4 effective strategies for hiv aids care should be validated and adapted for use in other chronic diseases
báo cáo khoa học: " A win-win solution?: A critical analysis of tiered pricing to improve access to medicines in developing countries" pptx
... market and industry is increasingly globalizing, competitive pharmaceutical producers in LMICs are emerging, unmet health needs in the developing world remain immense, and political demand for access ... approaches to measuring affordability have been proposed, including benchmarking medicine prices against per capita gross national income (GNI), setting prices against “catastrophic” household health ... markets by indication However, similar discounts are also needed for use against other fungal infections such as meningococcal meningitis in people living with HIV/ AIDS, illustrating the public...
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Herbal Antibiotics Natural Alternatives for Treating Drug-Resistant Bacteria doc
... ulcerations in the gastrointestinal tract, from gums to rectum; for active infections in the sinuses when used as snuff or sinus wash; for active infections in the vagina when used as a douche; for active ... same actions), and (within a certain range) grapefruit seed extract (see individual entry) Ginger (Zingiber Officinale) Family: Zingiberaceae Part used: The root is used for medicine and food Collection: ... against bacteria (Information on how to make herbal preparations from these herbs can be found in chapter 4, Making and Using Herbal Medicines For instance, the tincture formula for echinacea says...
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Báo cáo y học: "Percutaneous laser disc decompression for thoracic disc disease: report of 10 cases"
... diagnostic test for chronic spinal pain Pain Physician 2008;11:631 -42 Singh V, Derby R Percutaneous lumbar disc decompression Pain Physician 2006;9:139 -46 Singh V, Manchikanti L, Benyamin RM, et al ... diameter of the working environment and because a running irrigant would reduce the laser's effectiveness and thus increase operating times Total lasing time was approximately minutes, but varied ... was used to create a stab incision of approximately ¼ inch Through the incision, an 18-gauge, 3.5-inch spinal needle was inserted and the needle was guided into the middle of the disc using fluoroscopy...
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Advances in StentTherapy for Ischaemic Heart Disease
... P=0.31 In Stent P=0.32 In Segment 8-month Clinical Event Rate Restenosis Rate (%) 14 Sirolimus (n=6 84) P=0. 54 12 Paclitaxel (n=699) 10 11.5 10.6 10 .4 9.2 P=0.62 5.5 4. 8 4. 7 4. 6 5.0 5 .4 1.8 P=0 .41 ... (83) 2.9% (15) 4. 4% (23) 0.6% (3) 3.8% (20) 23.2% (122) 27.2% ( 143 ) 9.3% (49 ) 27 .4% ( 144 ) 30.1% (158) 0 .4 0.9 0.3 0 .4
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Tài liệu Báo cáo khoa học: Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters docx
... Ile 54 are frequent in APV resistance and the I54M mutation causes six-fold increased IC50 [20] Mutation I54V appears in resistance to indinavir, lopinavir, nelfinavir and SQV [13] I54V in combination ... 3713 HIV protease mutants altering hydrophobic clusters 41 42 43 44 45 46 47 48 49 50 51 52 C-H Shen et al important for the differential activity of retroviral proteases J Mol Biol 267, 46 7 47 5 ... in A with black lines indicating PRWT and ˚ red lines indicating the mutant Interatomic distances of > 4. 3 A are shown in dash-dot lines to indicate the absence of favorable interaction FEBS...
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Tài liệu Báo cáo khoa học: Progress for dengue virus diseases Towards the NS2B–NS3pro inhibition for a therapeutic-based approach ppt
... putative methyltransferase domain in NS5 protein of 2998 35 36 37 38 39 40 41 42 43 44 45 46 47 48 flaviviruses and lambda protein of reovirus J Gen Virol 74, 733– 740 Tan BH, Fu J, Sugrue RI, Yap ... NS2A, NS2B, and NS3 J Virol 64, 43 64 43 74 Preugschat F & Strauss JH (1991) Processing of nonstructural proteins NS4A and NS4B of dengue virus in vitro and in vivo Virology 185, 689–697 Brinkworth ... Chem 46 , 41 49 41 64 16 Allison SL, Schalich J, Stiasny K, Mandl CW & Heinz FX (2001) Mutational evidence for an internal fusion peptide in flavivirus envelope protein E J Virol 75, 42 68 42 75 17 Beasley...
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Tài liệu EXTERNAL SYMPTOMS FOR DIAGNOSING POULTRY DISEASES ppt
... Infectious coryza; chronic respiratory disease; infectious bronchitis; influenza Mouth Symptom Pustules Crusts at margins Beak soft, rubbery Possible Cause Nutritional deficiency-vitamin A Nutritional ... yellow jasmine poisoning Newcastle disease; fowl cholera; brain infection; improper injection of Marek's vaccine Newcastle disease; nutritional deficiency-thiamin Nutritional deficency-vitamin E; ... deficiencies-pantothenic acid or biotin Nutritional deficiencies-vitamin D or calcium-phosphorus imbalances White coat over tongue and Wet form of fowl pox in mouth Mycotoxins; chemical injury Ulcers Wattles...
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Tài liệu Báo cáo Y học: Receptor crosstalk Implications for cardiovascular function, disease and therapy ppt
... Y., Kanamori, T., Matsuda, Y & Kinoshita, M (1996) Endogenous atrial natriuretic peptide 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 inhibits endothelin-1 in dogs with severe congestive ... (NPRs) belong to the so-called type I transmembrane single-chain receptors containing three domains: intracellular catalytic GC, adjacent kinase-like and extracellular ligand-binding domains They ... not be sustained, because of compelling evidence revealing that catecholamines not only transduce their signalling via both a- and b-AR subtypes [11], but also in uence the downstream signalling...
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For Chronic Kidney Disease: Evaluation, Classification and Stratification doc
... Urine Albumin in Adults 1 04 Spot Urine Dipstick Albumin vs Timed Urine Albumin in Adults .105 Spot Urine Protein-to-Creatinine Ratio vs Timed Urine Protein in Adults 105 Spot Urine ... Albumin-to-creatinine ratio • When monitoring proteinuria in adults with chronic kidney disease, the protein-to-creatinine ratio in spot urine samples should be measured using: • Albumin-to-creatinine ratio; ... Albumin-to-Creatinine Ratio vs Timed Urine Albumin in Adults 106 Spot Urine Protein-to-Creatinine Ratio vs Timed Urine Protein in Nondiabetic Children 106 Spot Urine Albumin-to-Creatinine...
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FACING THE REALITY OF DRUG-RESISTANT TUBERCULOSIS: CHALLENGES AND POTENTIAL SOLUTIONS IN INDIA pot
... retraining, on-the-job training, continuing education, and advanced training in management Training in problem solving, supervision, management, and planning is needed to supplement core training ... Challenges and Potential Solutions in India: Summary of a Joint Workshop by the Institute of Medicine, the Indian Nation 24 DRUG-RESISTANT TUBERCULOSIS IN INDIA administered for a minimum of months (intensive ... first- and second-line drugs should be considered in developing a regimen At least four anti-TB drugs that are certain, or almost certain, to be effective should be used When evidence of effectiveness...
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Medicines for Reproductive Health: Ensuring Access to Quality Assured Products potx
... expected to increase by 23% between 2000 and 20153 As such, demand for contraceptives exceeds supplies in many developing countries and is increasing In response to the growing desire for novel ... NET-EN - combined injection, Cyclofem - combined injection, Mesigyna Intrauterine devices - copper T - LNG-releasing Vaginal rings - copper T - LNG-releasing Vaginal rings - Monthly combined Implants ... standards of quality, safety and efficacy for HIV/ AIDS, malaria and tuberculosis It is supporting the improvement in manufacturing capacity by prequalifying products which have been assessed, inspected...
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INFLUENZA VIRUS a model for learning about disease
... rules re: DNA and RNA Parvoviruses contain single-stranded DNA Reoviruses contain double-stranded RNA DNA Viruses ssDNA dsDNA linear circular RNA Viruses Mostly single-stranded ... can only be seen with an electron microscope Animal viruses Proviruses- around 20 nm in diameter Mimiviruses- up to 45 0 nm in length Viewing viruses Special stains and an electron ... genomes that are ready for immediate translation into proteins Negative-sense RNA: genomes have to be converted into the proper form to be made into proteins Segmented- individual genes exist...
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Báo cáo khoa học: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract Implications for Parkinson’s disease docx
... substance P, vasoactive intestinal polypeptide, enkephalins, somatostatin, gastrin ⁄ cholecystokinin, neurotensin and dopamine beta-hydroxylase Neuroscience 5, 689– 744 FEBS Journal 2 74 (2007) 1212–1223 ... encoding these enzymes have previously been identified in tissues forming a physiological and enzymatic barrier against the environment Adh1 and Adh4 have been observed in the epithelial lining ... involvement in the metabolism of nitric oxide [ 14] ADH4 was first identified in gastric mucosa [15] and is the only form of ADH not expressed in liver ADH4 appears to be mainly involved in retinoid metabolism...
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Managing drug resistant tuberculosis ppt
... F15/ LAM4/KZN strain of Mycobacterium tuberculosis in KwaZulu-Natal, South Africa Clin Infect Dis 2007 ;45 : 140 9- 14 National Institute for Health and Clinical Excellence Tuberculosis: clinical diagnosis ... resistant to at least isoniazid and rifampicin and also to a fluoroquinolone and a second line injectable agent (amikacin, capreomycin, or kanamycin) Drug resistance in new tuberculosis cases (primary ... possible tuberculosis as this may hinder the diagnosis of tuberculosis and risks promoting the development of tuberculosis strains that are resistant to fluoroquinolones Principles of treatment informed...
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Radiological Findings of Extensively Drug-Resistant Pulmonary Tuberculosis in Non-AIDS Adults: Comparisons with Findings of Multidrug-Resistant and Drug-Sensitive Tuberculosis docx
... pulmonary TB and to compare the observed findings with findings of DS TB and non-XDR MDR TB in non -AIDS patients MATERIALS AND METHODS Our Institutional Review Board approved this study Patient informed ... of and a reconstruction interval of mm For the 4- 64- detector row CT scanners, scanning and image reconstruction was performed with a beam width of 0.625-10 mm and a beam pitch of 0.875-1.675 and ... 30 (71) 30 (71) 07 (17) 23 (55) 29 (69) 17 (40 ) 10 ( 24) 04 (10) 04 (10) 06 ( 14) (71) (86) (86) (86) (43 ) (0)0 (43 ) (43 ) (29) (43 ) (43 ) ( 14) (29) < 0. 046 < 0.369 < 0.380 < 0.015 < 0.319 < 0.191...
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Safe and Effective Medicines for Children: Studies Conducted Under the Best Pharmaceuticals for Children Act and the Pediatric Research Equity Act potx
... of labeling changes excludes some labeling changes for biologics (including vaccines) that were approved before September 27, 2007, and FDA was unable to supply the missing information Therefore, ... their use (including whether they had been validated for use with the age groups to be studied) in written requests and clinical reviews To approve the labeling of drugs for pediatric use, FDA and ... interested in better information to guide clinical care for children For the most part, the committee examined studies intended to support initial labeling of a drug or biologic for use in pediatric...
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Báo cáo khoa học: Amyloid–cholinesterase interactions Implications for Alzheimer’s disease pot
... acetylcholinesterases in other tissues J Biol Chem 262, 44 41 44 44 10 Geula C & Mesulam M (1989) Special properties of cholinesterases in the cerebral cortex of Alzheimer’s disease Brain Res 49 8, 185–189 11 Inestrosa ... the acetylcholinesterase-induced b-amyloid aggregation J Med Chem 48 , 44 44 44 56 Amyloid–cholinesterase interactions 35 Kwon YE, Park JY, No KT, Shin JH, Lee SK, Eun JS, Yang JH, Shin TY, Kim DK, ... disease In this context preliminary data from our laboratory indicates that acetylcholinesterase increases the Ab1 42 oligomeric formation, the incubation of acetylcholinesterase with Ab1 42 for h increases...
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Addressing the Threat of Drug-Resistant Tuberculosis potx
... 7-3Global clinical portfolio of TB drugs in development, 86 7 -4 Federal funding for HIV/ AIDS, 1982–2008, 89 7-5Funding for TB from the National Institute of Allergy and Infectious Diseases in fiscal ... data and described firsthand their experiences with MDR and XDR TB in multiple countries, including China, Cambodia, Ethiopia, Russia, and South Africa In addition, to provide baseline information ... rapid and reliable diagnostic methods that can be used at the point of care; Investment in the pipeline of new drugs, as well as proper use of existing first- and second-line therapies; Investment...
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Guideline for Alzheimer’s Disease Management pdf
... affected individual has much to invest in improving and maintaining quality of life, being involved in treatment planning, and contributing opinions and expressing desires related to specific plans for ... activity should be provided in the morning and early afternoon • Patients should be dressed during daytime hours • Caffeine and nicotine should be avoided, and nighttime fluids and diuretics should be ... involving them in care planning, heeding their opinions and wishes, and referring them to community resources, including the Alzheimer’s Association Patient and Family: Advance Planning for Care...
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Delamanid for Multidrug-Resistant Pulmonary Tuberculosis pdf
... that inhibits mycolic acid synthesis, has shown potent in vitro and in vivo activity against both drug-susceptible and drug-resistant strains of M tuberculosis in preclinical development.8,9 In ... and negative for MDR TB 160 Were included in the intention-totreat group and were assessed for safety 125 (78.1%) Were included in the modified intention-to-treat group and assessed for efficacy ...
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