cells in ammatory macrophages and hepatotoxicity
Báo cáo y học: "Role of regulatory T cells in experimental arthritis and implications for clinical use" potx
... sufficient to suppress an ongoing chronic autoimmune inflammatory process This idea had already been hinted at by a series of studies in RA and other chronic autoimmune joint inflammatory diseases such ... decreases the infiltrate in joints Furthermore, RA patients relapse shortly after withdrawal of anti-TNF-α [19] and thus, despite the dampening of joint inflammation and the reinstatement of ... proinflammatory cytokine secretion from activated T cells and monocytes After anti-TNF-α treatment the ‘hibernated’ peripheral blood CD4+CD25+ Treg pool recovered and powerfully inhibited, as in...
- 3
- 336
- 0
Báo cáo y học: "Relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage" potx
... immunoglobulin (Ig) superfamily and a ligand for CD6, which is involved in T-cell adhesion and co-stimulation [17] Besides being expressed on thymic epithelial cells, activated T cells, Blymphocytes, and ... carbon dioxide in serum-free DMEM/F12 Nutmix (DMEM/F12; Invitrogen, Karlsruhe, Germany) containing 0.1% pronase E (Sigma-Aldrich, Taufkirchen, Germany) in a spinner flask for fine mincing and digestion ... dexamethasone, 0.2 mM indomethacin, and 0.5 mM 3isobutyl-1-methylxanthine (all Sigma-Aldrich) and 10 mg/mL insulin (NovoNordisk, Mainz, Germany) Intracellular lipid droplets in adipogenic cultures...
- 15
- 370
- 0
Báo cáo khoa học: Protection of chylomicron remnants from oxidation by incorporation of probucol into the particles enhances their uptake by human macrophages and increases lipid accumulation in the cells ppt
... remnants are able to induce foam cell formation in human monocyte-derived macrophages (HMDM) [21] and in human and murine macrophage cell lines [22–24], and that, in striking contrast to LDL, ... containing 70% trilinolein, 2% cholesterol, 5% cholesteryl ester and 25% phospholipids, in Tricine buffer (20 mM, pH 7.4) containing 0.9% NaCl, followed by density-gradient centrifugation and binding ... cells THP-1 monocytes were maintained in suspension in RPMI1640 containing 10% fetal bovine serum, mM glutamine, 100 UÆmL)1 penicillin, 100 mgÆmL)1 streptomycin and 50 mM 2-mercaptoethanol (culture...
- 11
- 291
- 0
Báo cáo Y học: Group IID heparin-binding secretory phospholipase A2 is expressed in human colon carcinoma cells and human mast cells and up-regulated in mouse inflammatory tissues doc
... and WiDr cells and weakly expressed in KM20L2 cells COX-2 was detected only in WiDr cells The two terminal PGE2-biosynthetic enzymes, cPGES and mPGES, were expressed in all cell lines Following ... the fifth painting and subjected to RNA extraction Replicate ear sections were fixed by formalin, embedded in paraffin and stained with hematoxylin and eosin to verify the progress of in ammation ... (WT) and two mutants of mIID in HEK293 cells, as assessed by RNA blotting (C) Membrane binding of the WT and two mutants of mIID After collecting the culture supernatants, the cells were incubated...
- 10
- 334
- 0
Báo cáo khoa học: Hodgkin Reed–Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo Novel insight into the inflammatory features of classical Hodgkin lymphoma ppt
... macrophages, eosinophils, mast cells, plasma cells, stromal cells and fibroblasts There is strong evidence that these in ltrating cells are involved in an in ammatory ⁄ reactive process creating ... determined by random selection of ten consecutive high power fields (HPFs) in hematoxylin and eosin stained paraffin sections In each HPF, the number of eosinophils or H-RS cells was determined and ... Hodgkin’s and Reed ⁄ Sternberg cells in Hodgkin’s lymphoma Int J Cancer 118, 1853–1861 Poppema S & van den Berg A (2000) Interaction between host T cells and Reed-Sternberg cells in Hodgkin lymphomas...
- 13
- 350
- 0
Báo cáo khoa học: "Macrophages, myofibroblasts and mast cells in a rat liver infected with Capillaria hepatica" ppsx
... relationship and role of macrophages, myofibroblasts and mast cells in the hepatic septal fibrosis induced by C hepatica We hypothesize that a similar mechanism involving macrophages, myo-fibroblasts and ... myofi- Capillaria hepatica infection in a rat liver 213 broblasts and mast cells were increased in animals with hepatic fibrosis and these cells might play a role in the formation of hepatic ... myofibroblasts and mast cells in the liver in the hepatic fibrous septa of an animal infected with C hepatica This finding is consistent with that previously seen in a rat model of CCl4-induced hepatic...
- 3
- 340
- 0
Báo cáo y học: "Inhibition of highly productive HIV-1 infection in T cells, primary human macrophages, microglia, and astrocytes by Sargassum fusiforme" pdf
... extract, does not inhibit cell growth, is not toxic to cells, and is suitable for in vitro testing of HIV-1 inhibition in 1G5 cells S fusiforme inhibits HIV-1 infection in T cells in a dose dependant ... post infection Figure Inhibition of infection with pseudotyped HIV-1 in T cells andhuman astrocytes Inhibition of infection with pseudotyped HIV-1 in T cells andhuman astrocytes (A) 1G5 T cells ... potent inhibitor of R5-tropic HIV-1 infection in primary human macrophages and microglia: inhibition is long lasting, not toxic to cells, and with similar inhibition kinetics to those observed in...
- 12
- 439
- 0
Báo cáo y học: "Aortic dissection associated with cogans’s syndrome: deleterious loss of vascular structural integrity is associated with GM-CSF overstimulation in macrophages and smooth muscle cells" docx
... matrixmetalloproteinase activity at the intima-media border (rich in activated 27F10-positive inflammatory cells) and in association with clusters of CD68-positive macrophages in deeper medial ... that although both collagen and elastin production was stimulated in SMC, the even greater increase in MMP activity in both inflammatory cells and SMC resulted in Weissen-Plenz et al Journal of ... (MMP1) and both gelatinases (MMP2 and MMP9) (CSx) compared with controls (ctrl) exceeding elastolysis and collagenolysis and thus a dramatic loss of structural integrity Interestingly, in areas...
- 5
- 376
- 0
Báo cáo y học: " Transcriptome profiling of primary murine monocytes, lung macrophages and lung dendritic cells reveals a distinct expression of genes involved in cell trafficking" pot
... grouped into trafficking related clusters such as integrins, Mmps, chemokine and chemokine receptors, and interleukins and interleukin receptors Integrins are key mediators of cell-cell interactions, ... Il18r1 interleukin alpha [NM_010554] interleukin [NM_031168] interleukin 18 [NM_008360] interleukin 17D [NM_145837] interleukin beta [NM_008361] interleukin 11 receptor, alpha chain [NM_010549] interleukin ... paid to genes involved in cell trafficking, namely integrins, metallopeptidases, chemokines and chemokine receptors, as well as interleukins and interleukin receptors (Table 1) In order to visualize...
- 16
- 320
- 0
Báo cáo y học: " Effect of Weight Reduction on Cardiovascular Risk Factors and CD34-positive Cells in Circulatio"
... extracellular water, intracellular http://www.medsci.org Int J Med Sci 2011, water and body mass index were determined for each participant before dieting intervention and each six days following intervention ... metabolism and inflammation, contributing to the maintenance of energy homeostasis and the pathogenesis of obesity-related metabolic and inflammatory complications [4] Endothelial damage and dysfunction ... circulating cells as “circulating EPCs” was based on the work [28], in which blood–derived cells from which endothelial cells in culture were developed were described as cells expressing CD34...
- 8
- 594
- 0
Tài liệu Báo cáo khoa học: Transcriptional upregulation of inflammatory cytokines in human intestinal epithelial cells following Vibrio cholerae infection pptx
... proin ammatory mediators, such as cytokines [14] However, little is known about the role of V cholerae in initiating and sustaining the innate in ammatory response in intestinal epithelial cells, ... T84 Caco-2 Proin ammatory Proin ammatory Proin ammatory Proin ammatory Proin ammatory C-X-C chemokine C–C chemokine Anti -in ammatory Acquired specific immune response (ASIR) Anti -in ammatory, ASIR ... RT-PCR in Int407 and T84 cells showed that all the proin ammatory cytokines, except IL-1a and IL-8, were induced to a greater extent in Int407 cells than in T84 cells upon V cholerae infection...
- 12
- 462
- 0
Tài liệu Báo cáo khoa học: Implication of the glutamine synthetase ⁄glutamate synthase pathway in conditioning the amino acid metabolism in bundle sheath and mesophyll cells of maize leaves doc
... Table Amino acid composition in leaves, and amino acid percentage ratio in the phloem exudates and leaves and xylem bleeding sap and leaves in the light and dark The amino acid composition in leaves ... total amount of alanine, serine and glycine was reduced from 33% in the light to 25% in the dark (Fig 7A) Glutamine and asparagine were the major amino acids in the xylem sap in both the light ... from that in xylem sap (Fig 7), suggesting that there was little contamination from xylem, and vice versa Glx (glutamine and glutamate: ve carbon amide and amino acid) and Asx (asparagine and aspartate:...
- 14
- 566
- 0
Tài liệu Báo cáo khoa học: Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1b-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids pdf
... role in the regulation of cell proliferation, including SMC, by inhibiting signalling molecules [45–47] Caveolin-3 is the main isoform in muscle cells, including SMC [30] Caveolin-1 and caveolin-3 ... cells incubated with the MAPK kinase (MEK) inhibitor, U0126 U0126 completely inhibited the cyclin D1 promoter activity in AA-pretreated SMC incubated with IL-1b and reduced it in cells incubated ... of BrdU into SMC was strongly stimulated by incubation in medium containing 10% (v/v) fetal bovine serum Although the incorporation of AA alone did not affect BrdU incorporation, incubating these...
- 12
- 499
- 0
Tài liệu Báo cáo khoa học: Various secretory phospholipase A2 enzymes are expressed in rheumatoid arthritis and augment prostaglandin production in cultured synovial cells docx
... sPLA2IIE is induced rather specifically in VSMC in synovial tissues with active RA In inactive RA sections, sPLA2-IIF showed sporadic and weak staining in individual cells (Fig 4Ca,b), and a few interstitial ... cases, intense staining of the granulation tissue in the sublining interstitium was evident Staining of the granulation tissue and lymph aggregates (red arrow) is magnified (Eb) Synovial lining cells ... virtually in all areas of RA tissues, in particular in synovial lining cells (B and C dark arrowheads) Aggregates of mononuclear cells (C, blue arrows) and fibroblasts (C, red arrows) in the sublining...
- 18
- 432
- 0
Tài liệu Báo cáo khoa học: Analyzing changes of chromatin-bound replication proteins occurring in response to and after release from a hypoxic block of replicon initiation in T24 cells pptx
... nucleosolic proteins The remaining pellet contains all DNA and structure bound proteins and is further referred to as chromatin-fraction Electrophoresis of proteins and Western blotting Cytosolic and nucleosolic ... BrdU staining and this again signifies that PCNA is only bound to chromatin portions where actively replicating DNA is present Recruitment of proteins involved in replication to chromatin during the ... hypoxically for h and then reoxygenated At the times indicated cells were pulse-labeled for with lCiÆmL)1 [3H]Thd while maintaining the respective incubation conditions during labeling and processed...
- 11
- 610
- 0
Báo cáo khoa học: Post-ischemic brain damage: pathophysiology and role of inflammatory mediators ppt
... factors In rodent models of transient MCAO, in ammatory genes (including cytokines, chemokines, adhesion molecules and pro -in ammatory enzymes) are upregulated a few hours after the insult and remain ... protein-1 (MCP-1) and macrophage in ammatory protein-1 alpha [24–26] These mediators induce the expression of the adhesion molecules ICAM-1 [27–30], P-selectin and E-selectin [31,32] and integrins ... communication and leukocyte recruitment in in ammatory and immune responses Increased mRNA expression for MCP-1 and macrophage in ammatory protein-1 alpha has been described in the rat brain after...
- 14
- 422
- 0
Báo cáo khoa học: Efficient inhibition of b-secretase gene expression in HEK293 cells by tRNAVal-driven and CTE-helicase associated hammerhead ribozymes doc
... scale Constructs containing inactive versions of Rz-1 and Rz-2 were obtained in the same way by using templates as described above but in which the guanosine nucleotides, marked in bold, had been ... encoding plasmids and 36 h postincubation the protein fraction was isolated from the cells and subjected to Western blotting analysis The extent of protein expression is much lower in the HEK293 cells ... expression in mammalian cells Proc Natl Acad Sci USA 99, 5515–5520 Yu, J.-Y., DeRuiter, S.L & Turner, D.L (2002) RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells...
- 9
- 434
- 0
Báo cáo khoa học: Enzymes that hydrolyze adenine nucleotides of patients with hypercholesterolemia and inflammatory processes potx
... Anti -in ammatory treatment 48 ± 55 ± 65 ± 56 ± 10 20 20 No Not receiving 20 20 No Not receiving 20 20 No Not receiving 20 20 No Not receiving Not receiving Not receiving Not receiving Not receiving ... platelets, we can understand their active role in this process and the importance of such hydrolysis In line with this, literature data indicate that adenine nucleotides and adenosine are important ... cells were incubated with anti-CD39 and anti-CD61 (20 lL per 106 cells) for 25 min, lysed with fluorescence activated cell sorter (FACS) reagent, and incubated again for 15 in the dark Cells were...
- 8
- 404
- 0
Báo cáo khoa học: Characterization, localization and possible anti-inflammatory function of rat histone H4 mRNA variants potx
... distributed, being also abundant in endocrine, neuroendocrine and central nervous system tissues such as the pituitaries, the spinal cord and the brain Both mRNAs were also detected in AMs, and their ... regulatory mechanisms, in addition to producing the extracellularly acting antiin ammatory peptides, remains to be investigated In conclusion, a growing body of evidence indicates that various ... Inhibition of LPS-induced rat interleukin-8 (IL-8) (GRO/CINC-1) The CXC chemokine IL-8 is a potent neutrophil chemotactic and activating agent As IL-8 and its rat analog, GRO ⁄ CINC-1, are reported...
- 14
- 429
- 0
Báo cáo khoa học: Alternative initiation of transcription of the humanpresenilin 1gene in SH-SY5Y and SK-N-SH cells The role of Ets factors in the regulation ofpresenilin 1 pptx
... domain ERM contains two DNA binding inhibitory domains flanking the Ets domain: the central 87 amino acid inhibitory domain is poorly conserved and virtually specific to ERM, and the C-terminal ... tenfold in SK-N-SH and cells Further deletion to +42 increased transcription in both cells lines: about fivefold in SH-SY5Y cells and twofold in SK-N-SH cells Further deletions to +6 did not result in ... examined in both SK-N-SH and SH-SY5Y cells (Fig 3A) Altering an Ets motif at )10 eliminated 80% of transcription in SK-N-SH cells whereas the mutation had only a minor effect (30%) in SH-SY5Y cells...
- 10
- 492
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008