and total sleep deprivation induced cell damage and apoptosis
Tài liệu Báo cáo khoa học: Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis docx
... untreated control cells; lane 4, Glu-Pg-treated cells; lane 5, Glu-Pg- and mAb A10.2-treated cells; lane 6, Glu-Pg- and mAb 34D3-treated cells Bands in lanes and correspond to forms I and II of plasmin(ogen) ... their respective contribution to Gluand Lys-Pg binding and activation onto fibrin and cells, as well as their effects on fibrinolysis and on plasmin -induced cell apoptosis The LBS specificity of these ... Lys-plasmin(ogen) binding and activation These structural–functional transitions are determinant in the initiation and development of both fibrinolysis and cell detachment -induced apoptosis and may therefore...
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Báo cáo khoa học: ERK and cell death: Mechanisms of ERK-induced cell death – apoptosis, autophagy and senescence doc
... Daniels MA (2009) ERK and cell death: ERK location and T cell selection FEBS J Martin P & Pognonec P (2009) ERK and cell death: cadmium toxicity, sustained ERK activation and cell death FEBS J Taylor ... ⁄ ERK pathway and senescence Mechanisms of ERK -induced senescence Cellular senescence is an irreversible form of cell cycle arrest that prevents proliferation of damaged cells or cells that have ... cisplatin -induced apoptosis in renal cells J Biol Chem 277, 43377–43388 15 ERK and cell death S Cagnol and J.-C Chambard 26 Arany I, Megyesi JK, Kaneto H, Price PM & Safirstein RL (2004) Cisplatin-induced...
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Báo cáo sinh học: " The herpes simplex virus UL20 protein functions in glycoprotein K (gK) intracellular transport and virus-induced cell fusion are independent of UL20 functions in cytoplasmic virion envelopment" docx
... production and virus -induced cell fusion The results suggest that virus -induced cell fusion mechanisms are not required for cytoplasmic virion envelopment Materials and methods Cells and viruses ... functioning in UL20p/gK intracellular transport and virus -induced cell fusion Conclusion These results show that UL20p domains required for UL20p and gK intracellular transport and TGN localization can ... confirmed Intracellular transport and TGN localization of UL20p mutants and gK Transport and localization of UL20p and gK was further assessed by transient coexpression of gK and UL20p and simultaneous...
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báo cáo khoa học: "Quantum dot-induced cell death involves Fas upregulation and lipid peroxidation in human neuroblastoma cells" pptx
... of FOXO3a, Fas ligand, and Bim, and induces cell apoptosis Int J Oncol 2006, 29(3):643-648 Maysinger D, Lovric J, Eisenberg A, Savic R: Fate of micelles and quantum dots in cells Eur J Pharm ... factor deprivation and additional QD-insult [14] These multiple insults to neuroblastoma cells lead to cell death both by apoptosis and necrosis The latter is characterized by mitochondrial and ... of CdTe QD -induced toxicity include multiple organelle damage and involve increased Fas receptor expression and cell membrane lipid peroxidation in SH-SY5Y neuroblastoma cells These damages bring...
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Báo cáo y học: " Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin c" ppsx
... CS -induced protein oxidation in vitro and apoptosis and lung damage in guinea pigs in vivo Effect of N-acetyl cysteine (NAC) on CS -induced protein oxidation in vitro and apoptosis and lung damage ... inducing protein oxidation, proteolysis and apoptosis both in vitro and in A549 epithelial cells pBSQ also mimics CS -induced inflammation, apoptosis and lung damage in vivo Tracing to the mechanism ... clear and more specific information about the cellular and molecular mechanisms of CS -induced lung damage [22] Using histopathlogy and morphometric measurements here we show that while oxidative damage...
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Báo cáo y học: " Skill execution and sleep deprivation: effects of acute caffeine or creatine supplementation - a randomized placebo-controlled trial" potx
... placebo treatment sleep deprivation was associated with a significant fall in performance (a) (p < 0.001) compared to non -sleep deprivation The 50 and 100 mg/kg creatine and and mg/kg caffeine ... interesting differences across acute sleep deprivation and across caffeine and creatine treatments In line with observations in other skill and psychomotor testing acute sleep deprivation reduced the accuracy ... non -sleep deprivation The 50 and 100 mg/kg creatine and and mg/kg caffeine doses were all associated with a significantly better performance (b) (p < 0.001) than the placebo conditions Acute sleep...
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Báo cáo khoa học: Molecular and functional characterization of a novel splice variant of ANKHD1 that lacks the KH domain and its role in cell survival and apoptosis docx
... tested cell lines and this siRNA was used in subsequent assays Following transfection of VBARP siRNA into HeLa and NT2 cells, physical observation revealed that cell death occurred in a dose- and cell- dependent ... of normal cellular events such as cell cycle and apoptosis, RNA interference studies were performed using VBARP siRNA and control siRNA Several VBARP siRNA duplexes were synthesized and purified ... HEK293 T cells expressing Vpr and VBARP by cotransfecting Vpr and VBARP-His using calcium phosphate transfection Forty-eight hours post transfection, the cells were lysed and the whole cell proteins...
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Báo cáo khoa học: G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis pptx
... facilitate cell survival and to prevent apoptotic cell death In fact, dominant negative alleles of Akt reduce the ability of growth factors, extracellular matrix and other stimuli to support cell survival ... neurons protected the cells against K+ -induced apoptosis [61] In neuronal PC12 cells, agonist activation of exogenously expressed muscarinic M1 receptors protected against apoptosis induced by growth ... activate Akt and cell survival [65], while an uncharacterized Gs-coupled receptor for the peptide hormone ghrelin protects pancreatic b-cells against induced apoptosis via both Akt and MAPK pathways...
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Báo cáo khoa học: Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis doc
... in vitro wound healing, cell migration and apoptosis, and for DP8 in wound healing, cell migration and apoptosis enhancement (Table 4) DP9 overexpression impaired 2452 cell behavior with regard ... involved in cell ECM interactions and influence apoptosis, but DP8 did not influence adhesion and only DP9 acted as a primary trigger of apoptosis DP8 and DP9 may also have in vivo roles as intracellular ... threshold and lowpass filter was used to count migrated cells by measuring the total area covered by cells (bright field) and the area covered by fluorescence-positive cells in the wound and nonwound...
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Báo cáo sinh học: " G0/G1 arrest and apoptosis induced by SARS-CoV 3b protein in transfected cells" pot
... Histogram of cell cycle arrest and cell apoptosis Histogram of cell cycle arrest and cell apoptosis Histogram showing the percentages of cells at various phases of cell cycle p3b/EGFP-N1 positive cells ... of cell cycle arrest and cell apoptosis by 3b protein expression Induction of cell cycle arrest and cell apoptosis by 3b protein expression p3b/EGFP-N1 plasmid was transfected into COS-7 cells, ... of cells from G0/G1 phase into S phase, and induced cells toward apoptosis Next, using similar method, we investigated the effects of p3b/EGFP-N1 on cell cycles in 293 and Vero cells In these cells,...
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báo cáo hóa học:" G0/G1 arrest and apoptosis induced by SARS-CoV 3b protein in transfected cells" pot
... Histogram of cell cycle arrest and cell apoptosis Histogram of cell cycle arrest and cell apoptosis Histogram showing the percentages of cells at various phases of cell cycle p3b/EGFP-N1 positive cells ... of cell cycle arrest and cell apoptosis by 3b protein expression Induction of cell cycle arrest and cell apoptosis by 3b protein expression p3b/EGFP-N1 plasmid was transfected into COS-7 cells, ... of cells from G0/G1 phase into S phase, and induced cells toward apoptosis Next, using similar method, we investigated the effects of p3b/EGFP-N1 on cell cycles in 293 and Vero cells In these cells,...
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Báo cáo khoa học: "SemiHemizygosity for Atm and Brca1 influence the balance between cell transformation and apoptosis" ppt
... loss for two genes - ATM and BRCA1 in primary cells for two endpoints: cell transformation and cell apoptosis Cells matching these criteria were derived from established Atm and Brca1 heterozygous ... the DNA damage induced by radiation is less efficiently repaired in double hemizygous cells and may point to an increased mutation accumulation in these cells after DNA damage is induced Apoptosis ... cells This elevated background of DNA damage may point to the higher vulnerability of these cells to DNA damage and cell transformation if additional damage is induced Micronucleus Assay Figure shows...
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Báo cáo khoa học: "The use of caspase inhibitors in pulsed-field gel electrophoresis may improve the estimation of radiation-induced DNA repair and apoptosis" pdf
... demonstrate that apoptosis induced by agarose is a component of total DNA breakage, and that the inhibition of apoptosis allows for more proper estimation of radiation -induced DNA DSB repair and apoptosis ... American Type Cell Collection (LGC Promochem, Barcelona, Spain), and human pancreatic carcinoma NP18 cell line NP18 cell line was perpetuated in our laboratory as cell culture and xenografts ... inference of the apoptosis Figure illustrates the effect of abrogating apoptosis in NP18 cells from a xenograft, showing clear differences between initial and residual radiation -induced damage depending...
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Báo cáo y học: "Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis" potx
... concentrations of resveratrol and/ or curcumin alone or with IL-1β as described in Materials and methods, and the effect of resveratrol and/ or curcumin on IL-1β -induced apoptosis was examined at the ... products (Bcl-2, Bcl-xL and TRAF1) Resveratrol and curcumin inhibited pro-apoptotic proteins (caspase-3, PARP) and matrix degrading gene products (MMP3 and MMP-9), and angiogenesis and inflammation ... collection and interpretation, and the manuscript preparation AM and MS conceived of the study design, and coordinated the studies, data interpretation and manuscript preparation All authors read and...
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báo cáo khoa học: " 6-Nitro-2-(3-hydroxypropyl)-1H-benz[de] isoquinoline-1,3-dione, a potent antitumor agent, induces cell cycle arrest and apoptosis" pot
... (Figure 3) and camptothecin and cis-platin used as standards (Figure 4) Apoptosis recorded in untreated control MOLT-4 and HL-60 cells were 3.61% and 2.54% respectively In MOLT-4, total apoptosis ... grids and stained with uranyl acetate and lead citrate The sections 87.56 Doxorubicin % of cells 1d Live cells Apoptotic cells Necrotic cells Figure Induction of apoptosis by compound 1i (10.0 and ... Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non-small cell cancer cells Cancer Lett 2007, 257:216-222 13 Thornberry NA: Caspases: Key mediators of apoptosis Chem...
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Tài liệu Báo cáo khoa học: Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis pdf
... (±standard error of the mean) (C) Cos-1 cells were transfected with vector only, JSP1-wt or -G2A Cells detached from the culture dish and attached cells were collected separately, and total cell ... tightly regulated mechanism for the disposal of damaged cells and to remove cells during normal growth and development [27,40] Cells that undergo apoptosis initially become rounded, which is accompanied ... inactive mutant, induced 30% of the transfected cells to float off the dish and undergo apoptosis Interestingly, the cells could tolerate high levels of the myristoylationdeficient mutant and remain...
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Tài liệu Báo cáo khoa học: Role of ceramide kinase in peroxisome proliferatoractivated receptor beta-induced cell survival of mouse keratinocytes ppt
... reduced cell survival and enhanced apoptosis induced by serum starvation [5] Although these previous reports suggest that CerK and C1P are involved in the regulation of cell survival or cell proliferation, ... h Total cellular lipids were extracted using the standard Bligh–Dyer protocol Total cellular Cer levels were measured by diacylglycerol kinase assay as described under Materials and methods and ... regulation of programed cell death in plants and in cell survival in mammalian cells [4] Arabidopsis, carrying a CerK mutation, exhibits a spontaneous cell- death phenotype and accumulates Cer late...
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Tài liệu Báo cáo khoa học: Intralysosomal iron chelation protects against oxidative stress-induced cellular damage doc
... stress -induced cell damage and a close correlation between initial lysosomal rupture and later development of cellular damage and death Results Hydrogen peroxide -induced mitochondrial injury and cell ... for cellular iron in transit through the lysosomal compartment and, thus, within hours, cells will start to become affected by iron starvation and nally die [5,12] Interestingly, dfo -induced apoptosis, ... and analyzed using the cellquest software Cells with reduced red uorescence were gated Assessment of cell proliferation Five hundred thousand cells were seeded per well and exposed for 30 to oxidative...
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Báo cáo khoa học: ATP-binding domain of heat shock protein 70 is essential for its effects on the inhibition of the release of the second mitochondria-derived activator of caspase and apoptosis in C2C12 cells potx
... V-FITC and pyridine iodination (PI) co-staining and analyzed by flow cytometry Q3 cells were regarded as control cells, whereas Q4 cells were considered as a measure of early apoptosis, Q2 cells ... inhibition of H2O2 -induced activation of caspases-9 and -3 and apoptosis (A) The effects of HSP70 and its deletion mutant proteins on the activation of caspases-9 and -3 were analyzed Cells over-expressing ... caspases-9 and -3 (Fig 6A) after exposure to H2O2 for h, as well as the inhibition of H2O 2induced apoptosis as assessed by the percentage of apoptotic cells (P < 0.05) (Fig 6B) and cell viability...
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