akt oxidative stress and apoptosis
Báo cáo khoa học: Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice pdf
... cardiac oxidative stress, myocyte apoptosis and the DCM phenotype Materials and methods * Animals WT CYP2E1 cTnTR141W Fig Determination of the levels of cytochrome c release, cleaved caspases and ... CYP2E1-mediated oxidative stress and myocyte apoptosis are also evident in cTnTR141W transgenic mice These results support a possible correlation between CYP2E1 expression and apoptosis in this ... hypothesis that oxidative stress and myocyte apoptosis play an important role in the pathogenesis of cardiovascular diseases such as ischemic heart disease, atherosclerosis, cardiomyopathy and cTnTR141W...
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Tài liệu OXIDATIVE STRESS AND DISEASES pptx
... OXIDATIVE STRESS AND DISEASES Edited by Volodymyr Lushchak and Dmytro V Gospodaryov Oxidative Stress and Diseases Edited by Volodymyr Lushchak and Dmytro V Gospodaryov ... 4 Oxidative Stress and Diseases Evidences for connection of oxidative stress with the stresses induced by other factors are promptly gained The potency of transition metals, some herbicides and ... pathologies and oxidative modification of proteins Most antioxidant and related enzymes are targets for oxidative modification Hence, if oxidative stress was primary event, possible oxidative modifications...
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Tài liệu Báo cáo khoa học: Enhancement of oxidative stress-induced apoptosis by Hsp105a in mouse embryonal F9 cells pptx
... JNK and p38 pathways are activated by cellular stresses and inflammatory cytokines, resulting in growth arrest and apoptosis, and have been implicated as key regulators of stress- induced apoptosis ... Hsp105 enhances oxidative stress- induced apoptosis (Eur J Biochem 269) 4147 Fig Enhancement of oxidative stress- induced apoptosis by over-expression of Hsp105a (A) F9, V1, S3 and S23 cells were ... and lower panels represent activated and total JNK or p38, respectively Ó FEBS 2002 Hsp105 enhances oxidative stress- induced apoptosis (Eur J Biochem 269) 4149 Fig Suppression of oxidative stress- induced...
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Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues ppt
... oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues Particle and Fibre Toxicology 2011 8:20 Submit your next manuscript to BioMed Central and ... lesions on a standard chow diet It is used for studies of hyperlipidemia and atherosclerosis, and has been used extensively in understanding the mechanisms of lipoprotein metabolism and atherosclerosis ... insights into the roles and mechanisms of PM2.5-associated physiology and pathology In summary, our data demonstrate the important effects of PM2.5 exposure on oxidative stress and mitochondrial alterations...
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Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc
... exposed to oxidative stress (2.5 mm and mm HA) with PARP inhibition and allowed to develop, the spores showed faster germination (32 h and 60 h) as compared to cells exposed to oxidative stress alone ... oxidative stress (Fig 4A,B) Under oxidative stress, partial inhibition of PARP activity led to altered growth, suggesting that oxidative stress could be leading to cell cycle arrest [22] and that ... 20 Oxidative stress induces PARP activation PARP activity in D discoideum was assayed at various time points (5, 10, 20 and 60 and h) after HA stress PARP activity was increased initially, and...
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Báo cáo khoa học: The silencing of adenine nucleotide translocase isoform 1 induces oxidative stress and programmed cell death in ADF human glioblastoma cells doc
... conductance and thus in the reduction of ROS production and oxidative stress Three previous studies [19,39,40] report that ANT1 overexpression induces apoptosis in a variety of immortalized fibroblasts and ... effects of BA, ATR and ANT1 siRNA on cell viability and glucose consumption (A,B) Cell growth curves analyzed by crystal violet assay in BA and vehicle-treated (A) and in ATR and vehicle-treated ... survival, thus indicating that ANT1 effect is mediated by oxidative stress A possible explanation for the ANT1-silencing effect on oxidative stress and cell survival could reside in the loss of the basal...
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Báo cáo khoa học: Oxidative stress and apoptotic events during thermal stress in the symbiotic sea anemone, Anemonia viridis potx
... hyperthermal stress on antioxidant induction and on apoptotic markers (caspase-like activation and ⁄ or DNA degradation) in order to demonstrate the concomitant involvement of oxidative stress and apoptosis ... studies and supports the occurrence of an oxidative stress period in heat stressed A viridis [24] We suggest that apoptosis induction could be the consequence of the previous oxidative stress ... of oxidative FEBS Journal 273 (2006) 4186–4198 ª 2006 The Authors Journal compilation ª 2006 FEBS 4193 Apoptosis and oxidative stress in bleaching S Richier et al stress in the animal host and...
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Báo cáo sinh học: "Adipose-Derived Mesenchymal Stem Cell Protects Kidneys against Ischemia-Reperfusion Injury through Suppressing Oxidative Stress and Inflammatory Reaction" ppt
... reducing apoptosis, and suppressing oxidative stress in this experimental setting of acute kidney IR injury The cause of discrepancy between mRNA and protein expressions of HO-1 on both day and day ... another anti -oxidative biomarker, was remarkably lower in group than in groups and 3, and significantly lower in group than in group at 24 h and 72 h after IR injury On the other hand, this protein ... [24] ADMSC Transplantation Attenuates Inflammatory Response, Suppresses Oxidative Stress, and Limits Cellular Apoptosis and Architectural Damage in Kidney Following Acute IR Injury–Impact of Immune...
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báo cáo hóa học: " Biomarkers of oxidative stress and its association with the urinary reducing capacity in bus maintenance workers" pptx
... variation in oxidative stress markers in healthy and type II diabetic men Chronobiol Int 2002, 19:423-439 68 Hardeland R, Coto-Montes A, Poeggeler B: Circadian rhythms, oxidative stress and antioxidative ... against oxidative stress [7] was verified by testing the correlation between levels of 8OHdG, reflecting oxidative stress, and the reducing capacity (corresponding to a defense against oxidative stress) ... significantly influenced by OC and NO x (both with random effect modelsTable and fixed models - Additional file Table S6), and particulate copper content (only for the random effect models-Table 3)...
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Báo cáo khoa học: " Induction of oxidative stress and lipid peroxidation in rats chronically exposed to cypermethrin through dermal application" pps
... of erythrocytes to handle the hydrogen peroxide to molecular oxygen and water [11,29] GSH-Pxs catalyze the peroxides and reduce the glutathione to form oxidized glutathione and water [30] A significant ... Press, New York, 1983 Andreyev AY, Kushnareva YE, Starkov AA Mitochondrial metabolism of reactive oxygen species Biochemistry (Mosc) 2005, 70, 200-214 Athar M Oxidative stress and experimental carcinogenesis ... Adam-Vizi V Effect of cypermethrin on oxidative stress after dermal application 259 10 11 12 13 14 15 16 17 18 19 20 21 22 Exacerbated responses to oxidative stress by an Na+ load in isolated nerve...
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Báo cáo y học: " Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells" potx
... 0.01, and §p < 0.001 compared with control group L = Live; A = Apoptosis; N = Necrosis References Kode A, Yang SR, Rahman I: Differential effects of cigarette smoke on oxidative stress and proinflammatory ... ethidium bromide and appeared red Percentage of viable (white bars), apoptotic (grey bars) and necrotic/late apoptotic (black bars) determined by counting as described in Materials and Methods Results ... necrosis with no or little evidence of apoptosis in human lung cancer cells (H1299) Figure Cigarette smoke extract caused necrosis with no or little evidence of apoptosis in human lung cancer cells...
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Báo cáo y học: " Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells" pps
... vitro and lung in vivo under oxidative stress Am J Physiol 1995, 269:L285-L292 Moodie FM, Marwick JA, Anderson CS, Szulakowski P, Biswas SK, Bauter MR, Kilty I, Rahman I: Oxidative stress and cigarette ... the stain were considered viable Assay of apoptosis and necrosis Morphological evidence of apoptosis and necrosis was obtained by means of acridine orange and ethidium bromide staining as described ... smoke extract (CSE 0.5 and 1.0%) dose-dependently increased the levels of nuclear NF-κB RelA/p65 in SAEC after hr treatment (Figures 11A and 11B) Discussion Oxidative stress and inflammatory events,...
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Báo cáo y học: "Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxiainduced mitochondrial mutagenesis in inflammatory arthritis" pot
... between oxidative stress, inflammation and angiogenesis, where increase in tpO2 and reduce oxidative stress observed in responders is associated with lower microscopic scores of T-cells (CD4 and ... oxidative stress and clinical parameters of disease activity and suggest that microscopically assessed levels of 4-HNE may closely reflect clinical scores of IA Synovial levels of oxidative stress, ... levels at T3 compared with T0 (data not shown) Synovial oxidative stress and clinical markers The relation of oxidative stress marker and clinical markers pre/post anti-TNF-a therapy is shown in Table...
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Hypersensitivity to cell death under glucose starvation involves oxidative stress and AMPK instability
... two isoforms of α-subunit (α1 and α2 by prkaa1 and prkaa2), two of β-subunit (β1 and β2 by prkab1 and prkab2), and three of γ-subunit (γ1, γ2 and γ3 by prkag1, prkag2 and prkag3) (Chen et al., 2009; ... be removed and recycled and the targeted proteins are degraded into small peptides (Glickman and Ciechanover, 2002; Hershko and Ciechanover, 1998; Komander and Rape, 2012; Naujokat and Sarić, ... and fragmentation, and membrane blebbing (Kerr et al., 1972; Long and Ryan, 2012) Apoptosis is executed through two pathways: the extrinsic pathway stimulated by extracellular death ligands and...
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Báo cáo khoa học: Increased expression of c-Fos by extracellular signal-regulated kinase activation under sustained oxidative stress elicits BimEL upregulation and hepatocyte apoptosis pot
... (ATZ) and mercaptosuccinic acid inhibited catalase and glutathione peroxidase, which are antioxidative enzymes that eliminate hydrogen peroxide, and caused sustained increases in ROS levels and apoptosis ... sustained oxidative stress This idea is supported by data showing that transient oxidative stress for or h did not induce apoptosis [38] In conclusion, ERK activation resulting from sustained oxidative ... apoptosis Therefore, the increase in c-Fos downstream of ERK activation is critical for BimEL upregulation and apoptosis The duration of exposure to oxidative stress affects c-Fos stability and...
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Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... direct and secondary excitotoxic neuronal injuries in vivo Excitotoxicity, oxidative stress and apoptosis comprise major routs of hypoxic-ischemic neuronal death Each route is likely activated and ... TBARS and decreased concentration of TAS supports the oxidative stress in anoxia and reperfusion and suggests a possible role for anti oxidants in preventing neuro- 153 degeneration in anoxia and ... transporter-I (GLT-1), and also microglial antiporter for cystine and glutamate which may release glutamate when the demand of glutathione synthesis was increased by oxidative stress (55) From our...
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Tài liệu OXIDATIVE STRESS – MOLECULAR MECHANISMS AND BIOLOGICAL EFFECTS doc
... and Volodymyr I Lushchak Chapter Oxidative and Nitrosative Stresses: Their Role in Health and Disease in Man and Birds 47 Hillar Klandorf and Knox Van Dyke Chapter Nitric Oxide Synthase and Oxidative ... glycoxidation and carbonyl /oxidative stress 30 Oxidative Stress Molecular Mechanisms and Biological Effects The existence of a strong relation between carbonyl and oxidative stresses can be ... OXIDATIVE STRESS MOLECULAR MECHANISMS AND BIOLOGICAL EFFECTS Edited by Volodymyr Lushchak and Halyna M Semchyshyn Oxidative Stress Molecular Mechanisms and Biological Effects...
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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
... Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury Cell Calcium 36, 257–264 441 Ca2+, mitochondria, ROS in neuronal disease C Chinopoulos and V Adam-Vizi 17 Andreyev AY, ... proteins residing in both the inner and outer mitochondrial membrane, that is activated by mitochondrial Ca2+ overloading and other factors including oxidative stress [88,89] In neurons the presence ... mechanisms and implications in human pathology IUBMB Life 52, 159–164 30 Barja G (1999) Mitochondrial oxygen radical generation and leak: sites of production in states and 3, organ specificity, and relation...
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Báo cáo khoa học: Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress pdf
... Transcriptional analysis of bcp2 under oxidative stress and characterization of mRNA 5¢ end 0,3 0,2 0,1 • 10 Time (h) Fig S solfataricus P2 cultures treated with different oxidative stress agents Sulfolobus ... 2, pUC19 and 10 mM DTT; lane 3, pUC19 and lM FeCl3; lane 4, pUC19, 10 mM DTT, and lM FeCl3; lane 5, pUC19, 10 mM DTT, lM FeCl3, and 50 lgÆmL)1 rBcp2; lane 6, pUC19, 10 mM DTT, lM FeCl3, and 50 ... involved in the oxidative stress in S solfataricus To detect differences in the response to various agents we induced oxidative stress with paraquat, an O2 ) generating compound, H2O2 and tert-butyl...
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