... processing oftissue grafts As the standards for tissue banking by the American Association ofTissue Banks (AATB), European Association ofTissue Banks (EATB), Asia Pacific Association of Surgical Tissue ... sustainability of the supply of quality tissues is very much dependent on the availability of trained manpower to continue with the operation oftissue banks and ensure that the products are clinically ... FA RADIATION IN TISSUE BANKING Basic Science and ClinicalApplicationsof Irradiated Tissue Allografts Editors Aziz Nather National University of Singapore, Singapore Norimah Yusof Malaysian Nuclear...
... ClinicalApplicationsof CE 1 ClinicalApplicationsof Capillary Electrophoresis Margaret A Jenkins Introduction Capillary ... Alternatively, mobilization of focused peaks may be achieved by the appli- ClinicalApplicationsof CE cation of a vacuum to the capillary, as well as maintenance of the high voltage (17,18) ... electrophoresis as a clinical tool J Chromatogr B 682, 23–34 Clinical Applicationsof CE Lehmann, R., Liebich, H M., and Voelter, W (1996) Application of capillary electrophoresis in clinical chemistry:...
... F,, the value offcorresponds to the slope of the regresston lme of a plot of In F, as a function of the number of cells per tube (c,), fitted through the origin A first approximation offcan also ... of the method of competitive PCR A series of PCR tubes containing an unknown amount of template (TO), in the example tentatively set at 1, 1s spiked with a dilution series of a known amount of ... detection of gene amplification or deletion and of aneuploidy (I) The application of PCR as a quantitatrve tool requrres the solution of the problem of how to reliably determine the initial amount of...
... atomic number of air is similar to that of soft tissue, differential 20 WoodPhysics, 1994; of electrons.) density of barium and No the are similar to those of iodine, but the size of the structures ... field of view of the subject The change in contrast that results from use of an air gap is shown in Figure 14 Patient ClinicalApplications Both grid and air gap techniques are effective means of ... irradiated tissue also of scattered x rays Grids The most common method of reducing the level of scattered radiation reaching the image receptor is use of grids (9) A grid is constructed of alternating...
... CLINICALAPPLICATIONSOF PHARMACOGENOMICS OF WARFARIN CHAN SZE LING (B.Sc(Pharmacy)(Hons)), NUS A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY NUS GRADUATE ... Sustainability of WPGT Due to the scarcity of resources, another necessary consideration for the clinical translation of WPGT is its economic sustainability At around US$400, the cost of WPGT is one of the ... price of the good or service in question), under-sensitivity to the magnitude of benefit, over-inflation of the valuation of the intervention in question (i.e budget constraint bias), dependence of...
... Chapter TissueRegeneration – A Clinical Science Whose Time Has Come Jamie Davies University of Edinburgh UK Introduction Tissue engineering is the application of knowledge gained in the study of ... development oftissue engineering is therefore a relatively recent phenomenon and only in this century has tissue engineering really taken off as a major area of research (Fig 1) Fig Rapid growth oftissue ... and applicationsoftissueregeneration ought to be a great strength for the field, encouraging the development of techniques suited to a wide range of problems and also to a wide range of health...
... opportunities Studied applicationsof endothelial-lineage cell therapy have demonstrated enhancement of new capillary formation in ischemic tissue (therapeutic vasculogenesis) and generation of an anti-thrombogenic ... approved by all members of the team Acknowledgements The finding of delivered cells over a small proportion of the luminal surface suggests direct but incomplete participation of CD34+ cells in endothelial ... phenotypic profile and purity Flow cytometry Purified cells were counted and re-suspended in seven 100 μL aliquots of PBS for FACS analysis, each containing approximately 105 cells After addition of Fc...
... Chapter TissueRegeneration – A Clinical Science Whose Time Has Come Jamie Davies University of Edinburgh UK Introduction Tissue engineering is the application of knowledge gained in the study of ... development oftissue engineering is therefore a relatively recent phenomenon and only in this century has tissue engineering really taken off as a major area of research (Fig 1) Fig Rapid growth oftissue ... and applicationsoftissueregeneration ought to be a great strength for the field, encouraging the development of techniques suited to a wide range of problems and also to a wide range of health...
... Tissue Engineering II Basics ofTissue Engineering and TissueApplications Volume Editors: Lee, K., Kaplan, D Vol 103, 2007 Tissue Engineering I Scaffold Systems for Tissue Engineering Volume Editors: ... aim is to present an overview of the state of the art of a selection of these technologies, punctuated with current applications in the research and development of cell-based therapies for human ... responsibility of the commercial sector Of course, there is significant overlap of emphasis Without proper coordination of activities, the ultimate goal of a successfully engineered tissue cannot...
... adjusted to the leg lengths of each subject, so that the hip and knee joints of the Lokomat were aligned with those of the subject During 22 Applicationsof EMG in Clinical and Sports Medicine ... choice of the cut-off frequency of an ideal lowpass filter for pre-filtering purposes therefore is 500 Hz, resulting in a typical Sampling Frequency of 1000 Hz, twice the cut-off frequency of pre-filtering ... the equations (31) and (28) in terms of Mi and yi resulted in the determination of the weights of the cubic spline ai, bi, ci and di 30 Applicationsof EMG in Clinical and Sports Medicine =6 ...
... strategies, a number of generic problems must be overcome for the development of successful clinicalapplications These include development of methods for reliably generating large numbers of specific ... committed to the desired cell types before transplantation The study of human ES cells has been controversial, and their use in clinicalapplications would be unacceptable to some patients and physicians ... whether transdifferentiation of MSCs or other stem cell populations occurs at a high enough frequency to be useful for stem cell replacement therapy Regardless of the source of the stem cells used...
... these strategies for cell replacement, the ex vivo or in situ generation of tissues provides an alternative means oftissue engineering (Chap 69) Stem cells are also excellent vehicles for cellular ... Heart Disease and Cardiomyocyte Regeneration Because of the high prevalence of ischemic heart disease, extensive efforts have been devoted to cell replacement of cardiomyocytes Historically, ... organ without the capacity for regeneration However, the heart has the ability to achieve low levels of cardiomyocyte regeneration as well as revascularization This regeneration is likely accomplished...
... has been reported, and clinical trials of such cells have begun for a number of neurologic disorders Clinical trials of a conditionally immortalized human cell line and of human umbilical cord ... the development of dyskinesia Transplantation of stem cell– derived dopamine-producing cells offers a number of potential advantages over fetal transplants, including the ability of stem cells ... experimental spinal cord injury Clinical trials of marrow-derived stem cells have already begun, and this may be the first disease targeted for the clinical use of ES cells Marrow-derived stem...
... However, such stem cell–based therapies are at a very early stage of development, and perfection of techniques for clinical transplantation of predictable, wellcharacterized cells will be a difficult ... members of a society Stem cell research raises questions about the definition of human life, and it has raised deep fears about our ability to balance issues of justice and safety with the needs of ... coadministration of scaffolding, artificial extracellular matrix, and/or growth factors to orchestrate differentiation of stem cells and their organization into appropriate constituents of the organ...
... remodeled by the host tissue [21] Therefore, the clinical application of cell/scaffold complexes for cartilage regeneration is anticipated There are numerous clinical methods of grading regenerated ... magnitude (the maximum magnitude of the measurement area divided by that of the intact cartilage of the nonoperated knee; %MM) is used as a quantitative index of cartilage regeneration conditions according ... below, left, and right of the center The percentage maximum magnitude (the maximum magnitude of the measurement area of the operated knee divided by that of the intact cartilage of the opposite, nonoperated...
... reports of resected cancers, liver ultrasound and x-ray of the thorax Locoregional tumor extention was studied by MRT in all cases Delineation of target volumes and normal tissues Immobilisation of ... not to be DVH of DVH of parotid glands: blue: to be spared, green: not to be spared Discussion One important issue of 3D-c-IMRT is normal tissue sparing Among several critical tissues exposed ... considered an indispensible characteristics of 3D-c-IMRT, which allows for optimization of fluence profiles to meet the prescribed doses for PTVs and critical normal tissues nearby to be spared Improved...
... goal of periodontal therapy is to control periodontal tissue inflammation and to produce predictable regenerationof periodontium lost as a result of periodontal disease In order to promote the regeneration ... promote the regenerationof the periodontium the appropriate positioning of cells capable of synthesizing collagen, cementum and bone is required The procedure of guided tissueregeneration (GTR) was ... principle of guided tissueregeneration (GTR) is utilized to exlude epithelium from the root surfaces and to promote selective repopulation of the root surface by multipotential cells The main goal of...
... 2.4 Potential applicationsof PHIs in tissue engineering As reviewed in chapter 1, clinicalapplicationsof engineered tissues are currently limited mainly to thin or avascular tissues due to ... regeneration and tissue engineering 113 6.3 Conclusions 114 References 115 vi Summary Clinicalapplicationsoftissue engineering are constrained by the ability of ... healing 28 2.4 Potential applicationsof PHIs in tissue engineering 31 Chapter Incorporation of a PHI into Scaffolds: A Vascularization Strategy for Tissue Engineering Applications 33 3.1 Introduction...
... expression of extracellular matrix proteins and new tissue formation Therefore, the properties of such biomaterials are crucial in determining the success of many tissue engineering applicationsTissue ... proteins and new tissue formation Hence, the properties of the scaffolding materials are crucial in determining the success of many tissue engineering applications The general tissue engineering ... possibility of creating a truly biofunctional scaffold for the basis of a complex tissue construct The potential application of this PEC fiber system was explored further with the incorporation of polypyrrole,...
... ENCAPSULATION OF POLYMERIC MICROSPHERES AS SCAFFOLD FOR LIVER TISSUEREGENERATION BY XINHAO ZHU (M Eng., B Eng., TsingHua University) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ... alternatives, such as regenerationof failed organs The science oftissue engineering, which combines the disciplines of engineering and life science to create functional tissue substitutes for ... functional tissue: (1) use of isolated cells or cell substitutes; (2) use of tissue- inducing substances; and (3) use of cells cultured on or within polymer matrices (Langer and Vacanti, 1993) All of...