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antioxidants in human health and disease pdf

Báo cáo khoa học: Regulation of matrix metalloproteinase activity in health and disease pdf

Báo cáo khoa học: Regulation of matrix metalloproteinase activity in health and disease pdf

Báo cáo khoa học

... integrin-binding ligandN-linked glycoprotein (SIBLING)Individual members of the SIBLING family are knownto bind strongly to both pro- and active forms ofspecific MMPs. Bone sialoprotein binds ... proMMP-binding partnersinvolved in activation.Allosteric activationGelatinase interactions with collagen and gelatinBinding of macromolecules or specific thiol-bindingreagents to an MMP with an intact ... activation by binding tothe 64 kDa intermediate form of MMP-2 [52]. Binding and activation of MMP-2 was abrogated in the pres-ence of avb3 integrin-binding macromolecules such asvitronectin and HKa...
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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

Báo cáo khoa học

... mutation in the BTK PH domain; arginine 28 is in dark blue, encircled in red. Bottom left: SH2 domain. Right: kinasedomain. The mutated residues are indicated in yellow, a-helices are in cyan, ... T-cell kinase (ITK) could in uence the infectivity of HIV and also have anti -in ammatory activity. Since 2006, several patients carry-ing a fusion protein, originating from a translocation joining ... Holland J, DaviesA, Flinter F, Hammarstrom L, Kinnon C, LevinskyR, Bobrow M et al. (1993) The gene involved in X-linked agammaglobulinaemia is a member of the srcfamily of protein-tyrosine kinases....
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in human malignancies and potential therapy pdf

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in human malignancies and potential therapy pdf

Báo cáo khoa học

... proteins. Thus, the MEN1 ⁄ LEDGF-interactingdomain linked to DNA-binding domains (AT-hook and MT domain) becomes disconnected from the PHDdomains, the FYRN domain, the transactivatingdomain, ... 2010)doi:10.1111/j.1742-4658.2010.07608.xThe increasing number of chromosomal rearrangements involving the human MLL gene, in combination with differences in clinical behavior and outcome for MLL-rearranged ... proteins. The common denominator in alldifferent MLL rearrangements is disruption of the MLLprotein in a region that prevents any subsequent pro-tein–protein interaction between the resulting...
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Modern Nutrition in Health and Disease pot

Modern Nutrition in Health and Disease pot

Sức khỏe giới tính

... myofibrillar protein from tissues containing myosin and actin (muscle, smooth muscle such as gut, skin). In man, 3-methylhistidine is quantitatively excreted into urine; in rat, 3-methylhistidine is also ... of Free Amino Acids in the BodyIt is important to bear in mind the differences in the relative amounts of N contained in extracellular and intracellular amino acid pools and in protein itself. ... to measure arginine kinetics in pediatric burn patients and determined little net de novo arginine synthesis, suggesting that under conditions of burn injury, insufficient arginine is made to...
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Báo cáo khoa học: Expression of cholinesterases in human kidney and its variation in renal cell carcinoma types pdf

Báo cáo khoa học: Expression of cholinesterases in human kidney and its variation in renal cell carcinoma types pdf

Báo cáo khoa học

... erythrocytes, and the difference between acetylcholinesterases of kid-ney and erythrocytes in the extent of binding with thelectins concanavalin A, Lens culinaris agglutinin(LCA), and Ricinus communis ... ofAlzheimer’s disease in the brain in vivo.Neurobiol Aging doi:10.1016/j.neurobiolaging.2010.04.028.26 Vidal CJ (2005) Expression of cholinesterases in brain and non-brain tumours. Chem Biol Interact ... in oligomers [11]. Five 5¢-alternative acetyl-cholinesterase mRNAs have been identified in mice and three in humans [11,12], and acetylcholinesterase-H,acetylcholinesterase-T and acetylcholinesterase-RmRNAs...
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Báo cáo khoa học: Nuclear localization of human spermine oxidase isoforms – possible implications in drug response and disease etiology pptx

Báo cáo khoa học: Nuclear localization of human spermine oxidase isoforms – possible implications in drug response and disease etiology pptx

Báo cáo khoa học

... decreases in intracellular spermine pools and increased spermidine levels in SMO1 and SMO5cells. These changes in spermine and spermidine levels in both SMO1 and SMO5 overexpressing cell lineswere ... (1991)Correlations between polyamine analogue-inducedincreases in spermidine ⁄ spermine N1-acetyltransferaseactivity, polyamine pool depletion, and growth inhibi-tion in human melanoma cell lines. Cancer Res ... theoxidation of spermine to spermidine diminishes nuclearspermine pools. Because spermine has essential roles in the the protection of DNA, including free radical scav-enging and DNA shielding, this reduction...
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The Neuronal Environment: Brain Homeostasis in Health and Disease pot

The Neuronal Environment: Brain Homeostasis in Health and Disease pot

Điện - Điện tử

... and mRNA binding to cytosolic and poly-some proteins in brain and peripheral tissues. Brain Res. Mol. Brain Res. 58, 170–177.39. Lauger, P. (1991) Na,K-ATPase, in Electrogenic Ion Pumps, Sinauer, ... HOMEOSTASIS AND NEUROLOGICAL DISEASE Substantial progress has been made in the understanding of the pathophysiology and mechanisms involved in the attenuation of brain homeostasis. In many diseases ... metabolites and to remove waste products.The Neuronal Environment: Brain Homeostasis in Health and Disease examines the function of all the components involved, including their perturbation dur-ing...
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Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt

Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt

Báo cáo khoa học

... modulated by lumican-evoked signaling,including vinculin and focal adhesion kinase [82].Lumican alters the relationship between actin filaments and b1 integrin, which in turn would affect focal adhe-sion ... with the EGF-binding domain [32]. Thestructural constraints of the EGFR binding regionsupport a stochiometry of 1 : 1 for the decorin pro-tein core and EGFR, suggesting that decorin is bio-logically ... leucine-rich proteoglycans (SLRPs) are involved in many aspectsof mammalian biology, both in health and disease. They are now being rec-ognized as key signaling molecules with an expanding...
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Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt

Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt

Báo cáo khoa học

... motif) that maintains them as inactivezymogens, and a catalytic domain with a z inc-binding site(Zn, HEXXHXXGXXH) and a conserved methionine(Met-turn) supporting the catalytic zinc. Interactionbetween ... (GAIP)-interacting C-terminus ⁄synectin and calc ium ⁄ calmodulin-associated serine kinase,since the C2 region contains a class II PSD-95 ⁄Discs-large ⁄ Zonula occludens protein-binding motifFXF, ... cysteine–zinc maintains proMMPs in an inac-tive state by preventing a water molecule from bindingto the zinc atom. All MMPs, with the exceptionof MMP-7, MMP-23 and MMP-26, also contain ahemopexin-like...
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Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx

Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx

Báo cáo khoa học

... Accumulating evidences indicate thatHSPGs act to inhibit cellular invasion by promotingtight cell–cell and cell–ECM interactions, and by main-taining the structural integrity and self-assembly ... signaling.Expression of HSulf-1 in cell lines derived from head and neck carcinoma inhibits cell growth, motility and invasion in vitro [17]. Similarly, overexpression ofHSulf-1 and HSulf-2 in ... theseemingly distinct protein domains observed in the 3Dmodel, namely the TIM-barrel and C-domain regions,mediate enzymatic and nonenzymatic functions of hep-aranase, respectively. Interestingly,...
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Poultry health and disease control in developing countries doc

Poultry health and disease control in developing countries doc

Nông nghiệp

... pivotal roles in the poultry industry, through protecting both poultry and human health (see Information Note on “Veterinary Roles in Health and Knowledge Transfer across a Poultry Industry”).The ... developing industry. The interfacing of industry and government poultry health production activities can then help to drive both (Bagust, 1999; Information Note on “Veterinary Roles in Health and ... health and disease control in developing countriesInformation Note on “Site Biosecurity and Supporting Strategies for Disease Control and Prevention”) work together to reduce the risk of introduction...
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THE HEALTH PROMOTING SCHOOL: INTERNATIONAL ADVANCES IN THEORY, EVALUATION AND PRACTICE pdf

THE HEALTH PROMOTING SCHOOL: INTERNATIONAL ADVANCES IN THEORY, EVALUATION AND PRACTICE pdf

Sức khỏe giới tính

... issuesrelated to maintaining adolescents’ health and well-being’ – suggesting thatthe school has a role to play in helping parents understand some of the key health challenges facing young people.Section ... Research in the Finnish ENHP SchoolsKerttu Tossavainen, Hannele Turunen and Harri Vertio 291 15 The Views of School Health Nurses on Promoting the Health and Well-Being of Young People in Finnish ... well being. There is littledoubt that teaching is a demanding profession, and if schools take seriously the health promoting school philosophy, the health and well being of teachers – and other...
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The Maternal Management of Children, in Health and Disease ppt

The Maternal Management of Children, in Health and Disease ppt

Sức khỏe giới tính

... child, and induce a state of body deficient in vigour, and unfit for maintaining full health: scrofula and other diseases would be induced. At the same time let the mother guard againstpampering, ... quantity, and as a consequence of thisprocess being interrupted, the food passing on into the bowel undigested, will there ferment and become sour,will inevitably produce cholic and purging, and in ... effectually to prevent indigestion, and bowel complaints, and the irritable condition of the nervoussystem, so common in infancy, and secure to the infant healthy nutrition, and consequent strength...
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