activation of guanylyl cyclase
Báo cáo khoa học: Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C pdf
... substrate, where guanylyl cyclase activity can be observed even in the absence of ligand Again, in contrast to the significant loss of ST-mediated activation of guanylyl cyclase activity, 50% of the activity ... soluble guanylyl cyclase as well as protein kinase G and activation of the soluble guanylyl cyclase leads to inhibition of Na+/H+ exchanger NHE3 [22] and apical Cl–/OH–exchange activity by activation ... means of regulation of a member of the guanylyl cyclase receptor family, by controlling the amounts of differentially glycosylated forms of GC-C in a cell Given the fact that the 130 kDa form of...
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Báo cáo khoa học: The functional genomics of guanylyl cyclase⁄natriuretic peptide receptor-A: Perspectives and paradigms potx
... forms of guanylyl cyclase found in the eye Proc Natl Acad Sci USA 92, 602–606 Yu S, Avery L, Baude E & Garbers DL (1997) Guanylyl cyclase expression in specific sensory neurons: a new family of chemosensory ... Pandey KN (1997) Expression of guanylyl cyclase- A ⁄ atrial natriuretic peptide receptor blocks the activation of protein kinase C in vascular smooth muscle cells Role of cGMP and cGMP-dependent ... of the molecular basis of the functional regulation of Npr1 and the mechanisms of ANP–NPRA action are not yet clearly understood Currently, natriuretic peptides are considered to be markers of...
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Báo cáo khoa học: Homologous desensitization of guanylyl cyclase A, the receptor for atrial natriuretic peptide, is associated with a complex phosphorylation pattern pot
... activation of the A-type natriuretic peptide receptor Mol Cell Biol 18, 2164–2172 Potter LR & Hunter T (1999) Identification and characterization of the phosphorylation sites of the guanylyl cyclase- linked ... Schroter et al ¨ Phosphorylation of the ANP receptor Guanylyl cyclase activity X-fold vs maximal activity A * 0.8 GC-A S487E all n = 0.4 0.2 GC-A 0.0 Basal 0.1 Guanylyl cyclase activity X-fold vs maximal ... References Kuhn M (2003) Structure, regulation, and function of mammalian membrane guanylyl cyclase receptors, with a focus on guanylyl cyclase- A Circ Res 93, 700–709 John SW, Krege JH, Oliver PM,...
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Báo cáo khoa học: ATP allosteric activation of atrial natriuretic factor receptor guanylate cyclase pot
... (1999) Regulation of photoreceptor membrane guanylyl cyclases by guanylyl cyclase activator proteins Methods 19, 521–531 Gibson AD & Garbers DL (2000) Guanylyl cyclases as a family of putative odorant ... motif of the ARM in the activation of ANF-RGC To assess this possibility, the 669WTAPELL675 deletion mutant of ANF-RGC was analyzed for ANF ⁄ staurosporine-dependent activation of the cyclase ... nonhydrolyzable analog of ATP, AMP-PNP mimicked 60–70% of the ATP effect with respect to ANF activation of ANF-RGC activity [22,25] The remaining 40–30% of ATP activity in ANF-RGC activation was predicted...
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Báo cáo khoa học: An internal ribosome entry site mediates the initiation of soluble guanylyl cyclase b2 mRNA translation potx
... Functional properties of a naturally occurring isoform of soluble guanylyl cyclase Biochem J 335, 125–130 Yuen PS, Potter LR & Garbers DL (1990) A new form of guanylyl cyclase is preferentially ... Schultz G (1991) Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase Interchangeability of the alpha-subunits of the enzyme FEBS Lett 292, 217–222 Russwurm M, Behrends ... NO-activated guanylyl cyclases expressed in cells Br J Pharmacol 139, 1032–1040 12 Nighorn A, Byrnes KA & Morton DB (1999) Identification and characterization of a novel beta subunit of soluble guanylyl cyclase...
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Báo cáo khoa học: Irregular dimerization of guanylate cyclase-activating protein 1 mutants causes loss of target activation ppt
... the ability of guanylyl cyclase- activating protein GCAP-2 to regulate photoreceptor guanylyl cyclase J Biol Chem 272, 14327–14333 11 Hwang, J.-Y & Koch, K.-W (2002) The myristoylation of the neuronal ... and a mechanism of photoreceptor guanylyl cyclase activation J Biol Chem 274, 25583–25587 21 Ermilov, A.N., Olshevskaya, E.V & Dizhoor, A.M (2001) Instead of binding calcium, one of the EF-hand ... M & Koch, K.-W (1999) Identification of a domain in guanylyl cyclase- activating protein 23 24 25 26 27 28 29 30 31 that interacts with a complex of guanylyl cyclase and tubulin in photoreceptors...
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Báo cáo khoa học: "Circadian pattern of activation of the medical emergency team in a teaching hospita"
... 08:00–18:00 (47% of calls during 42% of the day), a substantial proportion of MET calls occur after normal working hours (53% of calls during 58% of the day), with the peak time of activity occurring ... the Austin Hospital and 2568 activations of the MET service Activation of the MET service was not uniform over the 24-hour period (Fig 1) Over the study period, 53% of the 2568 calls occurred in ... time, a detailed analysis of the level of utilization of a MET service over a 24-hour period and found a significant increase in the number of MET calls around periods of nursing handover and routine...
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Tài liệu Báo cáo khoa học: Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis pdf
... preferentially the phosphorylation of the p46 isoform of JNK, whereas sorbitol treatment induced phosphorylation of both the p46 and p55 isoforms To confirm functional activation of the JNK signaling pathway, ... by distinct sets of stimuli [1–4] Of particular importance to this study is the JNK family of MAPKs, which are predominantly activated by proinflammatory cytokines and a variety of environmental ... extent of MAPK activation depends not only on the activity of kinases, but also the protein phosphatases that dephosphorylate the Tyr and Ser ⁄ Thr residues in substrate proteins that are part of...
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Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf
... mechanism for furin-mediated activation of transmembrane substrates The activation of ADAM17 by furin [68] and our observation of an interaction between GRASP55 and the ICD of ADAM17 (C Roghi and L ... to AAA573 could explain the reduction of the level of cell surface expression of this mutated version of MT1-MMP It is important to note that perturbation of the GRASP55 interaction with TGF-a ... 2010 FEBS C Roghi et al Role of GRASP55 in MT1-MMP activation ting that the disruption of the interaction between MT1-MMP and GRASP55 could affect the activation of the protease Taken together,...
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Tài liệu Báo cáo khoa học: Lipopolysaccharide-evoked activation of p38 and JNK leads to an increase in ICAM-1 expression in Schwann cells of sciatic nerves ppt
... summary, upregulation of ICAM-1 expression in SCs after direct stimulation with LPS occurred via activation of MAPKs, especially the p38 and SAPK ⁄ JNK pathways Activation of MAPK pathways might ... accumulation and antigen-induced activation of T cells in inflammatory demyelinating diseases of the PNS As mentioned above, MAPKs were implicated in the activation of NF-jB in SCs in response to ... LPS-induced activation of the p38 and SAPK ⁄ JNK MAPK cascades is responsible for the synthesis of ICAM-1 in SCs Discussion The present study demonstrated that LPS induces ICAM-1 expression in SCs of...
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Tài liệu Báo cáo khoa học: Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signaling pptx
... activation was strongly inhibited by selective inactivation of the AP-1 site and completely inhibited by simultaneous inactivation of the AP-1 and PEA-3 ⁄ ETS-1 sites Selective inactivation of ... activation was strongly inhibited by selective inactivation of the AP-1 site and completely inhibited by simultaneous inactivation of the AP-1 and PEA-3 ⁄ ETS-1 sites Selective inactivation of ... sustained activation of Rac by overexpression of the Rac-specific activator, Tiam1, or overexpression of V12-Rac1, strongly induces transcriptional upregulation of tissue inhibitor of metalloproteinase...
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Tài liệu Báo cáo khoa học: Activation of the Torpedo nicotinic acetylcholine receptor The contribution of residues aArg55 and cGlu93 ppt
... agonist of the WT nAChR and it elicits a maximum current of only 1.5 ± 0.1% of the ACh response (data not shown) The WT receptor was activated by PTMA with an EC50 of 57 lm and a Hill coefficient of ... concentration-effect curves for the activation of WT nAChR(n) and inhibition of the ACh-induced response of aR55F (s) mutant receptors (Table 2, see text for details) (B) Inhibition of ACh-evoked currents ... EC50 value for activation of that subtype Similar data show a lack of significant effect of dTC on the aR55W and R55E mutant receptors (data not shown) Fig compares the density of binding sites...
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Tài liệu Báo cáo khoa học: Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4b-phorbol 12-myristate 13-acetate pptx
... [16], and also affects the type of cellular response that is evoked [17,18] Activation of ERK is required for proliferation of fibroblasts [19] and constitutive ERK activation frequently occurs in ... expression of genes involved in cell cycle progression include Elk1, c-fos, c-Jun and c-myc [9,15] The duration of ERK activation (transient or sustained) determines the repertoire of target genes ... the synergistic effect EGF concentration-dependency of synergistic activation To investigate the synergistic activation in the second phase of the time profile further, we measured the ERK-PP concentration...
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Tài liệu Báo cáo Y học: Phosphorylation of initiation factor-2a is required for activation of internal translation initiation during cell differentiation ppt
... translational activation of the IRES-containing mRNA Since internal translation is independent of the 5¢-cap structure of the mRNA, we did not focus our attention on the changes in the activity of the ... translation of specific mRNAs during the course of differentiation During the early developmental stages of Xenopus, Caenorhabditis elegans and Drosophila, the translation of subclasses of mRNAs ... StuI–NcoI 7.5-kb fragment of pLL to generate pLML pcK3L was generated by insertion of the NcoI (filled)– BamHI 0.3-kb fragment of pTM1-K3L [18] into the HindIII (filled)–BamHI sites of pcDNA3 (Invitrogen)...
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Tài liệu Báo cáo Y học: The solution structure and activation of visual arrestin studied by small-angle X-ray scattering pot
... concentration range of 30–150 lM (1.3–6.5 mgÆmL)1), 90 lL of arrestin solution was mixed with 10 lL of 10 mM peptide solution to yield a final peptide concentration of mM For higher concentrations of arrestin ... and arrestin in the presence of phosphopeptide is given at the top of the (B) and (C), expressed as a percentage of the total signal from the detector Activation of visual arrestin (Eur J Biochem ... wild-type arrestin The effect of the R175Q mutation on the properties of arrestin is consistent with the observed effect of the phosphopeptide: both cause activation of arrestin but produce very...
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Báo cáo khoa học: Involvement of lysine 1047 in type I collagen-mediated activation of polymorphonuclear neutrophils doc
... process Results Inhibition of collagen-mediated activation of PMNs by 6-amino-hexanoic acid In a first set of experiments, the potential involvement of lysine residues in PMN activation was evaluated ... the results obtained in arbitrary units) and activation of PMNs by a1CB6 peptides was expressed as a ratio of the intensity of activation to the amount of a1CB6 peptides deposited The results are ... results obtained in arbitrary units), and activation of PMN by a1CB6 peptides was expressed as a ratio of the intensity of activation to the amount of a1CB6 peptides deposited The results are...
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Báo cáo khoa học: Activation of nematode G protein GOA-1 by the human muscarinic acetylcholine receptor M2 subtype Functional coupling of G-protein-coupled receptor and G protein originated from evolutionarily distant animals doc
... indicating that the side effect of the activation of GAR-3 is limited Furthermore, the phenotype of gar-3 loss -of- function mutants is almost wildtype with the exception of a faster pharyngeal pumping ... directly fused at the C-terminus of M2 A myc-epitope tag was added at the N-terminus of M2 To prevent rapid degradation, the central part of the third intracellular loop of M2 was deleted [26] Asn ... presence of 0.2 mM atropine; solid line, in the absence of atropine atropine (Fig 3A), suggesting that carbamylcholine induced the substitution for GTPcS in GOA-1 The IC50 value of the displacement of...
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Báo cáo khoa học: Stimulation of fibroblast proliferation by neokyotorphin requires Ca2+ influx and activation of PKA, CaMK II and MAPK/ERK pdf
... general, the action of neokyotorphin in L929 cells appears be similar to that of cAMP Results Effect of neokyotorphin in the absence of growth factors To test the ability of neokyotorphin to ... 7) The activity of lm neokyotorphin was inhibited over the whole concentration range of H-89, confirming the involvement of PKA in the effect of neokyotorphin As for participation of the other H-89-suppressed ... may be due to the pleiotropicity of the role of the sensitive forms of PKC in L929 cell proliferation [36] In the presence of bisindolylmaleimide XI, the effect of neokyotorphin did not change...
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Báo cáo khoa học: Adenine nucleotides inhibit proliferation of the human lung adenocarcinoma cell line LXF-289 by activation of nuclear factor jB1 and mitogen-activated protein kinase pathways doc
... cells via activation of NF-jB Attenuation of LXF-289 cell proliferation by ATP is mediated by the activation of the MEK ⁄ ERK1 ⁄ 2, PI3K and p38 MAPK pathways Activation and translocation of the ... Inhibition of proliferation of LXF-289 lung tumor cells Effects of P2 receptor agonists The influence of the different P2 receptor agonists is shown as percentage inhibition of the proliferation of LXF-289 ... proliferation of LXF-289 cells by regulation of cell cycle progression through activation of several signal transduction pathways The delay in cell cyle progression through activation of P2Y receptors...
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Báo cáo khoa học: Activation of activating transcription factor 2 by p38 MAP kinase during apoptosis induced by human amylin in cultured pancreatic b-cells ppt
... dose-responsive effect of hA on activation of p38 kinase In parallel experiments, we studied the effects of inhibition of ERK1 ⁄ and p38 kinase on hA-induced caspase-3 activation and apoptosis ... activation in islet b-cells, through activation of the JNK pathway [15,23] In the current study, we planned to determine whether either of the other two MAP kinases, ERK and p38 kinase, and activation ... indicating that increased activation of ATF-2 is correlated with induction of apoptosis and the ability of hA to form b-sheet-containing aggregates In contrast, we found that levels of nonphosphorylated...
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