a— inborn errors of cholesterol synthesis
Báo cáo khoa học: Insect cytokine, growth-blocking peptide, is a primary regulator of melanin-synthesis enzymes in armyworm larval cuticle pptx
... GBP contributes to the enhancement of gene expression for two key enzymes of melanin synthesis, TH and DDC, and by further examining the mechanism of enhancement of expression for both enzymes in ... to northern blot of total RNAs from dorsal (D) and ventral (V) integuments rRNA TH and DDC Analysis of ~ kb of the 5¢-flanking region of both enzyme genes showed the presence of five common cis-elements ... incubation of the dorsal integument with GBP enhanced the expression levels of both genes Incubation of isolated tissues with nm GBP elevated the expression levels of both genes, whereas the addition of...
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Báo cáo khoa học: A transcription factor of lipid synthesis, sterol regulatory element-binding protein (SREBP)-1a causes G1 cell-cycle arrest after accumulation of cyclin-dependent kinase (cdk) inhibitors pdf
... activity in a wide range of genes involved in the synthesis of cholesterol, fatty acids, and phospholipids All mammalian cells require these lipids for the duplication of membranes in cell division ... and cerulenin were added to CHOBP1a as inhibitors of the biosynthesis of cholesterol and fatty acids, respectively Neither attenuated the effect of SREBP-1a (Fig 2C), excluding the possibility ... of huge amounts of lipids in the transgenic hepatocytes may contribute to the inhibition of cell growth Effects of endogenous SREBP-1 on cell growth To determine the physiological relevance of...
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Tài liệu Báo cáo khoa học: The crystal structure of human a-amino-b-carboxymuconatee-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis ppt
... the non-enzymatic synthesis of QA, ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway, and is a medically relevant enzyme in light of the important ... understanding of the ACMSD catalytic mechanism is still incomplete In light of the reported ACMSD upregulation in the liver of streptozotocin-induced diabetic rats and the suppression of such elevation ... design of enzyme inhibitors with potential medical interest Crystal structure of human ACMSD C-ter N-ter Results and Discussion Overall quality of the model The three-dimensional structure of hACMSD...
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Tài liệu Báo cáo khoa học: Interferon-a induces sensitization of cells to inhibition of protein synthesis by tumour necrosis factor-related apoptosis-inducing ligand ppt
... regulates the extent of formation of the eIF4F initiation complex and hence the rate of 5¢-cap-dependent protein synthesis [4–6] Exposure to IFNs often alters the sensitivity of cells to agents ... the extent of apoptosis but also the ability of TRAIL to regulate the initiation of translation at the level of eIF2a phosphorylation and 4E-BP1 dephosphorylation Control of protein synthesis ... Effects of IFNa treatment on the sensitivity of cells to inhibition of protein synthesis by TRAIL We have previously shown that protein synthesis is rapidly downregulated following exposure of cells...
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Báo cáo khoa học: Mycobacterium tuberculosis possesses a functional enzyme for the synthesis of vitamin C, L-gulono-1,4-lactone dehydrogenase doc
... characterization of l-gulonolactone oxidase from chicken kidney microsomes Biochemistry 21, 5076– 5082 14 Loewus FA (1999) Biosynthesis and metabolism of ascorbic acid in plants and of analogs of ascorbic ... ⁄ PAGE revealed the presence of one protein band of about 70 kDa (Fig 1, lane 2) The identity of the protein was confirmed by enterokinase treatment After digestion of the affinity-purified GSTtagged ... Characterization of the recombinant dehydrogenase of M tuberculosis L-gulono-1,4-lactone Fig Heterologous expression and purification of the recombinant L-gulono-1,4-lactone dehydrogenase (Rv1771) of M tuberculosis...
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Báo cáo khoa học: Increased sensitivity of glycogen synthesis to phosphorylase-a and impaired expression of the glycogen-targeting protein R6 in hepatocytes from insulin-resistant Zucker fa ⁄ fa rats pptx
... slope of the double log plot of glycogen synthesis against phosphorylase-a 1994 Fig Sensitivity of glycogen synthesis to phosphorylase-a as a function of glucose concentration Glycogen synthesis ... glycogen synthase and inhibition of glycogen synthesis The rate of glycogen synthesis, but not the activity of glycogen synthase, inversely correlated with the activity of phosphorylase-a in hepatocytes ... hepatocytes (Fig 2C) Effects of activity and concentration of phosphorylase-a on glycogen synthesis To test the role of the phosphorylated form of phosphorylase independently of changes in total phosphorylase...
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Báo cáo khoa học: Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis doc
... role of dephosphorylation of phosphorylase in the regulation of glycogen synthesis CP-91149 (2.5 lM) caused a similar stimulation of glycogen synthesis and inactivation of phosphorylase to that of ... and presence of insulin were superimposed over a wide range of activities of In view of the above findings that inactivation of phosphorylase mimics insulin stimulation of glycogen synthesis (Figs ... glycogen synthesis [35,36] As the twofold activation of glycogen synthase by inhibition of GSK-3 has a negligible effect on glycogen synthesis (this study), the stimulation of glycogen synthesis...
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Báo cáo khoa học: Kinetic studies on endo-b-galactosidase by a novel colorimetric assay and synthesis of N -acetyllactosamine-repeating oligosaccharide b-glycosides using its transglycosylation activity pptx
... point of cleavage One mM of each substrate was used for the determination of relative hydrolytic rates –, not hydrolyzed even in the presence of 10 mU of the enzyme Colorimetric assay of endo-b-galactosidase ... value of was 31% of that of However, the kcat/Km value of 4, in which Glc had been replaced with GlcNAc, was only 0.9% of that of The same tendency was seen in a comparison of and This was also ... action of endob-galactosidases Furthermore, the mode of linkage of sugar residues A to B was strict for the binding locus in the active site, because conversion of the (1–4) into (1–3)-linkages of...
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a novel method for the synthesis of titania nanotubes using
... the diffusion of F− ions and simultaneous effusion of the [TiF6 ]2− ions The faster rate of formation of TiO2 nanotubes using ultrasonic waves can be explained by the faster mobility of the F− ions ... saturation of current with time indicates the development of repassivation, the saturation of nanotube formation These results are in line with the findings of our FESEM studies (Fig 2) Anodization of ... and effusion of the [TiF6 ]2− ions from the channel It is well known that the cavitation effect of ultrasonication results in implosion of bubbles near the solid surface [20] Collapse of transient...
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a novel method for the synthesis of cao nanoparticle
... reaction of the 2-CEPS with CaO program for GC: The carrier gas was helium nanoparticles with a flow rate of mL.min-1 The initial and For this purpose, 10 μL of 2-CEPS, mL of final temperature of the ... mechanochemical synthesis, reverse micelle adsorbents along with surfactants in micro- and finally ultrasonic process[25-27] A emulsions for detoxification of pesticides suitable process for synthesis of ... explored work, the synthesis of CaO nanoparticles by the promising decomposition applications of Co-Precipitation in the absence and presence nanosized metal oxides such as AP-MgO, AP- of Polyvinylpyrrolidone...
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báo cáo hóa học: " Differential regulation of Aβ42-induced neuronal C1q synthesis and microglial activation" pptx
... accumulation of Aβ in neurons Enhancement of Aβ-induced C1q synthesis by RGD Figure Enhancement of Aβ-induced C1q synthesis by RGD a C1q and β-actin mRNAs were assessed by RT-PCR in slices after days of ... shown) Inhibition of Aβ-induced C1q synthesis by APV Figure Inhibition of Aβ-induced C1q synthesis by APV a C1q and βactin mRNAs were assessed by RT-PCR in slices after days of no peptide, 30 ... depending on the state of activation of microglia [9,10] Correlative studies on AD patients and animal models of AD strongly suggest that accumulation of reactive microglia at sites of Aβ deposition...
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Báo cáo hóa học: " A Temperature Window for the Synthesis of Single-Walled Carbon Nanotubes by Catalytic Chemical Vapor Deposition of CH4 over Mo2-Fe10/MgO Catalyst" pptx
... the influence of growth temperature on the purity of prepared tube samples, we give the curve (Fig 4) showing the dependence of ID/IG on the growth temperature From Fig 4, two kinds of ID/IG distributions ... in the results and are coated by plenty of amorphous carbons Conclusions A temperature window of SWCNTs growth by catalytic chemical vapor deposition of CH4 over Mo-Fe/MgO catalyst has been studied ... the self-decomposition of CH4 The temperature window of SWCNTs efficiently growth is between 800 and 950 °C, and the optimum growth temperature is about 900 °C Fig Influence of growth temperature...
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Báo cáo hóa học: " A Versatile Route for the Synthesis of Nickel Oxide Nanostructures Without Organics at Low Temperature" doc
... for the synthesis of other functional oxide materials Experimental Preparation of NiO Nanostructures In a typical synthesis, appropriate amount of nickel powder was taken with 20 mL of distilled ... knowledge, this is the first report of synthesis where water is used as a solvent as well as a source of oxygen Our studies lay down a convenient producer for the synthesis of NiO nanostructures at low ... temperature approach to the synthesis of NiO nanoparticles and nanoflowers by a soft reaction of nickel powder and water without using organic dispersant or capping agent To the best of our knowledge, this...
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báo cáo khoa học: " Habituation to thaxtomin A in hybrid poplar cell suspensions provides enhanced and durable resistance to inhibitors of cellulose synthesis" potx
... the restoration of cell sensitivity to the inhibitor of cellulose synthesis However, while the composition of the cell walls of DCB-habituated bean cells cultured in the absence of DCB for several ... suggest that a sub-population of TA(-)hab cells remained susceptible to TA Because the modified composition of the cell walls of TA(-)hab cells was reminiscent of that of DCB- and IXB-habituated ... presence of IXB in contrast to TA(-)hab cells that were subcultured in the absence of TA As mentioned earlier, there is experimental evidence suggesting that the mode of action of TA resembles that of...
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Báo cáo y học: " Variability over time and correlates of cholesterol and blood pressure in systemic lupus erythematosus: a longitudinal cohort study" pptx
... Definitions of variables Age and disease duration at the time of each visit were reported in years Disease dura- Page of tion was calculated from the date of physician diagnosis of SLE to the date of ... time, 64.7% of patients varied between having normal and elevated TC levels, with hypercholesterolemia recorded for 36% of the total number of visits Likewise, the status of 46.4% of patients ... interpretation of results, and preparation of manuscript; DDG, in the study design, collection of data, interpretation of results, and preparation of manuscript; DI, in the study design, analysis of data,...
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Báo cáo y học: " Importance of cumulative exposure to elevated cholesterol and blood pressure in development of atherosclerotic coronary artery disease in systemic lupus erythematosus: a prospective proof-of-concept cohort study" pdf
... at the level of the heart Korotkoff phase V (disappearance) was recorded as DBP Calculation of ‘summary measures’ of TC, SBP and DBP For each of TC, SBP and DBP, an arithmetic mean of all available ... minimum effective dose of corticosteroids The demonstration of a cardioprotective association of antimalarials highlights the staple role of this class of drugs in the management of patients with SLE ... analysis of data, interpretation of results, and preparation of manuscript DDG and MBU participated in the study design, collection of data, interpretation of results, and preparation of manuscript...
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Báo cáo y học: "Markers of collagen synthesis and degradation are increased in serum in severe sepsis: a longitudinal study of 44 patients" pdf
... basis as an organ specific SOFA score of one to two and organ failure as a SOFA score of three to four A patient was defined to have MOF if the daily SOFA scores of two or more organ systems ... because of a lack of previous studies on collagen turnover in severe sepsis Results Patients A total of 1361 patients admitted to the ICU over a period of 1.5 years were screened for eligibility Of ... at the beginning of the study Of the different organs, collagen synthesis in lungs has been most profoundly studied in critical illness ARDS is the most severe manifestation of acute lung injury...
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A Study on Sentence Errors of the English Compositions of the Second Year Students at Diplomatic Academy of Vietnam = Nghiên cứu lỗi về câu trong các bài viết c
... Table The frequency of stringy sentences Table The frequency of “the sentence structure errors of the other types” Table The sources of errors iv TABLE OF CONTENTS Pages Statement of authorship ... consists of the steps as being suggested by Corder (1981: 36): 1) identification of errors, 2) description of errors, and 3) explanation of errors Research questions What are sentence errors made ... language and the process of language learning Corder (1981: 36) suggests three key steps of EA research: 1) identification of errors, 2) description of errors, and 3) explanation of errors Among the...
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Efficient texture synthesis with a small set of tiles
... Texture synthesis results of our ω-tile approach with input of stochastic pattern… ………………………………………….……….…… …… 37 Figure 5.3 Texture synthesis results of our ω-tile approach with input of stochastic ... Texture synthesis results of our ω-tile approach with input of stochastic pattern.………………………… …………………………… … … 39 Figure 5.5 Texture synthesis results of our ω-tile approach with input of semistructured ... Texture synthesis results of our ω-tile approach with input of semistructured pattern.……………………………………………… ….… 42 Figure 5.7 Texture synthesis results of our ω-tile approach with input of semistructured...
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A facile construction of the tricyclic 5 7 6 scaffold of fungi derived diterpenoids the rst total synthesisof (±) heptemerone g and a new approach to danishefsky s intermediate for a guanacastepene
... total synthesis of (±)-heptemerone G (2) and in a synthesis of the (±)-guanacastepene precursor Key features of the synthesis include an efficient new synthetic sequence for annulation of the ... led to the formation of mixtures of products After considerable experimentation, we found that treatment of a suspension of 11 in ethylene glycol with Scheme Construction of the required stereogenic ... OTMS c) O O O d) O O O e) O 8 17 18 Scheme Highlights of the proposed scheme for the synthesis of We now report the first total synthesis of heptemerone G (2) and, en route, a new synthetic approach...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008