disease X among those who have disease C and πX and πC are short forms for πX|T and πC|T Relative risk (RR) ... rX ~C rX rC ~ X rC , or RR(iX )3 = , or RR(iC )3 = , or RR(rX )3 = , or RR(rC )3 = iX C iX iC X iC rX C rX rC X rC , and , and ( 39 ) , and Interaction (3): Mortality for the joint group This...
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An Animal Model of Pediatric Combined Pituitary Hormone Deficiency Disease
... Gonadotropin-releasing hormone GnRH Gonadotropin-releasing hormone receptor GnRH-R Growth hormone GH Growth hormone-releasing hormone GHRH Growth hormone-releasing hormone receptor GHRHR High mobility ... example, once corticotropin-releasing factor is secreted from the hypothalamus, it travels to the anterior pituitary where it binds to the corticotropin-releasing factor receptor on the corticotrope ... growth factor (FGF), wingless/integrated (WNT), and hedgehog families Extrinsic signals and transcription factors expressed from the ventral diencephalon and developing infundibulum important for...
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tudies of common variations in two candidate genes of dyslipidemia and coronary artery disease
... 137 vi SUMMARY Coronary artery disease is a disorder with multiple genetic and environmental factors and dyslipidemia is one of most prominent risk factors The major purpose of this study ... environmental factors with age (Watkins and Farrall, 2006) A family history of premature coronary, cerebrovascular or peripheral vascular disease has been well-established risk factor for CAD by ... CAD is a major cause of morbidity and is a leading contribution to mortality worldwide, especially in developed countries (Murray and Lopez, 1997) According to the Heart Disease and Stroke Statistics...
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Báo cáo y học: "Clinical Symptoms Associated with Asystolic or Bradycardic Responses on Implantable Loop Recorder Monitoring in Patients with Recurrent Syncope"
... frequently asymptomatic and self-limited, is present in almost 80% of patients with WNV infection associated with neurologic disease The unique pattern of multifocal chorioretinitis can help establish ... Nile virus: epidemiology and clinical features of an emerging epidemic in the United States Annu Rev Med 2006;57:181-94 Khairallah M, Ben Yahia S, Ladjimi A, et al Chorioretinal involvement in ... can help establish an early diagnosis of the disease while serologic testing is pending Therefore, an ocular examination, including ophthalmoscopy and FA in selected cases, should be part of the...
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Báo cáo y học: "Clinical Symptoms Associated with Asystolic or Bradycardic Responses on Implantable Loop Recorder Monitoring in Patients with Recurrent Syncope"
... study and 24 hour holter monitor and month event recorder prior to implantation of ILR Another patients who had received loop implants during the same time frame and had no arrhythmia recorded ... nature and were witnessed by family members or friends None of our patients had loss of bladder or bowel controls during these episodes Palpitations: Patient histories were reviewed for presence or ... SPSS The continuous data was presented as mean ±SD and categorical data as percentages T-test for comparison of means and chi-square test for categorical data was used Significance was achieved with...
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Some register features in agreement between the united states of america and the socialist republic of vietnam on trade relations = một số đặc điểm ngữ vực trong hiệp định thương mại việt mỹ
... the channel use, oral or written and on the speaker or writer’s xvii intention, and which is determined by more or less use of nominalizations, personal references, action verbs or complex noun ... including therefore both the channel taken by the language spoken or written, extempore or prepared and its genre or rhetorical mode, as narrative, didactic, persuasive, “phatic communion” and so on” ... lexical words in the text, or even just the nouns You will want to find and answer to these two questions: Semantic domains: Which discipline lexical words refer to? Certain words are more common...
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